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All Journal Medical Journal of Indonesia Indonesian Journal of Cancer Jurnal Profesi Medika: Jurnal Kedokteran dan Kesehatan Journal Of Nursing Practice Faletehan Health Journal Indonesian Journal of Global Health research Journal of Holistics and Health Sciences (JHHS) Proceedings of the International Conference on Nursing and Health Sciences Indonesian Journal of Cancer Proceedings Book of International Conference and Exhibition on The Indonesian Medical Education and Research Institute
Achmad Fauzi Kamal
Faculty Of Medicine Universitas Indonesia/Cipto Mangunkusumo Hospital, Indonesia
Biochemistry, Genetics & Molecular Biology Economics, Econometrics & Finance Education Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Medicine & Pharmacology Neuroscience Nursing Public Health

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Optimal time point for evaluation in a chronic peripheral nerve injury rat model: a preclinical study Widodo, Wahyu; Dilogo, Ismail Hadisoebroto; Kamal, Achmad Fauzi; Antarianto, Radiana Dhewayani; Wuyung, Puspita Eka; Siregar, Nurjati Chairani; Octaviana, Fitri; Kekalih, Aria; Suroto, Heri; Aprilya, Dina; Canintika, Anissa Feby
Medical Journal of Indonesia Vol. 35 No. 1 (2026): March
Publisher : Faculty of Medicine Universitas Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.13181/mji.oa.257778

Abstract

BACKGROUND Peripheral nerve injury (PNI) can cause severe functional disabilities and progresses dynamically over time. Since evaluations held at different time points will yield different results, finding an optimal model for PNI comparison is needed. This study aimed to create an animal model of chronic denervation that simulates the progress of nerve injury. METHODS 6 male Sprague-Dawley rats underwent complete sciatic nerve transection in their right hind limbs, with severed nerve ends secured to a nearby muscle to prevent nerve regrowth. The rats were sacrificed at 2, 3, and 4 weeks. The assessment included walking analysis (pre- and post-injury), wet muscle weight measurement, and histological examination. RESULTS Progressive gastrocnemius muscle degeneration was observed at 3 different time points. Minimal degenerative changes were noted at 2 weeks, while extensive fibrosis (83.25 [12.19]% collagen area) appeared in the 4th week. The 3rd-week samples showed lymphocyte infiltrations, muscular atrophy, and progressive fibrosis, making it the best model for chronic PNI. CONCLUSIONS A 3-week chronic denervation model is proposed as a long-term PNI for further regenerative research.
Platelet-Rich Plasma as a Pharmacopuncture Agent in Cervical Myofascial Pain Nareswari, Irma; Kamal, Achmad Fauzi; Mihardja, Hasan; Yunus, Reyhan Eddy; Jusuf, Ahmad Aulia; Harahap, Alida Roswita; Wahyuni, Luh Karunia; Werdhani, Retno Asti; Handayani, Selfi; Rukmindar, Dion
Proceedings Book of International Conference and Exhibition on The Indonesian Medical Education Research Institute Vol. 9 No. - (2025): Proceedings Book of International Conference and Exhibition on The Indonesian M
Publisher : Writing Center IMERI FMUI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.69951/proceedingsbookoficeonimeri.v9i-.310

Abstract

Chronic cervical myofascial pain (CMP) is a prevalent musculoskeletal disorder characterized by persistent neck pain, inflammation, functional impairment, and altered pain processing. Conventional treatments, including pharmacological therapy and physical rehabilitation, often provide limited and temporary relief. Increasing evidence suggests that chronic CMP involves not only peripheral nociceptive input but also nociplastic pain mechanisms driven by sustained neuroimmune dysregulation and central sensitization. Pharmacopuncture, combining acupuncture point stimulation with localized injection of therapeutic agents, has evolved with the introduction of regenerative biologics such as platelet-rich plasma (PRP). PRP contains concentrated platelets and bioactive growth factors, including VEGF, PDGF, and TGF-β, which exert anti-inflammatory and tissue-reparative effects. Emerging data indicate that PRP pharmacopuncture may reduce pro-inflammatory cytokines (e.g., IL-1β and TNF-α), modulate regulated cell death pathways (e.g., apoptosis and pyroptosis), and promote the restoration of myofascial tissue homeostasis. These mechanisms may contribute to both peripheral tissue repair and attenuation of nociplastic pain processing. This narrative review synthesizes current clinical and experimental evidence on the biological mechanisms and therapeutic potential of PRP pharmacopuncture in chronic CMP. Available studies report meaningful improvements in pain intensity and functional outcomes compared with conventional acupuncture or pharmacotherapy alone. However, substantial methodological heterogeneity may arise from PRP preparation protocols, acupoint selection, and outcome measures, limiting the ability to draw definitive conclusions. High-quality randomized controlled trials incorporating standardized protocols and mechanistic biomarkers are required to establish PRP pharmacopuncture as an evidence-based integrative treatment for chronic CMP.
Co-Authors Ahmad Aulia Akbar Nur Aprilya, Dina APRIZAL, RIZA Aria Kekalih Bambang Gunawan Besral Canintika, Anissa Feby Debie Dahlia Eka Wiratnaya Elfrida Ratnawati Errol Untung Hutagalung Evelina Kodrat Evelina Kodrat Fitri Octaviana Harahap, Alida Roswita Hasan Mihardja HENDRA MASKA, HENDRA Heri Suroto Heru Widyawarman, Heru Idia Indar Anggraeni Ismail Hadisoebroto Dilogo Jessica Fiolin Kasiyah M. Junus Kurniadi Husodo, Kurniadi Ludwig A. Pontoh Luh Karunia Wahyuni, Luh Karunia Masfuri Masfuri Nareswari, Irma Nurjati Chairani Siregar Pakasi, Trevino Aristarkus Peter Giarso Priyanto Priyanto Priyanto Puspita Eka Wuyung Radiana Dhewayani Antarianto Retno Asti Werdhani Reyhan Eddy Yunus Rino Pattiata RINO PATTIATA Risa Dumastoro RIZA APRIZAL Rukmindar, Dion Sahrudi Sahrudi Saptawati Bardosono Selfi Handayani Setyowati Sholahuddin Rhatomy SIREGAR, NURYATI CHAIRANI THARIQAH SALAMAH, THARIQAH Wahyu Widodo Wahyu Widodo Wulyo Rajabto Yogi Prabowo YOGI PRABOWO YOSHI PRATAMA DJAJA, YOSHI PRATAMA