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All Journal HAYATI Journal of Biosciences Jurnal Hortikultura Indonesia (JHI) Majalah Obat Tradisional Journal of Tropical Biodiversity and Biotechnology Syntax Literate: Jurnal Ilmiah Indonesia FENOMENA Jurnal Riset Biologi dan Aplikasinya Journal of Multidisciplinary Applied Natural Science Makara Journal of Science Sewagati Prosiding Seminar Nasional Pengabdian kepada Masyarakat (SINAPMAS) Edubiotik : Jurnal Pendidikan, Biologi dan Terapan
Anjar Tri Wibowo
1Department Of Biology, Faculty Of Science And Technology, Airlangga University, Surabaya, Indonesia. 2Biotechnology Of Tropical Medicinal Plants Research Group, Faculty Of Science And Technology, Airlangga University, Surabaya, Indonesia
Agriculture, Biological Sciences & Forestry Arts Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Decision Sciences, Operations Research & Management Earth & Planetary Sciences Economics, Econometrics & Finance Education Energy Engineering Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Mathematics Medicine & Pharmacology Physics Public Health Social Sciences Other

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Journal : HAYATI Journal of Biosciences

 1 
Gynura procumbens Adventitious Root Extract Altered Expression of Antioxidant Genes and Exert Hepatoprotective Effects Against Cadmium-Induced Oxidative Stress in Mice Sugiharto; Dwi Winarni; Anjar Tri Wibowo; Ufairanisa Islamatasya; Idqa Nurtri Bhakti; Nabilatun Nisa; Boon Chin Tan; Yosephine Sri Wulan Manuhara
HAYATI Journal of Biosciences Vol. 29 No. 4 (2022): July 2022
Publisher : Bogor Agricultural University, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.4308/hjb.29.4.479-486

Abstract

Exposure to cadmium (Cd) could increase of reactive oxygen species (ROS) and changes in expression of antioxidant genes. Gynura procumbens is a medicinal plant that is rich in phenolic and flavonoid compounds. The aimed of study to evaluate the hepatoprotective effect of G. procumbens adventitious root (GAR) extract against Cd toxicity, especially expression rate of hepatic antioxidant genes. Twenty-five male mice were treated as follows: P1 (control), P2 (Cd100mg/L), P3 (GAR100mg/L + Cd100mg/L), P4 (GAR200mg/L + Cd100mg/L), and P5 (GAR300mg/L + Cd100mg/L). The samples (blood and liver) were collected for analysis of malondialdehyde (MDA) levels, superoxide dismutase (SOD) and catalase (CAT) activities, and their relative gene expression were determined. The hematological assay showed Cd-treated administered with GAR extract increased the number of red blood cells (RBC), haemoglobin concentration (HGB), hematocrit (HCT), mean corpuscular volume (MCV), and mean corpuscular haemoglobin (MCH), but reduced the level of alanine aminotransferase (ALT) and aspartate aminotransferase (AST). In addition, the GAR extract decreased the MDA production, but increased the activities of SOD and CAT. These enzymatic activities were positively correlated with their respective gene transcripts. Our study revealed that GAR extract administration showed marked hepatoprotective effects against Cd-induced oxidative stress.
Optimization of Biomass and Secondary Metabolite Production in Gynura procumbens (Lour.) Merr. Adventitious Roots Culture by Using the Method of Subculture and Fed-batch Cultivation in a Bioreactor Dannis Yuda Kusuma; Alfinda Novi Kristanti; Anjar Tri Wibowo; Boon Chin Tan; Yosephine Sri Wulan Manuhara
HAYATI Journal of Biosciences Vol. 30 No. 5 (2023): September 2023
Publisher : Bogor Agricultural University, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.4308/hjb.30.5.797-807

Abstract

The valuable extract of bioactive compounds from Gynura procumbens has been widely manufactured into various health products. The demand for these compounds is continuously increasing, but production through conventional farming methods is insufficient due to limited agricultural land and environmental stresses. An alternative to producing plant biomass is in vitro cultivation methods. This method requires less space and enables biomass propagation in a controlled condition that can facilitate stable and efficient production of plant secondary metabolites. This study evaluated the effect of inoculum subculture periods and culture methods on G. procumbens biomass and secondary metabolite production in a bioreactor. The 3-L airlift balloon type-bubble bioreactors was modified in this study to adopt the treatment of 1st-5th subculture periods and fed- and batch-cultivation strategies. We found the G. procumbens adventitious root culture was optimally derived from the 1st subculture produced biomass of 148.02±1.45 g FW and 8.59±0.12 g DW, and TPC (14.48±1.08 mg GAE/g DW) and TFC (116.89±0.44 mg KE/g DW and 33.97±0.13 mg QE/g DW). Additionally, the fed method after 28 days of culture using double distilled water replenishment improved adventitious root biomass (213.75±35.00 g FW and 11.21±0.18 g DW), while nutrient replenishment improved TFC (52.14±0.44 mg KE/g DW and 14.54±0.13 mg QE/g DW). These results can be used to optimize the cultivation of G. procumbens adventitious roots in a large-scale bioreactor.
Phenotypic and Estimated Genetic Variability in Endemic Diospyros celebica Bakh. and Widely-spread D. blancoi A.Dc. Cultivated at Purwodadi Botanic Garden, Indonesia Abywijaya, Ilham Kurnia; Rindyastuti, Ridesti; Jihans, Fira Fitria; Wibowo, Anjar Tri
HAYATI Journal of Biosciences Vol. 31 No. 4 (2024): July 2024
Publisher : Bogor Agricultural University, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.4308/hjb.31.4.781-792

Abstract

The endemic Diospyros celebica and widely spread D. blancoi are two valuable species of Diospyros (the genus of persimmons and ebonies) that have been conserved at botanic gardens in Indonesia. Understanding the biological contrasts between endemic and widely spread species is essential for plant conservation. This study aims to compare the phenotypic and estimated genetic variability between the endemic D. celebica and the widely spread D. blancoi to support their conservation. Fifty-three morphological characters from fifteen selected living plant specimens at Purwodadi Botanic Garden were measured directly or using variable encoding methods. Unpaired two-samples Wilcoxon test and hierarchical cluster analysis were used to compare morphological variations between both species. Further, genetic variabilities were estimated from encoded morphological characters using GenAlEx 6.503 software. The two Diospyros’ morphological characters were significantly different, except for the lamina length, pairs of leaf vein, number of flowers in each inflorescence, and the fruit sulci presence. The cluster analysis successfully distinguished D. celebica from D. blancoi according to thirteen comparable morphological characters. The endemic D. celebica has lower genetic variability (female/bisexual %P = 86.21%, He = 0.259, uHe = 0.277; male P = 54.29%, He = 0.195, uHe = 0.234) than the widely spread D. blancoi (female/bisexual %P = 86.76, He = 0.311, uHe = 0.355). Due to the importance of genetic diversity in plant conservation, both species’ population size needs to be maintained, if not increased, to preserve the existing phenotypic and genetic variabilities within the cultivated populations at the botanic garden.
Co-Authors Abdul Rahman Siregar, Abdul Rahman Abywijaya, Ilham Kurnia Agus Supriyanto Alfinda Novi Kristanti Almando Geraldi Awik Puji Dyah Nurhayati Ayu Lestari, Dewi Boon Chin Tan Boon Chin Tan BUDI SETIADI DARYONO Cahyo Wulandari Chrisetioningsih, Nadia Immanuela Dannis Yuda Kusuma Dannis Yuda Kusuma Djarot Sugiarso Dwi Kusuma Wahyuni Dwi Winarni Felayati, Themas Firli Rahmah Primula Dewi Hamidah . Himawan, Tyas Ikhsan Idqa Nurtri Bhakti Intan Ayu Pratiwi, Intan Ayu Jihans, Fira Fitria Junairiah Junairiah Kusuma, Dannis Yuda Latifah, Vida Rahma Listijani Suhargo, Listijani Manikya Pramudya Meitha, Karlia Miftahudin . Muhammad Hilman Fu'adil Amin Nabilatun Nisa Novitasari, Yeyen Nugrahapraja, Husna Nugroho, Giri Nur Syamsiatul Fajar, Nur Syamsiatul Priyono, Dwi Sendi Putri, Wahyu Aristyaning Putro, Karso Suryo Rachman, Mifta Pratiwi Ridesti Rindyastuti S. Sugiharto Sahat Saragih Sartika, Dian Sebastian, Alfino Sofyana, Neng Tanty Sri Puji Astuti Wahyuningsih, Sri Puji Astuti Subiastuti, Aprilia Sufi Sugiharto TATIK CHIKMAWATI Tuty Arisuryanti Ufairanisa Islamatasya Wijayanti, Ely Tri Yekti Asih Purwestri Yosephine Sri Wulan Manuhara Yosephine Sri Wulan Manuhara Yusuf, Adib Fakhruddin