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All Journal Natural Science: Journal of Science and Technology Jurnal Riset Mahasiswa Manajemen (JRMM) Biocelebes Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) Pharmacology and Clinical Pharmacy Research JSFK (Jurnal Sains Farmasi & Klinis) Jurnal Ilmu Kefarmasian Indonesia Jurnal Ilmiah Medicamento Medical Sains : Jurnal Ilmiah Kefarmasian Sciences of Pharmacy Medical Sains : Jurnal Ilmiah Kefarmasian
Akhmad Khumaidi
Jurusan Farmasi, Fakultas MIPA, Universitas Tadulako, Palu, Indonesia
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Decision Sciences, Operations Research & Management Health Professions Immunology & microbiology Medicine & Pharmacology Public Health

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FORMULASI TABLET ANTIOKSIDAN EKSTRAK BAWANG HUTAN (ELEUTHERINE BULBOSA MILL.URB) Karmini, Karmini; Yuliet, Yuliet; Khumaidi, Akhmad
Natural Science: Journal of Science and Technology Vol 3, No 3 (2014): Volume 3 Number 3 (December 2014)
Publisher : Univ. Tadulako

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (358.209 KB)

Abstract

Telah dilakukan penelitian mengenai formulasi tablet antioksidan ekstrak bawang hutan (Eleutherine bulbosa mill.urb) dengan tujuan untuk mengetahui pengaruh penggunaan variasi konsentrasi ekstrak bawang hutan pada mutu fisik dan aktivitas antioksidan tablet, mengetahui konsentrasi ekstrak yang memenuhi mutu fisik yang paling optimum dan mengetahui aktivitas antioksidan (IC50) dari tiap formula. Ekstrak dibuat dengan metode maserasi menggunakan pelarut etanol 96%. Proses pembuatan tablet dengan metode granulasi basah. Dilakukan uji mutu fisik granul dan uji mutu fisik tablet. Uji aktivitas antioksidan dilakukan secara in-vitro menggunakan metode DPPH pada formula 1, formula 2, formula 3 dan kontrol negatif dengan penggunaan Vitamin C sebagai kontrol positif. Data hasil pengukuran dianalisis secara statistik menggunakan metode ANOVA. Hasil penelitian menunjukkan bahwa penggunaan variasi konsentrasi ekstrak bawang hutan dengan konsentrasi 3,57%, 7,14% dan 10,71% pada sediaan tablet memperoleh mutu fisik tablet yang baik pada penyimpanan selama ± 1 bulan. Hasil uji aktivitas antioksidan dengan IC50 yang diperoleh pada hari ke-1 dan hari ke-28 kontrol negatif, formula 1, formula 2, dan formula 3 berturut-turut adalah 2110 ppm dan 2210 ppm; 126,18 ppm dan 135,73 ppm; 91,00 ppm dan 95,45 ppm; 46,87 ppm dan 50,93 ppm; dibandingkan dengan IC50 Vitamin C sebesar 4,93 ppm. Formula 1 mempunyai mutu fisik tablet yang paling optimum. Aktivitas antioksidan dari tiap formula masuk dalam kategori dari sangat kuat sampai sedang.
AKTIVITAS EKSTRAK ETANOL DAUN PEPOLO (Bischofia javanica BLUME) TERHADAP PENYEMBUHAN LUKA BAKAR PADA KELINCI (Oryctolagus cuniculus) Zainuddin, Suhaeni; Yusriadi; Khumaidi, Akhmad
Jurnal Ilmiah Medicamento Vol 5 No 2 (2019): Jurnal Ilmiah Medicamento
Publisher : Fakultas Farmasi Universitas Mahasaraswati Denpasar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36733/medicamento.v5i2.848

Abstract

Tumbuhan daun pepolo (Bischofia javanica Blume) merupakan salah satu tumbuhan yang digunakan untuk pengobatan luka bakar. Penelitian ini bertujuan untuk mengetahui aktivitas ekstrak daun pepolo terhadap penyembuhan luka bakar pada kelinci (Oryctolagus cuniculus). Pengujian aktivitas ekstrak etanol daun pepolo menggunakan 5 ekor kelinci yang dibagi dalam 5 kelompok perlakuan yaitu kontrol negatif (basis gel tanpa ekstrak), ekstrak etanol daun pepolo dalam basis gel dengan konsentrasi 5%, 10%, 15% dan kontrol positif (gel Bioplacenton). Pengukuran diameter luka dilakukan pada hari ke- 1, 3, 5, 7, 9, 11, 13, 15, 17, 19, dan 21. Data yang diperoleh dianalisis secara statistik dengan Metode One Way Anova. Hasil analisis statistik menunjukkan bahwa ekstrak daun pepolo pada konsentrasi 5%, 10% dan 15% memiliki aktivitas penyembuhan luka bakar. Penyembuhan luka bakar yang efektif yaitu konsentrasi 15%, yang memberikan penyembuhan sebesar 92,34%.
Faktor faktor yang Mempengaruhi Keputusan Pembelian Sepeda Motor Yamaha Mio Sporty Akhmad Khumaidi
Jurnal Riset Mahasiswa Manajemen Vol. 1 No. 1 (2013): April
Publisher : Fakultas Ekonomika dan Bisnis Universitas Kanjuruhan Malang

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Abstract

Yamaha sebagai pelopor sepeda motor matik di Indonesia dapat menggusur dominasi Honda dalam angka penjualan dengan produk Yamaha Mio Sporty, telebih adanya perubahan selera konsumen dari sepeda motor bebek ke sepeda motor matik. Mahasiswa Universitas kanjuruhan Malang sebagai bagian dari konsumen pengguna sepeda motor dijadikan sampel penelitian untuk mengetahui perilaku konsumen yang terdiri dari Faktor Budaya, Faktor Sosial, Faktor Pribadi dan Faktor Psikologi yang dapat mempengaruhi keputusan penbelian sepeda motor matik Yamaha Mio Sporty. Penelitian ini menggunakan metode peneltian explanatory reseach  untuk mengetahui hubungan kausal antara variabel bebas dengan variabel terikat, dengan sumber data diperoleh dari 40 responden. Pengambilan sampel menggunakan teknik purposive sampling dimana responden adalah pemilik sekaligus pengguna sepeda motor matik merek Yamaha Mio Sporty sebagai sarana transportasi ke kampus melalui pengisian kuisioner. Variabel yang diteliti terdiri dari variabel bebas yaitu faktor budaya (X1),faktor sosial (X2), faktor pribadi (X3), dan faktor psikologi (X4), dan  variabel terikat adalah keputusan pembelian (Y).  Analisis data menggunakan analisis regresi berganda, uji F, uji t, dan uji asumsi klasik. Hasil penelitian menunjukkan adanya pengaruh yang signifikan antara perilaku konsumen yang terdiri dari Faktor Budaya, Faktor Sosial, Faktor Pribadi dan Faktor Psikologi terhadap keputusan pembelian sepeda motor matik Yamaha Mio Sporty baik secara partial maupun secara simultan.  Faktor Sosial merupakan faktor yang berpengaruh dominan  terhadap keputusan pembelian sepeda motor matik merek Yamaha Mio Sporty oleh Mahasiswa Universitas Kanjuruhan Malang
KEANEKARAGAMAN JENIS TUMBUHAN OBAT TRADISIONAL DAN PEMANFAATANNYA PADA SUKU KULAWI DI DESA MATAUE KAWASAN TAMAN NASIONAL LORE LINDU Suhendar Arham; Akhmad Khumaidi; Ramadhanil Pitopang
Biocelebes Vol. 10 No. 2 (2016)
Publisher : Biology Department, Mathematics and natural science, Tadulako University

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Abstract

Ethnobotany is the study of medicinal plants of plant utilization in both everyday and cultural mores of a nation. The objective of this research was to identified the diversity of traditional medical plant and its utilization in kulawi local people at Mataue village Lore Lindu National Park. The research was conducted during April to May 2014 at Kulawi Sub-district of Sigi Regency Central Sulawesi. Identification process had been done at Biodiversity Laboratory, Faculty of Mathematics and Natural Sciences, Tadulako University. Methods which used on this study were survey and descriptive, consists of field survey and semi structural interview based on questionnaire. Outcome of the research showed that  there were 49 plant species covered from 30 families which were traditionally used as medicine. Leaves organ was the most widely applied as medicine with 58%  percentage, habitus type which highly found was herbaceous type with 51% percentage, and the most treated disease by the traditional medicine was non-communicable disease as much as 36%. Key words :Ethno botany, Medical Plant, Kulawi Local People.
STUDI ETNOBOTANI TUMBUHAN OBAT PADA MAYARAKAT KAILI RAI DI DESA TARIPA KECAMATAN SINDUE KABUPATEN DONGGALA SULAWESI TENGAH Sri Wahyuni A. Bana; Akhmad Khumaidi; Ramadhanil Pitopang
Biocelebes Vol. 10 No. 2 (2016)
Publisher : Biology Department, Mathematics and natural science, Tadulako University

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Abstract

This study aims to document the types of medicinal plants, how to use medicinal plants, the type of disease that can be cured, and perentase habitus herbs are used daily by the village community Taripa village and to utilization. This study was conducted in April-May 2014. The method used in this study is a combination of qualitative research methods and quantitative research. Recorded 41 species from 28 families were used by villagers Taripa as medicine. The cooking methods, namely by boiling, crushed, chewed, squeezed, the topical and sliced. Organs of traditional medicinal plants in use are the leaves, roots, stems, roots, rhizomes, fruits, bark, and stem. Plant organs most widely utilized is the percentage of leaves with the use of 63 %. The percentage of plants that use and know ledge of the highest of orange (Citrus aurantifolia) by 98 % and the lowest percentage is hiptis (Hyptis capitata) Only by 16 %. Keywords: Medicinal plants, ethnobotany, taripa village
FORMULASI KRIM ANTIOKSIDAN EKSTRAK DAUN KAPAS (Gossypium sp.) Hasniar Hasniar; Yusriadi Yusriadi; Akhmad Khumaidi
Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) (e-Journal) Vol. 1 No. 1 (2015): (March 2015)
Publisher : Universitas Tadulako

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (403.453 KB) | DOI: 10.22487/j24428744.2015.v1.i1.4830

Abstract

Gossypium sp. leaf is one of the plants that contain flavonoids that can act as antioxidants. This study aims to look at the effect of combination of the stearic acid and triethanolamine which function as emulsifier in creams and determine antioxidant activity of cream Gossypium sp. leaf extract. Cream is formulated with a variety of stearic acid and triethanolamine emulsifier that F1 (8%: 2%), F2 (12%: 3%), F3 (16%: 4%). Tests carried out at the first day and the 28th days. Evaluation preparations include organoleptic test, homogeneity, viscosity, pH, and type of the cream. The results showed that the variation of concentration emulsifier that fill quality preparations with some parameters such as organoleptic, homogeneity, the type of cream and viscosity. pH of cream does not qualify are 4.5-6, but still in the neutral pH range (pH ± 7). Antioxidant activity of the cream has a large reduce power at the first day DPPH reduce percent value for F1, F2, and F3 are 80,73%, 83,05% and 83,51% respectively, while after the storage at the 28th days DPPH reduce percent value for F1, F2, and F3 are 80,43%, 82,49% and 79,02% respectively. Preparation creams that fill physical quality cream is F1 by using emulsifier triethanolamine and stearic acid with a concentration of 8%: 2%
UJI AKTIVITAS ANTIDIABETES KOMBINASI GLIBENKLAMID DAN EKSTRAK DAUN SALAM (Syzygium polyanthumWight.) TERHADAP MENCIT (Mus musculus) YANG DIINDUKSI ALOKSAN Steffi Liem; Yuliet Yuliet; Akhmad Khumaidi
Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) (e-Journal) Vol. 1 No. 1 (2015): (March 2015)
Publisher : Universitas Tadulako

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (216.813 KB) | DOI: 10.22487/j24428744.2015.v1.i1.4831

Abstract

Pharmacological therapy of Diabetes Mellitus (DM) is to use antidiabetic oral. Herbal medicine are also often used as an alternative treatment by patients. Even in some cases found patients combine drugs and herbal medicine to speed up the healing of DM. This study aims to know the effects of a combination of glibenclamide and bay leaf ethanol extract (BLEE) to decrease blood glucose levels and to determine its optimal combination dose as antidiabetic. The method was inducted alloxan at dose of 120 mg/kg BW intraperitoneally. The animal test used were mice which divided into 8 groups of tests, the negative control (Na CMC 0,5 %), positive control (glibenclamide 0,65 mg/kg BW), combination 1(glibenclamide+BLEE 250 mg/kg BW), combination 2 (glibenclamide+BLEE 500 mg/kg BW), combination 3 (glibenclamide+BLEE 750 mg/kg BW), BLEE 1 (250 mg/kg BW), BLEE 2 (500 mg/kg BW), and BLEE 3 (750 mg/kg BW). After 14 days study, data were analyzed by ANOVA showed the difference in decrease of blood glucose levels combination 2 (230±23,69) mg/dL and combination 3 (233,75±9,93) mg/dL were significantly different to the negative control (4±6,82) mg/dL, positive control (150,75±11,34) mg/dL, combination 1 (170±10,51) mg/dL, BLEE 1 (134,5±4,61) mg/dL, BLEE 2 (151,25±6,72) mg/dL, and BLEE 3 (158,75±17,64) mg/dL. While combination 2 and combination 3 were not significantly different. Combination of glibenclamide and bay leaf ethanol extract decreased blood glucose levels greater than a single dosage glibenclamide or bay leaf extract. Optimal doses decreased blood glucose levels was combination 2.
UJI EFEK ANALGETIKA EKSTRAK BUAH KAKTUS (Opuntia elatior Mill.) PADA MENCIT (Mus musculus) YANG DIINDUKSI ASAM ASETAT Gissa Amellia; Ihwan Ihwan; Akhmad Khumaidi
Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) (e-Journal) Vol. 1 No. 1 (2015): (March 2015)
Publisher : Universitas Tadulako

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (375.895 KB) | DOI: 10.22487/j24428744.2015.v1.i1.4834

Abstract

Pain is a mechanism of body defense. One way to allay or decreasing the pain is using medicines that have analgetic effect. The aim of this study is determine the analgetic effect of cactus fruits (Opuntia elatior Mill.) extract and the most effective dose to giving analgetic effect. This study used writhing method by the injection acetic acid 1% as induced. Group I as a negative control used natrium carboxy methylcellulose 1%, group II as a positive control used aspirin suspension which dosage was 1,3 mg/20g BB, group III as a extract of cactus fruits give to dose 50 mg/kg BB, group IV dose 100 mg/kg BB, and group V dose 150 mg/kg BB. The result shows that cactus fruits extract to giving analgetic effect judging from the reduction strength writhing reflex to protection percentage at dose 50 mg/kg BB (11,26%), 100 mg/kg BB (42,10%), 150 mg/kg BB(60,14%) and the positif control (75,34%), at the positif control shows that higher protection percentage. Effectiveness percentage analgetic extract of cactus fruits at dose of 50 mg/kg BB (14,4%), 100 mg/kg BB (55,36%), 150 mg/kg BB (79,95%) and positif control (100%). The data which is got from the calculation later is analyzed by Kruskal Wallis. The result showed that at dose of 150 mg/kg BB is p: 0,016 (p<0,05) when compared with the positive control. So that is different significantly between dose 150 mg/kg BB and the positive control. The extract showed a optimal analgetic effect characterized by a significant reduction in the number of writhes or abdominal stretches in mice with dose 150 mg/kg BB body weight used when compared to the cactus fruits extract dose 50 and 100 mg/kg BB
STUDI ETNOFARMASI TUMBUHAN BERKHASIAT OBAT PADA SUKU BANGGAI DI KABUPATEN BANGGAI LAUT, PROVINSI SULAWESI TENGAH Nur Khairiyah; Syariful Anam; Akhmad Khumaidi
Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) (e-Journal) Vol. 2 No. 1 (2016): (March 2016)
Publisher : Universitas Tadulako

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (116.558 KB) | DOI: 10.22487/j24428744.2016.v2.i1.5224

Abstract

A study of nutritious herbs etnopharmacy has been done to Banggai ethnic from March to June 2015 in Banggai Laut Regency, Central Sulawesi. This research aims at identifying every kind of herbs parts used as traditional medicine, types of diseases cured using herbs by Banggai ethnic in Banggai Laut Regency, and the percentage of the usage by the informant about herbs as a traditional medicine. This is a descriptive research that uses qualitative method and take the sample purposively through open-ended interview involved 7 informants asked by questionnaire. The result of this research revealed that there are 54 types of herbs divided into 31 family used as medicine. The most widely used herbs is from 5 species of Zingiberaceae family and Lamiaceae family. Interview result revealed that there are 10 types of chronic diseases, 3 infectious diseases, non-communicable diseases 27, and 5 used for health care body. The parts of herbs used are leaf (49 percent), stem, sap, fruit, rhizomes, roots, tubers, herbs and bark. The Banggai ethnic precede the herbs through boiled, mashed, squeezed, shredded, soaked, brewed and then consumed, drunk, rubbed, pasted, applied directly. Processing methods most often done is boiled and drunk the herbs straightly. The higher belief the society has in the herbs ability to cure the diseases the higher use of herbal medicine as an alternative of diseases healing.
IDENTIFIKASI SENYAWA FLAVONOID PADA FRAKSI ETIL ASETAT BENALU BATU (Begonia sp.) ASAL KABUPATEN MOROWALI UTARA Agus Ritna; Syariful Anam; Akhmad Khumaidi
Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) (e-Journal) Vol. 2 No. 2 (2016): (October 2016)
Publisher : Universitas Tadulako

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (176.335 KB) | DOI: 10.22487/j24428744.2016.v2.i2.5957

Abstract

Benalu Batu Plant (Begonia sp.) in family Begoniaceae is a plant used by the people of North Morowali to treat tumors and cancers. It generally contains saponins, tannins, flavonoids and polyphenols. This research aimed to identify flavonoid compounds contained in ethyl acetate fraction of Begonia sp. The simplicia was extracted using maceration method and partitioned using n-hexane, ethyl acetate and water. The Ethyl acetate extract was then fractionated by nine eluent combinations using separation method of Vacuum Liquid Chromatography (VLC) and Preparative Thin Layer Chromatography (Prep TLC). One fraction was obtained and was suspected to contain flavonoid compounds after Shinode and Pew color reagent test. In the result of Ultraviolet-Visible Spectroscopy with methanol at wavelength range of 200-550 nm, the isolates showed absorption peaks at 275 nm (peak 1) and 225 nm (peak 2). Based on the wavelength of flavonoid compounds contained in the fraction, Begonia sp. showed similarities to the absorption peak of flavan-3-ol or flavanols
Co-Authors A. Lasongke, Putri Faradila A.A. Ketut Agung Cahyawan W A.Mirza Fauzan Gazali, A.Mirza Fauzan Agus Ritna Agustinus Widodo Anak Agung Istri Sri Wiadnyani Armini Syamsidi Arsa Wahyu Nugrahani Asabri, Moh. Yusup Asriana Sultan Bahar, Zulhaerana Cahyani, Rezki Calsum, Umi Ediati Sasmito Ediati Sasmito EDIATI SASMITO Febriani Gunawan Febriyanto Rerung Gissa Amellia Hasniar Hasniar I Nengah Suwastika Ian Dianto Ihwam Ihwan Ismail, Ihwan Karmini Karmini Khairiah Kartini Khildah Khaerati Kumalahayati Maulina Lale Fitriani Nurul Islami Maulida, Mohammad Farid Mohammad Farid Maulida Musdalifah Musdalifah Nanang Fakhrudin, Nanang Nur Khairiyah Nurlina Ibrahim Nuur Aanisah Primadia, Rizki Putri, Ayu Dinawati Ramadhanil pitopang Recky Patala Rinaldi Rinaldi Siti Anisa Siti Nuari Sitti Kholidah Sri Normayunita, Sri Sri Wahyuni A. Bana Steffi Liem Suhaeni Zainuddin Suhendar Arham Sulaiman, Sri Sulistiana Syaiful Anam Syariful Anam Torokano, Semuel Triana Hertiani Yuliet Yuliet Yusriadi Yusriadi Yustika Yustika Yustika, Yustika Zainuddin, Suhaeni