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All Journal Natural Science: Journal of Science and Technology Jurnal Farmasi Udayana Jurnal Veteriner Jurnal Riset Mahasiswa Manajemen (JRMM) Biocelebes Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) Pharmacology and Clinical Pharmacy Research JSFK (Jurnal Sains Farmasi & Klinis) Jurnal Ilmu Kefarmasian Indonesia Jurnal Ilmiah Medicamento Medical Sains : Jurnal Ilmiah Kefarmasian Sciences of Pharmacy Medical Sains : Jurnal Ilmiah Kefarmasian

Akhmad Khumaidi

Jurusan Farmasi, Fakultas MIPA, Universitas Tadulako, Palu, Indonesia

Author-ID : 298677

Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Decision Sciences, Operations Research & Management Health Professions Immunology & microbiology Medicine & Pharmacology Public Health Veterinary

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FORMULASI TABLET ANTIOKSIDAN EKSTRAK BAWANG HUTAN (ELEUTHERINE BULBOSA MILL.URB) Karmini, Karmini; Yuliet, Yuliet; Khumaidi, Akhmad
Natural Science: Journal of Science and Technology Vol 3, No 3 (2014): Volume 3 Number 3 (December 2014)
Publisher : Univ. Tadulako

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (358.209 KB)

Telah dilakukan penelitian mengenai formulasi tablet antioksidan ekstrak bawang hutan (Eleutherine bulbosa mill.urb) dengan tujuan untuk mengetahui pengaruh penggunaan variasi konsentrasi ekstrak bawang hutan pada mutu fisik dan aktivitas antioksidan tablet, mengetahui konsentrasi ekstrak yang memenuhi mutu fisik yang paling optimum dan mengetahui aktivitas antioksidan (IC50) dari tiap formula. Ekstrak dibuat dengan metode maserasi menggunakan pelarut etanol 96%. Proses pembuatan tablet dengan metode granulasi basah. Dilakukan uji mutu fisik granul dan uji mutu fisik tablet. Uji aktivitas antioksidan dilakukan secara in-vitro menggunakan metode DPPH pada formula 1, formula 2, formula 3 dan kontrol negatif dengan penggunaan Vitamin C sebagai kontrol positif. Data hasil pengukuran dianalisis secara statistik menggunakan metode ANOVA. Hasil penelitian menunjukkan bahwa penggunaan variasi konsentrasi ekstrak bawang hutan dengan konsentrasi 3,57%, 7,14% dan 10,71% pada sediaan tablet memperoleh mutu fisik tablet yang baik pada penyimpanan selama ± 1 bulan. Hasil uji aktivitas antioksidan dengan IC50 yang diperoleh pada hari ke-1 dan hari ke-28 kontrol negatif, formula 1, formula 2, dan formula 3 berturut-turut adalah 2110 ppm dan 2210 ppm; 126,18 ppm dan 135,73 ppm; 91,00 ppm dan 95,45 ppm; 46,87 ppm dan 50,93 ppm; dibandingkan dengan IC50 Vitamin C sebesar 4,93 ppm. Formula 1 mempunyai mutu fisik tablet yang paling optimum. Aktivitas antioksidan dari tiap formula masuk dalam kategori dari sangat kuat sampai sedang.

AKTIVITAS EKSTRAK ETANOL DAUN PEPOLO (Bischofia javanica BLUME) TERHADAP PENYEMBUHAN LUKA BAKAR PADA KELINCI (Oryctolagus cuniculus) Zainuddin, Suhaeni; Yusriadi; Khumaidi, Akhmad
Jurnal Ilmiah Medicamento Vol 5 No 2 (2019): Jurnal Ilmiah Medicamento
Publisher : Fakultas Farmasi Universitas Mahasaraswati Denpasar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36733/medicamento.v5i2.848

Tumbuhan daun pepolo (Bischofia javanica Blume) merupakan salah satu tumbuhan yang digunakan untuk pengobatan luka bakar. Penelitian ini bertujuan untuk mengetahui aktivitas ekstrak daun pepolo terhadap penyembuhan luka bakar pada kelinci (Oryctolagus cuniculus). Pengujian aktivitas ekstrak etanol daun pepolo menggunakan 5 ekor kelinci yang dibagi dalam 5 kelompok perlakuan yaitu kontrol negatif (basis gel tanpa ekstrak), ekstrak etanol daun pepolo dalam basis gel dengan konsentrasi 5%, 10%, 15% dan kontrol positif (gel Bioplacenton). Pengukuran diameter luka dilakukan pada hari ke- 1, 3, 5, 7, 9, 11, 13, 15, 17, 19, dan 21. Data yang diperoleh dianalisis secara statistik dengan Metode One Way Anova. Hasil analisis statistik menunjukkan bahwa ekstrak daun pepolo pada konsentrasi 5%, 10% dan 15% memiliki aktivitas penyembuhan luka bakar. Penyembuhan luka bakar yang efektif yaitu konsentrasi 15%, yang memberikan penyembuhan sebesar 92,34%.

Faktor faktor yang Mempengaruhi Keputusan Pembelian Sepeda Motor Yamaha Mio Sporty Akhmad Khumaidi
Jurnal Riset Mahasiswa Manajemen Vol. 1 No. 1 (2013): April
Publisher : Fakultas Ekonomika dan Bisnis Universitas Kanjuruhan Malang

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Yamaha sebagai pelopor sepeda motor matik di Indonesia dapat menggusur dominasi Honda dalam angka penjualan dengan produk Yamaha Mio Sporty, telebih adanya perubahan selera konsumen dari sepeda motor bebek ke sepeda motor matik. Mahasiswa Universitas kanjuruhan Malang sebagai bagian dari konsumen pengguna sepeda motor dijadikan sampel penelitian untuk mengetahui perilaku konsumen yang terdiri dari Faktor Budaya, Faktor Sosial, Faktor Pribadi dan Faktor Psikologi yang dapat mempengaruhi keputusan penbelian sepeda motor matik Yamaha Mio Sporty. Penelitian ini menggunakan metode peneltian explanatory reseach untuk mengetahui hubungan kausal antara variabel bebas dengan variabel terikat, dengan sumber data diperoleh dari 40 responden. Pengambilan sampel menggunakan teknik purposive sampling dimana responden adalah pemilik sekaligus pengguna sepeda motor matik merek Yamaha Mio Sporty sebagai sarana transportasi ke kampus melalui pengisian kuisioner. Variabel yang diteliti terdiri dari variabel bebas yaitu faktor budaya (X1),faktor sosial (X2), faktor pribadi (X3), dan faktor psikologi (X4), dan variabel terikat adalah keputusan pembelian (Y). Analisis data menggunakan analisis regresi berganda, uji F, uji t, dan uji asumsi klasik. Hasil penelitian menunjukkan adanya pengaruh yang signifikan antara perilaku konsumen yang terdiri dari Faktor Budaya, Faktor Sosial, Faktor Pribadi dan Faktor Psikologi terhadap keputusan pembelian sepeda motor matik Yamaha Mio Sporty baik secara partial maupun secara simultan. Faktor Sosial merupakan faktor yang berpengaruh dominan terhadap keputusan pembelian sepeda motor matik merek Yamaha Mio Sporty oleh Mahasiswa Universitas Kanjuruhan Malang

Aktivitas Antibakteri Ekstrak Etanol Daun Kapas (Gossypium barbadense L.) terhadap Staphylococcus epidermidis dan Propionibacterium acnes akhmad khumaidi; Arsa Wahyu Nugrahani; Febriani Gunawan
Jurnal Farmasi Udayana Vol. 9, No. 1, Tahun 2020
Publisher : Departement of Pharmacy, Faculty of Mathematics and Natural Science, Udayana University

Gossypium barbadense L. is one of the plants that has the potential to be developed into an antibacterial agent. This study aims to determine the antibacterial ability of chemical compounds in ethanol extract of Gossypium barbadense L. leaves to Staphylococcus epidermidis and Propionibacterium acnes bacteria which are characterized by the formation of inhibitory zones. Extraction of Gossypium barbadense L. leaves was carried out by maceration using 96% ethanol. Antibacterial activity testing was carried out by agar diffusion method with a cylinder plate technique and the extract was made a concentration series. TLC bioautography and chromogenic reagents are used in the identification of groups of compounds that have antibacterial activity. The results showed that the ethanol extract of Gossypium barbadense L. leaves gave the greatest inhibition at 70% extract concentration ie 11.40 ± 0.32 mm against Propionibacterium acnes and 50% extract concentration against Staphylococcus epidermidis bacteria which was 12.28 ± 0.63 mm. The group of compounds that are thought to be responsible for antibacterial activity are flavonoids. Keywords: Antibacterial, Gossypium barbadense L. Leaves, Propionibacterium acnes, Staphylococcus epidermidis

Ekstrak Etanol Daun Eboni Menurunkan Kadar Glukosa Darah Tikus Jantan yang Diinduksi Aloksan (ETHANOLIC EXTRACT OF EBONI LEAF DECREASE BLOOD GLUCOSE LEVEL IN ALLOXAN INDUCED MALE RATS) Khairiah Kartini; Akhmad Khumaidi; Khildah Khaerati; Ihwam Ihwan
Jurnal Veteriner Vol 19 No 3 (2018)
Publisher : Faculty of Veterinary Medicine, Udayana University and Published in collaboration with the Indonesia Veterinarian Association

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (108.636 KB)

Eboni (Diospyros celebica Bakh.) leaf is part of the plant which used on empirically to decrease blood glucose levels. This study aims to knowing the activity of ethanol extract of ebony leaf in decrease blood glucose levels and the effective dose equivalent to glibenclamide. The study use 25 white rats male (Rattus norvegicus L.) which divided in 5 groups, that is negative control (0.5% NaCMC), positive control (glibenclamide 0.45 mg / kgBW), Etanolic Extarac Eboni Folium (EEDE) 200 mg / kgBW, EEDE 350 mg / kgBW, EEDE 500 mg / kgBW. All groups of white rats were used alloxan induction with dose 140 mg / kgBW intraperitoneal. Three days, after induction, rats with elevated blood glucose levels e”200 mg/dL were treated for 21 days orally. Blood glucose measurement was performed 5 times on days 0, 3, 10, 17, and 24. Blood glucose data was analyzed using One Way ANOVA with 95% confidence level. It is reveled that ebony leaf extract had activity in decrease blood glucose level by alloxan induction method where the effective dose equivalent to glibenclamide was dose 500 mg/kgBW.

Aktivitas Antidiare Ekstrak Etanol Daun Jarak Merah (Jatropha gossypifolia) pada Mencit yang Diinduksi Bakteri Escherichia coli Arsa Wahyu Nugrahani; Lale Fitriani Nurul Islami; Akhmad Khumaidi
Jurnal Veteriner Vol 22 No 3 (2021)
Publisher : Faculty of Veterinary Medicine, Udayana University and Published in collaboration with the Indonesia Veterinarian Association

Obat diare alami yang secara empiris digunakan oleh masyarakat salah satunya adalah daun jarak merah (Jatropha gossypifolia L.). Tujuan yang ingin dicapai dalam penelitian ini yaitu untuk mengetahui aktivitas antidiare ekstrak etanol daun jarak merah terhadap mencit jantan yang diinduksi supaya diare dengan bakteri Escherichia coli dan pada dosis berapa ekstrak daun jarak merah efektif sebagai antidiare. Rancangan Acak Lengkap secara in vivo dipilih sebagai desain penelitian dengan enam perlakuan. Jumlah bakteri Escherichia coli sebagai penginduksi diare disetarakan dengan 9,0 x 108 CFU/mL dengan volume pemberian sebanyak 0,5 mL. Variasi dosis ekstrak yang digunakan yaitu 28 mg/20 g BB, 56 mg/20 g BB dan 84 mg/20 g BB. Parameter yang diamati antara lain waktu saat mulai terjadi diare, frekuensi buang air besar, perubahan konsistensi feses, bobot feses dan lama terjadinya diare (durasi). Sidik ragam satu arah dengan taraf kepercayaan 95% digunakan untuk menganalisis data. Hasil penelitian dengan parameter waktu saat mulai terjadi diare pada pemberian dosis ekstrak daun jarak merah 84 mg/20 g BB memberikan waktu terlama di antara dosis uji lainnya (82,5 menit). Pada pemberian dosis tersebut, memberikan hasil frekuensi diare terendah (0,32 kali), konsistensi feses terendah (0,64) dan bobot feses terendah (0,053 g) serta lama diare yang tersingkat (157.5 menit). Hasil-hasil tersebut menunjukkan tidak berbeda bermakna dengan kontrol positif loperamid maupun kontrol positif kotrimoksazol. Berdasarkan hasil penelitian, dosis efektif ekstrak daun jarak merah sebagai antidiare yaitu 84 mg/20 g BB.

KEANEKARAGAMAN JENIS TUMBUHAN OBAT TRADISIONAL DAN PEMANFAATANNYA PADA SUKU KULAWI DI DESA MATAUE KAWASAN TAMAN NASIONAL LORE LINDU Suhendar Arham; Akhmad Khumaidi; Ramadhanil Pitopang
Biocelebes Vol. 10 No. 2 (2016)
Publisher : Biology Department, Mathematics and natural science, Tadulako University

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (402.227 KB)

Ethnobotany is the study of medicinal plants of plant utilization in both everyday and cultural mores of a nation. The objective of this research was to identified the diversity of traditional medical plant and its utilization in kulawi local people at Mataue village Lore Lindu National Park. The research was conducted during April to May 2014 at Kulawi Sub-district of Sigi Regency Central Sulawesi. Identification process had been done at Biodiversity Laboratory, Faculty of Mathematics and Natural Sciences, Tadulako University. Methods which used on this study were survey and descriptive, consists of field survey and semi structural interview based on questionnaire. Outcome of the research showed that there were 49 plant species covered from 30 families which were traditionally used as medicine. Leaves organ was the most widely applied as medicine with 58% percentage, habitus type which highly found was herbaceous type with 51% percentage, and the most treated disease by the traditional medicine was non-communicable disease as much as 36%. Key words :Ethno botany, Medical Plant, Kulawi Local People.

STUDI ETNOBOTANI TUMBUHAN OBAT PADA MAYARAKAT KAILI RAI DI DESA TARIPA KECAMATAN SINDUE KABUPATEN DONGGALA SULAWESI TENGAH Sri Wahyuni A. Bana; Akhmad Khumaidi; Ramadhanil Pitopang
Biocelebes Vol. 10 No. 2 (2016)
Publisher : Biology Department, Mathematics and natural science, Tadulako University

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (384.169 KB)

This study aims to document the types of medicinal plants, how to use medicinal plants, the type of disease that can be cured, and perentase habitus herbs are used daily by the village community Taripa village and to utilization. This study was conducted in April-May 2014. The method used in this study is a combination of qualitative research methods and quantitative research. Recorded 41 species from 28 families were used by villagers Taripa as medicine. The cooking methods, namely by boiling, crushed, chewed, squeezed, the topical and sliced. Organs of traditional medicinal plants in use are the leaves, roots, stems, roots, rhizomes, fruits, bark, and stem. Plant organs most widely utilized is the percentage of leaves with the use of 63 %. The percentage of plants that use and know ledge of the highest of orange (Citrus aurantifolia) by 98 % and the lowest percentage is hiptis (Hyptis capitata) Only by 16 %. Keywords: Medicinal plants, ethnobotany, taripa village

FORMULASI KRIM ANTIOKSIDAN EKSTRAK DAUN KAPAS (Gossypium sp.) Hasniar Hasniar; Yusriadi Yusriadi; Akhmad Khumaidi
Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) (e-Journal) Vol. 1 No. 1 (2015): (March 2015)
Publisher : Universitas Tadulako

Gossypium sp. leaf is one of the plants that contain flavonoids that can act as antioxidants. This study aims to look at the effect of combination of the stearic acid and triethanolamine which function as emulsifier in creams and determine antioxidant activity of cream Gossypium sp. leaf extract. Cream is formulated with a variety of stearic acid and triethanolamine emulsifier that F1 (8%: 2%), F2 (12%: 3%), F3 (16%: 4%). Tests carried out at the first day and the 28th days. Evaluation preparations include organoleptic test, homogeneity, viscosity, pH, and type of the cream. The results showed that the variation of concentration emulsifier that fill quality preparations with some parameters such as organoleptic, homogeneity, the type of cream and viscosity. pH of cream does not qualify are 4.5-6, but still in the neutral pH range (pH ± 7). Antioxidant activity of the cream has a large reduce power at the first day DPPH reduce percent value for F1, F2, and F3 are 80,73%, 83,05% and 83,51% respectively, while after the storage at the 28th days DPPH reduce percent value for F1, F2, and F3 are 80,43%, 82,49% and 79,02% respectively. Preparation creams that fill physical quality cream is F1 by using emulsifier triethanolamine and stearic acid with a concentration of 8%: 2%

UJI AKTIVITAS ANTIDIABETES KOMBINASI GLIBENKLAMID DAN EKSTRAK DAUN SALAM (Syzygium polyanthumWight.) TERHADAP MENCIT (Mus musculus) YANG DIINDUKSI ALOKSAN Steffi Liem; Yuliet Yuliet; Akhmad Khumaidi
Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) (e-Journal) Vol. 1 No. 1 (2015): (March 2015)
Publisher : Universitas Tadulako

Pharmacological therapy of Diabetes Mellitus (DM) is to use antidiabetic oral. Herbal medicine are also often used as an alternative treatment by patients. Even in some cases found patients combine drugs and herbal medicine to speed up the healing of DM. This study aims to know the effects of a combination of glibenclamide and bay leaf ethanol extract (BLEE) to decrease blood glucose levels and to determine its optimal combination dose as antidiabetic. The method was inducted alloxan at dose of 120 mg/kg BW intraperitoneally. The animal test used were mice which divided into 8 groups of tests, the negative control (Na CMC 0,5 %), positive control (glibenclamide 0,65 mg/kg BW), combination 1(glibenclamide+BLEE 250 mg/kg BW), combination 2 (glibenclamide+BLEE 500 mg/kg BW), combination 3 (glibenclamide+BLEE 750 mg/kg BW), BLEE 1 (250 mg/kg BW), BLEE 2 (500 mg/kg BW), and BLEE 3 (750 mg/kg BW). After 14 days study, data were analyzed by ANOVA showed the difference in decrease of blood glucose levels combination 2 (230±23,69) mg/dL and combination 3 (233,75±9,93) mg/dL were significantly different to the negative control (4±6,82) mg/dL, positive control (150,75±11,34) mg/dL, combination 1 (170±10,51) mg/dL, BLEE 1 (134,5±4,61) mg/dL, BLEE 2 (151,25±6,72) mg/dL, and BLEE 3 (158,75±17,64) mg/dL. While combination 2 and combination 3 were not significantly different. Combination of glibenclamide and bay leaf ethanol extract decreased blood glucose levels greater than a single dosage glibenclamide or bay leaf extract. Optimal doses decreased blood glucose levels was combination 2.

Co-Authors A. Lasongke, Putri Faradila A.A. Ketut Agung Cahyawan W A.Mirza Fauzan Gazali, A.Mirza Fauzan Agus Ritna Agustinus Widodo Anak Agung Istri Sri Wiadnyani Armini Syamsidi Arsa Wahyu Nugrahani Asabri, Moh. Yusup Asriana Sultan Bahar, Zulhaerana Cahyani, Rezki Calsum, Umi Ediati Sasmito Ediati Sasmito EDIATI SASMITO Febriani Gunawan Febriyanto Rerung Gissa Amellia Hasniar Hasniar I Nengah Suwastika Ian Dianto Ihwam Ihwan Ismail, Ihwan Karmini Karmini Khairiah Kartini Khildah Khaerati Kumalahayati Maulina Lale Fitriani Nurul Islami Maulida, Mohammad Farid Mohammad Farid Maulida Musdalifah Musdalifah Nanang Fakhrudin, Nanang Nur Khairiyah Nurlina Ibrahim Nuur Aanisah Primadia, Rizki Putri, Ayu Dinawati Ramadhanil pitopang Recky Patala Rinaldi Rinaldi Siti Anisa Siti Nuari Sitti Kholidah Sri Normayunita, Sri Sri Wahyuni A. Bana Steffi Liem Suhaeni Zainuddin Suhendar Arham Sulaiman, Sri Sulistiana Syaiful Anam Syariful Anam Torokano, Semuel Triana Hertiani Yuliet Yuliet Yusriadi Yusriadi Yustika Yustika Yustika, Yustika Zainuddin, Suhaeni

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