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All Journal Natural Science: Journal of Science and Technology Jurnal Farmasi Udayana Jurnal Veteriner Jurnal Riset Mahasiswa Manajemen (JRMM) Biocelebes Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) Pharmacology and Clinical Pharmacy Research JSFK (Jurnal Sains Farmasi & Klinis) Jurnal Ilmu Kefarmasian Indonesia Jurnal Ilmiah Medicamento Medical Sains : Jurnal Ilmiah Kefarmasian Sciences of Pharmacy Medical Sains : Jurnal Ilmiah Kefarmasian

Akhmad Khumaidi

Jurusan Farmasi, Fakultas MIPA, Universitas Tadulako, Palu, Indonesia

Author-ID : 298677

Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Decision Sciences, Operations Research & Management Health Professions Immunology & microbiology Medicine & Pharmacology Public Health Veterinary

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UJI EFEK ANALGETIKA EKSTRAK BUAH KAKTUS (Opuntia elatior Mill.) PADA MENCIT (Mus musculus) YANG DIINDUKSI ASAM ASETAT Gissa Amellia; Ihwan Ihwan; Akhmad Khumaidi
Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) (e-Journal) Vol. 1 No. 1 (2015): (March 2015)
Publisher : Universitas Tadulako

Pain is a mechanism of body defense. One way to allay or decreasing the pain is using medicines that have analgetic effect. The aim of this study is determine the analgetic effect of cactus fruits (Opuntia elatior Mill.) extract and the most effective dose to giving analgetic effect. This study used writhing method by the injection acetic acid 1% as induced. Group I as a negative control used natrium carboxy methylcellulose 1%, group II as a positive control used aspirin suspension which dosage was 1,3 mg/20g BB, group III as a extract of cactus fruits give to dose 50 mg/kg BB, group IV dose 100 mg/kg BB, and group V dose 150 mg/kg BB. The result shows that cactus fruits extract to giving analgetic effect judging from the reduction strength writhing reflex to protection percentage at dose 50 mg/kg BB (11,26%), 100 mg/kg BB (42,10%), 150 mg/kg BB(60,14%) and the positif control (75,34%), at the positif control shows that higher protection percentage. Effectiveness percentage analgetic extract of cactus fruits at dose of 50 mg/kg BB (14,4%), 100 mg/kg BB (55,36%), 150 mg/kg BB (79,95%) and positif control (100%). The data which is got from the calculation later is analyzed by Kruskal Wallis. The result showed that at dose of 150 mg/kg BB is p: 0,016 (p<0,05) when compared with the positive control. So that is different significantly between dose 150 mg/kg BB and the positive control. The extract showed a optimal analgetic effect characterized by a significant reduction in the number of writhes or abdominal stretches in mice with dose 150 mg/kg BB body weight used when compared to the cactus fruits extract dose 50 and 100 mg/kg BB

STUDI ETNOFARMASI TUMBUHAN BERKHASIAT OBAT PADA SUKU BANGGAI DI KABUPATEN BANGGAI LAUT, PROVINSI SULAWESI TENGAH Nur Khairiyah; Syariful Anam; Akhmad Khumaidi
Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) (e-Journal) Vol. 2 No. 1 (2016): (March 2016)
Publisher : Universitas Tadulako

A study of nutritious herbs etnopharmacy has been done to Banggai ethnic from March to June 2015 in Banggai Laut Regency, Central Sulawesi. This research aims at identifying every kind of herbs parts used as traditional medicine, types of diseases cured using herbs by Banggai ethnic in Banggai Laut Regency, and the percentage of the usage by the informant about herbs as a traditional medicine. This is a descriptive research that uses qualitative method and take the sample purposively through open-ended interview involved 7 informants asked by questionnaire. The result of this research revealed that there are 54 types of herbs divided into 31 family used as medicine. The most widely used herbs is from 5 species of Zingiberaceae family and Lamiaceae family. Interview result revealed that there are 10 types of chronic diseases, 3 infectious diseases, non-communicable diseases 27, and 5 used for health care body. The parts of herbs used are leaf (49 percent), stem, sap, fruit, rhizomes, roots, tubers, herbs and bark. The Banggai ethnic precede the herbs through boiled, mashed, squeezed, shredded, soaked, brewed and then consumed, drunk, rubbed, pasted, applied directly. Processing methods most often done is boiled and drunk the herbs straightly. The higher belief the society has in the herbs ability to cure the diseases the higher use of herbal medicine as an alternative of diseases healing.

IDENTIFIKASI SENYAWA FLAVONOID PADA FRAKSI ETIL ASETAT BENALU BATU (Begonia sp.) ASAL KABUPATEN MOROWALI UTARA Agus Ritna; Syariful Anam; Akhmad Khumaidi
Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) (e-Journal) Vol. 2 No. 2 (2016): (October 2016)
Publisher : Universitas Tadulako

Benalu Batu Plant (Begonia sp.) in family Begoniaceae is a plant used by the people of North Morowali to treat tumors and cancers. It generally contains saponins, tannins, flavonoids and polyphenols. This research aimed to identify flavonoid compounds contained in ethyl acetate fraction of Begonia sp. The simplicia was extracted using maceration method and partitioned using n-hexane, ethyl acetate and water. The Ethyl acetate extract was then fractionated by nine eluent combinations using separation method of Vacuum Liquid Chromatography (VLC) and Preparative Thin Layer Chromatography (Prep TLC). One fraction was obtained and was suspected to contain flavonoid compounds after Shinode and Pew color reagent test. In the result of Ultraviolet-Visible Spectroscopy with methanol at wavelength range of 200-550 nm, the isolates showed absorption peaks at 275 nm (peak 1) and 225 nm (peak 2). Based on the wavelength of flavonoid compounds contained in the fraction, Begonia sp. showed similarities to the absorption peak of flavan-3-ol or flavanols

STUDI ETNOFARMASI TUMBUHAN BERKHASIAT OBAT PADA SUKU KAILI LEDO DI KABUPATEN SIGI, PROVINSI SULAWESI TENGAH Ian Dianto; Syariful Anam; Akhmad Khumaidi
Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) (e-Journal) Vol. 1 No. 2 (2015): (October 2015)
Publisher : Universitas Tadulako

Ethnomedicinal study on LedoKaili tribe has been conducted from January to April 2015 in Sigi Regency, Central Sulawesi. This study aims to know and to inventory the various species of plants, their parts, and ways of utilization used to treat any types of disease and how the by the tribe. This research is descriptive using qualitative methods and snowball sampling technique through open-ended interviews to 10 informants by using questionnaire. Based on the study results, plants used as medicine were known as many as 86 species coming from 37 familia in which four species have notbeen identified yet. The most widely used plants are from familia Zingiberaceae (8 species). Plant parts used include leaf, stem, fruit, root, rhizome, tuber, herb, bark, sap, and flower. Leafisthe part of the plant used with the highest percentage (53%). Local people use medicinal plants for purposes of chronic, infectious, and non-infectious diseases. Besides being able to treat people's illnesses,the plants were also used for body health care as well as dietary supplements. Ways of processing medicinal plants is done by boiling, crushing, squeezing, shredding and soaking. The most widely is boiled with percentage of 60%. As for how to use medicinal plants, the people use them in ways of drinking, eating, rubbing, dropping, and tapping/attaching. Drinking is the most usual way to use them with a percentage of 74%

Isolasi Senyawa Flavonoid Ekstrak Biji Pinang Merah (Areca vestiaria Giseke) Dan Uji Sitotoksiknya Melalui Uji Brine Shirimp Lethality Test (BSLT): Isolation of Flavonoid Compounds of Red Pinang's Seed Extract (Areca vestiaria Giseke) And Cytotoxic Test by Brine Shirimp Lethality Test (BSLT) Febriyanto Rerung; Syariful Anam; Akhmad Khumaidi
Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) (e-Journal) Vol. 3 No. 1 (2017): (March 2017)
Publisher : Universitas Tadulako

Cytotoxic test is one method to predict the development of compounds that are toxic to the cell that is an absolute requirement for anticancer drugs. The aim of this study is to isolate flavonoids and determine LC50 value of the activity of the Red Pinang seed extract (Areca vestiaria Giseke). Extracts prepared by maceration method using ethanol 96%. Isolation is done through a range of methods includes partitioning using n-hexane, a preliminary test using the color reagent and KLT, isolation by preparative thin layer chromatography, thin layer chromatography multi eluent, UV-Vis spectrophotometer analysis and cytotoxic test isolates. The results showed that isolates flavonoid seed extract of Red Pinang (Areca vestiaria Giseke) has the medium potential of being a cytotoxic agent with LC50 values of 583.445 ppm.

Isolasi dan Identifikasi Senyawa Flavonoid Ekstrak Etanol Buah Naga Merah (Hylocereus polyrhizus (F.A.C.Weber) Briton & Rose): Isolation and Identification of Flavonoid Compounds from Ethanol Extract of Red Dragon Fruits (Hylocereus polyrhizus (F.A.C.Weber) Briton & Rose Siti Nuari; Syariful Anam; Akhmad Khumaidi
Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) (e-Journal) Vol. 3 No. 2 (2017): (October 2017)
Publisher : Universitas Tadulako

Telah dilakukan penelitian mengenai isolasi dan identifikasi senyawa flavonoid dari ekstrak etanol buah naga merah (Hylocereus polyrhizus (F.A.C.Weber) Briton & Rose). Ekstrak buah naga merah diperoleh melalui maserasi serbuk buah naga merah dengan pelarut etanol 96%. Ekstrak etanol yang diperoleh di partisi dengan metode partisi cair-cair menggunakan pelarut n-heksana, etil asetat dan air. Hasil partisi ekstrak etil asetat kemudian dilakukan pemisahan dengan Kromatografi vakum cair, sedangkan ekstrak air dihidrolisis terlebih dahulu dengan HCl lalu dipartisi dengan etil asetat (fraksi etil asetat). Berdasarkan hasi pemurnian ekstrak etil asetat dan fraksi etil asetat dengan KLT Preparatif diperoleh 5 isolat tetapi hanya isolat 3 yang positif senyawa flavonoid. Hasil spektroskopi UV-Vis isolat 3 menghasilkan puncak pada 330 nm (pita I) dan 280 nm (pita II), sedangkan pada penambahan pereaksi geser tidak mengalami pergeseran batokromik dan hipsokromik. Berdasarkan data-data yang diperoleh isolat 3 diduga merupakan golongan senyawa flavanon.

Analisis Korelasi antara Efek Proliferasi Limfosit dengan Kandungan Fenolik dan Flavonoid Subfraksi Etil Asetat Myrmecodia tuberosa (Non Jack) Bl. secara In Vitro pada Mencit BALB/C AKHMAD KHUMAIDI; TRIANA HERTIANI; EDIATI SASMITO
JURNAL ILMU KEFARMASIAN INDONESIA Vol 13 No 1 (2015): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (979.102 KB)

Ethyl acetate fraction of Myrmecodia tuberosa (non Jack) Bl. expressed potential immunomodulatory effect in preliminary study. This study was aimed to determine the stimulation index of each subfraction towards lymphocyte of BALB/C mice by in vitro technique and to explore the activityof lymphocyte proliferation correlated to total phenolic contents. lymphocyte proliferation assay was performed by MTT. Determination of total flavanoid content was done by a colorimetric method while the total phenolic was tested by the Folin-Ciocalteu method. The result showed stimulation index profile was positively correlated with the total flavanoid content( R2 = 0,606) while weak correlation was observed on the total phenolic content (R2 = 0,167).

Aktivitas Antibakteri Fraksi Allium ascalonicum Linn A562275sal Lembah Palu terhadap Shigella dysenteriae Akhmad Khumaidi; Kumalahayati Maulina; Arsa Wahyu Nugrahani
JURNAL ILMU KEFARMASIAN INDONESIA Vol 17 No 2 (2019): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

Shallot (Allium ascalonicum Linn.) is one of the typical plants of Central Sulawesi which is used as traditional medicine such as to treat infectious diseases. This study aims to determine the fractions that have high activity from bulbs and leaves in inhibiting the growth of Shigella dysenteriae bacteria and determining the organic compounds that have antibacterial activities. Extraction was carried out by maceration method using ethanol 96% for both samples. Liquid-liquid fractionation was used as a fractionation method using hexane, ethyl acetate and water solvents, sequenly. The antibacterial activity test used the diffusion method with the pile technique and TLC-bioautography. The results showed that ethyl acetate fraction gave the highest activity of bulbs samples, while in leaves samples ethyl acetate fraction and hexane fraction were able to provide good inhibitory activity. The organic compounds were identified by thin layer chromatography method. Flavonoids compounds have identified for bulbs samples (Rf 0.18). In the leaves samples, steroids compounds were identified in the ethyl acetate fraction (Rf 0.62) and terpenoid compounds (Rf 0.48) in the hexane fraction. Based on the result, the shallot is potentially be developed as an antibacterial material.

Profil Proliferasi Sel Limfosit Benalu Batu (Begonia medicinalis) Asal Kabupaten Morowali UTARA Provinsi Sulawesi Tengah Akhmad Khumaidi; Agustinus Widodo; Arsa Wahyu Nugrahani; Ediati Sasmito; Nanang Fakhrudin
JURNAL ILMU KEFARMASIAN INDONESIA Vol 18 No 1 (2020): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

The plant of Benalu Batu (Begonia medicinalis) from the North Morowali regency has been used empirically and is known to have anticancer activity. The study aims to determine the profile of the activity of lymphocytes cell proliferation of extracts and fractions of Benalu Batu in vitro as well to measure the correlation of total flavonoid content against the stimulating index of lymphocytes cell proliferation. The extraction of simplicia by using the maceration method with methanol solvent. The liquid-liquid partition method is used in the fractionation of methanol extracts with hexane, ethyl acetate, and water solvents, sequentially. Test of lymphocytes cell proliferation using MTT reduction (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) method with concentration series 10, 20, 50, and 100 μg/mL. The total of flavonoids content of extracts and fractions were determined by using colorimetric method. The stimulation index (IS) is used in measuring the activity of lymphocytes cell proliferation. The test results showed that the methanol extracts, hexane fraction, ethyl acetate, and water may increase the proliferation of lymphocytes in the entire test concentration. The concentration of test influences on increasing the stimulation of the proliferation of lymphocytes cells. A test concentration of 100 μg/mL has the highest stimulation index on each test sample and its stimulant index value of hexane fraction, ethyl acetate fraction, methanol fraction and water fraction were 10.12, 6.56, 4.82, and 4.17, respectively. Total flavonoids content and stimulation indices have very low correlation (r = 0,082) and concentrations of 10 μg/mL have the highest correlation coefficient (r2 = 0.18). The results showed that the hexane and ethyl acetate fractions can be developed as immunostimulant materials for the anticancer supportive therapeutic agents despite having a very low correlation to the flavonoid levels.

AKTIVITAS EKSTRAK ETANOL DAUN PEPOLO (Bischofia javanica BLUME) TERHADAP PENYEMBUHAN LUKA BAKAR PADA KELINCI (Oryctolagus cuniculus) Suhaeni Zainuddin; Yusriadi; Akhmad Khumaidi
Jurnal Ilmiah Medicamento Vol 5 No 2 (2019): Jurnal Ilmiah Medicamento
Publisher : Fakultas Farmasi Universitas Mahasaraswati Denpasar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36733/medicamento.v5i2.848

Tumbuhan daun pepolo (Bischofia javanica Blume) merupakan salah satu tumbuhan yang digunakan untuk pengobatan luka bakar. Penelitian ini bertujuan untuk mengetahui aktivitas ekstrak daun pepolo terhadap penyembuhan luka bakar pada kelinci (Oryctolagus cuniculus). Pengujian aktivitas ekstrak etanol daun pepolo menggunakan 5 ekor kelinci yang dibagi dalam 5 kelompok perlakuan yaitu kontrol negatif (basis gel tanpa ekstrak), ekstrak etanol daun pepolo dalam basis gel dengan konsentrasi 5%, 10%, 15% dan kontrol positif (gel Bioplacenton). Pengukuran diameter luka dilakukan pada hari ke- 1, 3, 5, 7, 9, 11, 13, 15, 17, 19, dan 21. Data yang diperoleh dianalisis secara statistik dengan Metode One Way Anova. Hasil analisis statistik menunjukkan bahwa ekstrak daun pepolo pada konsentrasi 5%, 10% dan 15% memiliki aktivitas penyembuhan luka bakar. Penyembuhan luka bakar yang efektif yaitu konsentrasi 15%, yang memberikan penyembuhan sebesar 92,34%.

Co-Authors A. Lasongke, Putri Faradila A.A. Ketut Agung Cahyawan W A.Mirza Fauzan Gazali, A.Mirza Fauzan Agus Ritna Agustinus Widodo Anak Agung Istri Sri Wiadnyani Armini Syamsidi Arsa Wahyu Nugrahani Asabri, Moh. Yusup Asriana Sultan Bahar, Zulhaerana Cahyani, Rezki Calsum, Umi Ediati Sasmito Ediati Sasmito EDIATI SASMITO Febriani Gunawan Febriyanto Rerung Gissa Amellia Hasniar Hasniar I Nengah Suwastika Ian Dianto Ihwam Ihwan Ismail, Ihwan Karmini Karmini Khairiah Kartini Khildah Khaerati Kumalahayati Maulina Lale Fitriani Nurul Islami Maulida, Mohammad Farid Mohammad Farid Maulida Musdalifah Musdalifah Nanang Fakhrudin, Nanang Nur Khairiyah Nurlina Ibrahim Nuur Aanisah Primadia, Rizki Putri, Ayu Dinawati Ramadhanil pitopang Recky Patala Rinaldi Rinaldi Siti Anisa Siti Nuari Sitti Kholidah Sri Normayunita, Sri Sri Wahyuni A. Bana Steffi Liem Suhaeni Zainuddin Suhendar Arham Sulaiman, Sri Sulistiana Syaiful Anam Syariful Anam Torokano, Semuel Triana Hertiani Yuliet Yuliet Yusriadi Yusriadi Yustika Yustika Yustika, Yustika Zainuddin, Suhaeni

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