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All Journal Prosiding Seminar Nasional Sains Dan Teknologi Fakultas Teknik Jurnal Ilmu Farmasi dan Farmasi Klinik (Journal of Pharmaceutical Science and Clinical Pharmacy) INDONESIAN JOURNAL OF PHARMACY Pharmascience Jurnal Farmasi Sains dan Komunitas Jurnal Ilmu Kefarmasian Indonesia Abdimas UNWAHAS : Jurnal Pengabdian Masyarakat UNWAHAS Jurnal Ilmiah Cendekia Eksakta Jurnal Kebidanan dan Keperawatan Aisyiyah Kartika : Jurnal Ilmiah Farmasi Jurnal Kefarmasian Indonesia

Yance Anas

Bagian Farmakologi Dan Farmasi Klinik Fakultas Farmasi Universitas Wahid Hasyim Semarang

Author-ID : 2992397

Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Economics, Econometrics & Finance Education Engineering Health Professions Immunology & microbiology Materials Science & Nanotechnology Mechanical Engineering Medicine & Pharmacology Nursing Public Health Social Sciences

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PENILAIAN KONSUMEN TERHADAP PERAN APOTEK SEBAGAI TEMPAT PELAYANAN INFORMASI OBAT DI KABUPATEN KUDUS Yance Anas; mohammad djatmiko; Aristya Nourwaqiana
Jurnal Ilmu Farmasi dan Farmasi Klinik JURNAL ILMU FARMASI DAN FARMASI KLINIK VOL.11 NO.1 JUNI 2014
Publisher : Universitas Wahid Hasyim Semarang

ABSTRACT Pharmacists in community pharmacy have a professional obligation to provide information on exact, safe and rational of drug use to the patient. The purpose of this study is to investigate the consumer’s assessment on the role of community pharmacy as a central of drug information services in all of pharmacy on Kudus regency. The study was performed through direct observation by using a questionnaire on consumers in all of pharmacy in Kudus regency. Respondent selection was determined by a combination of proportional random and accidental sampling. Data analysis performed including a compliance analysis using the Likert scale. Respondent’s answers were categorizing with a normal standard distribution. Cartesian diagram is used to determine the order of priority of the factors that affect consumer satisfaction. The results show that the majority of pharmacy consumers (61.03 %) are satisfies with the drug information services in community pharmacy. Level of concordance between consumer expectations and satisfaction in accepting drug information at community pharmacy are 90% - 99%. The consumer knowledge about the safety of medication use and their attitudes on the role of community pharmacists is quite high. They still doubt about the truth of drug information provided by pharmacist or pharmacist assistant. Consumers expect a guarantee of the truth and credibility of drug information provided by the pharmacist and pharmacist assistant in community pharmacy. Keywords : Drug information service, community pharmacy, consumer assessment

ANALISIS BIAYA DAN GAMBARAN PENGGUNAAN ANTIBIOTIK PADA PASIEN DEMAM TIFOID RAWAT INAP DI PUSKESMAS TLOGOSARI KULON TAHUN 2007 mohammad djatmiko; sugiyanti sugiyanti; yance anas
Jurnal Ilmu Farmasi dan Farmasi Klinik JURNAL ILMU FARMASI DAN FARMASI KLINIK VOL. 5 NO. 2 DESEMBER 2008
Publisher : Universitas Wahid Hasyim Semarang

ABSTRACTThyfoid fever is a suddenly fever causing by Salmonella Typhii infection. Pharma coeconomi research can help pharmacologist and nursing for deciding exact and efficient antibiotic medicine using. Direction of this research showing description of antibiotic using which consist of choosing group and type of antibiotic, single or combination using, oral on injection antibiotic supply, identification of component and therapy cost, calculating medicine using cost comparison against therapy cost on typhoid fever room caring patient in Puskesmas Tlogosari Kulon on 2007. This research is retrospective with descriptive data analysis. Data taken from 183 medical report of room caring typhoid fever patient on Puskesmas Tlogoari Kulon on 2007. Information from medical record is patient identity, medicine therapy, laboratory and caring time. Therapy cost counted from healthy tariff service book of Puskesmas Tlogosari Kulon. The result of research showing description of antibiotic using in typhoid fever room caring on Puskesmas Tlogosari Kulon on 2007 consist of : the most antibiotic used penisilin 40,45%, kuinolon 23,16%, kloramfenikol 22,64% the most antibiotic used ampisilin 34,35%, siprofloksasin 23,16%, kloramfenikol 17,81%, the most single giving antibiotic is kloranfenikol 5,15%, siprofloksasin 4,46%, combination antibiotic is ampisilin and siprofloksasin 26,80%, ampisilin and kloramfenikol 15,98%, the most givig way is oral combination and injection 82,52%,. Component and therapy cost of typhoid fever patient consist of : antibiotic cost Rp. 87.404,- non antibiotic cost Rp. 104.168,- accommodation and administration Rp.85.131,- visit cost or medician visit consultation Rp. 31.902,- act cost Rp. 25.306 and supporting checking cost Rp. 37.279. Medicine using cost comparison is 51,61% against total therapy cost Rp. 371.189,- Key word : cost analysis, tifoid fever, Puskesmas Tlogosari Kulon

UJI AKTIVITAS PENINGKAT DAYA INGAT FRAKSI ETIL ASETAT EKSTRAK ETANOL BUAH KEMUKUS (Piper cubeba L. f) PADA MENCIT JANTAN GALUR BALB/C DENGAN METODE RADIAL ARM MAZE (RAM) Junvidya Heroweti; Yance Anas; Idress Muhammed Hama
Jurnal Ilmu Farmasi dan Farmasi Klinik Jurnal Ilmu Farmasi & farmasi Klinik Vol 16 No 1 Juni 2019
Publisher : Universitas Wahid Hasyim Semarang

ABSTRACTNeurodegenerative is often associated with aging. The aging process will affect the decrease in nerve cells, especially brain nerve cells. Ethyl acetate fraction of kemukus fruit ethanol extract (FEAEE) of kemukus fruit has been investigated as a memory enhancer with the Morris water maze (MWM) method. One of the shortcomings of the Morris water maze method is that it causes stress in test animals, thus affecting their memory. This study aims to determine the memory enhancing activity of FEAEE of kemukus fruit with the radial arm maze method This research is an experimental study with pre and posttest matched control group design using 25 male mice, Balb/c strains divided into 5 groups. Mice group 1 as a negative control group were given a 1% CMC Na solution of 17.5 mg/mL. Group mice 2 - 5 were given FEAEE of kemukus fruit with doses of 63, 126, 252, and 504 mg/kgBB, respectively. Test material is given orally for 21 days. Observations were made on the frequency of mice passing the platform correctly and incorrectly and calculating memory scores using the radial arm maze (RAM) method. Differences in memory scores were analyzed by the Mann Whitney test. The results showed that FEAEE steamed fruit has memory enhancing activity. Memory activity was indicated at doses of 63 and 252 mg / kg.Keywords: steamed fruit (Piper cubeba, L. f), ethyl acetate fraction, memory score, radial arm maze

AKTIVITAS ANTIDIARE EKSTRAK ETANOL DAUN NANGKA (Artocarpus heterophyllus Lam.) DAN DAUN ANGSANA (Pterocarpus indicus Wild.) PADA MENCIT JANTAN GALUR BALB/C Yance Anas; Devi Nisa Hidayati; Aristya Kurniasih; Lalu Ksatria D.S.
Jurnal Ilmu Farmasi dan Farmasi Klinik JURNAL ILMU FARMASI & FARMASI KLINIK VOL. 13 NO. 1 JUNI 2016
Publisher : Universitas Wahid Hasyim Semarang

ABSTRACT Traditionally, jackfruit leaves (Artocarpus heterophyllus Lam.) and angsana leaves (Pterocarpus indicus Wild.) have been used as an herb for diarrhea treatment. The purpose of this experimental study was to investigate the antidiarrheal effect of jackfruit leaves ethanol extract (JLEE) and angsana leaves ethanol extract (ALEE) on Balb/C male mice with castor oil-induced diarrhea method. The study design is a randomized matched two group post test-only. JLEE and ALEE produced by maceration. An antidiarrheal activity of both of extracts compared with loperamide-HCl 10 mg/Kg BW. JLEE (100, 200 and 400) mg/Kg BW and ALEE (80, 160 and 320) mg/Kg BW significantly (p <0.05) decrease the amount of liquid and soft feces, and delay the onset of diarrhea compared with controls (NaCl 0.9% 10 mL/Kg BW). The ability JLEE 400 mg/Kg BW and EEDA 320 mg/Kg BW on inhibiting the formation liquid and soft feces are higher than loperamide HCl 10 mg/Kg BW with antidiarrheal effect amounted to 72.31%, 65.47%, and 54.46% respectively. The potency of JLEE and ALEE as antidiarrheal (ED50) are (20.85 and 3.52) mg/Kg BW respectively. However, in this study, a single dose of loperamide-HCl, JLEE and ALEE treatments are not able to heal the diarrhea symptom (p> 0.05). Keywords: Antidiarrheal, castor oil-induced diarrhea,ethanol extract, Artocarpus heterophyllus Lam., Pterocarpus indicus Wild.

AKTIVITAS STIMULANSIA EKSTRAK ETANOL BUNGA DAN DAUN CENGKEH (Syzygium aromaticum (L) Merr. & Perry.) PADA MENCIT JANTAN GALUR SWISS BESERTA IDENTIFIKASI GOLONGAN SENYAWA AKTIFNYA Yance Anas; Niken Puspitasari; Maulita Cut Nuria
Jurnal Ilmu Farmasi dan Farmasi Klinik Jurnal Ilmu Farmasi & Farmasi Klinik Vol.10 No.1 Juni 2013
Publisher : Universitas Wahid Hasyim Semarang

ABSTRACT Keywords : Cloves’ buds and leaves (Syzygium aromaticum (L) Merr. & Perry.) ethanol extracts, stimulant, locomotoric activity, hole-board, open field, terpenoid, alkaloids One of the clove properties is as a stimulant. The purposes of this experimental study were to investigate stimulant effect of clove’s buds and leaves ethanol extracts through locomotoric activity studies on male Swiss strain mice and to identify its active compounds. The experiment was performed with pretest and posttest control group design. Thirty two mice ware divided into eight treatment groups. Locomotoric activity study was performed with hole-board and open-field method. Mice in group I (negative control) provide orally CMC-Na 1% 25 mL/kg BW. Mice in group II (caffeine group) provided orally caffeine 25 mg/kg BW. Six other treatment groups provide clove’s buds and leaves ethanol extracts (100, 200, and 400) mg/kg BW respectively. Frequency of mice head-deeping into holes in the floor and duration of movement in 5 minutes were accessed before and after treatment with extract. Data analyzed using paired-sample T test (p: 0.95). The result showed clove’s buds and leaves ethanol extracts to have stimulant properties on male Swiss strain mice through enhancing locomotoric activity in hole-board method (p<0.05). Clove’s buds and leaves ethanol extracts (100, 200 and 400) mg/Kg BW treatment on male Swiss strain mice can significantly increase mice head-deeping frequency into holes in the floor and exploratory behavior (p<0.05). There was no significant different on mice duration movement (p>0.05). Terpenoid and alkaloid active compounds in clove’s buds and leaves ethanol extracts though to play an important role in enhancing male Swiss strain mice locomotoric activities.

UJI AKTIVITAS REPELLENT FRAKSI N-HEKSAN EKSTRAK ETANOLIK DAUN MIMBA (Azadirachta indica A. Juss) TERHADAP NYAMUK AEDES AEGYPTI Muhamad Djatmiko; Yance Anas; Sri Murti Handayani
Jurnal Ilmu Farmasi dan Farmasi Klinik Prosiding Seminar Nasional "Peranan dan Kontribusi Herbal dalam Terapi Penyakit Degeneratif"
Publisher : Universitas Wahid Hasyim Semarang

Daun mimba dipercaya masyarakat dapat menolak hinggapan nyamuk Aedes aegypti, sehingga dapat digunakan sebagai repellent. Penelitian ini bertujuan untuk membuktikan aktifitas repellent fraksi n-heksan ekstrak etanolik daun mimba terhadap nyamuk Aedes aegypti, dan mengidentifikasi senyawa golongan terpenoid dalam fraksi n-heksan tersebut. Ekstrak etanolik daun mimba dibuat dengan menggunakan metode Maserasi dan selanjutnya difraksinasi dengan menggunakan pelarut n-heksan. Fraksi n-heksan ekstrak etanolik daun mimba konsentrasi 10, 20, 40% dalam pelarut etanol dioleskan pada pergelangan tangan bagian atas hingga ujung jari dan kemudian dimasukkan ke dalam sangkar nyamuk. Tiap sangkar nyamuk berisi 30 ekor nyamuk Aedes aegypti betina berumur 3-5 hari yang telah dipuasakan selama 24 jam. Pengujian dihentikan apabila terdapat hinggapan nyamuk untuk pertama kalinya. Data yang diperoleh berupa rata-rata waktu penolakan terhadap hinggapan nyamuk. Analisa statistik dilakukan terhadap data waktu penolakan menggunakan uji Kruskal-Wallis yang dilanjutkan dengan uji Mann-Whitney pada taraf kepercayaan 95%. Identifikasi senyawa aktif golongan terpenoid dilakukan dengan menggunakan Kromatografi Lapis Tipis (KLT). Hasil penelitian menunjukkan bahwa fraksi n-heksan ekstrak etanolik daun mimba mengandung senyawa aktif golongan terpenoid. Pada konsentrasi 20 dan 40%, fraksi n-heksan tersebut memiliki aktivitas sebagai repellent karena dapat menolak hinggapan nyamuk Aedes aegypti secara berturut-turut selama 329 dan 915 detik (5,48 dan15,25 menit). Kata kunci : Repellent, fraksi n-heksan ekstrak etanolik daun mimba, Aedes aegypti

AKTIVITAS ANTIPLASMODIUM EKSTRAK HIDROTROPI DAUN SAMBILOTO (Andrographis paniculata Ness.) SECARA In Vitro PADA Plasmodium falciparum STRAIN G-2300 RESISTEN KLOROQUIN Yance Anas; Rita Dwi Ratnani; Laeli Kurniasari; Indah Hartati
Jurnal Ilmu Farmasi dan Farmasi Klinik Vol 17, No 01 (2020): Jurnal Ilmu Farmasi & farmasi Klinik Vol 17 No. 01, Juni 2020
Publisher : Universitas Wahid Hasyim Semarang

ABSTRACT The bitter leaf extract (Andrographis paniculata Ness.) has long been known as an anti-malarial. Our previous research has developed a bitter leaf hydrotrophy extract (BLHE) using a sodium acetate 2 mol/L as a hydrotop compound solution. The extraction process lasts for 2 hours, faster than conventional extraction. The result is two types of BLHE with different stirring temperatures, at 30°C (BLHE1) and 35°C (BLHE2). This study meant to determine and compare the in vitro antiplasmodial activity BLHE1 and BLHE2. The anti-plasmodial activity of BLHE1 and BLHE2 (0.1- 50.0) g/mL performed on a G-2300 strain of P. falciparum (chloroquine-resistant) after incubated for 48 hours (triplicate). The percentage of parasitemia determined through an examination of blood smears stained with Giemsa. The percentage of growth inhibition of P. falciparum evaluates by comparing percentage of growth with the control group and IC50 determine by probit analysis. The results showed that BLHE1 and BLHE2 respectively were able to inhibit the growth of P. falciparum of 14.62% - 43.25% (IC50: 59.689 μg/mL) and 24.06% - 49.48% (IC50: 44.541 μg/mL). Based on these data, BLHE should produce with sodium acetate 2 mol/L, with stirring at 35°C, because this condition will obtain BLHE that active as anti-plasmodial. Keywords: Anti-plasmodial, bitter leaf hydrotrophy extract, P. falciparum strain G-2300, in vitro

PENGEMBANGAN MODEL HEWAN PERCOBAAN TIKUS DIABETES MELLITUS TIPE 2 KARENA RESISTENSI INSULIN YANG DIINDUKSI DENGAN HUMAN INSULIN JANGKA PANJANG Yance Anas; Ria Rositasati; Meita Rafika Fitriani; Suharjono Suharjono
Jurnal Ilmu Farmasi dan Farmasi Klinik Jurnal Ilmu Farmasi & Farmasi Klinik Volume 12 No.2 Desember 2015
Publisher : Universitas Wahid Hasyim Semarang

ABSTRACT Hyperinsulinemia may precede insulin resistance in patients with Type 2 diabetes. In this study, we tried to reveal an influence of long-term treatment of human insulin to hyperglycemic and insulin resistance in male Wistar rats. Before the experiment, blood-glucose levels measured two hours after 2 g/Kg glucose imposition. Rats receive human insulin (0.45-1.80) IU/KgBW/day subcutaneously every day for 14 days. Furthermore, human insulin 1.8 IU/KgBW/day also provide a period of7,14and 21days. At theend of the experiment,we mademeasurements ofblood-glucoselevelstwo hoursafterthe imposition glucose.There are, the influence oflong-termtreatment of human insulin determined bycomparing the blood-glucoselevelsbeforeandafter insulin treatment. Insulin resistance isdeterminedby comparing thehypoglycemiceffect of glibenclamide 10 mg/Kg BW to the control group. The results concluded that the humaninsulin1.80 IU/KgBW/day treatment for 14dayscan improveblood-glucoselevel'sWistarmale ratsup to126.369mg/dL(p<0.05)withpatternsdoes notdepend onthe length of timeof administration.The averageof % hypoglycemiceffect of glibenclamide10mg/kgBW in ratswhoreceived treatment with human insulin 1.80IU/kg BW/dayswereat 18,31%,smaller thancontrols (62.20%) (p<0.05). Decrease in hypoglycemic effects of glibenclamide 10 mg/kg BW caused by mice has insulin resistance might be due to a result of long-term insulin administration. Keywords : Human insulin, insulin resistance, Type 2 diabetes animal models

EFEK ANTIDIARE EKSTRAK ETANOL DAUN PARIJOTO (Medinilla speciosa Blume) PADA MENCIT JANTAN GALUR BALB/C Yance Anas; Desi Rakhmawati; Layyinatul Fuadah; Nola Carina Rahayu
Jurnal Ilmu Farmasi dan Farmasi Klinik Jurnal Ilmu Farmasi & farmasi Klinik Vol 16 No 1 Juni 2019
Publisher : Universitas Wahid Hasyim Semarang

ABSTRACTParijoto is one of a rare plant species in Indonesia, and its leaves have traditionally been utilized to treat diarrhea in the area of Kudus Regency, Indonesia. Parijoto leaves contain active compounds of tannin and flavonoid which have antidiarrheal properties. This investigation intends to demonstrate the antidiarrheal effect of parijoto leaf ethanol extract (EEDP) on male Balb/C mice castor oil-induced diarrheal and reveal its antidiarrheal mechanism through antimotility and antisecretory testing. EEDP made by maceration method. The antidiarrheal effects of three series level EEDP (500; 1,000 and 2,000) mg / Kg BB tested on diarrhea mice induced by castor oil. Concurrently, the antimotility and antisecretory effects of EEDP investigated with the intestinal transit method and castor oil-induced enteropooling. The data in this study were the onset of diarrhea, the weight of liquid-formless stools (for 8 hours), the ratio of digestion tracts passed by norit markers, and the volume of intestinal contents. These data were analyzed statistically at the 95% confidence level. The examination presumed that EEDP was able to respite the onset of diarrhea and diminish the formation of liquid-formless feces in male Balb/C mice induced by castor oil. The antidiarrheal mechanism of EEDP also exhibited in this study through its effects as antimotility and antisecretory.Keywords: Parijoto leaf ethanol extract, antidiarrheal, antimotility, antisecretory

EFEKTIVITAS FRAKSI AKTIF EKSTRAK ETANOL LABU SIAM (Sechium edule (Jack) Sw) SEBAGAI ANTIHIPERTENSI PADA TIKUS HIPERTENSI YANG DIINDUKSI MONOSODIUM GLUTAMAT Yance Anas; Ika Nilam Cahyani; Ulum Firnanda Sukma
Jurnal Ilmu Farmasi dan Farmasi Klinik Vol 18, No 01 (2021): Jurnal Ilmu Farmasi & Farmasi Klinik
Publisher : Universitas Wahid Hasyim Semarang

ABSTRACT Previous studies accomplished that the chayote ethanol extract (Sechium edule (Jack) Sw) had an antihypertensive effect. To get and identify the active compound, we fractionated the extract and evaluated its antihypertensive activity. This study aims to investigate the antihypertensive effect of the n-hexane fraction (HF-CEE) and ethyl acetate fraction of chayote ethanol extract (EAF-CEE) in monosodium glutamate (MSG)-induced hypertensive rats. We made the chayote extract using the maceration method by soaking the chayote simplicia in ethanol 70%. HF-CEE and EAF-CEE were obtained by stratified fractionation using n-hexane and ethyl acetate. An antihypertensive effect of the fraction measured on MSG-induced hypertension male Wistar rats after MSG 100 mg/kg BW/day (p.o) treatment for 14 days. The study concluded that HF-CEE and EAF-CEE had an antihypertensive effect in MSG-induced hypertensive rats. The EAF-CEE antihypertensive effect is higher than HF-CEE. Therefore, the FEAF-CEE active compounds need to be isolated, identified, developed, and their potential as an antihypertensive candidate. Keywords: Antihypertensive, chayote, ethyl-acetate fraction, Sechium edule, monosodium glutamate

Co-Authors Agung Endro Nugroho Agung Endro Nugroho Agung Endro Nugroho Agung Hendro Nugroho Ali Imron Amprih Martha Amprih Martha, Amprih Aniq, Nur Aristya Kurniasih Aristya Nourwaqiana Azizah, Ulfah Laily Darmanto Darmanto Desi Rakhmawati Devi Endah P. Devi Nisa Hidayati Diana Nur Afifah, Diana Nur Dita Desti D_Khilyati Erika Indah Safitri Esri Rusminingsih - Febi Ariska Wahyu Putri Fitria, Risha Fillah Hardhono Susanto Heroweti, Junvidya Idress Muhammed Hama Ika Nilam Cahyani Ika Nilam Cahyani Imam Faozi Indah Hartati Irmawati, Putri JOKO TRI WIBOWO Kenyo Alexandra Oktaviani Kiki Damayanti Kiki Damayanti, Kiki Laeli Kurniasari Laeli Kurniasari Lalu Ksatria D.S. Layyinatul Fuadah Mamik Dwi Anggraini Marlina, Windy Maulita Cut Nuria Maulita Cut Nuria Meita Rafika Fitriani MOHAMAD ASPOLLAH SUKARI mohammad djatmiko Muhamad Djatmiko Mustagfirin Mustagfirin Nabila, Talcha Naimi Amalia Hatimah Niken Puspitasari Nola Carina Rahayu Nunung Yuniarti NUR CHAKIM Pramesti Dewi PUGU NOVI ARSITO Puji Astuti Puji Astuti Puji Hartati Putri Irmawati Retno Murwanti Ria Rositasati Ririn Lispita Wulandari risha fillah fithria Risha Fillah Fithria Risha Fillah Fitria Rita Dwi Ratnani Sekar Indah Ningtyas Siti Nurikha Siti Wahidatun Nisa Sri Murti Handayani SUGENG RIYANTO Sugeng Riyanto Sugiyanti Sugiyanti Suharjono, Suharjono Sumantri Sumantri Talcha Nabila Tri Murti Andayani Ulum Firnanda Sukma Ulum Firnanda Sukma Wibowo, Judiono widi astuti r Windy Marlina Wulandari, Febri Yunita Midkha

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