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All Journal Prosiding Seminar Nasional Sains Dan Teknologi Fakultas Teknik Jurnal Ilmu Farmasi dan Farmasi Klinik (Journal of Pharmaceutical Science and Clinical Pharmacy) INDONESIAN JOURNAL OF PHARMACY Pharmascience Jurnal Farmasi Sains dan Komunitas Jurnal Ilmu Kefarmasian Indonesia Abdimas UNWAHAS : Jurnal Pengabdian Masyarakat UNWAHAS Jurnal Ilmiah Cendekia Eksakta Jurnal Kebidanan dan Keperawatan Aisyiyah Kartika : Jurnal Ilmiah Farmasi Jurnal Kefarmasian Indonesia

Yance Anas

Bagian Farmakologi Dan Farmasi Klinik Fakultas Farmasi Universitas Wahid Hasyim Semarang

Author-ID : 2992397

Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Economics, Econometrics & Finance Education Engineering Health Professions Immunology & microbiology Materials Science & Nanotechnology Mechanical Engineering Medicine & Pharmacology Nursing Public Health Social Sciences

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POTENSI HIPOGLIKEMIK EKSTRAK ETANOLIK DAUN SRIKAYA Yance Anas; Kenyo Alexandra Oktaviani; Suharjono Suharjono
Jurnal Ilmu Farmasi dan Farmasi Klinik JURNAL ILMU FARMASI DAN FARMASI KLINIK VOL. 7 NO. 2 DESEMBER 2010
Publisher : Universitas Wahid Hasyim Semarang

ABSTRACT Active compounds in the leaves of sugar apple is believed to lower blood sugar levels, so it can be used as an oral hypoglycemic agent in the treatment of diabetes. The purpose of this research is to prove the hypoglycemic effect of ethanol extract of sugar apple leaves in Wistar male rats. The research was conducted by using oral glucose test in the group of rats who received treatment doses of sugar apple leaves etanolik extract (75.6, 151.2 and 302.4) mg / KgBW and control groups. Test materials were given 30 minutes before loading 2g/KgBB glucose orally. Research data is the blood glucose level every time which is converted into data AUC0-300 and % hypoglycemic effect. Potential hypoglycemic effects (ED50) were measured using probit analysis. Statistical analysis performed using Kruskal-Wallis test followed by Mann-Whitney test at the level of 95%. In addition, also identified the active compound flavonoid with qualitative chemical analysis method. The results showed that ethanol extract of leaves of sugar apple dose (75.6, 151.2 and 302.4) mg / kg has a hypoglycemic effect on male wistar rats subjected to glucose (P <0.05), with the percentage hipogllikemik effect amounts to (11.05, 23, 01 and 42.793)%. Potency (ED50) etanolik extract sugar apple leaves as hypoglycemic agents amounted to 339 mg / KgBW. In this study, ethanol extract of sugar apple leaves positive active compounds containing flavonoid. Key words: hypoglycemic, sugar apple

Efek Antihipertensi Ekstrak Etanol Kombinasi Rambut dan Biji Jagung (Zea mays L.) pada Tikus Hipertensi yang Diinduksi Monosodium Glutamat Yance Anas; Naimi Amalia Hatimah
Jurnal Ilmu Farmasi dan Farmasi Klinik Jurnal Ilmu Farmasi & Farmasi Klinik Vol 15 No 1 Juni 2018
Publisher : Universitas Wahid Hasyim Semarang

INTISARI Penelitian sebelumnya membuktikan bahwa infus rambut dan jus biji jagung memiliki efek antihipertensi pada tikus jantan sehingga dapat dikembangkan dalam bentuk ekstrak. Penelitian ini bertujuan untuk membuktikan efek antihipertensi ekstrak etanol kombinasi rambut dan biji jagung (EEK-RBJ) pada tikus hipertensi yang diinduksi monosodium glutamat (MSG). EEK-RBJ dibuat menggunakan metode maserasi. Tikus hipertensi dibuat dengan cara pemberian MSG 100 mg/kgBB/hari selama 14 hari sampai tekanan darah sistol ≥ 155 mmHg. Tikus hipertensi yang digunakan sebanyak 25 ekor, dibagi menjadi 5 kelompok yaitu kelompok kontrol hipertensi (CMC-Na 0,5% 12,5 mL/kgBB/hari), kelompok furosemid 5,04 mg/kgBB/hari), dan kelompok EEK-RBJ (125, 250 dan 500) mg/kgBB/hari. Sediaan uji diberikan satu kali sehari selama 14 hari (p.o). Data yang diamati adalah perbedaan tekanan darah sistol dan diastol sebelum dan setelah pemberian sediaan uji serta perbedaan penurunan tekanan darah. Data perbedaan tekana darah dianalisa secara statistik menggunakan uji t-berpasangan atau uji Wilcoxon (P: 0,95). Hasil penelitian menyimpulkan bahwa EEK-RBJ (125, 250 dan 500) mg/Kg BB/hari selama 14 hari mampu menurunkan tekanan darah sistol dan diastol tikus hipertensi dengan pola tergantung dosis. EEK-RBJ 500 mg/Kg BB/hari dapat menurunkan tekanan darah sistol dan diastol tikus hipertensi yang diinduksi MSG berturut-turut sebesar 20,04 mmHg dan 13,16 mmHg. Kata Kunci: Efek antihipertensi, ekstrak kombinasi, rambut dan biji jagung, MSG ABSTRACT In previous studies, infusion of silk and corn seed combination have antihypertensive effects, so it can develop in the form of extracts. The purpose of this study is to reveal the antihypertensive effect of a silk and seed corn ethanol extract (SSC-EE) on MSG-induced hypertensive rats. SSC-EE produced with maceration. MSG 100 mg/kg BW/day for 14 days orally used to induce hypertension condition in male Wistar rats until systolic blood pressure ≥ 150 mmHg. Twenty-five of hypertensive rats divided into five groups. Hypertensive rats in Group I treated with CMC-Na 0.5% 12.5 mL/kg BW/day and group II treated with Furosemide 5.04 mg/kg BW/day. Meanwhile, group III, IV and V treated with SSC-EE (125, 250 and 500) mg/kg BW/day. SSC-EE was treated orally once daily for 14 days. Systolic and diastolic blood pressure, before and after of extracts treatment and blood pressure decline was observed and analyzed statistically using paired t-test or Wilcoxon test (P: 0.95). The results show that SSC-EE (125, 250 and 500) mg/Kg BW/day for 14 days can decrease the MSG-induced hypertensive rats systolic and diastolic blood pressure (p<0.05) with the dose-dependent manner. SSC-EE 500 mg/Kg BW/day decrease the systolic and diastolic blood pressure of 20.04 mmHg and 13.16 mmHg, respectively. Keywords: Antihypertensive effect, combination extract, silk and seed corn, MSG

POTENSI FRAKSI n-HEKSAN EKSTRAK ETANOL RIMPANG LENGKUAS [Alpinia galanga (L.) Swartz.] DALAM MENINGKATKAN KUALITAS SPERMA DAN SPERMATOGENESIS Yance Anas; Imam Faozi; Suharjono Suharjono
Jurnal Ilmu Farmasi dan Farmasi Klinik Prosiding Seminar Nasional "Peluang Herbal Sebagai Alternative Medicine"
Publisher : Universitas Wahid Hasyim Semarang

ABSTRACT Flavonoids and steroid's compounds have been identifying in the galangal rhizome [Alpinia galanga (L.) Swartz.]. This compound has hormonal and antioxidant effects and can improve the spermatogenesis and quality of spermatozoa. The purpose of this study is to find out the effects of the n-hexane fractions from galangal rhizome ethanol extract (HFGREE) on male Swiss mice spermatogenesis and quality of spermatozoa. This research is a laboratory experimental with randomized matched post test only controls group design. Twenty-four male Swiss mice (8-weeks old) divided among four groups: control groups (mice treated with CMC 1.0% 10 mL.kg-1.day-1), and three groups of mice treated with HFGREE (1.29; 2.58 and 5.16) mg.kg-1.day-1 for 30 days. All mice sacrificed at day 31. Furthermore, testicular tissue sections are used to calculate the score of spermatogenesis. Spermatozoa in the epididymis were used to assess the quality of spermatozoa. The results showed the HFRGEE (2.58 and 5.16) mg.kg-1.day-1 for 30 days, significantly elevate spermatogenesis score, and improve the spermatozoa count, spermatozoa motility, healthy and normal spermatozoa of male Swiss mice (p<0.05). Further studies can focus on the identification of active compounds in HFGREE that play a role in improving spermatogenesis and quality of spermatozoa. Key words: n-hexane fraction, galangal rhizome ethanol extract, spermatogenesis, quality of spermatozoa

KAJIAN REVERSIBILITAS INTERAKSI MARMIN TERHADAP RESEPTOR HISTAMIN H1, ASETILKOLIN MUSKARINIK Ach-M3 dan β2-ADRENERGIK Yance Anas; Agung Hendro Nugroho; Sugeng Riyanto
Jurnal Ilmu Farmasi dan Farmasi Klinik JURNAL ILMU FARMASI DAN FARMASI KLINIK VOL.11 NO.2 DESEMBER 2014
Publisher : Universitas Wahid Hasyim Semarang

ABSTRAK Penelitian terdahulu menyimpulkan bahwa marmin (7-(6’,7’-dihidroksigeranil-oksi) kumarin) dapat menghambat kontraksi otot polos trakea marmut terisolasi melalui efeknya sebagai antagonis reseptor H1 dan Ach-M3. Marmin juga sedikit meningkatkan efek relaksasi otot polos trakea yang diinduksi oleh isoproterenol melalui interaksinya terhadap reseptor β2-adrenergik. Penelitian ini bertujuan untuk mengevaluasi efek reversibelitas interaksi marmin terhadap reseptor H1, Ach-M3 dan β2-adrenergik. Penelitian ini menggunakan metode percobaan organ terisolasi. Uji reversibilitas dilakukan setelah perlakuan marmin (10 dan 100 μM) terhadap kontraksi/relaksasi otot polos trakea yang diinduksi oleh agonis (histamin, metakolin dan isoproterenol). Otot polos trakea dicuci selama 30 menit dengan penggantian larutan bufer Krebs setiap lima menit. Setelah dicapai kondisi yang stabil, selanjutnya dilakukan pengukuran kontraksi atau relaksasi kembali dengan pemberian konsentrasi bertingkat histamin (10-8 – 10-3) M, metakolin (10-8 – 10-3) M dan isoproterenol (1 x 10-7 – 3 x 10-3 M). Data disajikan dalam bentuk nilai pD2 (rata-rata ± SEM) yang diperoleh dari kurva hubungan negatif logaritma konsentrasi agonis yang menghasilkan setengah respon (kontraksi/relaksasi) maksimal. Hasil penelitian menunjukkan bahwa interaksi marmin terhadap protein reseptor H1, Ach-M3, dan β2-adrenergik otot polos trakea bersifat reversibel. Hasil analisis varian satu jalan menyimpulkan perbedaan nilai pD2 histamin, metakolin dan isoproterenol sebelum dan setelah perlakuan marmin tidak bermakna secara statistik (p>0,05). Kata Kunci : Farmakodinamik marmin, uji reversibelitas, reseptor H1, Ach-M3 dan β2–adrenergik, percobaan organ terisolasi ABSTRACT Previous studies concluded that amarmin(7 - (6 ', 7'-dihidroxygeranyl-oxy) coumarin) shown to inhibit isolated guinea-pig tracheal smooth muscle contraction through its effect as an H1and Ach-M3receptor's antagonist. Marmin also slightly increases tracheal smooth muscle relaxation induced by isoproterenol through its interaction on β2-adrenergic receptor. The purpose of this experimental study was to evaluate the reversibility of marmin interaction on H1, Ach-M3 and β2-adrenergic receptors.The study conducted using in vitro isolated-trachea experimental. Reversibility studies performed after marmin (10 and 100) μM treatment on tracheal smooth muscle contraction/relaxation induced by agonists (histamine, methacholine and isoproterenol). Trachea was washed for 30minuteswith Krebs buffer solution replacement every five minutes. Furthermore, trachea contracted or relaxed with series histamine (10-8 – 10-3) M; methacholine (10-8 – 10-3) M and isoproterenol (10-7 – 3.10-3) M. Data were expressed as mean±SEM. The pD2values are derived from the negative logarithm to base 10 of the agonist's concentration which cause a half maximal response to the contraction or relaxation.The results showed that the marmin interaction on H1, Ach-M3, and β2-adrenergic receptors are reversible. One-way Anova concluded that histamine, metacholine and isoproterenol pD2 value before and after marmin (10 and 100) μM treatments are not different statistically (p>0.05). Key Word : Marmin reversibility studies, H1, Ach-M3 and β2-adrenergic receptors, isolated organ experimen

AKTIVITAS ANTIDIABETES FRAKSI n-HEKSAN EKSTRAK ETANOL DAUN LENGLENGAN (Leucas lavandulifolia JE. Smith) PADA TIKUS NEONATAL STZ-INDUCED TYPE-2 DIABETES MELLITUS Yance Anas; Risha Fillah Fithria; Maulita Cut Nuria; Yunita Midkha; Agung Endro Nugroho; Puji Astuti
Jurnal Ilmu Farmasi dan Farmasi Klinik Prosiding Seminar Nasional "Perkembangan Terbaru Pemanfaatan Herbal Sebagai Agen Preventif Pada Tera
Publisher : Universitas Wahid Hasyim Semarang

ABSTRAK Dalam penelitian ini, kami melakukan fraksinasi ekstrak etanol daun lenglengan dengan pelarut n-heksan untuk menyederhanakan kandungan zat aktif yang terkandung di dalamnya dan mengevaluasi efek antidiabetesnya. Penelitian ini bertujuan untuk mengevaluasi efek antidiabetes fraksi n-heksan ekstrak etanol daun lenglengan (FHDL) pada tikus neonatal STZ-induced type-2 diabetes mellitus. STZ 90 μg/KgBB diberikan secara i.p pada 35 ekor anak tikus galur Wistar umur 2 hari. Pada usia 3 bulan, dilakukan pengukuran kadar glukosa pre-prandial dan post-prandial. Sebanyak 25 ekor tikus neonatal STZ-induced type-2 diabetes mellitus dikelompokkan ke dalam lima kelompok perlakuan, terdiri dari kelompok kontrol diabetes (CMC-Na 0,5%; 25 mL/KgBB), kelompok glibenklamid 5 mg/KgBB dan tiga kelompok FHDL (62,5; 125 and 250) mg/KgBB. Sediaan uji diberikan selama 28 hari. Kadar glukosa darah pre-prandial dan post-prandial diukur pada hari ke-0, 7, 14 dan 28. FHDL secara signifikan berhasil menurunkan kadar glukosa darah pre-prandial dan post-prandial tikus neonatal STZ-induced type-2 diabetes mellitus (p<0,05). Perlakuan FHDL 62,5 mg/KgBB selama 28 hari memiliki efek antidiabetes yang tinggi, yaitu mampu menurunkan kadar glukosa darah pre-prandial tikus sebesar 45,99%. Perlakuan FHDL 250 mg/KgBB juga signifikan menurunkan kadar glukosa darah post-prandial tikus (p<0,05) dengan efek antidiabetes pada hari ke-7, 14 dan 28 berturut-turut adalah sebesar 19,28%; 22,68% dan 24,92%. Kata Kunci: Daun Lenglengan, Efek Antidiabetes, Fraksi n-Heksan, Neonatal STZ-induced type-2 diabetes mellitus

STANDARDISASI SPESIFIK DAN NON SPESIFIK EKSTRAKSI HIDROTROPI ANDROGRAPHOLID DARI SAMBILOTO (Andrographis paniculata) Rita Dwi Ratnani; Indah Hartati; Yance Anas; Devi Endah P.; Dita Desti D_Khilyati
Jurnal Ilmu Farmasi dan Farmasi Klinik Prosiding Seminar Nasional "Peluang Herbal Sebagai Alternative Medicine"
Publisher : Universitas Wahid Hasyim Semarang

ABSTRACT Several active compounds has been found in Andrographis paniculata, including andrographolide (deoxy andrographolide, andrographolide, neo andrographolide and 14-deoxy-11,12-didehydroandrographolide) and kalmeghin. The active compounds properties and its levels in extract medicinal plants cannot be guaranteed to always be in a constant amount. This may be due to variations in the quality of medicinal plants, such as seeds, grow location, climate, conditions (age and harvest method), as well as post-harvest process and extraction method. Therefore, standardization of the extract should be performed to ensure the quality of the extract before it is produced on an industrial scale. The purpose of this study is to standardize the sambiloto hydrotropic extract. Specific parameters such as the organoleptic properties of the extract and identification of andrographolide compound as marker compounds. In contrast, the non-specific parameter includes drying shrinkage, microbiological contamination levels, heavy metal contamination levels, ash levels, the solubility of extracts in water and ethanol. The results showed that the organoleptic properties hydrotropic sambiloto extract are in powder form dense, dry, dark green, characteristic odor and bitter taste. Andrographolide compound as a marker compound in the sambiloto extract was identified by TLC method. The non-specific parameters of sambiloto hydrotropic extract were shrinkage drying of 13.5%, microbiological contamination of (3.1x107) CFU/g, heavy metal contamination (Cd levels of 0.104 ppm, and Pb levels of 2.248 ppm), ash levels of 37.5%, and the solubility extracts in water and ethanol are 40.8 % dan 42.0% respectively. Key words: Andrographis paniculata, extract standardization, specific and non-specific

PENGARUH PEMBERIAN JUS KECAMBAH KACANG HIJAU (Vigna radiata (L.) R. Wilczek)TERHADAP KUALITAS SPERMATOZOA DAN SPERMATOGENESIS MENCIT JANTAN GALUR SWISS Yance Anas; Nur Chakim; Suharjono Suharjono
Jurnal Ilmu Farmasi dan Farmasi Klinik Jurnal Ilmu Farmasi & Farmasi Klinik Volume 12 No. 1 Juni 2015
Publisher : Universitas Wahid Hasyim Semarang

ABSTRACT Efficacy of mung bean sprouts as natural fertility enhancer for men was not widely investigated and published. The objective of this study is to investigate the effect of mung bean sprout’s juice on male Swiss mice spermatozoa quality and spermatogenesis. An experimental study performed with randomized matched two-group post test only design approach. Thirtymale mice were dividedinto fivegroups randomly, which consist of a control group (CMC25mL/kg BW/day); d-α-tocopherol group (556 IU/kg BW/day) and three mung beans sproutjuice groups (33, 66 and 132) mg/kg BW/day. Mice treated every dayfor 20days orally. Micewere sacrificed; testis and epididymis were collected and examined. The spermatozoa quality (count, progressive motility and normal morphology) and spermatogenesis observed. The results showedthatmung bean sproutsjuice treatment (33, 66 and 132) mg/Kg BW/day for 20 days did not enhance male Swiss strain mice fertility. Spermatogenesis score, count and normal morphology spermatozoa that receive treatment with mung bean sprout juice was not significantly different to the control group (p>0.05). Conversely; mung bean sprouts juice treatment lead to decrease male Swiss strain mice spermatozoa progressive motility (p<0,05). Keywords: Mung bean sprouts (Vigna radiata (L.) R.Wilczek) juice, spermatozoa quality, spermatogenesis.

AKTIVITAS ANTIDIABETES FRAKSI n-HEKSAN EKSTRAK ETANOL DAUN LENGLENGAN (Leucas lavandulifolia JE. Smith) PADA TIKUS DM TIPE-2 YANG MENGALAMI RESISTENSI INSULIN Yance Anas; Risha Fillah Fithria; Maulita Cut Nuria; Amprih Martha; Agung Endro Nugroho; Puji Astuti
Kartika : Jurnal Ilmiah Farmasi Vol 3 No 1 (2015)
Publisher : Fakultas Farmasi Universitas Jenderal Achmad Yani, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26874/kjif.v3i1.93

ABSTRACTÂ This study is an effort to discover new anti-diabetic compounds from natural productsÂ in the type-2 diabetes mellitus treatment. The purpose of this study was to determine the potential of n-hexane fraction (FHDL) from lenglengan leaf ethanol extract as an antidiabetic in insulin resistance type-2 diabetic Rat. Insulin resistance was induced by administration of long-acting insulin (LantusÂ®) 1.80 IU.Kg BW-1.day-1 for 14 days. Insulin resistance rats tested by using parameter fasting blood glucose (FBG), before and after treatment of long-acting insulin. Rat has to type-2 diabetes due to insulin resistance when FBG on day 18 exceeded 85 mg.dL-1.Â Test results show the animal had insulin resistant. Â Rat with the insulin resistance is divided into five treatment groups consisting of one group of diabetic control (treats with CMC-Na 0.5%, 25 mL.Kg BW-1.day-1), three dose groups ofÂ FHDL (62.5; 125 and 250) mg.Kg BW-1.day-1 and a positive control group (treatsÂ withÂ metformin 150 mg.Kg BW-1.day-1). FHDL and metformin 150 mg.Kg BW-1.day-1 were administered once daily for 14 days. FBG data, before and after treatments were compared. FBG assay is using a reagent kit. The results showed that FHDL (125 and 250) mg.Kg BW-1.day-1 and metformin 150 mg.Kg BW-1.day-1 are shown to have antidiabetic effects in insulin resistance type-2 diabetic rat. FHDL 250 mg.Kg-1.day-1 antidiabetic effect (25.87%) is equivalent to metformin 150 mg.Kg BW-1.day-1 (21.50) (p>0.05). The results of this research can proceed to find the novel antidiabetic compound from the lenglengan leaf ethanol extracts.Â Key wordsÂ Â : n-Hexane fraction, Lenglengan extract, Anti-diabetic effects, Insulin resistance, Type-2 diabetic rats.Â

Effectiveness of Moringa oleifera extract supplementation in increasing Glucagon-like peptide-1 (GLP-1) in prediabetic model Rusminingsih, Esri; Susanto, Hardhono; Afifah, Diana Nur; Wibowo, Judiono; Anas, Yance
Jurnal Kebidanan dan Keperawatan Aisyiyah Vol. 20 No. 1 (2024): Juni
Publisher : Universitas Aisyiyah Yogyakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31101/jkk.3553

Prediabetes is a serious global health problem. The prevalence of prediabetes is estimated to be higher than that of diabetes mellitus (DM), and 5%-12.5% of prediabetic patients will develop DM. Epidemiological studies showed that consumption of polyphenol-rich foods impacts blood glucose control and improves insulin resistance. Moringa leaves contain high levels of flavonoids that are effective in glucose control. This study aimed to determine the effect of moringa leaf extract supplementation on increasing GLP-1 levels in prediabetes models. This study used a randomized controlled trial-post-test-only design. Twenty-five male Rattus norvegicus were divided into five groups, namely the normal group, the prediabetes group, and three intervention groups, each given moringa leaf extract at a dose of 75 mg/kgbb, 150 mg / kgbb and 225 mg / kgbb. After 4 weeks of intervention, a GLP-1 examination was conducted. Data analysis using the ANOVA test. There was a significant difference in GLP-1 levels in the intervention group compared to the prediabetes control group (p<0.05). GLP-1 levels increased as the dose given increased. In the intervention group, the dose of 225 mg/kg bw showed the highest increase in GLP-1 levels, but there was no significant difference compared to the 150 mg/kg bw dose group. Moringa leaf extract supplementation is proven to increase GLP-1 in the Rattus norvegicus model. The effect gets better with increasing doses. Further development and testing related to this supplementation are needed so it can be used as a safe non-pharmacological treatment for prediabetes and DM patients.

Antihyperpigmentation Effect of The Combination of Turmeric (Curcuma domestica Val.) and Bitter Melon Leaves (Momordica Charantia L.) Ethanol Extracts on Guinea Pig Skin Fitria, Risha Fillah; Anas, Yance; Safitri, Erika Indah
Jurnal Kefarmasian Indonesia VOLUME 8, NOMOR 1, FEBRUARI 2018
Publisher : Pusat Penelitian dan Pengembangan Biomedis dan Teknologi Dasar Kesehatan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22435/jki.v8i1.3724

Turmeric (T) and Bitter Melon leaves (BM) extract has been proven in decreasing melanin contents in in vitro study, but their single extracts effects were lower than the positive control. A study confirmed the combination of plants extracts had melanogenic effect better than the positive control and their single extracts. This study aimed to investigate the anti-hyperpigmentation effect of the combination of T and BM extract on guinea pig skin and compared with the positive control group. This study used a post-test control design. Twenty-five guinea pigs were divided into 5 groups. The negative control group was given by dimethyl sulfoxide; the positive control group was given by a pharma cream that consists of hydroquinone, tretinoin, and fluocinolone acetonide. The combination of extracts was given to experimental groups with doses 500 μg/mL of T and 200 μg/mL of BM; 750 μg/mL of T and 400 μg/mL of BM; 1.000 μg/mL of T and 600 μg/mL of BM, respectively. All groups exposed to UV-B light in 2 minutes/day for 2 weeks. Each experimental group was given 1 ml combination extract once a day for 2 weeks and in the last step, skin biopsies were done. The histopathological examination was conducted by staining with Fontana-Masson and Nuclear Fast Red. The average percentage of melanin area were compared in all group and analyzed with the Kruskal Wallis test followed by Mann-Whitney test with 95% of confidence level. The result showed group-2 and 3 had the better effect than pharma cream.

Co-Authors Agung Endro Nugroho Agung Endro Nugroho Agung Endro Nugroho Agung Hendro Nugroho Ali Imron Amprih Martha Amprih Martha, Amprih Aniq, Nur Aristya Kurniasih Aristya Nourwaqiana Azizah, Ulfah Laily Darmanto Darmanto Desi Rakhmawati Devi Endah P. Devi Nisa Hidayati Diana Nur Afifah, Diana Nur Dita Desti D_Khilyati Erika Indah Safitri Esri Rusminingsih - Febi Ariska Wahyu Putri Fitria, Risha Fillah Hardhono Susanto Heroweti, Junvidya Idress Muhammed Hama Ika Nilam Cahyani Ika Nilam Cahyani Imam Faozi Indah Hartati Irmawati, Putri JOKO TRI WIBOWO Kenyo Alexandra Oktaviani Kiki Damayanti Kiki Damayanti, Kiki Laeli Kurniasari Laeli Kurniasari Lalu Ksatria D.S. Layyinatul Fuadah Mamik Dwi Anggraini Marlina, Windy Maulita Cut Nuria Maulita Cut Nuria Meita Rafika Fitriani MOHAMAD ASPOLLAH SUKARI mohammad djatmiko Muhamad Djatmiko Mustagfirin Mustagfirin Nabila, Talcha Naimi Amalia Hatimah Niken Puspitasari Nola Carina Rahayu Nunung Yuniarti NUR CHAKIM Pramesti Dewi PUGU NOVI ARSITO Puji Astuti Puji Astuti Puji Hartati Putri Irmawati Retno Murwanti Ria Rositasati Ririn Lispita Wulandari risha fillah fithria Risha Fillah Fithria Risha Fillah Fitria Rita Dwi Ratnani Sekar Indah Ningtyas Siti Nurikha Siti Wahidatun Nisa Sri Murti Handayani Sugeng Riyanto SUGENG RIYANTO Sugiyanti Sugiyanti Suharjono, Suharjono Sumantri Sumantri Talcha Nabila Tri Murti Andayani Ulum Firnanda Sukma Ulum Firnanda Sukma Wibowo, Judiono widi astuti r Windy Marlina Wulandari, Febri Yunita Midkha

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