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All Journal Prosiding Seminar Nasional Sains Dan Teknologi Fakultas Teknik Jurnal Ilmu Farmasi dan Farmasi Klinik (Journal of Pharmaceutical Science and Clinical Pharmacy) INDONESIAN JOURNAL OF PHARMACY Jurnal Ilmu Kefarmasian Indonesia Abdimas UNWAHAS : Jurnal Pengabdian Masyarakat UNWAHAS Jurnal Ilmiah Cendekia Eksakta Jurnal Kebidanan dan Keperawatan Aisyiyah Kartika : Jurnal Ilmiah Farmasi Jurnal Kefarmasian Indonesia Journal of Pharmascience
Yance Anas
Bagian Farmakologi Dan Farmasi Klinik Fakultas Farmasi Universitas Wahid Hasyim Semarang
Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Economics, Econometrics & Finance Education Engineering Health Professions Immunology & microbiology Materials Science & Nanotechnology Mechanical Engineering Medicine & Pharmacology Nursing Public Health Social Sciences

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Sand Granules Ekstrak Etanol Daun Kirinyuh (Eupatorium inulifolium Kunth.) sebagai Larvasida Alami Pemberantas Demam Berdarah Dengue Puji Hartati; Yance Anas; Ririn Lispita Wulandari
Journal of Pharmascience Vol. 7 No. 1 (2020): Jurnal Pharmascience
Publisher : Universitas Lambung Mangkurat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/jps.v7i1.8067

Abstract

ABSTRAK             Penelitian sebelumnya telah mengungkap efek larvasida ekstrak etanol daun kirinyuh (Eupatorium inulifolium Kunth.) terhadap larva nyamuk Aedes aegypti. Ekstrak ini selanjutnya dapat dikembangkan dalam bentuk sediaan sand granules sehingga mudah digunakan sebagai larvasida alami. Penelitian ini bertujuan untuk mendapatkan formula sand granules ekstrak etanol daun Eupatorium inulifolium Kunth (EEDE) yang memenuhi standar karakteristik fisik granul dan menguji efek larvasidanya pada larva nyamuk Aedes aegypti. Sand granules EEDE dibuat dengan metode  granulasi basah dengan variasi konsentrasi kollidon (1%-5%), explotab (1%-3%) dan sacharum lactis (78,44%-84,44%). Karakteristik fisik berbagai formula Sand granules EEDE yang diuji adalah kecepatan alir dan sudut diam. Uji efek larvasida dilakukan pada 25 ekor larva instar III nyamuk Aedes aegypti selama 24 jam dengan replikasi sebanyak 5 kali. Hasil penelitian menunjukkan bahwa semua formula Sand granules EEDE (F1-F5) memenuhi standar karakteristik fisik dengan kecepatan alir (16,69-19,35) g/detik dan sudut diam granul 32,94°-35,76°. F1-F5 juga memiliki efek larvasida terhadap larva nyamuk Aedes aegypti dengan persentase kematian larva dalam 24 jam sebesar (33,0-39,2) %. Akan tetapi, efek larvasida tersebut lebih kecil dibandingkan dengan EEDE 670 ppm (49,6%) dan Temefos® 0,01 ppm (100,0%). Hasil penelitian ini juga menyimpulkan bahwa proses pembuatan sand granules akan menyebabkan penurunan efek larvasida EEDE. Kata Kunci: Daun kirinyuh, efek larvasida, karakteristik fisik, sand granules  ABSTRACT Previous studies reported Eupatorium inulifolium Kunth. leaves ethanol extract (ELEE) have a larvicidal effect on Aedes aegypti larvae. This extract can be developed into sand granules formulation, making it easy to use as a natural larvicidal. This study means to obtain the ELEE sand granules formula that meets the granule's physical characteristics standard, and asses it's a larvicidal effect on Aedes aegypti larvae. Sand granules of ELEE produced with the wet granulation method. The differences between formulas are variations of Kollidon (1%-5%), Explotab (1%-3%), and Saccharum Lactis (78.44%-84.44%) concentration. The physical characteristics of the various KLEE sand granules formulas observed are flow rate and angle of repose. The assay of the ELEE larvicidal effect was carried out on twenty-five Aedes aegypti Instar III larvae for 24 hours with five replications. The results showed that all ELEE sand granules formulas (F1-F5) met the physical characteristics standard, with a flow rate (16.69-19.35) g/sec and an angle of repose 32.94 °-35.76°. F-F5 also had larvicidal effects on Aedes aegypti larvae, with larval mortality within 24 hours (33.0-39.2) %. However, their larvicidal effect is slight compared to ELEE 670 ppm (49.6%) and Temefos® 0.01 ppm (100.0%). This study also concludes that the process of sand granules preparation will diminish the larvicidal effects of ELEE. Keywords: Kirinyuh leaves, larvacidal effect, physical characteristics, sand granules
Co-Authors Agung Endro Nugroho Agung Endro Nugroho Agung Endro Nugroho Agung Hendro Nugroho Ali Imron Amprih Martha Amprih Martha, Amprih Aniq, Nur Aristya Kurniasih Aristya Nourwaqiana Darmanto Darmanto Desi Rakhmawati Devi Endah P. Devi Nisa Hidayati Diana Nur Afifah, Diana Nur Dita Desti D_Khilyati Erika Indah Safitri Esri Rusminingsih - Febi Ariska Wahyu Putri Fitria, Risha Fillah Hardhono Susanto Heroweti, Junvidya Idress Muhammed Hama Ika Nilam Cahyani Ika Nilam Cahyani Imam Faozi Indah Hartati Irmawati, Putri JOKO TRI WIBOWO Kenyo Alexandra Oktaviani Kiki Damayanti Kiki Damayanti, Kiki Laeli Kurniasari Laeli Kurniasari Lalu Ksatria D.S. Layyinatul Fuadah Mamik Dwi Anggraini Marlina, Windy Maulita Cut Nuria Maulita Cut Nuria Meita Rafika Fitriani MOHAMAD ASPOLLAH SUKARI mohammad djatmiko Muhamad Djatmiko Mustagfirin Mustagfirin Nabila, Talcha Naimi Amalia Hatimah Niken Puspitasari Nola Carina Rahayu NUR CHAKIM Pramesti Dewi PUGU NOVI ARSITO Puji Astuti Puji Astuti Puji Hartati Putri Irmawati Ria Rositasati Ririn Lispita Wulandari risha fillah fithria Risha Fillah Fithria Risha Fillah Fitria Rita Dwi Ratnani Sekar Indah Ningtyas Siti Nurikha Siti Wahidatun Nisa Sri Murti Handayani Sugeng Riyanto SUGENG RIYANTO Sugiyanti Sugiyanti Suharjono Sumantri Sumantri Talcha Nabila Tri Murti Andayani Ulum Firnanda Sukma Ulum Firnanda Sukma Wibowo, Judiono widi astuti r Windy Marlina Yunita Midkha