Article Per Year (5 Year)
p-Index From 2021 - 2026
1.152
P-Index
This Author published in this journals
All Journal Prosiding Seminar Nasional Sains Dan Teknologi Fakultas Teknik Jurnal Ilmu Farmasi dan Farmasi Klinik (Journal of Pharmaceutical Science and Clinical Pharmacy) INDONESIAN JOURNAL OF PHARMACY Pharmascience Jurnal Farmasi Sains dan Komunitas Jurnal Ilmu Kefarmasian Indonesia Abdimas UNWAHAS : Jurnal Pengabdian Masyarakat UNWAHAS Jurnal Ilmiah Cendekia Eksakta Jurnal Kebidanan dan Keperawatan Aisyiyah Kartika : Jurnal Ilmiah Farmasi Jurnal Kefarmasian Indonesia
Yance Anas
Bagian Farmakologi Dan Farmasi Klinik Fakultas Farmasi Universitas Wahid Hasyim Semarang
Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Economics, Econometrics & Finance Education Engineering Health Professions Immunology & microbiology Materials Science & Nanotechnology Mechanical Engineering Medicine & Pharmacology Nursing Public Health Social Sciences

Published : 32 Documents Claim Missing Document
Claim Missing Document
Check
Articles

Found 32 Documents
Search

 1   2   3   4 
Aktivitas Antiparkinson Ekstrak dan Fraksi Buah Kemukus (Piper cubeba L.) pada Tikus Putih Galur Sprague Dawley Damayanti, Kiki; Anas, Yance; Marlina, Windy; Nabila, Talcha; Irmawati, Putri
Jurnal Kefarmasian Indonesia VOLUME 12, NOMOR 2, AGUSTUS 2022
Publisher : Pusat Penelitian dan Pengembangan Biomedis dan Teknologi Dasar Kesehatan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22435/jki.v0i0.5964

Abstract

Pathophysiologies underlying the Parkinson's disease is oxidative stress, can be treat with antioxidants from natural sources, including Piper cubeba L. Flavonoids are reported as antioxidants. This study aimed to analyse the flavonoids content and antiparkinson activity from the ethanolic extract of cubeb fruits (EECF), ethyl acetate fraction of ethanolic extract of cubeb fruits (EAFEECF), n-hexane fraction of ethanolic extract of cubeb fruits (NHFEECF). This research is an experimental study with a post test only control group design. Eighty four rats were divided into 14 groups. Group 1 is a normal group, group 2-3 are negative controls which were given aquadest and olive oil, respectively. Positive control groups, 4 and 5 were given levodopa 27 mg/kgBW and vitamin E 180 IU/kgBW, respectively. Group 6-14 were given EECF, EAFEECF, and NHFEECF at doses 150, 300, 600 mg/kgBW. Group 2-14 were induced with haloperidol 2 mg/kgBW intraperitoneally 45 minutes after administration of the material tests. The materials are given once a day for 7 days. The length of time the rats can hold on to the rotarod was tested on days 0, 4, 7, 11, 14. The curve showed the data on the survival time of rats on a rotarod versus time, then the AUC0-14 was calculated using the trapezoidal method. The AUC0-14 were analyzed using Mann Whitney test at 95%CI. The flavonoids content were analysed using TLC. The results showed that the EECF, EAFEECF, and NHFEECF contained flavonoids, and antiparkinson activity except for the NHFEECF at doses 150 and 600 mg/kgBW.
Exposure of Histone Deacetylase-2 Inhibitor Curcumin and Its Analogues in Self-Nano Emulsifying Drug Delivery System Change Memory and Cognitive Function, Anxiety, and Social Interaction Behavior in Mouse Yuniarti, Nunung; Wulandari, Febri; Azizah, Ulfah Laily; Anas, Yance; Murwanti, Retno
Jurnal Farmasi Sains dan Komunitas (Journal of Pharmaceutical Sciences and Community) Vol 21, No 2 (2024)
Publisher : Sanata Dharma University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24071/jpsc.009660

Abstract

Class 1 and 2 histone deacetylase inhibitors (HDACI) have been reported as novel therapeutic approaches to treat neurodegenerative disorders, depression, anxiety, and cognitive deficits. HDACI ameliorated deficits in cognition and stress-related behaviors in a wide range of neurologic and psychiatric disorders. Preclinically, behavioral bioassay can be used to predict the influence of new compounds for treatment of these illnesses. Curcumin and its new analogues PGV-0 and PGV-1 have been reported to inhibit HDAC2. However, reports regarding the effect of curcumin and its analogues on memory and cognitive function, anxiety, and social interaction behavior are as yet to be examined. Mice were divided into control and treated groups. Brain disorder was induced by oral administration of 10% ethanol in sodium-CMC for 7 days. Curcumin, PGV-0, PGV-1, and sodium butyrate (as positive control) were then given orally once a day for 21 days. The behavior tests of social interaction, open field, radial 8-arm-maze, and passive avoidance were performed on day 29. To increase dissolution and bioavailability of the compounds, they were formulated in a self-nano emulsifying drug delivery system (SNEDDS). Brains were isolated and analyzed using PCR to investigate the expression of genes related to neurobehavioral disorders hdac2, trkB, and bdnf. In different doses, curcumin, PGV-0, and PGV-1 increased social interaction capability, declined anxiety level, and improved long-term memory and cognitive function. The mechanism proposed is: HDACI curcumin and its analogues (PGV-0 and PGV-1) that keep the histone protein in acetylation state increase bdnf expression. The increased trkB expression is increasing the activation of the bdnf gene because trkB is the primary receptor of bdnf that supports the survival of existing neurons and encourages the growth and differentiation of new neurons and synapses. Thus, those mechanisms could improve long-term memory and cognitive function, increase social interaction, and reduce anxiety in ethanol-induced mice with brain disorders.
Co-Authors Agung Endro Nugroho Agung Endro Nugroho Agung Endro Nugroho Agung Hendro Nugroho Ali Imron Amprih Martha Amprih Martha, Amprih Aniq, Nur Aristya Kurniasih Aristya Nourwaqiana Azizah, Ulfah Laily Darmanto Darmanto Desi Rakhmawati Devi Endah P. Devi Nisa Hidayati Diana Nur Afifah, Diana Nur Dita Desti D_Khilyati Erika Indah Safitri Esri Rusminingsih - Febi Ariska Wahyu Putri Fitria, Risha Fillah Hardhono Susanto Heroweti, Junvidya Idress Muhammed Hama Ika Nilam Cahyani Ika Nilam Cahyani Imam Faozi Indah Hartati Irmawati, Putri JOKO TRI WIBOWO Kenyo Alexandra Oktaviani Kiki Damayanti Kiki Damayanti, Kiki Laeli Kurniasari Laeli Kurniasari Lalu Ksatria D.S. Layyinatul Fuadah Mamik Dwi Anggraini Marlina, Windy Maulita Cut Nuria Maulita Cut Nuria Meita Rafika Fitriani MOHAMAD ASPOLLAH SUKARI mohammad djatmiko Muhamad Djatmiko Mustagfirin Mustagfirin Nabila, Talcha Naimi Amalia Hatimah Niken Puspitasari Nola Carina Rahayu Nunung Yuniarti NUR CHAKIM Pramesti Dewi PUGU NOVI ARSITO Puji Astuti Puji Astuti Puji Hartati Putri Irmawati Retno Murwanti Ria Rositasati Ririn Lispita Wulandari risha fillah fithria Risha Fillah Fithria Risha Fillah Fitria Rita Dwi Ratnani Sekar Indah Ningtyas Siti Nurikha Siti Wahidatun Nisa Sri Murti Handayani Sugeng Riyanto SUGENG RIYANTO Sugiyanti Sugiyanti Suharjono, Suharjono Sumantri Sumantri Talcha Nabila Tri Murti Andayani Ulum Firnanda Sukma Ulum Firnanda Sukma Wibowo, Judiono widi astuti r Windy Marlina Wulandari, Febri Yunita Midkha