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All Journal Journal of Food and Pharmaceutical Science Indonesian Journal of Pharmaceutical Science and Technology Majalah Obat Tradisional Indonesian Journal of Natural Pigments Jurnal Ilmiah Farmako Bahari JURNAL INOVASI DAN PENGABDIAN MASYARAKAT INDONESIA Media Farmasi Indonesia Journal of Food and Pharmaceutical Sciences Indonesian Journal of Jamu
Lia Kusmita
Sekolah Tinggi Ilmu Farmasi Yayasan Pharmasi
Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Education Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Neuroscience Public Health Social Sciences Other

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Optimization of Solvent Type on Antioxidant Activity of Spirulina platensis Extract and Its Pharmaceutical Tablet Formulation Bagiana, I Kadek; Franyoto, Yuvianti; Mutmainah; Kusmita, Lia
Jurnal Jamu Indonesia Vol. 10 No. 3 (2025): Jurnal Jamu Indonesia
Publisher : Tropical Biopharmaca Research Center, IPB University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29244/jji.v10i3.414

Abstract

Spirulina platensis contains nutrients such as proteins, essential amino acids, fatty acids, minerals, pigments, carotenoids, and vitamins, which have strong antioxidant properties. This study evaluated the impact of extraction solvents (70% methanol, 70% ethanol, and 70% acetone) on antioxidant activity, with the most effective extract formulated into tablets. Extraction was performed by maceration. Tablet preparations were characterized by moisture content, flow rate, angle of repose, organoleptic properties, weight uniformity, hardness, disintegration time, and friability. The results showed that the 70% methanol extract exhibited the highest antioxidant activity (IC₅₀ = 45.57 ± 0.01 ppm), superior to 70% acetone (IC₅₀ = 67.15 ± 0.07 ppm) and 70% ethanol (IC₅₀ = 85.32 ± 1.21 ppm), although lower than vitamin C (IC₅₀ = 3.52 ± 0.01 ppm). Tablets prepared from 70% methanol extract fulfilled all pharmaceutical quality requirements.
Co-Authors Ahmad Fuad Masduqi Andriyani, Silvi Awang Surya Wiguna, Awang Surya Diah Permata Wijayanti Endang Diyah Ikasari Endang Dwi Wulansari Franyoto, Yuvianti Franyoto, Yuvianti Dwi Franyoto, Yuvianto Dwi Handung Nuryadi I Kadek Bagiana Ika Puspitaningrum Muchlisin, Sakti Mudianta, I Wayan MUTMAINAH Mutmainah -, Mutmainah Mutmainah Mutmainah Nugraheni, Christi Karina Ocky Karna Radjasa Prastyo Abi Widyananto Purwanto, Ungsari Rizki Eka Rahmadi Prasetijo Ririn Suharsanti, Ririn Ryan Radix Rahardhian, Muhammad Sri Achadi Nugraheni Sulistyani Sulistyani Trisnayanthi, Ni Nyoman Ayu Indah Wiwin Supiyanti, Wiwin