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All Journal HAYATI Journal of Biosciences Jurnal Agronomi Indonesia (Indonesian Journal of Agronomy) Jurnal Teknologi Dan Industri Pangan Sainteks Microbiology Indonesia BIOTROPIA - The Southeast Asian Journal of Tropical Biology Biotropika Indonesian Journal of Biotechnology Jurnal Sumberdaya Hayati Indonesian Journal of Chemistry Marine Research in Indonesia Biosaintifika: Journal of Biology & Biology Education Menara Perkebunan Jurnal Tanah dan Iklim Journal of Health and Nutrition Research Makara Journal of Science Biodiversitas Journal of Biological Diversity
YULIN LESTARI
Departemen Biologi, Fakultas Matematika Dan Ilmu Pengetahuan Alam, Institut Pertanian Bogor, Kampus IPB Dramaga, Bogor 16680, Indonesia
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Earth & Planetary Sciences Economics, Econometrics & Finance Immunology & microbiology Industrial & Manufacturing Engineering Materials Science & Nanotechnology Mechanical Engineering Medicine & Pharmacology Nursing Public Health Veterinary

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Enzyme production, antibacterial and antifungal activities of actinobacteria isolated from Ficus deltoidea rhizosphere ISRA JANATININGRUM; YULIN LESTARI
Biodiversitas Journal of Biological Diversity Vol. 23 No. 4 (2022)
Publisher : Society for Indonesian Biodiversity

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.13057/biodiv/d230429

Abstract

Abstract. Janatiningrum I, Lestari Y. 2022. Enzyme production, antibacterial and antifungal activities of actinobacteria isolated from Ficus deltoidea rhizosphere. Biodiversitas 23: 1950-1957. Actinobacteria have long been known to have the ability to produce bioactive compounds and secondary metabolites. Actinobacteria from the rhizosphere of Ficus deltoidea Jack were expected to produce beneficial secondary metabolite compounds with antibacterial, antifungal activity, and enzymes. A total of 34 different actinobacteria were isolated from F. deltoidea rhizosphere soil. They were assessed for their antimicrobial activity against four fungi, four bacteria, and enzymatic activity. The enzyme activity test showed that almost all isolates had amylase, protease, and cellulase activities. The results of antibacterial indicated that 61.8% of all isolates are active against bacterial tested, i.e., Bacillus subtilis ATTC 3061 (10), Staphylococcus aureus ATCC 6538 (13), and Escherichia coli ATCC 8739 (3). The antifungal test showed that 64.8% of the isolates had antifungal activity against four fungal tested, i.e., Fusarium oxysporum (13), Candida albicans (7), Colletotrichum capsici (17). Based on the enzymes production, antibacterial activity, and antifungal activity, RTB 1 and RTB 34 isolates were selected to be characterized by morphological and 16S rRNA gene identification. The morphological characterization and molecular identification showed that RTB 1 and RTB 34 belong to the Streptomyces genus. This study indicated that the selected actinomycetes could be antimicrobial and enzyme sources.
Endophytic actinobacteria of Eleutherine palmifolia as antioxidant producer AFINA PUTRI SHABIRA; ARIS TJAHJOLEKSONO; YULIN LESTARI
Biodiversitas Journal of Biological Diversity Vol. 23 No. 8 (2022)
Publisher : Society for Indonesian Biodiversity

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.13057/biodiv/d230844

Abstract

Abstract. Shabira AP, Tjahjoleksono A, Lestari Y. 2022. Endophytic actinobacteria of Eleutherine palmifolia as antioxidant producer. Biodiversitas 23: 4209-4215. Endophytic actinobacteria can generate bioactive compounds similar to those produced by the host plant. The Eleutherine palmifolia (L.) Merr is an example of a widely utilized host plant in the Dayak community. Flavonoids, which have antioxidant effects, are among the bioactive compounds found in E. palmifolia. The antioxidant activity of bioactive compounds produced by endophytic actinobacteria of E. palmifolia remains unidentified. The aim of this study was to examine the antioxidant activity of bioactive compounds produced by endophytic actinobacteria of E. palmifolia. Antioxidant activity from isolates actinobacteria was determined quantitatively using the DPPH and ABTS methods. Identification of the types of bioactive compound in the samples was identified using TLC assay and bioautography test. Analysis of flavonoid levels was performed using colorimetric aluminum chloride (AlCl3). The result showed that the extraction of six isolates of endophytic actinobacteria with ethyl acetate solvent had different yields. The extract of endophytic actinobacteria EPB 6 isolate produced the highest (0.013%) yield. The extract of endophytic actinobacteria EPB 3 isolate had the best antioxidant activity, with 53.85 mg/mL (DPPH) and 42.43 mg/mL (ABTS). The extract of endophytic actinobacteria EPB 3 isolate and E. palmifolia had the same blue spots in TLC analysis, indicating the presence of bioactive compounds flavonol and flavones groups. The bioautography test of EPB 3 isolate endophytic actinobacteria extract produced yellow color, indicating qualitatively antioxidant activity. The total flavonoid content of the EPB 3 isolate extract was also higher (25.30 QE/mg) than the other five isolates, while it was 46.03 QE/mg in E. palmifolia extract. It is clear from the present study that the endophytic actinobacteria extract can produce antioxidants.
Antibacterial diketopiperazines from marine sponge-associated Actinobacteria against multidrug-resistant bacteria AFINA LARASATI; SRI BUDIARTI; YULIN LESTARI
Biodiversitas Journal of Biological Diversity Vol. 26 No. 12 (2025)
Publisher : Society for Indonesian Biodiversity

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.13057/biodiv/d261245

Abstract

Abstract. Larasati A, Budiarti S, Lestari Y. 2025. Antibacterial diketopiperazines from marine sponge-associated Actinobacteria against multidrug-resistant bacteria. Biodiversitas 26: 6480-6489. The global rise of Multidrug-Resistant (MDR) bacterial infections has created an urgent demand for new antibacterial agents. Marine actinomycetes, particularly those associated with marine sponges, are considered a promising source of bioactive secondary metabolites. This study explored the antibacterial potential of 12 actinobacterial isolates obtained from the marine sponge Callyspongia sp., collected from the waters of Kepulauan Seribu, Indonesia. Among these, the isolate Cal24h exhibited the highest antibacterial activity. Based on previous 16S rRNA gene sequence analysis, this isolate was identified as Streptomyces tendae. Optimization of its culture conditions significantly enhanced inhibition zones against four MDR bacterial strains: 18.57±0.08 mm for Enteropathogenic Escherichia coli (EPEC) K1.1, 19.70±0.09 mm for Pseudomonas aeruginosa, 20.09±0.20 mm for Bacillus subtilis, and 20.54±0.31 mm for Methicillin-Resistant Staphylococcus aureus (MRSA). The Minimum Inhibitory Concentration (MIC) values of the ethyl acetate extract ranged from 62.5 to 125 µg/mL. Further analysis using GC-MS and LC-MS revealed the presence of diketopiperazine compounds, including Cyclo(Leu-Pro), Cyclo(L-Pro-L-Val), and Cyclo(Pro-Phe), all known for their antibacterial properties. Notably, this study is the first to report the use of a modified A1 medium to enhance antibacterial metabolite production in sponge-derived Streptomyces, representing a novel cultivation strategy. Cultivation in A1 medium yielded the highest extract quantity and exhibited the strongest antibacterial activity among all media tested. This study provides the first diketopiperazine production by S. tendae associated with the Indonesian sponge Callyspongia sp., thereby underscoring the untapped potential of sponge-derived actinobacteria as promising sources of antibacterial compounds against multidrug-resistant pathogens.
Co-Authors A. HAITAMI Abdjad Asih Nawangsih AFINA LARASATI AFINA PUTRI SHABIRA Ali Khomsan Alifian Ariansyah Aliful Karim ALINA AKHDIYA AMOR TRESNA KARYAWATI Amor Tresna Karyawati, Amor Tresna Anas Dinurrohman Susila ANDO KATSUHIKO Ando Katsuhiko Anja Meryandini Antonius Suwanto ARI SUSILOWATI Ariansyah, Alifian Aris Tjahjoleksono Aris Tri Wahyudi ARTINI PANGASTUTI Artini Pangastuti Arum Asiyanti Suhastyo, Arum Asiyanti Arum Asriyanti Suhastyo BAMBANG MARWOTO Batara, Lily Noviani Budi Wirawan Deden Saprudin DEDY DURYADI SOLIHIN DEDY DURYADI SOLIHIN Dedy Duryadi Solihin Didy Sopandie DITA, SASMIATI FARACH Dwi Andreas Santosa DWI RETNOWATI Dyah Iswantini DYAH NOOR HIDAYATI Efendi, Firda Sri Egra, Saat Elisa Sopiatul Fitriani Endang Sukara Evi Triana EVI TRIANA FAHRRUROZI FAHRRUROZI Farhana Halimah Rusyda Ferry Mutia Fily Larasati Fitriandini, Risa GINA KARTINA Gina Kartina GINA KARTINA Hadi Riyadi Hamim Hamim HIDEKI YAMAMURA Iman Rusmana Inayah, Mazidah Noer Indah Puspita SARI Irmanida Batubara ISRA JANATININGRUM ISRA JANATININGRUM Isra Janatiningrum Iswandi Anas Iswandi Anas Katrin Roosita Katsuhiko Ando KATSUHIKO ANDO Laksmita Prima SANTI Lenni Fitri Lenni Fitri Lia Aseptin Murdini Lilis Nuraida Maggy T. Suhartono MAGGY TENNAWIJAYA SUHARTONO Maggy Thenawidjaja Suhartono Mahyarudin, Mahyarudin Marina Ratte Min Rahminiwati Misa Otoguro MISA OTOGURO MONA PRIMANITA Munif Ghulamahdi Niken Financia Gusmawati Nita Rosalinda Prayitno NITA ROSALINDA PRAYITNO Nunuk Widhyastuti NUNUK WIDHYASTUTI NUNUK WIDHYASTUTI Puspita Lisdiyanti PUSPITA LISDIYANTI Puspita Lisdiyanti PUSPITA LISDIYANTI RASTI SARASWATI RASTI SARASWATI RATIH DEWI HASTUTI RATIH DEWI HASTUTI Ratih Dwi Hastuti RIKA RAFFIUDIN Rina Oktasari Risa Fitriandini ROHMATUSSOLIHAT ROHMATUSSOLIHAT RONI RIDWAN Roni Ridwan RONI RIDWAN Saat Egra Shanti Ratnakomala SHANTI RATNAKOMALA Shanti Ratnakomala SHANTI RATNAKOMALA SHINJI MIYADOH Sipriyadi Sipriyadi Sipriyadi Sri Budiarti SRI BUDIARTI Sri Budiarti Poerwanto Suryo Wiyono SUSILOWATI1 SUSILOWATI1 TARUNI SRI PRAWAST MIEN KAOMINI ANY ARYANI DEDY DURYADI SOLIHIN Titi Candra Sunarti TOMOHIKO TAMURA TOMOHIKO TAMURA Tomohiko Tamura TRI RATNA SULISTIYANI TRIO HENDARWIN TRIO HENDARWIN Umi Fatmawati Winanda, Witri Witri Winanda Yantyati Widyastuti Yantyati Widyastuti Yantyati Widyastuti YANTYATI WIDYASTUTI Zaenal Abidin