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All Journal journal of internal medicine Indonesian Journal of Tropical and Infectious Disease The Indonesian Biomedical Journal Syntax Literate: Jurnal Ilmiah Indonesia Biomolecular and Health Science Journal Indonesian Journal of Clinical Pathology and Medical Laboratory (IJCPML) Majalah Biomorfologi (Biomorphology Journal) JOURNAL OF COMMUNITY MEDICINE AND PUBLIC HEALTH RESEARCH CURRENT INTERNAL MEDICINE RESEARCH AND PRACTICE SURABAYA JOURNAL Indian Journal of Forensic Medicine & Toxicology Narra J Journal of Scientech Research and Development The Indonesian Journal of Gastroenterology, Hepatology and Digestive Endoscopy Folia Medica Indonesiana
Ummi Maimunah
Division Of Gastroentero-hepatology, Department Of Internal Medicine, Faculty Of Medicine, Universitas Airlangga/Dr Soetomo General Hospital, Surabaya
Humanities Biochemistry, Genetics & Molecular Biology Computer Science & IT Earth & Planetary Sciences Education Environmental Science Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Law, Crime, Criminology & Criminal Justice Medicine & Pharmacology Neuroscience Public Health Social Sciences Other

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Journal : Narra J

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Correlation between interleukin-6 expression in post-mortem core liver biopsy and degree of liver injury in patients with fatal COVID-19 Maimunah, Ummi; Maharani, Andi RK.; Soegiarto, Gatot; Rahniayu, Alphania; Gunawan, Vania A.; Wiratama, Priangga A.; Djuanda, Stephanie N.; Supriadi, Supriadi; Marhana, Isnin A.; Semedi, Bambang P.; Lefi, Achmad; Kusumastuti, Etty H.; Suyanto, Edi; Lilihata, Jilientasia G.; Anggoro, Adhitri; Rinjani, Lalu GP.; Rosyid, Alfian N.; Wahyu, Dwi; Fauziah, Dyah; Rahaju, Anny S.; Kurniasari, Nila; Ariani, Grace; Nugroho, Gilang MS.; Yandi, I KR.; Nugraha, Ricardo A.
Narra J Vol. 3 No. 3 (2023): December 2023
Publisher : Narra Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52225/narra.v3i3.463

Abstract

Excessive release of interleukin-6 (IL-6) during the progression of coronavirus disease 2019 (COVID-19) induces cytokine storms, resulting in multi-organ damages including liver injury, similar in nature with mechanism of viral hepatitis. Systemic IL-6 has been associated with the incidence of liver injury among COVID-19 patients; however, studies on IL-6 expression in the liver tissue are completely lacking. The aim of this study was to measure the IL-6 expression in the liver tissues and to determine its correlation with the degree of liver injury in fatal COVID-19 patients. Through this first cross-sectional study, IL-6 expression was measured through immunohistochemical staining and the degree of liver injury was identified based on level of serum alanine aminotransferase (ALT). The Spearman correlation test was used to identify the correlation between IL-6 expression and the degree of liver injury. A total of 47 deceased COVID-19 patients were included and IL-6 expression was observed in all post-mortem liver specimens, ranging from mild to strong expression. Liver injury at various degrees (mild to severe) was found in more than half (59.5%) of the cases. The Spearman correlation analysis suggested a statistically insignificant correlation between liver IL-6 expression and the degree of liver injury (r=0.152; p=0.309). In conclusion, even IL-6 expression was observed in all post-mortem liver specimens, there was an insignificant correlation between IL-6 expression in the liver tissue with the degree of liver injury among fatal COVID-19 patients, suggesting that IL-6 was not the only main factor contributing to liver damage in COVID-19 patients.
Association between COVID-19 severity with liver abnormalities: A retrospective study in a referral hospital in Indonesia Maimunah, Ummi; Kholili, Ulfa; Vidyani, Amie; Sugihartono, Titong; Tanaya, Willa M.; Wessels, Firda I.; Alshawsh, Mohammed A.; Miftahussurur, Muhammad
Narra J Vol. 4 No. 2 (2024): August 2024
Publisher : Narra Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52225/narra.v4i2.816

Abstract

Coronavirus disease 2019 (COVID-19) is characterized by an acute respiratory infection with multisystem involvement and the association of its severity to liver function abnormalities is not well characterized. The aim of this study was to assess the association between the severity of COVID-19 patients and liver function abnormalities. This retrospective study included adult patients with confirmed COVID-19, which were classified as non-severe or severe according to World Health Organization guidelines. Liver function test results were compared between the severity groups. A total of 339 patients were included of which 150 (44.25%) were severe cases. The male-to-female ratio was 0.9:1 and 3:2 in the non-severe and severe groups, respectively (p=0.031). Aspartate aminotransferase (AST), alanine transaminase (ALT), and total bilirubin levels and acute liver injury (ALI) incidence were significantly higher in the severe group compared to non-severe group (p<0.001, p<0.001, p=0.025, p=0.014, respectively). In contrast, albumin levels were significantly lower (p=0.001). Multivariate analysis showed that ALI was significantly associated with human immunodeficiency virus (HIV) infection (odds ratio (OR): 5.275; 95% confidence interval (CI): 1.165–23.890, p=0.031), hemoglobin level (OR: 1.214; 95%CI: 1.083–1.361, p=0.001), and hypoalbuminemia (OR: 2.627; 95%CI: 1.283–5.379, p=0.008). Pre-existing liver diseases were present in 6.5% of patients. No significant differences were observed between the groups based on COVID-19 severity and ALI presence. Liver function test abnormalities, including ALI, are more prevalent in patients with severe COVID-19 infection. HIV infection, high hemoglobin levels, and hypoalbuminemia may be potential risk factors for ALI.
Co-Authors , Sulistiawati Adaninggar PN Alphania Rahniayu Alshawsh, Mohammed A. Amie Vidyani Anggoro, Adhitri Annisa Zahra Mufida Ariani, Grace Arin Nurtya Artaria Tjempakasari, Artaria Aryati Aryati -, Aryati Aswin, R. Haryanto atika Bernadetta Jonan Bramantono Bramantono, Bramantono Brimantyo, Dio Budi W Budi Widodo Budi Widodo Budi Yuwono Chatarina Umbul Wahyuni Denny Vianto Diah Rizki Rahma Dini Djuanda, Stephanie N. DYAH FAUZIAH, DYAH Edi Suyanto Eko Budi Koendhori, Eko Budi Endang Retnowati Erik Hasudungan Esti Rohani Fauziah Diayu Retnaningtyas Gatot Soegiarto Gilda Hartecia Gunawan, Vania A. Hadisuwarno, Wiharjo Hartecia, Gilda Hernomo Ontoseno Kusumobroto HERNOMO ONTOSENO KUSUMOBROTO Herry Purbayu Hertanto, Carisa Irene I Made Subhawa Harsa Imelda Maria Loho, Imelda Maria Imro'ati, Tri Asih Inne Tria Ramafita Isna Mahmudah Iswan A Nusi Iswan A Nusi Iswan A Nusi Iswan Abbas Nusi Izzatul Fithriyah Jonan, Bernadetta Khairu Zein Kusumastuti, Etty H. KUSUMASTUTI, ETTY HARY Lefi, Achmad Lilihata, Jilientasia G. Maharani, Andi RK. Marhana, Isnin A. Maria Inge Lusida MOCHAMAD AMIN Muhammad Aafi Baharuddin Attamimi Muhammad Miftahussurur Munawaroh Fitriyah Nadya Wulandari Alshanti Natasya Ariesta Selyardi Putri Nenci Siagian Nila Kurniasari Nugraha, Ricardo A. Nugroho, Gilang MS. Nurtya, Arin Pangestu Adi PN, Adaninggar Poernomo B Setiawan Poernomo Boedi Setiawan Poernomo Budi Setiawan Priyo Budi Purwono Puspa Wardhani Puspa Wardhani Puspitasari, Yessy Putra, Rheza Rahmadika Putri, Dyeneka Rustanti Indreswara Rahaju, Anny S. Retno Handajani Rinjani, Lalu GP. Rosyid, Alfian N. Rudyanto Rudyanto Ruslan, S. Eriaty N. Savita, Lady Semedi, Bambang P. Setiawan, Poernomo B Setiawati, Rosy Shahnaz Azzahra Soelistijo, Soebagijo Adi SOETJIPTO . Sulistiawati Suprapto Ma’at Supriadi Supriadi Tanaya, Willa M. Thamrin, Husin Titong Sugiharto Titong Sugihartono Tjahjadi, Angela Kimberly Tri Asih Imro&#039;ati Ulfa Kholili Wahyu, Dwi Wessels, Firda I. Widodo, Budi Willy Sandhika Wirantara, Hendy Wiratama, Priangga A. Wiwin Retnowati Wungu, Citrawati Dyah Kencono Yandi, I KR. Yetti Hernaningsih Yoshio Yamaoka Yoshio Yamaoka, Yoshio Yudith Annisa Ayu Rezkitha, Yudith Annisa Ayu Zein, Khairu