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Journal : Jurnal AFAMEDIS

POLA PERESEPAN OBAT ANTIDIABETIK PADA PASIEN DIABETES MELITUS TIPE 2 DI POLI PENYAKIT DALAM RS “X” SIDOARJO PERIODE OKTOBER- DESEMBER 2019 Yugo Susanto; Sri Bangun Lestari; Elly Purwati
AFAMEDIS Vol. 1 No. 2 (2020): Jurnal Farmasi Indonesia Afamedis
Publisher : Akademi Farmasi Mitra Sehat Mandiri Sidoarjo

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Abstract

Penelitian ini dilakukan untuk mengetahui pola peresepan obat antidiabetik pada pasien diabetes melitus tipe 2 di poli penyakit dalam RS “X” Sidoarjo periode Oktober-Desember 2019 sesuai dengan pedoman terapi ADA (American Diabetes Association) 2020. Penelitian ini dilakukan secara deskriptif yang bertujuan untuk menyajikan gambaran lengkap mengenai suatu keadaan secara objektif dengan metode total sampling dan pengambilan data secara retrospektif. Sampel dalam penelitian ini mengambil sejumlah 50 lembar resep yang masuk kriteria inklusi dan tercatat di pengumpul data meliputi nama obat, dosis obat, dan aturan pemakaiaan yang telah dianalisis. Berdasarkan data penelitian, dapat disimpulkan 72% pasien DM tipe 2 menggunakan terapi pengobatan OAD (Obat Anti Diabetik). Terapi pengobatan OAD tunggal sebesar 36% menjadi pilihan utama, OAD dari golongan Biguanide sebesar 26% adalah lini pertama dan agen farmakologi awal yang disukai. Terapi pengobatan OAD+Insulin sebesar 28%, dan pemilihan insulin long- acting sebesar 18%, sedangkan terapi pengobatan OAD kombinasi sediaan dari golongan biguanide+sulfonilurea sebesar 16%.
PENGARUH VARIASI KONSENTRASI CROSPOVIDONE SEBAGAI SUPER DISINTEGRAN TERHADAP MUTU FISIK ORAL FAST DISSOLVING TABLET Yugo Susanto
AFAMEDIS Vol. 4 No. 1 (2023): JURNAL FARMASI INDONESIA AFAMEDIS
Publisher : Akademi Farmasi Mitra Sehat Mandiri Sidoarjo

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Abstract

Ondansetron HCL is a 5-HT3 (serotonin) receptor antagonist drug which was recently introduced as an anti-vomiting drug. Ondansetron HCL is available in the form of 4 mg tablets. .The manufacture of OFDT ondansetron HCL in this formulation was to find out which results were more optimal than the different concentrations of crospovidone disintegrant with concentrations of 2%, 3%, and 4%. Oral Fast Dissolving Tablet (OFDT) are solid drug tablets that are easily disintegrated when placed on the tongue and can provide a rapid therapeutic effect. This study aims to determine the concentration of crospovidone on the physical quality of Oral Fast Dissolving Tablet. The method used in this research is experimental. Three different formulations were tested. The maximum wevelength of ondansetron HCl is 248nm. The concentrations used in the calibration of ondansetron HCl were 6 ppm, 8 ppm, 10 ppm, 12 ppm, 14 ppm, 16 ppm and 18 ppm. The results obtained were tested using SSPSS one way anova. In this study, the independent variables were several rations of crospovidone concentration, namely 2%, 3% and 4%.