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Journal : Journal of Global Pharma Technology

Inverse Correlation between Combination of Antiretroviral Therapy with the level of Serum Interleukin-6, Ferritin, and Hepcidin in HIV Patients with Anemia Chronic Disease I Ketut Agus Somia; Ketut Tuti Parwati Merati; I Made Bakta; Ida Bagus Putra Manuaba; Wayan Putu Sutirta Yasa; I Dewa Made Sukrama; Ketut Suryana; Rudi Wisaksana
Journal of Global Pharma Technology .
Publisher : Journal of Global Pharma Technology

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Abstract

Background: The purpose of this study was to determine whether the cARV therapy correlates with the serum level of IL-6, ferritin, and hepcidin in HIV infected patients with ACD.Methods: A cross-sectional study conducted in HIV patients with ACD, aged 15-65 years with exclusion criteria such as chronic renal disease, chronic liver disease, treated for anemia in the last 3 months, taking iron supplements in the last 3 months, history of blood transfusion in the last 1 year, suffering from acute infection, tuberculosis infection, malignancy, hepatitis C virus infection, acute hypersensitivity reaction and pregnancy. Blood specimen examined by high sensitivity human IL-6 In vitro ELISA, DRG Hepcidin- 25 ELISA, serum ferritin by agglutination method and CD4 cell count by flow cytometry. Results: A total of 86 HIV patients with ACD consist of 42 subjects with experienced cARV and 44 subjects with naive cARV. There are several differences between cARV naïve and experienced cARV including: Hb (g/dl) [ 10.8 ( 9.88 – 11.75) Vs. 11.60 (11.00 – 12.34) p: 0.058 ], serum iron (mg/dl) [ 50.00 (31 – 66.8) Vs. 71.40 (56.00 – 108.00) p: 0.121 ), serum ferritin (ug/dl) [ 630 ( 194 – 1101) Vs. 195.40 (128.25 – 589.47) p: 0.008 ], IL-6 (pg/mL) [7.20 (3.88 – 10.76) Vs. 4.03 (1.69 – 8.49) p: 0.009), serum hepcidin (ng/mL) [45.54 (16.74 – 95.31) Vs. 23.35 (6.58 – 49.99) p: 0.007] , CD4 cell count (cell/uL) [31.5 (14.25 – 90.75) Vs. 307 (168.5 – 458.75) p : < 0.001)] There is a significant inverse correlation between the cARV therapy with level of serum IL-6 ( r: - 0. 285, p: 0.008), ferritin (r: - 0.321, p: 0.007) and hepcidin (r: - 0.293, p: 0.006). While there was a significant positive correlation between the cARV therapy with CD4 cell count (r: 0.676, p: 0.001). There was no correlation between the cARV therapy with serum iron levels ( r: 0.176, p: 0.121).Conclusion: There is an inverse correlation between the cARV therapy with serum level of IL-6, ferritin, and hepcidin in HIV patients with ACD.  Keywords: cARV, ACD, IL-6, Ferritin, Hepcidin.
Co-Authors A. A. Bawa Putra Amaral, Meriana Barreto Anak Agung Mas Putrawati Triningrat Angelina S Tallo Ari Andayani Ari Suryathi, Ni Made Aria, Anselmus Danus Ariesanti Tri Handayani, Ariesanti Tri Arsani, Ida Ayu Anom Ashri Rizki Hidayati Atmaja, I Made Ari Dwi Suta Atmaja Bagus Komang Satriyasa Candra Dwipayana Hamdin Darma, I Ketut Dea Emmanuel Desak Made Purnama Dewi Elfrida Magdalena Manurung Elvira, . Emmy Sahara Ezra Naibaho Fatmayoni, I Gusti Agung Ayu Intan Faturrahman Gede Wirya Kusuma Duarsa Golden, I Nyoman Gusti Ayu Putu Eka Dewi Prihantari Gusti Ngurah Sutapa Handayani, Ida Ayu Paramita Haqqika Pasha Harthawan, I Gusti Ngurah Putra I Dewa Made Sukrama I Gusti Ayu Putu Eka Dewi Prihantari I Gusti Ngurah Putra Harthawan I Ketut Agus Somia I Ketut Widiana I Ketut, Darma I M. Sumarya, I M. I Made Bakta I Made Gede Darma Susila I Made Jawi I Made Oka Adi Parwata I Made Sudarmaja I Nengah Wirajana I Nyoman Gede Arya Astawa I Nyoman Semadi I Putu Bagus Arya Pradnyana I Wayan Budi Sentana I Wayan Gede Jayanegara I Wayan Putu Sutirta Yasa I Wayan Suasnawa I Wayan Suirta I Wayan Wita I. A Raka Astiti Asih Ida Ayu Anom, Arsani Ida Ayu Ria Paramita Handayani Ida Bagus Made Asmara Dwipa Ida Bagus Made Suryatika Irma Nuraeni Salsabila Iryanti Eka Suprihatin Junitasari, Putu Diah Krisna Ketut Priya Premayanti Ketut Putu Yasa Ketut Suryana Ketut Tuti Parwati Merati Komang Ayu Triana Indah Luh Gede Anggasari Dewi M, Yusuf Made Baruna Jayadilaga N. Adiputra Ni G. A. M. Dwi Adhi Suastuti Ni Kadek Dahliani Ni Ketut Puspa Sari Ni Luh Putu Kartika Mardiani Ni Luh Rustini Ni Made Ari Suryathi Ni Made Ayu Surasmiati Ni Made Linawati Ni Made Puspawati Ni Made Suaniti Ni Nyoman Trisnawati Ni Putu Rahayu Artini Ni Wayan Dian Irmayani, Ni Wayan Dian Ni Wayan Purnami Rusadi Poniman, S. Pradana, I Gede Evan Pratama, Tohir Rendra Putrawati Triningrat, Anak Agung Mas Putri, Ni Luh Nova Dilisca Dwi Putu Diah Krisna Junitasari Rudi Wisaksana Sagung Ngurah Mayuni Saputra, I Putu Abdi Sari, Desak Made Indah Paramitha Sri Wahjuni Sudartana, I Ketut Sugeng Santoso Sukarata, I Putu Gde Suryanadi, Ni Made Sutyawan, I Wayan Eka Triningrat, Anak Agung Mas Putrawati Wibawa, I Made Dwi Surya Widiyanti, I Gusti Ayu Winly, Winly Yudith Rizkia Widyawati