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All Journal Health Science Journal of Indonesia eJournal Kedokteran Indonesia The Indonesian Journal of Gastroenterology, Hepatology and Digestive Endoscopy

Murdani Abdullah

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Author-ID : 3161479

Biochemistry, Genetics & Molecular Biology Dentistry Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing Public Health

Published : 58 Documents Claim Missing Document

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Articles

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Hematochezia in Patient with Colorectal Polyps Ellen Susanti; Ari Fahrial Syam; Murdani Abdullah; Vera Yuwono
The Indonesian Journal of Gastroenterology, Hepatology, and Digestive Endoscopy VOLUME 5, ISSUE 1, April 2004
Publisher : The Indonesian Society for Digestive Endoscopy

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24871/51200432-35

More than 95% colorectal cancers arise from neoplastic adenomatous polyps (adenomas). The malignant potential of polyps depends on size, amounts, histological type and degree of dysplasia. The prevalence of adenoma increases with age. Patient whose age more than 40 years old with rectal bleeding as presenting symptom should never be ascribed solely to coexisting haemorrhoids without a through evaluation of the colon and rectum. We reported a case of hematochezia due to colorectal polyps with coexisting hemorrhoids as suspected bleeding source. Colonoscopy examination demonstrated colorectal adenomatous polyps in rectum and sigmoid. Polypectomy was done and tissue biopsy Result was tubular adenoma with mild dysplasia. Keywords: Adenomatous polyp, hematoschezia

Chronic Inflammation in Colorectal Carcinogenesis: Role of Inflammatory Mediators, Intestinal Microbes, and Chemoprevention Potency Irwin Tedja; Murdani Abdullah
The Indonesian Journal of Gastroenterology, Hepatology, and Digestive Endoscopy VOLUME 14, NUMBER 1, April 2013
Publisher : The Indonesian Society for Digestive Endoscopy

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24871/141201329-34

Colorectal carcinogenesis is a multi-factorial process which involves accumulation of genetic defect, protein modification, and cell interaction with matrix in colonic epithelial cells. Chronic inflammation is suspected to play role in carcinogenesis by inhibiting apoptosis, impairing DNA, and chronically stimulating mucosal proliferation. Alteration in intestinal microbes’ population, either in one particular species or in overall composition, may also cause chronic inflammation which increase the risk of developing adenoma or carcinoma.Inflammatory mediators and intestinal microbes have diverse effect in colorectal carcinogenesis. Several may increase host anti-tumor immunity, while the others may increase tumor growth. Various ways of interactionshave just started to be partially understood. In addition, colorectal cancer chemoprevention is a promising and important knowledge due to limited success of current available therapy. Chemopreventive agents are currentlybeing studied and have different success rate.Keywords: inflammation, microbes, chemoprevention, carcinogenesis, colorectal cancer

Hospital-based Survey on Knowledge and Attitude toward Colorectal Cancer Screening among Indonesian Population Murdani Abdullah; Achmad Fauzi; Ari Fahrial Syam; Dadang Makmun; Marcellus Simadibrata; Chudahman Manan; Joseph JY Sung; Abdul Aziz Rani
The Indonesian Journal of Gastroenterology, Hepatology, and Digestive Endoscopy VOLUME 10, ISSUE 2, August 2009
Publisher : The Indonesian Society for Digestive Endoscopy

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24871/102200951-55

Background: Several western countries have recommended colorectal cancer (CRC) screening, however the yield of CRC screening is still low. The acceptability of CRC screening is influenced by people’s knowledge and attitude. This study was conducted to evaluate the knowledge and attitude of Indonesian people toward CRC screening. Method: Adult Indonesian population aged 19–65 years was recruited in this hospital-based survey. Knowledge and attitude toward CRC screening were assessed by using structured questionnaires consisting of nine chapters. Result: There were 614 respondents recruited in this study. Most respondents (36.2%) incorrectly pointed out abdominal pain or pain around anus as the symptom of bowel cancer. Regarding CRC risk factors, eating fruits or vegetables rarely was the most frequent answer (28.5%) encountered. Only one-third (28%) of respondents mentioned colonoscopy as the Method for CRC screening. There were 38.1% of respondents who believed that CRC screening test might be harmful to the body. Up to 70.8% of the respondents agreed and strongly agreed that CRC screening test might cause physical discomfort. Two fifth (41.5%) of respondents believed that CRC screening test was embarrassing. More than half (58.8%) of respondents were afraid of having the CRC screening test. The test was too expensive according to 79.5% of respondents. Conclusion: The knowledge on CRC symptoms, risk factors, and screening tests is still low among Indonesian population. Our study result indicates that the lack of knowledge and the discouraging attitude among Indonesian population will be the major barriers to implement CRC screening in Indonesia. Keywords: colorectal cancer, screening, knowledge, attitude

Non-invasive Markers for Diagnosis of Liver Cirrhosis in Chronic Hepatitis B Jeffry Beta Tenggara; Irsan Hasan; Andri Sanityoso; Murdani Abdullah
The Indonesian Journal of Gastroenterology, Hepatology, and Digestive Endoscopy VOLUME 12, NUMBER 3, December 2011
Publisher : The Indonesian Society for Digestive Endoscopy

Background: Indonesia is an endemic country for hepatitis B viral infection. Thus, early diagnosis of cirrhosis is important to be established with regard to prompt treatment and to determine the patients’ prognosis. Liver biopsy which is a gold standard in diagnosing liver cirrhosis has several limitations, such as expensive and invasive. The objective of this study was to identify the accuracy of non-invasive markers: aspartate/alanine transaminase ratio (AAR), age-platelet index (API), aspartate transaminase to platelet ratio index (APRI), spleen to platelet ratio index (SPRI), and age-spleen-platelet ratio index (ASPRI) in predicting cirrhosis in chronic hepatitis B patients. Methods: A diagnostic study was performed in Division of Hepatology and Hepatology Outpatient Clinic, Depatment of Internal Medicine, Cipto Mangunkusumo Hospital between January 2009 and July 2010, with the participation of 71 chronic hepatitis B patients who had undergone liver biopsy consecutively. Stage of fibrosis was determined based on the METAVIR scoring system. Five non-invasive markers: AAR, API, APRI, SPRI, and ASPRI were compared with liver biopsy Results. Statistical analysis was performed by using T-test and Spearman correlation test using SPSS version 13. Results: API, APRI, SPRI, and ASPRI had significant correlation with the incidence of liver cirrhosis in hepatitis B infection (p 0.05). However, AAR had no correlation with the incidence of cirrhosis. Using the cut-off point of 1.19, APRI was the best marker with area under curve (AUC) 0.91, sensitivity 83.3%, and specificity 89.2%. Conclusion: Non-invasive markers were suitable in predicting cirrhosis and have the potential to decrease the number of liver biopsy in chronic hepatitis B patients. Keywords: non-invasive markers, chronic hepatitis B, liver cirrhosis

National Consensus on the Use of Sedation Drugs in the Gastrointestinal Endoscopic Procedures Daldiyono Daldiyono; Abdul Aziz Rani; Marcellus Simadibrata; Ari Fahrial Syam; Achmad Fauzi; Dadang Makmun; Murdani Abdullah; Indra Marki; Kaka Renaldi
The Indonesian Journal of Gastroenterology, Hepatology, and Digestive Endoscopy Vol 18, No 2 (2017): VOLUME 18, NUMBER 2, AUGUST 2017
Publisher : The Indonesian Society for Digestive Endoscopy

Gastrointestinal endoscopy is rapidly developing and several gastrointestinal endoscopy equipment are available for both diagnostic and therapeutic purposes. Proper sedation is critical in performing endoscopic procedures, both for patients and physicians. This consensus is used as a guideline and not as a legal standard in performing endoscopic services. This consensus explained the definition, indication, contraindication, and complication prevention during sedation. Factors affecting the need of sedation is patient factors, procedure factors, and sedation level. Diagnostic or therapeutic upper gastrointestinal tract endoscopy which not complicated can be performed with minimal sedation or moderate sedation, while deep sedation can be considered for longer and more complex procedures. Furthermore, assessment and selection of sedation was explained, followed by the guide to choose pharmacological sedation and analgesics. Currently, diazepam, midazolam, propofol, fentanyl, and pethidine is the most likely used sedation during gastrointestinal endoscopy, with midazolam as the preferred medication of choice. This consensus also explained the antidote of each drug and the recovery after procedure. This consensus aimed to improve gastrointestinal endoscopic procedure services in Indonesia.

Intractable Diarrhea due to Secondary Gastrointestinal Amyloidosis in a Patient with History of Leprosy Chyntia Olivia MJ; Tito Ardi; Evy Yunihastuti; Ari Fahrial Syam; Murdani Abdullah
The Indonesian Journal of Gastroenterology, Hepatology, and Digestive Endoscopy VOLUME 9, ISSUE 1, April 2008
Publisher : The Indonesian Society for Digestive Endoscopy

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24871/91200824-29

Amyloidosis is not a single disease but a term for diseases that share a common feature: the extracellular deposition of pathologic insoluble fibrillar proteins in organs and tissues. In both primary and secondary amyloidosis, the most commonly involved organ system is the gastrointestinal system, with the colon being the most frequently involved organ. A 30 years-old male, complained of diarrhea since 4 months prior to admission. The colonoscopy examination revealed pancolitis, ileitis, and the result from histopathological examination showed chronic destructive ileocolitis with 40-70% amyloidosis of mucosa. The abdominal ultrasonography showed chronic cholecystitis, multiple cholelithiasis and minimally ascites. The esophagogastroduodenoscopy revealed candida esophagitis, erosive pangastritis grade V, pyloring gapping, erosive duodenitis, bile reflux gastritis and esophagitis, and the result from histo-pathological examination showed amyloidosis on gastric mucosa.The immunofixation electrophoresis was negative for monoclonal light chains, and the serum protein electrophoresis showed normal pattern. Enteral and parenteral nutritional therapy were given. Secondary infection was treated by antibiotics. Complication and organ failure occured lately. This chalenging case demonstrated complicated management of gastestinal amyloidosis. Keywords: gastrointestinal amyloidosis, intractable diarrhea, leprosy

Candida Esophagitis: A Retrospective Study of Upper Gastrointestinal Endoscopic Grading and the Characteristic Profile Steven Sumantri; Marcellus Simadibrata; Moch Ikhsan Mokoagow; Deddy Gunawanjati; Seri Mei Maya Ulina; Bona Adhista; Novie Rahmawati Zirta; Riahdo Saragih; Daldiyono Daldiyono; Abdul Aziz Rani; Murdani Abdullah; Ari Fahrial Syam; Chudahman Manan; Dadang Makmun; Achmad Fauzi
The Indonesian Journal of Gastroenterology, Hepatology, and Digestive Endoscopy VOLUME 12, NUMBER 2, August 2011
Publisher : The Indonesian Society for Digestive Endoscopy

Background: Candida esophagitis is a common abnormality found on esophagogastroduodenoscopy (EGD) procedure in patients with recognizable risk factors. However, the finding is frequently incidental as most of them are asymptomatic. There has been no study on the characteristics of Candida esophagitis in Indonesia. The aim of this study was to describe the degree of Candida esophagitis and its characteristics in patients who underwent EGD procedure at Cipto Mangunkusumo Hospital. Method: A retrospective study was conducted on all EGD procedures at the Gastroenterology Procedure Room, Internal Medicine Department, Cipto Mangunkusumo Hospital, between January 2007 and December 2009 with a total of 2,311 samples. The study was carried out by visually examining all endoscopic procedures and grading them according to the Kodsi severity grading (1976), and evaluating medical records. Data analysis was performed using Microsoft Excel 2007. Results: During the study period, Candida esophagitis was found in 2.6% patients with predominant male (68.9%) and the average age was 49.8 ± 15 years. The chief complaints found were dyspepsia (34.4%), melena (21.3%) and dysphagia (4.9%) and 32.8% patients were asymptomatic. The most frequent risk factors were age ≥ 60 years old (28.3%), proton pump inhibitor or H2 receptor antagonist user (26.4%), and antibiotics (17.0%). Grade II Kodsi candidiasis was the most prevalent degree in this study (44.3%). Conclusion: Candida esophagitis was one frequent finding in endoscopy based on the complaint of dyspepsia in patients with certain risk factors. However, the results of this study still need further validation in prospective studies. Keywords: Candida esophagitis, esophagogastroduodenoscopy, risk factors, grading

Role of Digestive Tract Hormone in Functional Dyspepsia Mohammad Adi Firmansyah; Dadang Makmun; Murdani Abdullah
The Indonesian Journal of Gastroenterology, Hepatology, and Digestive Endoscopy VOLUME 14, NUMBER 1, April 2013
Publisher : The Indonesian Society for Digestive Endoscopy

Dyspepsia is a complaint commonly found in daily practice. Functional dyspepsia is considered if the organic cause of dyspepsia is not found. The pathophysiology of functional dyspepsia has not been fully understood.However there are three main pathophysiology, which are: motility disturbance, non-motility disturbance, and psychosocial factor. Several digestive tract hormones are ghrelin, motilin, cholecystokinin (CCK), peptide YY (PYY), somatostatin, glucagon-like-peptide 1 (GLP), are thought to play role in the pathophysiology of functional dyspepsia, particularly in the regulation of digestive tract motility. Currently, a new paradigm in digestive tract disturbance treatment is developing, such as motilin receptor agonist therapy (for example mitemcinal) and ghrelin receptor agonist therapy, which is used as one of the new modalities in treatment of dyspepsia.Keywords: dyspepsia, functional dyspepsia, motilin, ghrelin, cholecystokinin, motilin receptor agonist, ghrelin receptor agonist

Management of Complicated Colonic Diverticulosis Ariadi Humardani; Ari F Syam; Murdani Abdullah; Ibrahim Basyir; Arman A Abdullah
The Indonesian Journal of Gastroenterology, Hepatology, and Digestive Endoscopy VOLUME 7, ISSUE 1, April 2006
Publisher : The Indonesian Society for Digestive Endoscopy

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24871/71200611-15

Prevalence of diverticular disease has been increasing worldwide in concert with the development of industrial era and the alteration of diet pattern to low dietary fiber. Mean age of patients is 60 years; peak incidence at age more than 50 years, 20% less than 50 years, 2-8% less than 40 years. About 50 - 90% of diverticular disease are left-sided especially sigmoid, while in Asian people are mostly right sided. The usual complaint of patient is abdominal pain. Complications that may occur due to diverticulosis are diverticulitis, abscess, fistula, obstruction and bleeding. The presence of complicated diverticulosis can be evaluated by plain X-rays, CT-scan, barium with contrast, ultrasonography and colonoscopy in addition of laboratory examination. The management of complicated diverticulosis usually consists of combination of medical therapy and surgery. Proper and immediate treatment will influence the prognosis of patients. Keywords: diverticular diseases, diverticulitis, abscess, fistula, obstruction, bleeding

Management of Duodenal Ulcer with Gastroesophageal Reflux Disease (GERD) with Intravenous Pantoprazole Ari Fahrial Syam; Murdani Abdullah; Marcellus Simadibrata; Dadang Makmun; Chudahman Manan; Daldiyono Hardjodisasto
The Indonesian Journal of Gastroenterology, Hepatology, and Digestive Endoscopy VOLUME 4, NUMBER 1, April 2003
Publisher : The Indonesian Society for Digestive Endoscopy

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24871/41200326-28

Proton pump inhibitors (PPIs) are the most effective anti secretory drugs available for controlling gastric acid acidity and volume. They are the drug of choice in the treatment for gastro esophageal reflux disease (GERD), Helicobacter pylori eradication, peptic ulcer and non steroidal anti-inflammatory drug (NSAID) gastropathy: For acute cases, an intravenous PPI is needed, especially for hospitalized patient. Recently, intravenous pantoprazole represents an alternative to intravenous histamine-2 receptor antagonists. We observed 2 patients who were treated with pantoprazole for duodenal ulcer, where one case had a complication of bleeding with a history of long term use of NSAID. After two weeks of treatment with pantoprazole, significant lesion healing from endoscopy findings was achieved in both cases. Keywords: peptic ulcer, upper gastrointestinal bleeding, proton pump inhibitors, pantoprazole

Co-Authors Aan Santi Abdul Aziz Rani ACHMAD FAUZI Adang Bachtiar Afifah Is Ahmad Fauzi Ahmad Soefyani Ahmar Abyadh Aida Lydia Ali Imron Yusuf Anastasia Yoveline Andri Sanityoso Ari F Syam Ari Fahrial Syam Ariadi Humardani Arif Mansjoer Arman A Abdullah Arman Adel Abdullah Birry Karim Bona Adhista Budi Tan Oto C Martin Rumende Ceva W. Pitoyo Chairul R Nasution Chatarina Umbul Wahyuni Chudahman Manan Chyntia Olivia MJ Cleopas Martin Rumende Czeresna Heriawan Soejono Dadang Makmun Daldiyono Daldiyono Daldiyono Hardjodisasto Daldiyono Hardjodisastro Dasril Nizam Debby Desmarini Deddy Gunawanjati Dharmika Djojoningrat Diah Rini Handjari Diany N Taher Djumhana A Dolly Dolven Kansera Dono Antono E. Mudjaddid A. Siswanto Deddy N.W.Achadiono Hamzah Shatri E. Mujaddid Edy Rizal Wahyudi Ekowati Rahajeng Ellen Susanti Elli Arsita Ening Krisnuhoni Eric Daniel Tenda Evy Yunihastuti Fadilah Fadilah Fahmi Razi Darkuthni Fransiska Hardi Fumiaki Kitahara Guntur Darmawan Haryanto Surya Hasan Mihardja Herdiman T Pohan Hiroyuki Otsuka Hotmen Sijabat Ibrahim Basyir Ika Prasetya Wijaya Ikhwan Rinaldi Indra Marki Irfan Maulani Irsan Hasan Irwin Tedja Ivo Novita Sah Bandar Jacobus Albertus Jane Estherina Jeffri Gunawan Jeffry Beta Tenggara Joseph JY Sung Julwan Pribadi Jumhana Atmakusuma Kaka Renaldi Katharina Setyawati Khie Chen Kuntjoro Harimurti Lies Luthariana Luluk Yunaini Lusiani Lusiani M Purnomo Isnaeni M Usman SM Marcellus Simadibrata Marcellus Simadibrata K Marthino Robinson Maruhum B.H. Marbun Masayuki A Fujino Masayuki A. Fujino Masdalina Pane Moch Ikhsan Mokoagow Mohammad Adi Firmansyah MUHAMMAD SYAFIQ Nata Pratama Novie Rahmawati Zirta Nur Rasyid Okto Dewantoro Pamela Abineno Pamela Abineno Damaledo Paulus Kusnanto Puji Sari Rabbinu Rangga Pribadi Raden Nur Ista Ralph Girson Ratu Ratih Kusumayanti Reinaldo Alexander Riahdo Saragih Rino A Gani Rino Alvani Gani Rizka Puteri Iskandar Rizki Yaruntradhani Ryan Ranitya Saleha Sungkar Salius Silih Sally Aman Nasution Sedijono Sedijono Seri Mei Maya Ulina Sofy Meilaini Steven Sumantri Suryantini Suryantini Suzana Ndraha Tadashi Sato Tito Ardi Tjahjadi Robert Tedjasaputra Toman L Toruan Tri Juli Edi T Velma Herwanto Vera Yuwono Wirasmi Marwoto Wulyo Rajabto Yonathan, I Wayan Murna Yuichiro Kojima Yustar Mulyadi

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