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The Role Placental TLR-7 Expression with Cord Blood HBV DNA and Placental HBV DNA: Peran Ekspresi TLR-7 Plasenta dengan HBV DNA Tali Pusat dan HBV DNA Plasenta Naeny Fajriah; Maisuri T. Chalid; Lenny Lisal; Efendi Lukas; St. Nur Asni; Rina Masadah
Indonesian Journal of Obstetrics and Gynecology Volume 10 No. 2 April 2022
Publisher : Indonesian Socety of Obstetrics and Gynecology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32771/inajog.v10i2.1564

Abstract

Abstract Objective: To determine the role of TLR-7 expression on intrauterine vertical transmission in pregnancy through identification of serum hepatitis B markers in both maternal and umbilical cord blood. Methods: Analysis of TLR expression was performed on 38 paraffin block samples of placental tissue acquired from mothers with HBV using TLR immunohistochemical staining. Results: 16 of 38 samples were acquired from mothers aged 26-30 years-old. Most of the samples were from primiparous mothers (52.6%). This study found no significant association between TLR-7 expression and HBV DNA in the placenta and cord blood (p = 1.000). However, we found a significant association between placental TLR-7 expression and maternal HBV DNA (p = 0.034). Meanwhile, placental HBeAg and HBV DNA were not associated with placental TLR-7 expression (p = 0.082; p = 1.000). Conclusion: There was no significant association between TLR-7 expression and HBV DNA in the placenta and cord blood, but we found a significant association between TLR-7 expression and maternal HBV DNA. Keywords: HBV DNA, Hepatitis B, intrauterine infection, placental toll-like receptor (TLR) 7,umbilical cord. Abstrak Tujuan: untuk melihat peran ekspresi TLR-7 terhadap transmisi vertikal intrauterina pada kehamilan melalui identifikasi marker serum hepatitis B pada darah ibu dan talipusar. Metode: Analisis ekspresi TLR dilakukan pada 38 sampel blok paraffin jaringan plasenta ibu yang menderita HBV dengan memakai pewarnaan imuhohistokimia TLR. Hasil: 16 dari 38 sampel berusia 26-30 tahun. Sebagian besar sampel merupakan kelompok primipara (52.6%). Penelitian ini tidak menemukan hubungan yang signifikan antara ekspresi TLR-7 di plasenta dan HBV DNA darah tali pusat (p = 1.000). Tapi, kami menemukan hubungan yang signifikan antara ekspresi TLR-7 plasenta dan HBV DNA ibu (p = 0,034). Sedangkan HBeAg dan HBV DNA plasenta tidak berhubungan dengan ekspresi TLR-7 plasenta (p = 0,082; p = 1.000). Kesimpulan: Tidak ada hubungan yang signifikan antara ekspresi TLR-7 dan DNA HBV di plasenta dan tali pusat, tetapi kami menemukan hubungan yang signifikan antara ekspresi TLR-7 dan DNA HBV ibu. Kata kunci: HBV DNA, Hepatitis B, infeksi intrauterina, plasenta, tali pusat, toll-like receptor (TLR) 7
Development and Validation of the "Redi: Sang Sel Pelayar" Storybook Series for Pediatric Cancer Patients Hanifah, Rif’at; Al atsari, Muhammad Azka; Ismail; Andira, Fiki Wahyu; Nour Hafifah, Andi Izza; Masadah, Rina; Muhiddin, Syurawasti
Golden Age: Jurnal Ilmiah Tumbuh Kembang Anak Usia Dini Vol. 9 No. 2 (2024)
Publisher : Program Studi Pendidikan Islam Anak Usia Dini, Fakultas Ilmu Tarbiyah dan Keguruan, UIN Sunan Kalijaga, Yogyakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14421/jga.2024.92-13

Abstract

This study aimed to develop and validate the "Redi: Sang Sel Pelayar" storybook series as an educational tool for pediatric cancer patients, enhancing their understanding of cancer and improving treatment adherence with age-appropriate content. Using Sugiyono's R&D method, the study progressed through defining, designing, developing, and disseminating stages. Five types of childhood cancers were addressed: leukemia, retinoblastoma, osteosarcoma, neuroblastoma, and nephroblastoma. This study demonstrates that illustrated storybooks are effective in helping children understand cancer and related medical processes. The storybooks, tailored to specific cancer types and age groups with adapted characters, make it easier for children to grasp their condition. The overall average score of our readability questionnaire was 3.9, which means that our book is categorized as readable (3.4 < Mean > 4.2 = Readable). There was also a significant increase in post-test scores after the children underwent intervention by reading storybooks (P: 0.015; 95% CI 0.013–0.018). Evaluations showed significant increases in children's knowledge after reading the books, along with positive changes in their behavior and understanding of cancer. The implications for pediatric oncology care are significant, suggesting that culturally relevant educational tools can reduce anxiety and improve adherence. Despite the promising findings, the study was limited by a small sample size and a lack of long-term effect measurements. Future research should focus on larger samples and longitudinal studies to better assess the impact on adherence and well-being. Overall, the "Redi: Sang Sel Pelayar" series offers a novel approach to pediatric oncology education, with potential applications for other chronic illnesses, proposing a valuable addition to standard pediatric care practices.
STRATIFIKASI RISIKO HIPERPLASIA ENDOMETRIUM DAN KANKER ENDOMETRIUM TIPE ENDOMETRIOID BERDASARKAN FAKTOR DEMOGRAFI, GEJALA GINEKOLOGI DAN EKSPRESI BETA CATENIN Maulana, Aries; Masadah, Rina; Nelwan, Berti Julian; Ghaznawie, Mahmud; Miskad, Upik Anderiani; Tawali, Suryani
Healthy Tadulako Journal (Jurnal Kesehatan Tadulako) Vol. 10 No. 2 (2024)
Publisher : Universitas Tadulako

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22487/htj.v10i2.1150

Abstract

Studi ini menganalisis hubungan antara faktor demografi, gejala ginekologi, dan ekspresi B-catenin di endometrium untuk mengembangkan stratifikasi risiko hiperplasia dan karsinoma endometrium. Studi ini menemukan bahwa distensi perut berhubungan dengan derajat patologi yang buruk, sedangkan peningkatan usia dan perdarahan uterus berhubungan dengan karsinoma. Namun, ekspresi B-catenin tidak dikaitkan dengan derajat patologis atau karsinoma. Penelitian ini juga mengembangkan model stratifikasi risiko pohon keputusan yang mampu membedakan antara hiperplasia non-atipikal dan hiperplasia/karsinoma atipikal dengan sensitivitas 80–94,8% dan spesifisitas 40,6–60%. Hal ini menunjukkan bahwa model stratifikasi risiko merupakan alat yang menjanjikan untuk mengidentifikasi wanita yang berisiko terkena hiperplasia dan karsinoma endometrium.
Significance of HBsAg Expression in Placental Tissue with Serum Positivity in Hepatitis B Virus-infected Mother Kalatiku, Jane Magdalena; J Nelwan, Berti; Zainuddin, Andi Alfian; Kaelan, Cahyono; Achmad, Djumadi; Masadah, Rina
Nusantara Medical Science Journal Volume 8 Issue 2, July - December 2023
Publisher : Faculty of Medicine, Hasanuddin University.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20956/nmsj.vi.20242

Abstract

Introduction:  Hepatitis B virus infection in fetal and newborn may result from the intrauterine vertical transmission. The purpose of our study is to determine the association between HBsAg expression in the placental and HBsAg serum in pregnant women. Methods: Total 67 placental tissues and serum were obtained from HBV-infected mothers. This study was conducted in various hospitals in Makassar, Indonesia from December 2017 until August 2018. Maternal serum and placental tissues were tested by ELISA and Immunohistochemistry staining. Results: 67 samples from placental tissues and serum were categorized into two different levels of serum titer and staining positivity. Twenty nine samples (43.3%) were categorized in low titer of HBsAg positive serum and 38 samples (56.7%) in high titer of  HBsAg positive serum. From the total of 67 placental samples, 43 (64.2%) samples had positive expression of HBsAg immunohistochemistry staining and 24 (34.8%) samples had negative expressions. Conclusions: There was a significant correlation between the expressions of HBsAg in the placental tissues and serum titers of HBV-infected mothers that is important in predicting the risk of transplacental transmission. The results of this study can be used as guidelines for the prevention and therapeutic approach of mother-to-child HBV infection.
Rasio Platelet Limfosit (PLR) sebagai Penanda Risiko Gangguan Fungsi Kognitif pada Pasien Diabetes Melitus Tipe 2 Wulaa, Nurwapina Langga; Muis, Abdul; Maricar, Nadra; Masadah, Rina; Sompa, Andi Weri; Umar, Husaini
Ghidza: Jurnal Gizi dan Kesehatan Vol. 8 No. 1 (2024): June
Publisher : Universitas Tadulako

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22487/ghidza.v8i1.1213

Abstract

Penelitian ini bertujuan untuk mengetahui hubungan ratio platelet limfosit (PLR) dengan fungsi kognitif pada pasien DMT2. Penelitian ini menggunakan rancangan penelitian observasional analitik dengan desain cross-sectional. Populasi penelitian adalah penderita DMT2 yang datang ke Poli Rawat Jalan RSWS dan RS Jejaring Pendidikan yang telah didiagnosis DMT2 oleh dokter spesialis penyakit dalam sesuai kriteria PERKENI 2015. Adapun besar sampel penelitian ditetapkan sebanyak 41 pasien. Variabel yang digunakan dalam penelitian ini adalah: Variabel Independen (Rasio platelet limfosit), Variabel Dependen (Gangguan kognitif), Variabel Antara (Proses inflamasi kronik), Variabel Perancu (Usia, jenis kelamin, Pendidikan, lama onset DMT2, komorbiditas), Variabel Kontrol (Stroke, Alzheimer, dementia lewy’s body, epilepsy). Analisis data yaitu analisis bivariat menggunakan uji Pearson atau Rank Spearman untuk menilai koefisien R, dan analisis multivariate menggunakan analisis regresi linier berganda. Data diolah melalui program SPSS. Hasil penelitian yaitu korelasi negatif antara nilai PLR dengan fungsi kognitif pada pasien DMT2. Semakin tinggi nilai PLR maka akan fungsi kognitif semakin rendah. Kemudian, Pada tingkat domain fungsi kognitif terdapat korelasi negatif antara nilai PLR dengan domain fungsi eksekutif, visuospasial, dan memori pada pasien DMT2. Adapun nilai cut-off pada nilai PLR untuk mendiagnosis gangguan kognitif adalah 186,1 dengan sensitivity: 57.58% dan specificity: 87,50%. Kesimpulan yaitu PLR dapat menjadi penanda risiko terjadinya gangguan fungsi kognitif pada pasien DMT2. Peningkatan nilai PLR dapat dikaitkan dengan penurunan fungsi kognitif pada pasien DMT2, terutama pada domain fungsi eksekutif, visuospasial, dan memori.
Leptin Expression in High-grade Serous Ovarian Carcinoma: The Controversy of Leptin Paradox in Ovarian Cancer Ham, Jonathan; Masadah, Rina; Nasser, Andi Sitti Halija Diawanti; Rauf, Syahrul; Nelwan, Berti Julian; Cangara, Muhammad Husni; Miskad, Upik Anderiani; Mardiati; Tawali, Suryani
Indonesian Journal of Obstetrics and Gynecology Volume 13. No. 1 January 2025
Publisher : Indonesian Socety of Obstetrics and Gynecology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32771/inajog.v13i1.2373

Abstract

Objectives : To analyse the characteristics and expression patterns of Leptin in high-grade serous epithelial ovarian carcinoma (HGSC), and to compare them with the overall serous ovarian carcinoma population. Methods : This was a cross-sectional study. A total of 77 paraffin-embedded tissue samples were collected from patients at the Wahidin Sudirohusodo Hospital over a period of 3 years. Immunohistochemical staining was performed using a polyclonal Leptin antibody. Data were analyzed using SPSS version 22.0. Results: Among HGSC patients, the majority (64.3%) were over 50 years old, and a significant portion (39.3%) were obese. Leptin showed strong cytoplasmic expression in 69.6% of HGSC tumor cells and in 100% of LGSC tumor cells (p-value = 0.004). There was no correlation between lymphovascular space invasion and leptin expression. Interestingly, leptin expression in overall serous ovarian carcinoma patients exhibited a protective effect against metastasis (p-value = 0.047), suggesting a leptin paradox exists in this type of cancer. However, this association was no longer significant when the analysis excluded the LGSC group (p-value = 0.193). Conclusion : This study suggest that leptin expression may not be a significant prognostic factor in HGSC. The appearance of the pseudo-leptin paradox phenomenon in several previous studies was confounded by sample populations with heterogeneous tumor morphology. Keywords: high-grade serous carcinoma, leptin paradox, immunohistochemistry, leptin, obesity
Reducing Women’s Cancer Rates: Early Detection of Breast Cancer and Cervical Cancer Through Self-Breast Exams (SADARI) and Pap Smears in Pinrang Regency, South Sulawesi Masadah, Rina; Nelwan, Berti Julian; Ham, Jonathan; Raharja, Siska Putri Wulandari; Gosal, Steffy Rebecca; Rauf, Syahrul
Jurnal Pengabdian kepada Masyarakat (Indonesian Journal of Community Engagement) Vol 11, No 1 (2025): March
Publisher : Direktorat Pengabdian kepada Masyarakat Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jpkm.99065

Abstract

Breast and cervical cancer constitute the two most prevalent cancer types globally, with a disproportionately high mortality rate among women. While cervical cancer ranks eighth in terms of incidence, it remains a significant public health concern. A common challenge is the community’s delay in seeking healthcare attributed to a dearth of information, consequently leading to delayed treatment. The Pinrang Regency Health Department and the Family Empowerment and Welfare Team (TP-PKK) of South Sulawesi identified a high incidence of breast and cervical cancer among women in the Pinrang region. A primary obstacle to addressing this issue is the absence of public awareness regarding breast and cervical cancer, including early warning signs, symptoms, and associated risks. This problem is compounded by the district’s lack of an anatomical pathology specialist, hindering public education efforts and diagnostic capabilities. The objective of this activity was to enhance awareness of early detection for these two gynecological cancers in order to reduce mortality and morbidity rates associated with cancer. The method comprised an educational session on breast and cervical cancer, practicing SADARI, attended by 145 participants, followed by Pap smear tests for 45 volunteers. Program effectiveness was evaluated through pretest and posttest. A Wilcoxon signed-rank test was conducted to compare pretest and posttest scores. The results revealed a highly significant increase in scores p = 0.000 (p<0.005), suggesting that the educational program was successful in improving participants’ knowledge. A significant proportion of participants (57.8%) reported undergoing a Pap smear for the first time, highlighting the need for enhanced awareness and knowledge-sharing efforts regarding early detection of cervical cancer. The Pinrang Regency Health Department and TP-PKK provided essential support and participation. The Institute for Research and Community Service (LPPM) funds this community service project. The project was executed under contract number 0031/UN.4.22/PM.01.01.2024.
SERVIKSKU SEHAT: UPAYA PENCEGAHAN DAN DETEKSI DINI PENYAKIT KANKER MULUT RAHIM Masadah, Rina; Hasanah, Huswatun; Manule, Yolanda; Rauf, Syahrul
Jurnal Dinamika Pengabdian Vol. 4 (2018): JURNAL DINAMIKA PENGABDIAN VOL. 4 NO. (EDISI KHUSUS) NOVEMBER 2018
Publisher : Departemen Budidaya Pertanian Fakultas Pertanian UNHAS

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20956/jdp.v4iK.5435

Abstract

Kanker mulut rahim (kanker serviks) merupakan jenis kanker pada wanita yang mempunyai angka kejadian kedua tertinggi di dunia setelah kanker payudara, dimana terdapat sekitar 529.828 kasus baru setiap tahunnya. Di antara tumor ganas ginekologi, kanker serviks menduduki peringkat pertama terbanyak di Indonesia. Umur penderita yang tersering adalah 45-50 tahun, dengan harapan hidup 5 tahun hanya 40-50%. Tingginya angka kejadian kanker serviks karena belum maksimalnya upaya pencegahan dan deteksi dini pada pasien, akibat masih kurangnya pengetahuan mengenai penyakit ini, serta rasa malu untuk memeriksakan diri karena membuka pakaian dalam dan memeriksakan alat kelamin. Pada umumnya pasien datang sudah dalam stadium lanjut sehingga angka kematian penyakit ini masih sangat tinggi. Penyuluhan mengenai penyakit kanker serviks dan pemeriksaan sel serviks secara rutin sangat penting dilakukan untuk menurunkan angka kesakitan dan kematian wanita akibat penyakit ini di Indonesia.  Dilakukan penyuluhan terhadap 95 ibu-ibu masyarakat kelurahan Antang yang berlokasi di Rumah Tahfidz Antang, dan pemeriksaan sel mulut rahim (Pap smear) pada 95 ibu tersebut. Penyuluhan dilakukan dengan menampilkan gambar interaktif, dilanjutkan dengan tanya jawab. Sebelum dan setelah penyuluhan dilakukan pre-test dan post-test; dan sebelum dilakukan Pap smear, ibu diwawancara dan dicatat mengenai keluhannya. Hasil post-test menunjukkan 80% ibu meningkat pemahamannya mengenai kanker mulut rahim. Hanya 3 ibu yang hasil Pap smearnya normal. Terdapat 91 ibu menderita infeksi berbagai macam mikroorganisme, dan 1 ibu menderita penyakit pre-kanker serviks. Hasil pemeriksaan Pap smear diberikan kembali ke ibu melalui ketua Yayasan, dan ibu yang menderita kelainan dirujuk ke Puskesmas.Kata kunci: Kanker serviks, pap smear, penyuluhan.
A Retrospective Comparative Study of Clinicopathological Features in High-Grade and Low-Grade Serous Ovarian Carcinoma Ham, Jonathan; Nasser, Andi S.H.D.; Masadah, Rina; Rauf, Syahrul; Nelwan, Berti J.; Miskad, Upik A; Cangara, Muhammad H; Tawali, Suryani
Healthy Tadulako Journal (Jurnal Kesehatan Tadulako) Vol. 11 No. 1 (2025)
Publisher : Faculty of Medicine, Universitas Tadulako

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22487/htj.v11i1.1558

Abstract

Backgroud: Ovarian carcinoma is the third most common malignancy in Indonesian women after breast and cervical cancer. Serous ovarian carcinoma is the most frequent subtype, divided into low-grade and high-grade types, each with distinct genetic and biological characteristics. Objective:This study aims to compare the clinicopathological features of high-grade and low-grade serous ovarian carcinoma. Methods: A retrospective cross-sectional study was conducted using 77 paraffin-embedded samples of serous ovarian carcinoma. Clinical and pathological data including age, body mass index (BMI), age at menarche, and parity were collected and analyzed using the chi-square test. Results: Patients aged >50 years accounted for most cases, with 64.3% presenting high-grade serous carcinoma (HGSC). Overweight/obesity was observed in 40.3% of cases. Early menarche (<13 years) was reported in 78%, and 42.7% were multiparous. No significant differences were found in clinical variables between HGSC and low-grade serous carcinoma (LGSC). Histopathologically, HGSC showed more pronounced cytologic atypia, necrosis, and metastasis. Conclusion: High-grade serous carcinoma demonstrates greater aggressiveness compared to its low-grade counterpart. Histopathological assessment plays a critical role in diagnosis, treatment decisions, and prognosis evaluation.
Intrauterine Transmission of Hepatitis B Cannot Be Ruled Out by A Single Negative Hepatitis B e Antigen (HBeAg) Result among Hepatitis B Surface Antigen (HBsAg) - Positive Pregnant Women Chalid, Maisuri Tadjuddin; Judistiani, Tina Dewi; Syahril, Rizalinda; Masadah, Rina; Febriani, Dwi Bahagia; Wahyuni, Ridha; Turyadi, Turyadi; Massi, Muh Nasrum
The Indonesian Biomedical Journal Vol 16, No 1 (2024)
Publisher : The Prodia Education and Research Institute (PERI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18585/inabj.v16i1.2726

Abstract

BACKGROUND: The risk factors for intrauterine transmission of hepatitis B virus (HBV) in hepatitis B surface antigen (HBsAg)-positive pregnant women are poorly understood. Numerous factors are considered to be involved, including placental barrier, obstetric environment, high viral load, and positivity of hepatitis B e antigen (HBeAg). This study was conducted to investigate the role of placenta barrier, clinical, and viral factors in intrauterine transmission of HBV.METHODS: A cross-sectional study was conducted involving 1,353 pregnant women who underwent HBsAg screening. Eighty-four (6.2%) women were detected as HBsAg positive and were examined for HBsAg level, anti-HBs, anti-HBc, HBeAg/hepatitis B e antibody (anti-HBe) status, and HBV DNA presence in cord blood. Quantitative HBV DNA was analyzed using real-time polymerase chain reaction (PCR).RESULTS: Eighty-four of 1,353 subjects were HBsAg-positive. HBV DNA was positive in 28/84 (33.7%) maternal sera, 19/79 (24.05%) placental specimens, and 9/83 (10.84%) in cord blood. There were significant associations between HBV DNA in maternal serum (p=0.000) and placental tissue (p=0.000) with HBV DNA in the cord blood. No clinical factors were associated with HBV DNA transmission in cord blood. Sixty percent of viral load >5.3 log10 copies/mL were found in the cord blood, of which 43.8% HBeAg positive and 3.1% HBeAg negative.CONCLUSION: Reduced transmission via compartments established the placenta’s barrier function in mother-to-child transmission. A high maternal viral load and positive HBeAg were risk factors for intrauterine transmission, while negative HBeAg still has the possibility of transmission.KEYWORDS: mother-to-child transmission, hepatitis B virus, intrauterine
Co-Authors Abdul Muis Abdul Qadar Punagi Achmad, Djumadi Agusalim Bukhari Al atsari, Muhammad Azka Andi Alfian Zainuddin Andi Alfian Zainuddin Andi Asadul Islam Andi Weri Sompa Andira, Fiki Wahyu Budu - Budu Budu Bukhari, Agussalim Cahyono Kaelan, Cahyono Cangara, Husni Cangara, Muhammad H Chalid, Maisuri Tadjuddin Djumadi Achmad Achmad Efendi Lukas Eka Sunarwidhi Prasedya Febriani, Dwi Bahagia Gaffar, Masyita Gosal, Steffy Rebecca Ham, Jonathan Hamsu Kadriyan Hanifah, Rif’at Huswatun Hasanah Ibrahim Labeda Ilhamjaya Patellongi Ismail J Nelwan, Berti Kalatiku, Jane Magdalena Lenny Lisal Luthfi, Muhammad Madaeng, Andi Sitti Nur Fatimah Maharani, Risma Maharani, Risma Mahmud Ghaznawie Maisuri T Chalid Maisuri T. Chalid Makarim, Ahmad Rifaat Dzaki Manule, Yolanda Marcellus Simadibrata Mardiati Maricar, Nadra Maulana, Aries Mochammad Hatta Muh. Nasrum Massi Muhammad Amsyar Akil Muhiddin, Syurawasti Naeny Fajriah Nasser, Andi S.H.D. Nasser, Andi Sitti Halija Diawanti Nelwan, Berti J. Nelwan, Berti Julian Nour Hafifah, Andi Izza Nova Audrey Luetta Pieter Prihantono Prihantono Raden Tina Dewi Judistiani Raharja, Siska Putri Wulandari Ridha Wahyuni, Ridha Rinda Nariswati Risma Maharani Risma Maharani Romdhoni, Achmad Chusnu Rosdiana Natzir Sianipar, Kelvin Leonardo St. Nur Asni Sumardin, Khairul Miftah Syahrial, Andi Muhammad Abdu Fadil Syahril, Rizalinda Syahrul Rauf Syahrul Rauf Syahrul Rauf Tawali, Suryani Tjahjadi Robert Tedjasaputra Truly D Dasril Turyadi Turyadi, Turyadi Umar, Husaini Upik A Miskad UPIK ANDERIANI MISKAD, UPIK ANDERIANI Winny N Leiwakabessy Wulaa, Nurwapina Langga