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All Journal Majalah Obstetri dan Ginekologi Jurnal Mikologi Indonesia Community Service Journal of Indonesia Journal of Health Community Service
Ratna Sofaria Munir
Departemen Farmakologi Dan Terapi, Fakultas Kedokteran Universitas Airlangga, Surabaya 60131
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Education Environmental Science Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health

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Pengaruh Monoklonal Antibodi Bovine Zona Pelusida 3 (bZP3) terhadap Diameter dan Atresia Folikel Ovarium Mencit (Mus musculus) Annisa Trissatharra; Sri Ratna Dwiningsih; Ratna Sofaria Munir
Majalah Obstetri dan Ginekologi Vol. 24 No. 1 (2016): Januari - April
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (223.533 KB) | DOI: 10.20473/mog.V24I12016.37-42

Abstract

Objectives: To identify the effect of monoclonal antibody bZP3 at ovarian follicles that undergo atresia and diameter of various ovarian follicles.Materials and Methods: This is a true experimental research with post only control group design. Samples were 36 female mices (Mus musculus) which is divided into 6 groups, there are 3 control groups (group 1, 2, and 3) injected by Phospatase Buffer Saline (PBS) 50µl and 3 treatment groups (group 4, 5, and 6) injected by Mab bZP3 50µl. Group 1 and 4 terminated at 5th day, group 2 and 5 terminated at 10th day, and group 3 and 6 terminated at 20th day. Evaluation of atretic ovarian follicles and diameter of ovarian follicles performed by hematoxylin eosin (HE) and the data processed by parametric statistic.Results: There are no significant in different among groups in the aspect of atretic follicles and diameter of folicles (p>0.05), but descriptively, number of follicles undergo atresia of the follicle primary, secondary, and tertiary treatment group was higher than the control group, except on the 20th day of observation time.Conclusion: administration of Mab bZP3 had no effect to amount of atretic follicles and diameter of folicles during observation time.
Perbandingan Efektivitas Antifungi Ekstrak Etanol Bawang Putih (Allium sativum) dan Nistatin dengan Metode Difusi Cakram terhadap Candida albicans Sarwendah Paramesti; Ratna Sofaria Munir; Pepy Dwi Endraswari
Jurnal Mikologi Indonesia Vol 3, No 1 (2019): Juni 2019
Publisher : Perhimpunan Mikologi Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (6736.339 KB) | DOI: 10.46638/jmi.v3i1.49

Abstract

Bawang putih (Allium sativum) merupakan obat yang sudah dimanfaatkan sejak zaman dahulu oleh Hippocrates, Pliny, dan Aristotle untuk kegunaan terapi. Bawang putih mempunyai efek sebagai antivirus, antibakteri, antifungi, dan antioksidan. Selain itu, bawang putih dapat digunakan sebagai anti-atherosklerosis dan anti-kanker (Bongiorno, 2008). Di sisi lain, nistatin merupakan antibiotik yang sangat efisien dalam pengobatan mikosis. Dalam sehari-hari, nistatin digunakan sebagai obat untuk mengatasi infeksi yang disebabkan oleh jamur genus Candida. Penyebab utama penyakit tersebut adalah sistem imun tubuh yang melemah akibat penyakit sistemik. Penyebab lainnya yaitu akibat adanya infeksi nosokomial yang ditularkan melalui tenaga medis mau pun alat-alat kesehatan yang telah terkontaminasi. Sejauh ini penelitian yang dilakukan sebelumnya untuk menentukan aktivitas antifungi yang dihasilkan oleh bawang putih saja, tanpa mengetahui perbandingan efektivitasnya dengan obat-obatan lain, sehinga perlu diadakan penelitian lebih lanjut mengenai hal tersebut. Tujuan penelitian ini adalah membandingkan efektivitas ekstrak etanol bawang putih (Allium sativum) dan nistatin sebagai antifungi yang dapat menghambat pertumbuhan jamur Candida albicans. Metode yang digunakan dalam penelitian adalah uji difusi menggunakan kertas cakram dengan 6 perlakuan. Konsentrasi ekstrak yang dipilih adalah 4g/ml (100%), 3g/ml (75%), 2g/ml (50%), dan 1g/ml (25%). Replikasi yang dilakukan dalam penelitian ini sebanyak 5 kali. Hasil data diperoleh dari pengukuran besar diameter zona hambat yang terbentuk di sekitar media perbenihan jamur Candida albicans yang sudah diinkubasikan pada suhu 37ºC selama 24 jam, dalam satuan milimeter. Kemudian, hasil tersebut akan dibandingkan dengan besar diameter zona hambat yang dihasilkan oleh obat nistatin untuk dinilai efektivitas keduanya. Hasil dari penelitian ini didapatkan bahwa besar diameter zona hambat yang dihasilkan oleh nistatin jauh lebih besar dibandingkan ekstrak etanol bawang putih (Allium sativum). Perlu dilakukan evaluasi baik dari segi tanaman, jamur, obat, cara ekstraksi mau pun metode penelitian agar dapat memberikan hasil yang lebih akurat.
A Socialization of the Benefits of Brotowali for Health at the Bringkan Lestari Nursing Home in Gresik RATNA SOFARIA MUNIR; Handayani, Handayani; Puspitasari, Renny Novi; Nihazzatuzai, Nihazzatuzai; Tauziah, Amalia; Ekayanti, Retno Diah Putri
Journal of Health Community Service Vol. 5 No. 2 (2025): Journal of Health Community Service: 2025 May Editor's Choice
Publisher : UNUSA Press

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Lestari Nursing Home is an active nursing home located in Bringkan village, Menganti sub-district, Gresik district. There are 40 elderly people who are permanent residents. Nursing homes often receive assistance in the form of food or basic necessities. Based on survey results, many elderly people do not know the benefits of the brotowali herbal plant. In fact, brotowali infusion and decoction have been used to treat high blood sugar. Due to the lack of knowledge among the elderly about the benefits of the brotowali herbal plant, the drafting team will hold outreach activities at the Lestari Nursing Home. The aim of this community service activity is to increase the knowledge of the elderly about the benefits of brotowali for health, and increase the awareness of the elderly to use brotowali herbal drinks for natural (herbal) health.  The method used is counseling. The topic given was about the benefits of brotowali for health with a target of 20 elderly people. The results of the counseling showed an increase in knowledge of 84%. The elderly seemed enthusiastic in this outreach activity as seen from their activeness when the question and answer discussion session was opened by the resource person.
INTRODUCTION TO DIABETES MELLITUS RISK FACTORS AS AN EARLY PREVENTION EFFORT AND UNDERSTANDING OF DIABETES AT ARROHYATI ORPHANAGE SURABAYA Choirotussanijjah; Renny Novi Puspitasari; Ratna Sofaria Munir; Muh. Nabil; Nesha Cantika Amalia; Malva Rania Jasmine
Community Service Journal of Indonesia Vol. 8 No. 1 (2026): Community Service Journal of Indonesia
Publisher : Institute for Research and Community Service, Health Polytechnic of Kerta Cendekia, Sidoarjo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36720/csji.v8i1.853

Abstract

Diabetes mellitus is a chronic metabolic disease whose prevalence continues to rise globally, including in Indonesia, and is often triggered by unhealthy lifestyle habits starting from a young age. Early prevention efforts through education about risk factors are crucial to reducing future incidence. This community service activity aimed to improve the knowledge of children and adolescents at Arrohyati Orphanage regarding diabetes mellitus risk factors. The method used was health education delivered through interactive lectures, discussions, and Q&A sessions. Knowledge evaluation was conducted through pre-test and post-test assessments. There were 16 participants with diverse characteristics, consisting of 9 females and 7 males, aged 6–18 years, with educational levels ranging from kindergarten to senior high school. The results showed an improvement in participants' understanding after the educational intervention. In the pre- test, 7 participants were categorized as having good knowledge, 4 were in the fair category, and 5 were in the poor category. After the educational session, the number of participants with good knowledge increased to 9, while fair and poor categories decreased to 3 and 4, respectively. These findings indicate a positive shift towards better understanding. The discussion confirms that health education significantly contributes to improving knowledge among children and adolescents, although repetition and environmental support are required to sustain the outcomes. In conclusion, education on diabetes mellitus risk factors effectively enhanced participants' understanding, and follow-up actions such as monitoring and caregiver involvement are needed to reinforce healthy lifestyle practices.
Co-Authors Annisa Trissatharra Choirotussanijjah Ekayanti, Retno Diah Putri Handayani Handayani Malva Rania Jasmine Muh. Nabil Nesha Cantika Amalia Nihazzatuzai, Nihazzatuzai Pepy Dwi Endraswari, Pepy Dwi Puspitasari, Renny Novi Renny Novi Puspitasari Sarwendah Paramesti Sri Ratna Dwiningsih Tauziah, Amalia