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All Journal MEDIA MEDIKA INDONESIANA JURNAL GIZI INDONESIA Journal of Nutrition College Journal of Educational, Health and Community Psychology Journal of Biomedicine and Translational Research Sari Pediatri Universa Medicina Paediatrica Indonesiana Health Notions Jurnal Gizi Klinik Indonesia Jurnal Epidemiologi Kesehatan Komunitas Medica Hospitalia Jurnal Locus Penelitian dan Pengabdian Media Penelitian dan Pengembangan Kesehatan

Maria Mexitalia

Department Of Pediatrics, Faculty Of Medicine, Universitas Diponegoro

Author-ID : 319949

Aerospace Engineering Automotive Engineering Biochemistry, Genetics & Molecular Biology Decision Sciences, Operations Research & Management Dentistry Education Electrical & Electronics Engineering Environmental Science Health Professions Immunology & microbiology Mathematics Medicine & Pharmacology Nursing Public Health

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Insulin-like growth factor-1 and growth in infants 0-6 months of age Bob Kevin Pardede; Agustini Utari; Maria Mexitalia
Paediatrica Indonesiana Vol 61 No 2 (2021): March 2021
Publisher : Indonesian Pediatric Society

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14238/pi61.2.2021.89-93

Background During infancy, growth is affected by many factors, including hormones. Insulin-like growth factor-1 (IGF-1) is a hormone with an important role in regulating somatic growth and organ development. Objective To analyze for possible correlations between IGF-1 levels and infant growth from 0-6 months of age. Methods A prospective study was conducted on 38 infants from birth to 6 months of age. Inclusion criteria were full-term newborns with normal birth weight and singleton birth. Serum IGF-1 was measured twice, from umbilical cord blood at birth and at 6 months of age. Anthropometric measurements were made every three months. Paired T-test was used to analyze mean IGF-1 among time points, and Pearsonâ€™s correlation test was used to analyze IGF-1 levels and growth. Results Mean IGF-1 level decreased from birth to 6 months of age (89.6 ng/mL vs. 48.3 ng/mL, respectively; P<0.001). Delta IGF-1 had positive significant correlations with delta weight at 3 months (r=0.347; P=0.033) and 6 months (r=0.386; P=0.017), as well as delta head circumference at 3 months (r= 0.356; P=0.028) and 6 months (r=0.357; P=0.028). However, there were significant negative correlations between umbilical cord IGF-1 with delta body weight (r= âˆ’0.459; P=0.004) and delta length at 6 months (r= âˆ’0.414; P=0.010). Conclusions. There iss a decrease in IGF-1 levels at the first 6 months of life. Umbilical cord IGF-1 level has negative correlations with the weight and length increment at the age of 6 months.

Beberapa Faktor Risiko Gizi Kurang dan Gizi Buruk pada Balita 12-59 Bulan (Studi Kasus di Kota Pontianak) Dedi Alamsyah; Maria Mexitalia; Ani Margawati; Suharyo Hadisaputro; Henry Setyawan
Jurnal Epidemiologi Kesehatan Komunitas Vol 2, No 1: Februari 2017
Publisher : Master of Epidemiology, School of Postgraduate Studies, Diponegoro University, Indonesia

Background: Moderate and severe malnutrition cases in Pontianak City increases each year although a nutritional improvement program has been held by the Health Department of Pontianak City.Method: The type of research was observational using the quantitative study design of case control study and the qualitative study through in-depth interview (mixed method). The number of samples was 80 people consisting of 40 people from case and 40 people from control. Assessment of nutritional using anthropometry measurement based on weight for height. Height measurement using microtoise and measure weighting scale.Results: The multivariate analysis found 2 variables signiﬁcantly associated with the prevalence of moderate and severe malnutrition in children under ﬁve years old aged 12-59 months, i.e.: poor of attitude toward food (OR = 6.980) and poor environmental health (OR =5.033). There were 9 variables which were not associated with nutritional status, not given exclusive breastfeeding, energy intake is less, protein intake is less, frequency of Severe Acute Respiratory Infection equal to over three times in the last two months, frequency of diarrhea equal to over three times in the last two months, low monthly family income, number of children more than two, low mother's education, and frequency of watching TV more than two hours a day.Conclusion: Based on the results above, it can be concluded that the risk factors associated with the prevalence of moderate and severe malnutrition are poor of mother's attitude toward food is poor health and poor environmental.

Perbedaan status gizi, kesegaran jasmani, dan kualitas hidup anak sekolah di pedesaan dan perkotaan Maria Mexitalia; Hendriani Sellina; Mohammad Syarofil Anam; Aya Yoshimura; Taro Yamauchi; Nurkukuh Nurkukuh; Bambang Hariyana
Jurnal Gizi Klinik Indonesia Vol 8, No 4 (2012): April
Publisher : Minat S2 Gizi dan Kesehatan, Prodi S2 IKM, FK-KMK UGM

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/ijcn.18216

Background: The differences in geographic, sosioeconomic and lifestyle between children in rural and urban areas infl uence their nutritional status. The urban children tended to be less active. The evidence suggested that physical activity improves cardiorespiratory fi tness and mental health in young people but study that compare those indicators among rural and urban children was scarce.Objective: To compare the nutritional status, physical fi tness, and quality of life between elementary school children in rural and urban areas.Method: A cross-sectional study was conducted at Semarang (urban) and Mlonggo (rural) Central Java in 2009. Inclusion criteria was school children aged 9-11 years and had no physical disability. Body composition was measured by Bioelectrical Impedance Analysis, physical activity by Global Physical Activity Questionnaire (GPAQ), physical fi tness by 20-m shuttle run test and quality of life by Pediatrics Quality of Life Questionnaire (PedQoL 4.0). The differences between nutritional status and physical activity were assessed by Chi Square test, while the differences between physical fi tness and quality of life were tested by independent t test (p<0.05).Result: One hundred sixty-two subjects were enrolled in the study (Semarang 82 students; 36 boys, 46 girls and Mlonggo 80 students; 40 boys, 40 girls). Body mass index (18.97 vs 15.16 kg/m2) and body fat (26.03% vs 18.03%) of urban children were higher than that of the rural’s (p<0.001). Children in rural area were signifi cantly more active, have higher physical fi tness level (VO2 max 28.54±1.79 ml/kg/min vs 21.57+1.79 ml/kg/min) (p<0.01), and have higher score in quality of life (2243 + 295,8) compared to the children from urban area (2133 + 369.4) (p<0.05). Conclusion: Rural school children have lower nutritional status than urban children, but they are more active and have higher physical fi tness level. They also have better quality of life.

Effects of Sorghum Cookies (Sorghum Bicolor L. Moench) on Fasting Glucose, Triglyceride, High-Density Lipoprotein level, and Body Fat Percentage in Adolescent Obesity Latifah Rachmawati; Maria Mexitalia; Muflihatul Muniroh; Diana Nur Afifah; Adriyan Pramono
Jurnal Gizi Indonesia (The Indonesian Journal of Nutrition) Vol 10, No 2 (2022): Juni
Publisher : Department of Nutrition Science, Faculty of Medicine, Universitas Diponegoro

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/jgi.10.2.181-188

Background: Adolescent obesity is related to the risk of metabolic syndrome. Several studies have proven the effect of dietary interventions on metabolic parameters in obese individuals. A source of complex carbohydrates that is still rarely developed in the obese diet is sorghum which contains resistant starch.Objective: The study was to reveal the effect of sorghum cookies on Fasting Glucose (FG), Triglycerides (TG), High-Density Lipoprotein (HDL), and Body Fat Percentage (BFP) in obese adolescents.Materials and Methods: This quasi-experiment with the pre-post control-group design was conducted on 20 boys and 20 girls (divided into 10-boy control group, 10-girl control group, 10-girl intervention group, and 10-girls intervention group) with the age range of 13–15 years who attended Junior High School 14 Semarang chosen by consecutive sampling. Weight, Height, and BFP were measured directly by BIA. Metabolic parameters (FG, TG, and HDL levels) were taken through venous and 10-hour fasting. Energy intake and physical activity were taken by interview using the food recall questionnaire for 6 days randomly and IPAQ. The intervention of sorghum cookies was given in 90 grams/day with 473 kcal/day for 28 days. The analysis of the effect of the intervention was conducted by a paired t-test and independent t-test.Results: At 28-days sorghum cookies intervention resulted in lower levels of FG, TG, and BFP in the intervention boy group (p < 0.05) and BFP in the girl group (p < 0.05). The intervention of sorghum cookies showed no effect on HDL levels in boys, and it did not affect FG, TG, or HDL levels of the girl subjects (p > 0.05). Conclusion: Obese adolescents who had been receiving intervention of 90 grams of sorghum cookies for 28 days appeared to have lower levels of fasting glucose, triglycerides, and body fat percentage.

Differences in Development and Diet of Stunting and Non-Stunting Children in the Rowosari Health Center Work Area, Semarang, Indonesia Avionita Latuihamallo; Ani Margawati; Maria Mexitalia; Annastasia Ediati; Ahmad Syauqy
Jurnal Gizi Indonesia (The Indonesian Journal of Nutrition) Vol 10, No 2 (2022): Juni
Publisher : Department of Nutrition Science, Faculty of Medicine, Universitas Diponegoro

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/jgi.10.2.161-167

Background: Stunting in children aged 36-59 months is caused by the intake of energy and protein below the average RDA recommendation. This low consumption has an impact on different growth and development disorders.Objectives: This study aimed to determine the differences in the development and diet of stunted and non-stunted children aged 36-59 months.Materials and Methods: This was an observational study with a cross-sectional approach, which was carried out at the work area of the Rowosari Health Center. The sample population consisted of 67 children aged 36-59 months, which were selected using the simple random sampling technique. The characteristics of the subjects and mothers were then collected using a questionnaire. Meanwhile, data on the diet and child development were obtained with the 24-hour recall method and Developmental Pre-Screening Questionnaire (KPSP), respectively.Results: The results showed that there were differences in the development as well as energy and protein adequacy level of stunted and non-stunted children with a p-value <0.05.Conclusion: There were several deviant developments in non-stunted toddlers due to the lack of nutritional intake, stimulation, interaction with the environment as well as the low knowledge of mothers about child care patterns.

Fear of Covid-19 And Work Engagement as Predictors of Psychological Distress in Medical Residents Kristiana Haryanti; Maria Mexitalia; Widawati Hapsari; Maria Bramanwidyantari; Wistiani Wistiani; Julian Dewantiningrum; Yudo Murti Mupangati; Muyassaroh Muyassaroh; Anna Mailasari Kusuma Dewi
Journal of Educational, Health and Community Psychology Vol 11 No 2 June 2022
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.12928/jehcp.v11i2.22587

This study aimed to see whether the Fear of Covid-19 and work engagement affect depression, anxiety, and stress of resident doctors. Pandemic situation of Covid-19 is not over yet with viral mutations from Covid-19 Delta to Omicron variants. Residents doctors were obliged to help in treatment even though their main duty was focusing on their study. As the Covid-19 is a deadly situation and should be handled with many safety protocols, this situation can be anxious for both the patient and the medical staff (including the residents) who work daily in hospital. This study focused on 877 public hospital residents Fear of Covid-19, depression, anxiety and stress. Regression analysis and Structural Equation Modeling (SEM) were used as statistical tools. The results showed that both Fear of Covid-19 and work engagement affect depression, anxiety, and stress. This article also details the impact of each aspect measured in this study.

THE EFFECT OF TABURIA FORTIFICATION AND NUTRITION EDUCATION OF MOTHERS TO ON NUTRITIONAL STATUS OF 12-24 MONTHS OLD CHILDREN IN INDONESIA : RANDOMIZED CONTROLLED TRIAL STUDY Yulia Wahyuni; Maria Mexitalia; M. Zen Rahfiludin
Journal of Nutrition College Vol 12, No 3 (2023): Juli
Publisher : Department of Nutrition Science, Faculty of Medicine, Universitas Diponegoro

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/jnc.v12i3.34518

ABSTRACTBackground: Mother's nutritional knowledge and parents' feeding practices will influence children's eating behavior which have an impact on the child's growth.Objective: The purpose of this study was to determine the effects of Taburia fortification and nutrition education of mothers on the nutritional status of children in Waipare Public health center in East Nusa Tenggara.Materials and Methods: This study was a randomized controlled trial. A total of 180 mothers and their children aged 12-24 months who had malnourished (z-score -3 to -2). The group divided into teams were the intervention group (IG) (n=90) and the control group (CG) (n=90). The IG give intervention for three months. The mothers were given nutrition education, while their children were given taburia. The CG, mothers were given nutrition education. Data feeding rules obtained using a self-administered feeding practice-Questionnaire (FPQ). Dietary intake assessment of macronutrient and micronutrient three-day food records, nutritional status, and percentage of child's sick day was conducted before and after the intervention.Results: The result of the study showed that there was no significant difference in the mean increase (P> 0.01) between knowledge scores in IG and CG, post-intervention. Lower percentage of sickness among children in IG than CG. The average nutrient intake, WAZ (0.97±0.52), WLZ (1.02±0.42) of IG increased and was higher than CG after the intervention. The LAZ of IG increased (0.34±0.66 SD) while on the CG declined (0.27±0,31 SD).Conclusion: Thus, The Taburia fortification intervention was useful in improving WAZ, LAZ, WLZ in children who experienced malnutrition, but the intervention nutrition education of mothers can increase WAZ and WLZ.

Ketogenic Diet for Treatment 2-Year 9 Month Old Boy With Intractable Epilepsy Wijaya, I Made Ananta; Putranti, Alifiani Hikmah; Mexitalia, Maria
Medica Hospitalia : Journal of Clinical Medicine Vol. 6 No. 2 (2019): Med Hosp
Publisher : RSUP Dr. Kariadi

Background:The ketogenic diet (KD) is a high-fat, low-carbohydrate, and normal-protein diet that has been used for the treatment of medically refractory childhood epilepsy since the 1920s.The KD includes 80% fat, 15% protein, and 5% carbohydrate; the ratio of fat to carbohydrate plus protein ranges from 2:1 to 4:1.The purpose of the case report was to learn benefits and factors that influence the administration of the ketogenic diet in intractable epilepsy. Case:A 2-years 9 months old boy since 3 month of age the child begins seizure. Five month the child was diagnosed with epilepsy received one type of anti epileptic drug (AED). Seven months of age the child began control in outpatient clinic Neurology Department of Dr. Kariadi Hospital with a diagnosis of general epilepsy, were given 2 type of AEDs. Since10 month of age the child was given 3 type of AEDs. The child still often seizure, at 15 months was diagnosed intractable epilepsyand at 29monthof age, was programed to have long term EEG and KD during hospitalization. Conclusion:The administration of KD in 2-years9 months old boy with intractable epilepsyshowed benefits in reducing the frequency of seizures. Key word : Ketogenic Diet, Intractable Epilepsy, Child

Vitamin D dan paparan sinar matahari untuk mencegah COVID-19. Fakta atau mitos ? Mexitalia, Maria; Susilawati, Martvera; Pratiwi, Rina; Susanto, JC
Medica Hospitalia : Journal of Clinical Medicine Vol. 7 No. 1A (2020): Med Hosp
Publisher : RSUP Dr. Kariadi

Latar Belakang : Paparan sinar matahari pada kulit merupakan cara terbaik untuk sintesis vitamin D. Kadar vitamin D yang adekuat dalam tubuh merupakan proteksi terhadap berbagai penyakit seperti penyakit degeneratif, kanker dan juga infeksi saluran napas. Beberapa penelitian menghubungkan kadar vitamin D yang rendah dengan morbiditas dan mortalitas COVID-19. Hal ini menyebabkan fenomena baru pada masyarakat yaitu kebiasaan berjemur. Tujuan : Artikel ini akan membahas tentang metabolisme vitamin D, peran sinar matahari dalam mengaktifkan vitamin D di dalam tubuh, dan peran vitamin D dalam berbagai penyakit, khususnya mekanisme imunitas untuk COVID-19. Diskusi : Vitamin D meningkatkan kekebalan alami seluler terutama dengan cara menginduksi peptida antimikroba, yang meliputi cathelicidin, LL-37, 1,25-dihdroxyvitamin D dan defensins. Selain itu vitamin D akan meningkatkan sekresi hidrogen peroksida pada sel monosit. Pemberian vitamin D dosis tinggi sebanyak 10.000 IU/hari selama beberapa minggu dilanjutkan 5000 IU/hari bermanfaat untuk mencegah COVID-19, walaupun hasilnya masih memerlukan penelitian lebih lanjut. Absorpsi sinar matahari ke dalam tubuh manusia dipengaruhi oleh warna kulit, penggunaan bahan pakaian dan tabir surya , dan luas pajanan. Paparan sinar matahari sebesar satu Minimal Erythemal Dose (MED) pada orang dewasa dapat meningkatkan konsentrasi vitamin D setara dengan suplementasi 10.000 – 25.000 IU. Penelitian pada bayi yang diberi paparan 3 kali seminggu @ 5 menit pada jam 10.00-14.00, dengan paparan 50% area tubuh selama 2 bulan, mendapatkan kenaikan 25(OH)D sebesar 8,9 ng/mL. Simpulan : Vitamin D yang diaktifkan oleh paparan sinar matahari sangat bermanfaat sebagai proteksi berbagai penyakit termasuk juga pada COVID-19, walaupun efektifitasnya masih memerlukan penelitian lebih lanjut. Kata Kunci : COVID-19, vitamin D, paparan sinar matahari Background : The exposured of sunlight on the skin is the best way for vitamin D synthesis. Adequate vitamin D levels are protection against various diseases such as degenerative diseases, cancer and also respiratory infections. Several studies have linked between low vitamin D levels with COVID-19 morbidity and mortality. This causes a new phenomenon in the community, namely sunbathing. Purpose : This review rearticle will discuss about vitamin D metabolism, the role of sunlight in activating vitamin D in the body, and the role of vitamin D in various diseases, specifically the immune mechanism for COVID-19.Discussion : Vitamin D increases cellular innate immunity mainly by inducing antimicrobial peptides, which include cathelicidin, LL-37, 1,25-dihdroxyvitamin D and defensins, and also increase the secretion of hydrogen peroxide in monocyte cells. The administration of high-dose vitamin D of 10,000 IU / day for several weeks followed by 5000 IU / day is useful to prevent COVID-19, although the results still require further research. The sun exposure to activated vitamin D body is affected by skin color, using of clothing and sunscreen, and area of ??exposure. Sun exposure of one Minimum Erythemal Dose (MED) in adults can increase vitamin D concentrations equivalent to 10,000 - 25,000 IU vitamin D supplementation. Study on infants who were given exposure 3 times a week @ 5 minutes at 10:00 to 14:00, with exposure 50% of body surface area for 2 months, increased 25(OH)D of 8.9 ng/mL. Conclusion : Vitamin D which is activated by sun exposure is very useful as protection for various diseases including COVID-19, although its effectiveness still requires further research. Keywords : vitamin D, sun exposure, COVID-19.

The association between adiponectin level and non alcoholic fatty liver disease (NAFLD) in obese adolescents Mexitalia, Maria; Romadhona, Suci
Medica Hospitalia : Journal of Clinical Medicine Vol. 7 No. 2 (2020): Med Hosp
Publisher : RSUP Dr. Kariadi

Background: Non alcoholic fatty liver disease (NAFLD) has been associated with cytokines and inflammatory mediators. Adiponectin has insulin sensitizing effects and has correlation with severity of NAFLD disease. However, the study about the relationship between adiponectin level and NAFLD is lacking. The objective of the study was to determine the association between adiponectin level and NAFLD in obese adolescents through the role of insulin resistance. Methods: This was a cross-sectional study, that was done in August 2007. The inclusion criteria were obese adolescents aged 11-14 years, and normal weight adolescent as control group. Adiponectin was assessed by using ELISA, insulin resistance was obtained by Homeostasis Model Assessment Insulin Resistance (HOMA-IR). NAFLD was confirmed by abdominal ultrasound, which represented by fatty liver imaging. The comparison of adiponectin level and HOMA-IR among 3 groups were analyzed by Kruskal Wallis test, meanwhile the correlation between adiponectin level and some variables were analyzed by spearman correlation. Result: There were 73 subjects, consisted of 37 obese and 36 non obese. Among obese subjects, 54.1% got NAFLD. All of our obese subjects were insulin resistance, the HOMA-IR level of obese non NAFLD was 6.1 and obese with NAFLD was 6.8. The adiponectin levels in normal children was (5.1mg / ml), obese non NAFLD (4.1mg / ml) and obese with NAFLD (4.0 mg / ml) (p <0.001). There were no association between adiponectin level and other variables. Conclusion: There were significant differences of adiponectin levels and insulin resistance measured by HOMA-IR between normal and obese subjects, but no significant differences between the obese groups with or without NAFLD. Keywords: NAFLD, adiponectin, HOMA-IR, obesity, adolescent.

Co-Authors Abdul Hakam Adhimah, Ayu Fauziyyah Adriyan Pramono Agustini Utari Ahmad Syauqy Alamsyah, Dedi Alamsyah, Dedi Ali Rosidi Alifiani Hikmah Putranti Ani Margawati Anindita Soetadji Annastasia Ediati Any Setyarini, Any Avionita Latuihamallo Aya Yoshimura Ayu Diana Meilantika Azusa Uemura Bagoes Widjanarko Bambang Hariyana Bandawati, Bandawati Bob Kevin Pardede Damianus Galih Panunggal Darwati Darwati Diana Nur Afifah, Diana Nur Dwi Pudjonarko Edi Dharmana Ekowati, Liana Endrinikapoulos, Ariana Erna Mirani Etika Ratna Noer Faiza, Arif Farid Agung Rahmadi, Farid Agung Fitri Hartanto Hapsari, Widawati Hardhono Susanto Hariyana, Bambang Hendriani Sellina Henry Setyawan Susanto Henry Setyawan Susanto Herman Kristanto Hesti Kartika Sari Ihat Hatimah Ika Rara Rosita Irawan Saputra, Gatot Isfandiyar Fahmi JC Susanto Julian Dewantiningrum Julian Dewantiningrum Jumianti Lestari Thamrin Juwita Pratiwi Kamilah Budhi Kamilah Budhi Rahardjani, Kamilah Budhi Kristiana Haryanti, Kristiana Kusuma Dewi, Anna Mailasari Latifah Rachmawati Leny Zabidi M. Supriatna M. Zen Rahfiludin Magdalena Sidhartani Maria Bramanwidyantari Maria Fatima Dete Dellu, Maria Fatima Dete Maria Martiani Martha Irene Kartasurya Mateus Sakundarno Mateus Sakundarno Mateus Sakundarno Adi, Mateus Sakundarno Miratul Haya MMDEAH Hapsari Mohamad Supriatna Mohammad Syarofil Anam Mohammad Syarofil Anam, Mohammad Syarofil Mohammad Zen Rahfiludin MS Anam Muflihatul Muniroh Muyassaroh Muyassaroh Neni Susilaningsih Ninung Kusumawati Ninung Rose Diana Kusumawati Noor Pramono Nurdiana Nurdiana Nurkukuh Nurkukuh Nurkukuh, Nurkukuh Nuryanto Nuryanto Nyoman Suci Widyastiti Perdani, Putri Pusaka, Semerdanta Rina Pratiwi Robi Andoyo Romadhona, Suci Rudy- susanto S.A. Nugraheni Saputra, Epriyan Sarjadi Sarjadi Sellina, Hendriani Soejoenoes, Ariawan Soemedi Hadiyanto Suci Romadhona Sudrajat, Agus Suhartono, Suhartono Suharyo Hadisaputro Suharyo Hadisaputro Susilawati, Martvera SyarofilAnam, Moh. T Mirza Iskandar Taro Yamauchi Taro Yamauchi Taro Yamauchi Taro Yamauchi Thamrin, Jumianti Lestari Wijaya, I Made Ananta Wistiani Wistiani Yetty M Nency Yoshimura, Aya Yudo Murti Mupangati Yulia Wahyuni Yusrina Istanti

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