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Journal : Health Notions

Green Tea Extract Increases The Number of Granulosa Cells and E2 Serum Levels of Female Rats Exposed by Cypermethrin Laili, Fitria Jannatul; Winarsih, Sri; Mintaroem, Karyono
Health Notions Vol 2 No 6 (2018): June 2018
Publisher : Humanistic Network for Science and Technology (Address: Cemara street 25, Ds/Kec Sukorejo, Ponorogo, East Java, Indonesia 63453)

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The Effect of Extra Virgin Olive Oil (EVOO) on Expression of Vascular Endhothelial Growth Factor (VEGF) and Arteriole Number on Endometrium of Female Rattus norvegicus of Wistar Strain Exposed to Rhodamin B Anisak, Siti; Sujuti, Hidayat; Sutrisno, Sutrisno; Mintaroem, Karyono; Nurseta, Tatit; Kalsum, Umi
Health Notions Vol 2 No 8 (2018): August 2018
Publisher : Humanistic Network for Science and Technology (Address: Cemara street 25, Ds/Kec Sukorejo, Ponorogo, East Java, Indonesia 63453)

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (505.013 KB)

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The Effect of Extra Virgin Olive Oil (EVOO) on Expression of Vascular Endhothelial Growth Factor (VEGF) and Arteriole Number on Endometrium of Female Rattus norvegicus of Wistar Strain Exposed to Rhodamin B Siti Anisak; Hidayat Sujuti; Sutrisno Sutrisno; Karyono Mintaroem; Tatit Nurseta; Umi Kalsum
Health Notions Vol 2, No 8 (2018): August
Publisher : Humanistic Network for Science and Technology (HNST)

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (505.013 KB) | DOI: 10.33846/hn.v2i8.242

Abstract

Rhodamin B is dangerous for body due to its ability to improve oxidative stress on various reproduction tissues on female. However, there is no significant scientific proof that Rhodamin B exposure influences VEGF and the number of arteriole on endometrium. VEGF and arteriole is crucial to angiogenesis process of endometrium. This study aimed at finding out the effect of EVOO on Expression of VEGF and Arteriole number of female Rattus Norvegicus of Wistar Strain exposed to Rhodamin B.Keywords: Rhodamin B, Extra Virgin Olive Oil (EVOO), Vascular Endothelial Growth Factor (VEGF), Arteriole
Green Tea Extract Increases the Number of Granulosa Cells and E2 Serum Levels of Female Rats Exposed by Cypermethrin Fitria Jannatul Laili; Sri Winarsih; Karyono Mintaroem
Health Notions Vol 2, No 6 (2018): June
Publisher : Humanistic Network for Science and Technology (HNST)

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (529.125 KB) | DOI: 10.33846/hn.v2i6.208

Abstract

1(CA), 2, 3 1(CA), Indonesia;  (Corresponding Author) 2, Indonesia 4, Indonesia ABSTRACT Green tea extract (GTE), Camellia sinensis, known as a very effective antioxidant to repair the damage of organs exposed by stress oxidative. Cypermethrin (CYP) is a harmful substance that can accumulate in the body and cause oxidative stress. This study aimed to demonstrate the effect of GTE in increasing the number of granulosa cells and E2 serum levels. Female rats (Rattus norvegicus) were randomly selected and divided into 5 groups, control group (KN), a group given only CYP 20 mg/kg body weight/day (KP), groups given CYP 20 mg/kg body weight/day and then treated with GTE 7, 14, 28 mg/kg body weight/day (P1, P2, and P3 respectively). Treatment was given for 28 days. The number of granulosa cells was counted by HSel software, E2 serum levels were determined via ELISA ASSAY. Treatment results with GTE 7, 14, and 28 mg/kg body weight/day significantly (p < 0.05) increased the number of granulosa cells and E2 serum levels relative to KN. Administration of GTE 28 mg/kg body weight/day caused the greatest increase in the number of granulosa cells and E2 serum levels. Our result suggests that GTE has potential prevention to stress oxidative by CYP exposure in granulosa cells and E2 serum. Keywords: Cypermethrin, E2, Granulosa Cells, Green tea