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All Journal International Journal of Public Health Science (IJPHS) HAYATI Journal of Biosciences Journal of Tropical Life Science : International Journal of Theoretical, Experimental, and Applied Life Sciences Jurnal Kedokteran Brawijaya Majalah Kedokteran Bandung Indonesian Journal of Urology MEDISAINS The Indonesian Biomedical Journal Health Notions Qanun Medika - Medical Journal Faculty of Medicine Muhammadiyah Surabaya Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Oceana Biomedicina Journal Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Journal of Global Pharma Technology
Karyono Mintaroem
Laboratorium Patologi Anatomi Fakultas Kedokteran Universitas Brawijaya-RSSA Malang
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Dentistry Earth & Planetary Sciences Environmental Science Health Professions Medicine & Pharmacology Nursing Public Health

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Journal : Journal of Global Pharma Technology

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The Alteration of SNAIL2 and MMP-9 Protein Expression of JEG-3 Choriocarcinoma Cell by Methanolic Extract of Tamarindus Indica Fruit Candra Rini Hasanah Putri; Sutiman Bambang Sumitro; Setyawati Soeharto; Karyono MIntaroem
Journal of Global Pharma Technology Volume 11 Issue 04.
Publisher : Journal of Global Pharma Technology

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Abstract

Objective: Tamarindus indica is one of the famous natural plant that has various effects on health. Recent research has begun to examine the effect of Tamarindus indica on cell malignancy. One of the things that happens in cell malignancy is an increasing ability of cell migration, which is characterized by increasing expression of Snail2 and MMP-9. This study was conducted to determine the effect of extract of Tamarindus indica Fruit Extract (TIFE) towards Snail2 and MMP-9 expression in JEG-3 cells.Methods :.TIFE were extracted by using methanol. JEG-3 cells were grown in culture medium treated with TIFE (at 0, 25, 50 and 100 µg/ml). Immunofluorescence staining was carried out, and observed under Confocal Laser Scanning Microscope.Result: Snail2 expression after treatment with TIFE 50 and 100 µg/ml higher than control- (P=0.015 ; P=0.001) whereas at MMP-9 expression there was a biphasic pattern, in which the MMP-9 expression peaked at concentration of 50 µg/ml (P=0.002), then MMP-9 expression decreased at 100 µg/ml concentration. Conclusion : The expression of Snail2 influence MMP-2 expression after treat with TIFE, so it might increase the potential for JEG-3 cell migration Keywords : Methanolic extract, Tamarindus indica, Snail2, MMP-9
Co-Authors A.A. Ketut Agung Cahyawan W Adinda Chika Anindita Ahsan Ahsan Aina Angelina Anggie Sasmita Kharisma Putri Anisak, Siti Candra Rini Hasanah Putri Dara Dasawulansari Syamsuri Desy Andari Dian Nugrahenny Dicky Faizal Irnandi Dicky Faturrachman Djoko Wahono Soeatmadji Dorta Simamora Edi Widjajanto Edi Widjajanto Edwin Widodo Eviana Norahmawati Fadli, Muhammad Luqman Fardizia Putri Alia Ferry Sandra Fitria Jannatul Laili Ghifary, Faathir Baihaqi Guruh Suprayitno Harun Al Rasyid Hidayat Sujuti Indriati Dwi Rahayu Kalsumy, Umi Lavina Sofia Ardani Loeki E Fitri, Loeki E Loeki Enggar Fitri Mayangsari, Elly Melati Puspita Sari Mohamad Slamet Chandra Kusuma Mulyohadi Ali Mulyohadi Ali Nathania Bella Claresta Niarti Ulan Sari Siarnu Nur Permatasari Nura Fattah Cantika Yoga Oski Illiandri Poerwosusanta, Hery Pudji Rahajoe Rahma, Zainabur Retnani, Diah Prabawati Retty Ratnawati Selvi Marcellia Setyawati Karyono Setyawati Soeharto Setyawati Soeharto Soemarko Soemarko Sri Winarsih sujarot dwi sasmito, sujarot dwi Sutiman Bambang Sumitro Sutrisno Sutrisno Tatit Nurseta Tatit Nurseta Tika Ardhini Wardoyo Tony Suharsono, Tony Tri Yudani Mardining Raras Winarko Luminturahardjo Wisnu Barlianto Wulandari, Angernani Trias Yuliyanik yuliyanik Zairin Noor Zairin Noor