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All Journal Sari Pediatri Paediatrica Indonesiana JOURNAL LA MEDIHEALTICO Archives of Pediatric Gastroenterology, Hepatology, and Nutrition Proceedings Book of International Conference and Exhibition on The Indonesian Medical Education and Research Institute
Mulya Rahma Karyanti, Mulya Rahma
Department Of Child Health, Faculty Of Medicine, Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia
Health Professions Medicine & Pharmacology Neuroscience Nursing Public Health Veterinary

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Occurrence of Covid-19 in Children Who Have Received Live-Attenuated Dengue Vaccination Rahma Karyanti, Mulya; Alam , Anggraini; Widyahening , Indah Suci; Hadinegoro, Sri Rezeki; Munasir , Zakiudin; Sasmono , R. Tedjo; Satari , Hindra Irawan
Proceedings Book of International Conference and Exhibition on The Indonesian Medical Education Research Institute Vol. 7 No. - (2023): Proceedings Book of International Conference and Exhibition on The Indonesian M
Publisher : Writing Center IMERI FMUI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.69951/proceedingsbookoficeonimeri.v7i-.188

Abstract

Background: Possible cross-reactions/ false positives were reported in rapid dengue serology tests because antigenic similarities between SARS-CoV-2 and DENV. The study aims to evaluate the occurrence of COVID-19 in children who received chimeric-yellow fever tetravalent dengue vaccine. Methods: A case-control study was conducted in five districts primary healthcares in Jakarta aged 12 years and above through history of COVID-19 questionnaire. Clinical and laboratory confirmation were obtained, and blood draw was performed to measure neutralization RBD IgG SARS-CoV-2 antibody titer. The dengue vaccine group consists of subjects who have received CYD-TDV in 2011-2012 and are willing to participate. The non-dengue vaccine group were matched; all have not received dengue vaccine. Results: This study included 207 cases and 212 controls, with median age in cases 19 years (IQR 5) and control 15 years (IQR 4). Nineteen subjects in the dengue vaccine group have already been infected with COVID-19 before being given COVID-19 vaccine, compared to 11 subjects in the non-dengue vaccine group (P=0.131). The occurrence of COVID-19 in the dengue vaccine group was significantly higher (16 subjects) than the non-dengue vaccine group (4 subjects)(P=0.005) after COVID-19 vaccinations were given. Neutralization RBD IgG SARS-CoV-2 antibody titer was 71.96 U/ml (IQR 39.47) in the dengue vaccine group and 51.92 U/ml (IQR 49.03) in the non-dengue vaccine group(P=0.361). Conclusion: Our study showed that the occurrence of COVID-19 in the dengue vaccine group was higher than in the non-dengue vaccine group, which may suggest no cross reaction from dengue antibodies towards COVID-19, more studies are warranted.
Co-Authors Abdul Latief Agus Firmansyah Agus Firmansyah Alam , Anggraini Amalia Almira Andi Annisa Rusyda Khafiyani Angelina Arifin Anggraini Alam, Anggraini Anis Karuniawati Annisa Putri Antonius H. Pudjiadi Ari Prayitno Arie Dian Fatmawati Arwin A.P Akib Aryono Hendarto Athiyatul Aufie Bambang Supriyatno Dadi Suyoko Damayanti Rusli Sjarif Darmawan B. Setyanto Deasy Grafianti Delly Chipta Lestari Desti Handayani Dewi Kartika Suryani Dewi Murniati Oman Dina Muktiarti, Dina Dion Darius Samsudin Djajadiman Gatot Eka Laksmi Hidayati, Eka Laksmi Evita B. Ifran Evita Karianni Bermanshah Ferry Liwang Fitria Nuraeni Hanifah Oswari Hardiono Pusponegoro Hartono Gunardi Hindra I. Satari I Wayan Gustawan Idham Amir Imanadhia, Ashfahani Indah S. Widyahening Irawan Mangunatmadja Irene Yuniar, Irene Karina Faisha Lucyana Alim Santoso Munasir, Zakiudin Nabila Maudy Salma Nagrani, Dimple Gobind Nanda Asyura Rizkyani Nia Kurniati Nia Kurniati Nia Kurniati Nicolas Gunawan Niken Wahyu Puspaningtyas Nina Dwi Putri Novie Amelia Chozie Novie Homenta Rampengan Novie Homenta Rampengan Partini Pudjiastuti Trihono Partini Pudjiastuti Trihono, Partini Pudjiastuti Pinka Nurashri Setyati Pramita Gayatri, Pramita Pratama Wicaksana Putra, Reynaldo Rahima Putri, Dewi Andini Rahmadiena, Qonita Rahmah, Nailah Rahman, Himawan Aulia Ratih Puspita Rhodia, Lia Rifan Fauzie, Rifan Rismala Dewi Rizqi Amalia Rosalina D Roeslani Rosalina Dewi Roeslani, Rosalina Dewi Rosyady, Maulana Sarita, Raisa Cecilia Sasmono , R. Tedjo Sasmono, R. Tedjo Setyo Handryastuti Shahab, Muhammad Rayyan Faher Shindy Claudya Aprianti Soedjatmiko Sri Rezeki Hadinegoro Sri Rezeki Hadinegoro Sri Rezeki Hadinegoro Sri Rezeki Hadinegoro, Sri Rezeki Sri Rezeki S Hadinegoro Sri Sulastri Katarnida Sudung O Pardede, Sudung O Sukman Tulus Putra Tania Paramita Taralan Tambunan Taralan Tambunan Yessi Yuniarti Yoga Devaera Yudiyanto, Ade Rachmat Yusticia Katar