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All Journal Jurnal Kedokteran Brawijaya Folia Medica Indonesiana Indonesian Journal of Tropical and Infectious Disease The Indonesian Biomedical Journal Sari Pediatri Paediatrica Indonesiana Jurnal Respirologi Indonesia Jurnal Respirasi (JR) JUXTA: Jurnal Ilmiah Mahasiswa Kedokteran Universitas Airlangga Journal of the Indonesian Medical Association : Majalah Kedokteran Indonesia JOURNAL OF COMMUNITY MEDICINE AND PUBLIC HEALTH RESEARCH Indian Journal of Forensic Medicine & Toxicology Jurnal Ilmu Medis Indonesia MEDICINUS Asian Journal of Social and Humanities
Retno Asih Setyoningrum
Departement Of Pediatric, Faculty Of Medicine, Universitas Airlangga, Surabaya, Indonesia
Biochemistry, Genetics & Molecular Biology Decision Sciences, Operations Research & Management Earth & Planetary Sciences Education Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Medicine & Pharmacology Neuroscience Public Health Other

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Journal : The Indonesian Biomedical Journal

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Zinc Administration Affects Bronchial Mucosal NF-κB p105/p50, p-NF-κB p65, IL-8, and IL-1β of Zinc-deficient Rats Reza Gunadi Ranuh; Andy Darma; Alpha Fardah Athiyyah; Ergia Latifolia; Retno Asih Setyoningrum; Boerhan Hidajat; Siti Nurul Hidayati; Anang Endaryanto; Ferry Sandra; Subijanto Marto Sudarmo
The Indonesian Biomedical Journal Vol 12, No 3 (2020)
Publisher : The Prodia Education and Research Institute (PERI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18585/inabj.v12i3.1041

Abstract

BACKGROUND: Risk of acute respiratory infections in children less than 5 years of age is up to 95%. Zinc deficiency is one of the main risk factors. This study aimed to explore the effect of zinc on the bronchial mucosae inflammatory status expressed by nuclear factor (NF)-κB p105/p50, NF-κB p65, interleukin (IL)-8, and IL-1β.METHODS: Twenty-four Wistar rats were divided into 4 groups: normal zinc diet group without zinc supplementation (Z1), normal zinc diet group with zinc supplementation (Z2), zinc deficient diet group without zinc supplementation (Z3), and zinc deficient diet group with zinc supplementation (Z4). NF-κB p105/p50, p-NF-κB p65, IL-8, and IL-1β were measured by immunohistochemical staining.RESULTS: The inflammatory status of bronchial mucosae between Z1 and Z2 groups showed no difference (p=0.055). However, the inflammatory status of bronchial mucosae between Z3 and Z4 groups showed significant difference (p<0.01). Multivariate factorial design showed that zinc supplementation was beneficial when given to zinc deficient diet group with regard to decrease p-NF-κB p65, IL-8 and IL-1β levels (p<0.001) and increase dendritic cell (p=0.022).CONCLUSION: Zinc administration under conditions of zinc deficiency affects the inflammatory status, as shown by the decrease of p-NF-κB p65, IL-8 and IL-1β and the increase of NF-κB p105/p50.KEYWORDS: zinc, NF-κB, p105/p50, p65, IL-8, IL-1β, rat
Zinc Supplementation Effect on the Bronchial Cilia Length, the Number of Cilia, and the Number of Intact Bronchial Cell in Zinc Deficiency Rats Andy Darma; Alpha Fardah Athiyyah; Reza Gunadi Ranuh; Wiweka Merbawani; Retno Asih Setyoningrum; Boerhan Hidajat; Siti Nurul Hidayati; Anang Endaryanto; Subijanto Marto Sudarmo
The Indonesian Biomedical Journal Vol 12, No 1 (2020)
Publisher : The Prodia Education and Research Institute (PERI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18585/inabj.v12i1.998

Abstract

BACKGROUND: Airway epithelium is the first line of defense against a variety of exposures. Inflammatory processes, hyperresponsiveness and zinc deficiency cause epithelial damage. Zinc is involved in apoptosis and microtubule formation. However, its role in the integrity of bronchial mucosa and cilia is unclear.METHODS: To assess the effect of zinc on the integrity of the bronchial epithelium, 24 male Rattus norvegicus strain Wistar rats were randomized into four experimental groups: normal zinc diet group without zinc supplementation, normal zinc diet group with 60 ppm zinc supplementation, zinc deficient diet group without zinc supplementation, and zinc deficient diet group with 120 ppm zinc supplementation. Bronchial mucosal integrity was measured with the number of epithelial cells, and the number and length of cilia.RESULTS: Number of cell in normal zinc diet group was 8.8±1.82, while it was only 8.1±1.08 in zinc deficient diet group (p<0.001). Number of cilia per cell was 4.6±1.08 in normal zinc diet group, compared to 4.0±0.79 in zinc deficient diet group (p<0.001). Ciliary length also differ by 7.68±0.66 μm in normal zinc diet group and only 5.16±0.91 μm in zinc deficient diet group (p<0.001).CONCLUSION: Zinc supplementation of the normal zinc diet group affected the length of bronchial cilia. Zinc supplementation of the zinc deficient diet group affected the integrity of the bronchial epithelium, which was shown by the number and length of cilia, and the number of epithelial cells.KEYWORDS: zinc, bronchial epithelial integrity, cilia length, number of cilia, epithelial cell 
Co-Authors Abdul Latief Azis Agoes Boediono Ahmad Suryawan Aida Fahira Rachma Aisah, Nurul Albarok, Muhammad Abdir Rahman Aldise Mareta, Aldise Alpha Fardah Athiyyah Amrina Rosyada Anang Endaryanto Ananto, Muhammad Arif Andri Kurnia Wahyudhi Andy Darma Arda Pratama Putra Chafid Arina Setyaningtyas Budi Utomo Budi Utomo Budi Utomo Chafid, Arda Pratama Putra Clarissa Cita Magdalena Darto Saharso Deasy Fetarayani Deby Kusumaningrum DEWI RAHMAWATI Dharmawati, Ira Didik Didik Handijatmo, Didik Diska Hanifah Nurhayati Djoko Poetranto, Djoko Dominicus Husada Dwi Putri Lestari Dwi Susanti Edith Frederika, Edith Eka Sri Handayani Ergia Latifolia Far-Far, Imanuel Ferry Sandra Gatot Soegiarto Hapsari Widya Ningtiar Hapsari, Rika Hedi Mustiko Hidajat, Boerhan Hubah Asyiroh I Dewa Gede Ugrasena I Gusti Made Reza Gunadi Ranuh I Gusti Ngurah Twi Adnyana Ismoedijanto Khoirunnisa Shafira Deshpande Kristianto, Wigit Laksmi Wulandari Lestari, Sally Rizkita Litiya Parahita Putri Firnadi Lucia Landia Setyowati, Lucia Landia Maharani, Rizky Arisanti Manillaturrochmah Manillaturrochmah Maranatha, Daniel Masaoki Yamaoka, Masaoki Mohammad Yamin Sunaryo Suwandi Muhammad Faris, Muhammad Muhammad Helmi Imaduddin Mustiko MD, Hedi Nabila Annisa Harum Neurinda Permata Kusumastuti Ni Made Mertaniasih Prananda Surya Airlangga Prasanti, Siva Allysha Pratista Oktafia Pudji Lestari Purwanto, Satiti Palupi Puspamaniar, Vania Ayu Ranti Dewanti Oktaviani Rarome, Berlian Beatrix Ratih Kumala Sari, Ratih Kumala Rebekah Setiabudi, Rebekah Resti Yudhawati Rifah Zafarani Soumena Rika Hapsari Salsabila, Sabila Sembiring, Yan Efrata Setiabudi, Rebekah Juniati Shofia Ihtasya SITI NURUL HIDAYATI Subijanto Marto Sudarmo Syafa'ah, Irmi Tia Harelina Tutwuri Handayani Umiastuti, Pirlina Utariani, Arie Visuddho, Visuddho Widati Fatmaningrum Wigit Kristianto Wiharjo Hadisuwarno Wiweka Merbawani Wungu, Citrawati Dyah Kencono Yuli Astika