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All Journal Public Health of Indonesia Jurnal Penelitian Pendidikan IPA (JPPIPA) JPSCR : Journal of Pharmaceutical Science and Clinical Research Jurnal Farmamedika (Pharmamedica Journal) Jurnal Ilmiah Farmasi Farmasyifa Lumbung Farmasi : Jurnal Ilmu Kefarmasian Jurnal Penelitian Farmasi dan Herbal Jurnal Ilmiah Jophus: Journal of Pharmacy UMUS Journal of Pharmaceutical and Health Research Jurnal Kesehatan Tambusai INPHARNMED Journal (Indonesian Pharmacy and Natural Medicine Journal) Proceedings Series on Health & Medical Sciences Medical Sains : Jurnal Ilmiah Kefarmasian Jurnal An-Najat: Jurnal Ilmu Farmasi dan Kesehatan Parapemikir Jurnal Ilmiah Farmasi CERATA Jurnal Sains, Teknologi dan Kesehatan Medical Sains : Jurnal Ilmiah Kefarmasian
Abdul Wahid Suleman
Universitas Megarezky
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Dentistry Education Engineering Environmental Science Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Nursing Physics Public Health Veterinary

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The Comparison and Test of Antioxidant Activity of Ethanol Extracts of Pangi Leaves and Seeds (Pangium Edule Reinw.) Using the DPPH (1,1-Diphenyl-2-Picrylhydrazyl) Method Suleman, Abdul Wahid; Sari, Nurmala; Safaruddin, Safaruddin; Adri, Tenri Ayu; Siradjuddin, Mutmainnah; Prihandari, Ayu
CERATA Jurnal Ilmu Farmasi Vol 15 No 2 (2024): Cerata Jurnal Ilmu Farmasi
Publisher : Universitas Muhammadiyah Klaten

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61902/cerata.v15i2.988

Abstract

The leaves and seeds of pangi (Pangium edule Reinw.) contain alkaloids, flavonoids, saponins, and tannins, which acts as antioxidants. Antioxidants are needed to protect the body and inhibit the negative impact of free radicals due to the oxidation reactions that occur. Antioxidants are compounds that inhibit oxidation reactions by binding free radicals and molecules. This research aims to determine the comparison of the antioxidants activity of pangi (Pangium edule Reinw.) leaves and seeds using the DPPH (1,1,-Diphenyl-2-Picrylhydrazyl) method. Reactive research method, experimentally, namely by carrying out serial dilutions of concentrations of 10, 20, 30, 40 and 50 ppm in each test solution, then adding the DPPH solution and measuring the antioxidants activity with a UV-Vis Spectrophotometer. After that, the IC50 (Inhibitor Concentration 50) value and the AAI (Antioxidant Activity Index) value are calculated, and the data were analyzed using ANOVA. The results of calculating the IC50 and AAI values are that the IC50 value of the pangi leaf ethanol extract is 49.6061 ppm (AAI=1.007), while the IC50 value of ethanol extract of pangi seeds is 50.2027 (AAI=0.9959). From the results of research and data analysis, it can be concluded that the ethanol extract of pangi leaves has higher antioxidant activity compared to the ethanol extract of pangi seeds.
Effect of Papaya Seeds (Carica papaya) and Gandarusa Leaves (Justicia gendarussa) on the Spermatozoa Quality of Male Mice Jangga Jangga; Abdul Wahid Suleman; Saparuddin Latu; Sri Wulan Rini
JPSCR: Journal of Pharmaceutical Science and Clinical Research Vol 9, No 1 (2024)
Publisher : Universitas Sebelas Maret

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20961/jpscr.v9i1.69885

Abstract

Papaya seeds (Carica papaya L.) and gandarusa leaves (Justicia gendarussa Burm.f.) are considered medicinal plants that can be used as natural male contraceptives. Papaya seeds contain alkaloids, triterpenoids, saponins, and papain. Meanwhile, the gandarusa leaves contain flavonoids. These compounds have the function of antifertility for men. The purpose of this study was to determine the effect of papaya seeds (Carica papaya L.) ethanol extracts, gandarusa leaves (Justicia gendarussa Burm.f.), and its combination on motility, viability, and morphology of male mice spermatozoa (Mus musculus) most effective decrease concentration on motility, viability, and morphology of male mice spermatozoa (Mus musculus). This research was an experimental study. The samples of this study were 18 male mice with a body weight of 20-30 grams, aged 3-5 months, and were divided into six groups. The treatments given were control, papaya seed ethanol extract, gandarusa leaves ethanol extract, and its combinations to concentrations of P1 Na CMC1%, P2 (papaya seed 100mg/kgW), P3 (gandarusa leaf 50mg/kgW), P4 (papaya seed : gandarusa leaf 50:50 mg/kgW), P5 (papaya seed : gandarusa leaf  50:100 mg/ kgW), P6 (papaya seed : gandarusa leaf 100:50 mg/kgW). The extract was given for 35 days. On the 36th day, the mice were dissected to take their epididymis to observe the spermatozoa's quality (motility, viability, morphology). Those observations used a light microscope. Data were analyzed using one-way ANOVA and LSD post hoc tests. This study resulted differences in P1, P2, P3, P4, P5, and P6 towards motility, viability, and morphology of spermatozoa (p< 0.05). The conclusion of this study showed that both single and combination ethanol extracts of papaya seeds and gandarusa leaves could reduce the motility, viability, and morphology of spermatozoa of male mice, and the effective dosage in reducing motility, viability, and morphology of spermatozoa is P3 gandarusa leaves 50mg/kgW.
Uji Aktivitas Antibakteri Ekstrak Rimpang Galoba (Horstedtia Alliacea) Terhadap Bakteri Staphylococcus Aureus Dan Escherichia Colli Maria Fenesia Fangohoi; Chikita Inaku; Abdul Suleman Wahid
An-Najat Vol. 3 No. 1 (2025): An-Najat: Jurnal Ilmu Farmasi dan Kesehatan
Publisher : STIKes Ibnu Sina Ajibarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59841/an-najat.v3i1.2371

Abstract

Galoba rhizome (Horstedtia alliacea) is a plant that is efficacious because it contains antibacterial compounds. It contains flavanoids and triterpenoids to inhibit bacterial growth. The purpose of this study was to determine the antibacterial activity of galoba rhizome extract against Staphylococcus aureus and Escherichia coli bacteria and to determine the concentration of the extract which had the largest inhibition zone in inhibiting the growth of Staphylococcus aureus and Escherichia coli bacteria. The extraction method used is repeated maceration. Antibacterial testing using the disc diffusion method, the results of the antibacterial activity test of Staphylococcus aureus with extract concentrations of 0.5%, 1% and 1.5% each had mean ± SD values, namely: 5.9 ± 0.76.7 .63 ± 0.96, 10.16 ± 2.63 and the results of the antibacterial activity test against Escherichia coli bacteria obtained inhibition zones at concentrations of 0.5%, 1% and 1.5% each having mean ± SD values, namely: 5, 98 ± 2.10, 6.69 ± 1.22, 8.19 ± 4.48. From this study it can be concluded that Galoba rhizome extract has antibacterial activity in inhibiting the growth of Staphylococcus aureus and Escherichia coli bacteria at a concentration of 1.5% which is included in the medium category.
Formulasi dan Uji Antibakteri Sediaan Bodywash Ekstrak Daun Pare (Momordica Charantia L) Kombinasi Kopi Robusta (Coffea Canephora L) terhadap Bakteri Staphyloccocus Aureus dan Staphyloccocus Epidermis Latu, Saparuddin; Inayah, Nurul; Syamsidar; Suleman, Abdul Wahid; Padjalangi, Andi Muhammad Yaqkin; Mansur
Proceedings Series on Health & Medical Sciences Vol. 7 (2025): Proceedings of the 1st National Seminar on Global Health and Social Issue (LAGHOSI)
Publisher : UM Purwokerto Press

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30595/pshms.v7i.1440

Abstract

Formulasi Dan Uji Antibakteri Sediaan Bodywash Ekstrak Daun Pare (Momordica chrantia L) Kombinasi Kopi Robusta (Coffea canephora L) Terhadap Staphylococcus aureus Dan Staphylococcus epidermis. Ekstrak daun pare (Momordica charantia L) dikenal kaya akan manfaat untuk kesehatan selain itu berfungsi juga sebagai antibakteri. Kopi robusta (Coffea canephora L) selain banyak peminatnya tetapi dapat juga berfungsi sebagai antibakteri. Tujuan penelitian ini untuk mengetahui kemampuan dari esktrak daun pare kombinasi kopi robusta dalam menghambat pertumbuhan bakteri Staphyloccocus aureus dan Staphyloccocus epidermis. Metode yang digunakan pada penelitian ini yaitu menggunakan metode semuran yang dilakukan dengan 3 perlakuan di masing-masing bakteri. Perlakuan tersebut terdiri dari konsentrasi 2%, 3% dan 5%. Hasil dari penelitian yang telah dilakukan semua konsentrasi mampu menghambat pertumbuhan bakteri yang dimana konsentrasi yang paling efektif menghambat pertumbuhan pada F2 (3%) sebesar 11,98mm untuk bakteri Staphylococcus aureus, sedangkan bakteri Staphylococcus epidermis juga pada F1 (2%) sebesar 11,3mm yang paling efektif menghambat bakteri. Kesimpulan dari hasil penelitian ini adalah konsentrasi 2%, 3% dan 5% mampu menghambat pertumbuhan bakteri Staphylococus aureus yaitu pada F2 (3%) dengan diameter zona hambat 11,98mm dan untuk bakteri Staphyloccus epidermis yaitu pada F1(2%) dengan zona hambat bakteri 11,3mm.
The Antibacterial Activity Test of Methanol and N-Hexane Fractions of Yellow Pumpkin Fruit Extract (Cucurbita moschata Duch) Against Escherichia coli and Staphylococcus aureus Suleman, Abdul Wahid; Saparuddin Latu; Sriyanty Sadsyam; Safaruddin; Pradila
CERATA Jurnal Ilmu Farmasi Vol 16 No 1 (2025): Cerata Jurnal Ilmu Farmasi
Publisher : Universitas Muhammadiyah Klaten

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61902/cerata.v16i1.1370

Abstract

Infectious diseases are still a major health problem in several countries, especially in developing countries. The medication used to treat bacterial infections is obtained by utilizing herbal plants obtained from natural ingredients. Pumpkin fruit extract (Cucurbita moschata) contains flavonoids. tannins, saponins, and alkaloids Pumpkin fruit is effective as an antidiabetic, an antihypertensive, an antitumor, an antibacterial, and an antioxidant. This study aims to determine the antibacterial activity of the methanol and n-hexane fractions of yellow pumpkin (Cucurbita moschata) fruit extract and at what concentration the methanol and n-hexane fractions of yellow pumpkin (Cucurbita moschata) fruit extract can have antibacterial activity against Escherichia coli and Staphylococcus aureus. This research uses laboratory-experimental research methods. Antibacterial testing in this research involved sterilization, making test solutions, and testing. The results of the antibacterial test on the inhibition zone of the methanol fraction of pumpkin fruit against Escherichia coli and Staphylococcus aureus bacteria at concentrations of 20%, 30%, and 40% were in the strong category, while the n-hexane fraction had an inhibition zone in the weak category for Escherichia coli and Staphylococcus aureus bacteria. Conclusion: The methanol and n-hexane fractions have antibacterial activity against Escherichia coli and Staphylococcus aureus, and the concentrations with antibacterial activity are 20%, 30%, and 40%.
Formulasi dan Uji Aktivitas Sediaan Salep Anti Jerawat Ekstrak Etanol Bunga Kenop (Gomphrena globosa) terhadap Staphylococcus aureus Suleman, Abdul Wahid; Yusuf, Muhammad; Safaruddin, Safaruddin; Pratiwi, Rizky Indah
INPHARNMED Journal (Indonesian Pharmacy and Natural Medicine Journal) Vol 7, No 2 (2023)
Publisher : Alma Ata University Press

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21927/inpharnmed.v7i2.3277

Abstract

Bunga kenop (Gomphrena globosa) mengandung senyawa flavonoid, saponin dan tanin yang dapat berfungsi sebagai antibakteri. Penelitian ini bertujuan untuk mengetahui ekstrak etanol bunga kenop dapat dibuat dalam bentuk formulasi sediaan salep anti jerawat yang stabil secara fisika dan kimia serta aktivitas sediaan sebagai anti jerawat terhadap Staphylococcus aureus. Metode penelitian ini dilakukan secara eksperimental, dengan membuat sediaan salep anti jerawat dari ekstrak etanol bunga kenop dengan variasi konsentrasi yaitu F1 (konsentrasi 7%), F2 (konsentrasi 8%), F3 (konsentrasi 9%), F4 (kontrol negatif), F5 (kontrol positif) dan menguji aktivitas sediaan terhadap Staphylococcus aureus menggunakan metode sumuran. Hasil penelitian menunjukkan bahwa formula salep anti jerawat ekstrak etanol Bunga Kenop stabil secara fisik dan kimia dan tidak terdapat perbedaan bermakna (p<0,05) sebelum dan sesudah Cycling test baik pada uji organoleptik, homogenitas, pH, daya sebar, daya lekat, dan viskositas. Pengujian aktivitas anti jerawat terhadap Staphylococcus aureus menunjukkan bahwa F1 (7%) diameter zona hambat 10,2±0,15 mm, F2 (8%) diameter zona hambat 10,9±0,50 mm, F3 (9%) diameter zona hambat 11,4±0,52 mm, F4 (K-) diameter zona hambat 0±0,00 mm, dan F5 (K+) diameter zona hambat 16,2±0,52 mm. Dari hasil yang diperoleh dapat disimpulkan bahwa ekstrak bunga kenop dapat dibuat dalam bentuk formulasi sediaan salep yang memiliki aktivitas antijerawat terhadap Staphylococcus aureus pada konsentrasi 7%, 8%, dan 9%
Formulation and Activity Test of Grapefruit Peel Extract Anti-Acne Gel Preparation (Citrus maxima Merr.) Against Staphylococcus aureus and Propionibacterium acne Bacteries Latu, Saparuddin; Jangga; Suleman, Abdul Wahid; Putri, Hardyanti Eka; Herman, Sriyana; Mahmudah, Rifa’atul; Rusli; Nurhikmah
Public Health of Indonesia Vol. 11 No. 3 (2025): July - September
Publisher : YCAB Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36685/phi.v11i3.1005

Abstract

Background: Grapefruit (Citrus maxima Merr.) peel is known to contain bioactive compounds such as alkaloids, tannins, and flavonoids, which exhibit potential antibacterial properties, particularly against acne-causing bacteria.Objective: This study aimed to formulate an anti-acne gel incorporating grapefruit peel extract, evaluate its antibacterial activity against Staphylococcus aureus (SA) and Propionibacterium acnes (PA), and determine the optimal extract concentration for inhibiting bacterial growth.Methods: A laboratory-based experimental study was conducted using the well diffusion (pitting) method to assess antibacterial activity. Gel formulations containing grapefruit peel extract at concentrations of 5%, 10%, and 15% were tested against SA and PA.Results: The formulated gels demonstrated acceptable physical stability. The inhibition zones against SA were as follows: 5% (F1) = 10.2 mm, 10% (F2) = 11.2 mm, and 15% (F3) = 11.1 mm. Against PA, the inhibition zones were: F1 = 11.7 mm, F2 = 13.3 mm, and F3 = 11.7 mm. The 10% formulation (F2) exhibited the highest antibacterial activity against both bacterial strains, falling within the "strong" inhibition category.Conclusion: Grapefruit peel extract can be successfully formulated into an anti-acne gel and demonstrates effective antibacterial activity against Staphylococcus aureus and Propionibacterium acnes. Among the tested concentrations, 10% was identified as the most effective for bacterial inhibition. Keywords: grapefruit peel; citrus maxima; extract; antibacterial activity; anti-acne gel
FORMULASI DAN UJI AKTIVITAS ANTIBAKTERI CLAY MASK KOMBINASI DAUN PEGAGAN (CENTELLA ASIATICA L) DAN DAUN AFRIKA (VERNONIA AMYGDALINA DEL) TERHADAP STAPHYLOCOCCUS AUREUS Sari, Putri Indah; Suleman, Abdul Wahid; Patti, Seliana
Jurnal Kesehatan Tambusai Vol. 5 No. 1 (2024): MARET 2024
Publisher : Universitas Pahlawan Tuanku Tambusai

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/jkt.v5i1.26198

Abstract

Daun pegagan (Centella asiatica L) dan daun afrika (Vernonia amygdalina Del) telah diidentifikasi mengandung senyawa flavonoid, alkaloid, tanin dan saponin yang memiliki potensi sebagai antibakteri. Penelitian ini bertujuan untuk mengetahui kombinasi ekstrak etanol daun pegagan dan daun afrika dapat di formulasikan menjadi sediaan clay mask yang stabil secara fisik dan kimia dan dapat menghambat bakteri Staphylococcus aureus. Metode penelitian ini merupakan eksperimental laboratorium, dengan membuat formulasi sediaan clay mask kombinasi ekstrak etanol daun pegagan dan daun afrika dengan berbagai konsentrasi yaitu Formula 1 (2,5%:7,5%), Formula 2 (5%:5%), Formula 3 (7,5%:2.5%), Formula 0 (tanpa ekstrak), Kontrol Positif (clay mask whitelab), kemudian dilakukan evaluasi sediaan yaitu berupa uji organoleptik, homogenitas, pH, daya sebar, viskositas, cycling test dan uji aktivitas antibakteri.  Hasil penelitian pada uji evaluasi sediaan, didapatkan hasil bahwa baik Formula 1 (2,5%:7,5%), Formula 2 (5%:5%) dan Formula 3 (7,5%:2.5%) stabil secara fisik dan kimia sedangkan pada uji aktivitas antibakteri hasil yang didapatkan pada Formula 1 (2,5%:7,5%) sebesar 15,58 mm ±0.39, Formula 2 (5%:5%), sebesar 15.01 mm ± 0.15, Formula 3 (7.5%:2.5%) sebesar 15.15 mm ± 0.38, Kontrol Positif sebesar 15.77 mm ± 0.89, Kontrol Negatif tidak memiliki zona hambat.  Kesimpulan penelitian ini sediaan clay mask kombinasi ekstrak etanol daun pegagan dan daun afrika memiliki aktivitas sebagai antibakteri terhadap Staphylococcus aureus dengan konsentrasi yang paling efektif yaitu pada Formula 1 (2,5%:7,5%) dengan zona hambat sebesar 15.58 mm ±0.39 termasuk kategori kuat.
Uji Aktivitas Formula Sediaan Masker Gel Peel Off Ekstrak Etanol Buah Patikala (Etlingera eatior (Jack) R.M Smith) terhadap Pertumbuhan Bakteri Penyebab Jerawat Suleman, Abdul Wahid; latu, Saparuddin; Padjalangi, Andi Muh Yagkin; Jangga, Jangga
Lumbung Farmasi: Jurnal Ilmu Kefarmasian Vol 5, No 1 (2024): Januari
Publisher : UNIVERSITAS MUHAMMADIYAH MATARAM

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31764/lf.v5i1.14011

Abstract

Buah Patikala memiliki senyawa flavonoid digunakan untuk menghambat mikroba. Tujuan penelitian untukmmengetahui ekstrak buahjpatikala dapat diformulasikan dalam masker peel off  yang secara fisika dan kimia serta untuk mengetahui seberapa  besar konsentrasi dari ekstrak buah patikala yang dapat menghambat bakteri penyebab jerawat. Jenis penelitian ini merupakan eksperimental meliputi evaluasi masker peel off secara fisik dan kimia serta pengujian aktivitas formula masker gel peel off ekstrak etanol buah patikala terhadap zona hambat pada bakteri penyebab jerawat yang terbagi mejadi 5 kelompok. Hasil penelitian menunjukkan bahwa ekstrak etanol buah patikala dapat diformulasikan serta stabil dalam bentuk sediaan masker gel peel off dan memiliki aktivitas antibakteri. Konsentrasi pada formula III merupakan konsentrasi yang memiliki aktivitas antibakteri paling optimal terhadap bakteri Propionibacterium acnes dengan luas zona hambat 9,91±0,18 mm. Konsentrasi pada formula III merupakan konsentrasi yang memiliki aktivitas antibakteri paling optimal terhadap bakteri Staphylococcus epidermidis dengan luas zona hambat 9,25±0,27mm.
Pemanfaatan Kolagen Tulang Ayam Broiler dalam Sediaan Serum: Nilai SPF, Eritema, Pigmentasi, Kelembapan Kulit Suleman, Abdul Wahid; Safaruddin, Safaruddin; Mustamin, Sharnawati; Wahyuningsih, Sri; Jannah, Miftahul
Journal of Pharmaceutical and Health Research Vol 6 No 3 (2025): October 2025
Publisher : Forum Kerjasama Pendidikan Tinggi (FKPT)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47065/jharma.v6i3.8459

Abstract

Chicken bones (Gallus gallus domestica) are a type of solid waste that contain protein sources in the form of collagen. Collagen is one of the main connective tissue proteins in animals, widely used as a biomedical material, and is effective as an anti-aging agent that helps prevent the appearance of aging signs on the skin. This study aims to determine the potential of broiler chicken bone collagen in serum formulations as a photoprotective, anti-pigmentation, and skin moisturizing agent. The research method used was an in vitro experimental method using a UV-Vis spectrophotometer. Collagen was extracted using NaOH and CH₃COOH 1 M, and serum formulations were prepared with concentrations F1 (1%), F2 (1.5%), F3 (2%), and F4 (2.5%). The SPF value, erythema and pigmentation levels, as well as skin moisture, were then determined. The results of the serum formulation showed physical and chemical stability, indicated by no significant differences before and after the cycling test in organoleptic, pH, homogeneity, viscosity, and spreadability evaluations. The SPF values of the serum preparations were: F1 (1%) = 2.814999, F2 (1.5%) = 3.287317, F3 (2%) = 4.659954, and F4 (2.5%) = 8.574363. The %Te and %Tp tests showed that F0 (without extract) fell under the “Sunblock <1” category, while F1, F2, F3, and F4 were categorized as “Fast tanning” with values between 45–86. In conclusion, this study demonstrates that chicken bone extract can be formulated into a serum preparation that is physically and chemically stable. The best SPF, %Te, and %Tp values were obtained in the F4 formula, categorized as optimal, with %Te and %Tp values in the fast tanning category. Additionally, the F4 formula increased skin moisture by 5%.
Co-Authors A. Nurnadya Arna Ardiansyah Habar Besse Yuliana Chikita Inaku Herman, Sriyana Jangga Jangga, Jangga Mahmudah, Rifa’atul Mansur Maria Fenesia Fangohoi Miftahul Jannah Muhammad Yusuf Mustamin, Sharnawati Najamuddin, Mirfaidah Ni Wayan Kamariasih Ningsih Samsy Dhuha Nova Clarita Dama Nurhikmah Nurmala Sari Nurul Inayah Padjalangi, Andi Muh Yagkin Padjalangi, Andi Muhammad Yaqkin Patti, Seliana Pradila Pratiwi, Elzha Meilya Pratiwi, Rizky Indah Prihandari, Ayu Putri, Hardyanti Eka Rizky Indah Pratiwi Rizky Indah Pratiwi, Rizky Indah RR. Ella Evrita Hestiandari Rusli Safaruddin Safaruddin Safaruddin, Safaruddin Saparuddin Latu Sari, Putri Indah Siradjuddin, Mutmainnah Sri Wahyuningsih Sri Wahyuningsih Sri Wulan Rini Sriyanty Sadsyam Sulaiman Syamsidar Tahirah Hasan Tenri Ayu Adri Tri Handayani Ummu Kalsum Wahid, Hilmiati Wahyuni Wahyuni Yanti Puspitasari Yusuf, Muhammad Zahira, Saliza