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All Journal Public Health of Indonesia Jurnal Penelitian Pendidikan IPA (JPPIPA) JPSCR : Journal of Pharmaceutical Science and Clinical Research Jurnal Farmamedika (Pharmamedica Journal) Jurnal Ilmiah Farmasi Farmasyifa Lumbung Farmasi : Jurnal Ilmu Kefarmasian Jurnal Penelitian Farmasi dan Herbal Jurnal Ilmiah Jophus: Journal of Pharmacy UMUS Journal of Pharmaceutical and Health Research Jurnal Kesehatan Tambusai INPHARNMED Journal (Indonesian Pharmacy and Natural Medicine Journal) Proceedings Series on Health & Medical Sciences Medical Sains : Jurnal Ilmiah Kefarmasian Jurnal An-Najat: Jurnal Ilmu Farmasi dan Kesehatan Parapemikir Jurnal Ilmiah Farmasi CERATA Media Kesehatan Politeknik Kesehatan Makassar Indonesian Journal of Medical and Pharmaceutical Science Medical Sains : Jurnal Ilmiah Kefarmasian
Abdul Wahid Suleman
Universitas Megarezky
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Dentistry Education Environmental Science Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Nursing Physics Public Health Veterinary

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Formulation and Anti-Aging Activity of Collagen Extract from Yellowfin Tuna (Thunnus albacares) Skin Cream in UV-B Induced Wistar Rats Jangga Jangga; Besse Yuliana; Abdul Wahid Suleman; Silvi Alfitri; Sulaiman Sulaiman
Media Kesehatan Politeknik Kesehatan Makassar Vol 21 No 1 (2026): Media Kesehatan
Publisher : Direktorat Politeknik Kesehatan Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32382/medkes.v21i1.2114

Abstract

Skin aging is a progressive biological process that can be accelerated by excessive ultraviolet (UV) exposure, leading to structural damage characterized by wrinkle formation, loss of elasticity, and rough skin texture. This study aimed to formulate an anti-aging cream containing collagen-rich skin extract of yellowfin tuna (Thunnus albacares) and to evaluate its anti-aging efficacy in a UV-B–induced skin aging model using Wistar rats (Rattus norvegicus). A laboratory experimental design was employed using 15 male rats divided into five groups: negative control (cream base), positive control (commercial anti-aging cream), and treatment groups containing 1%, 3%, and 5% yellowfin tuna skin extract. The dorsal skin was exposed to UV-B radiation for 17 minutes daily for 10 consecutive days, followed by topical application of the respective formulations. Wrinkle severity was assessed macroscopically using a visual scoring system (0 = normal texture; 1 = shallow wrinkles; 2 = deep wrinkles with laxity). All formulations demonstrated acceptable physical stability, with pH values ranging from 4.98 to 5.48 and viscosity remaining within the acceptable range after cycling tests. Anti-aging evaluation revealed a dose-dependent improvement in wrinkle scores. The 5% formulation showed the most pronounced effect, with the median wrinkle score decreasing from 2 on day 1 to 0 on day 10, whereas the negative control group showed only a slight reduction from 2 to 1 during the same period. The 3% formulation demonstrated moderate improvement, while the 1% formulation exhibited fluctuating results. In conclusion, yellowfin tuna skin extract can be successfully formulated into a stable oil-in-water cream, and the 5% concentration exhibited the highest anti-aging activity in UV-B–exposed rats, supporting its potential as a marine-derived natural ingredient for topical anti-aging applications.
The Comparison and Test of Antioxidant Activity of Ethanol Extracts of Pangi Leaves and Seeds (Pangium Edule Reinw.) Using the DPPH (1,1-Diphenyl-2-Picrylhydrazyl) Method Abdul Wahid Suleman; Nurmala Sari; Safaruddin Safaruddin; Tenri Ayu Adri; Mutmainnah Siradjuddin; Ayu Prihandari
CERATA Jurnal Ilmu Farmasi Vol 15 No 2 (2024): Cerata Jurnal Ilmu Farmasi
Publisher : Universitas Muhammadiyah Klaten

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61902/cerata.v15i2.988

Abstract

The leaves and seeds of pangi (Pangium edule Reinw.) contain alkaloids, flavonoids, saponins, and tannins, which acts as antioxidants. Antioxidants are needed to protect the body and inhibit the negative impact of free radicals due to the oxidation reactions that occur. Antioxidants are compounds that inhibit oxidation reactions by binding free radicals and molecules. This research aims to determine the comparison of the antioxidants activity of pangi (Pangium edule Reinw.) leaves and seeds using the DPPH (1,1,-Diphenyl-2-Picrylhydrazyl) method. Reactive research method, experimentally, namely by carrying out serial dilutions of concentrations of 10, 20, 30, 40 and 50 ppm in each test solution, then adding the DPPH solution and measuring the antioxidants activity with a UV-Vis Spectrophotometer. After that, the IC50 (Inhibitor Concentration 50) value and the AAI (Antioxidant Activity Index) value are calculated, and the data were analyzed using ANOVA. The results of calculating the IC50 and AAI values are that the IC50 value of the pangi leaf ethanol extract is 49.6061 ppm (AAI=1.007), while the IC50 value of ethanol extract of pangi seeds is 50.2027 (AAI=0.9959). From the results of research and data analysis, it can be concluded that the ethanol extract of pangi leaves has higher antioxidant activity compared to the ethanol extract of pangi seeds.
Formulasi dan Uji Aktivitas Sediaan Salep Anti Jerawat Ekstrak Etanol Bunga Kenop (Gomphrena globosa) terhadap Staphylococcus aureus Abdul Wahid Suleman; Muhammad Yusuf; Safaruddin Safaruddin; Rizky Indah Pratiwi
INPHARNMED Journal (Indonesian Pharmacy and Natural Medicine Journal) Vol. 7 No. 2 (2023)
Publisher : Alma Ata University Press

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21927/inpharnmed.v7i2.3277

Abstract

Bunga kenop (Gomphrena globosa) mengandung senyawa flavonoid, saponin dan tanin yang dapat berfungsi sebagai antibakteri. Penelitian ini bertujuan untuk mengetahui ekstrak etanol bunga kenop dapat dibuat dalam bentuk formulasi sediaan salep anti jerawat yang stabil secara fisika dan kimia serta aktivitas sediaan sebagai anti jerawat terhadap Staphylococcus aureus. Metode penelitian ini dilakukan secara eksperimental, dengan membuat sediaan salep anti jerawat dari ekstrak etanol bunga kenop dengan variasi konsentrasi yaitu F1 (konsentrasi 7%), F2 (konsentrasi 8%), F3 (konsentrasi 9%), F4 (kontrol negatif), F5 (kontrol positif) dan menguji aktivitas sediaan terhadap Staphylococcus aureus menggunakan metode sumuran. Hasil penelitian menunjukkan bahwa formula salep anti jerawat ekstrak etanol Bunga Kenop stabil secara fisik dan kimia dan tidak terdapat perbedaan bermakna (p<0,05) sebelum dan sesudah Cycling test baik pada uji organoleptik, homogenitas, pH, daya sebar, daya lekat, dan viskositas. Pengujian aktivitas anti jerawat terhadap Staphylococcus aureus menunjukkan bahwa F1 (7%) diameter zona hambat 10,2±0,15 mm, F2 (8%) diameter zona hambat 10,9±0,50 mm, F3 (9%) diameter zona hambat 11,4±0,52 mm, F4 (K-) diameter zona hambat 0±0,00 mm, dan F5 (K+) diameter zona hambat 16,2±0,52 mm. Dari hasil yang diperoleh dapat disimpulkan bahwa ekstrak bunga kenop dapat dibuat dalam bentuk formulasi sediaan salep yang memiliki aktivitas antijerawat terhadap Staphylococcus aureus pada konsentrasi 7%, 8%, dan 9%
Formulasi Sediaan Body Scrub Berbahan Cangkang Telur Ayam dengan Penambahan Minyak Zaitun sebagai Pelembab Alami Abdul Wahid Suleman; Sri Rahayu Putri Indra; Irwan Irwan; Rizky Indah Pratiwi
INPHARNMED Journal (Indonesian Pharmacy and Natural Medicine Journal) Vol. 9 No. 2 (2025)
Publisher : Alma Ata University Press

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21927/inpharnmed.v9i2.6131

Abstract

Body scrub sebuah perawatan tubuh yang disebut juga sebagai facial untuk tubuh. Penggunaan bahan dasar body scrub dengan menggunakan bahan bahan alam salah satunya cangkang telur ayam dan minyak zaitun karena memiliki kandungan CaCo3 yang bersifat abrasif yang membantu mengangkat sel kulit mati dan penambahan minyak zaitun bertujuan untuk meningkatkan kelembapan kulit. Penelitian ini bertujuan untuk mengetahui apakah cangkang telur ayam dengan penambahan minyak zaitun dapat dijadikan sebagai sediaan body scrub yang stabil dan mengetahui konsentrasi paling efektif untuk sediaan body scrub. Metode yang digunakan adalah metode penelitian eskperimental laboratorium dimana cangkang telur ayam dan minyak zaitun diformulasikan menjadi sediaan body dimana cangkang telur ayam dihaluskan untuk digunakan sebagai scrub sedangkan minyak zaitun digunakan sebagai pelembab. Formulasi mempunyai tiga konsentrasi cangkang telur ayam yaitu konsentrasi 20%, 30%, 40% dan kontrol negatif. Hasil penelitian ini menunjukkan bahwa cangkang telur ayam dengan penambahan minyak zaitun) sediaan body scrub F1,F2,F3 dan Kontrol negatif dapat dijadikan body scrub yang stabil dalam fisika kimia dan dapat dijadikan sebagai sediaan body scrub dan konsentrasi paling efektif dari keempat formulasi yaitu formulasi denga konsentrasi 30% yang dilihat dari persentase kelembapan.
Effect of Papaya Seeds (Carica papaya) and Gandarusa Leaves (Justicia gendarussa) on the Spermatozoa Quality of Male Mice Jangga Jangga; Abdul Wahid Suleman; Saparuddin Latu; Sri Wulan Rini
JPSCR: Journal of Pharmaceutical Science and Clinical Research Vol 9, No 1 (2024)
Publisher : Universitas Sebelas Maret

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20961/jpscr.v9i1.69885

Abstract

Papaya seeds (Carica papaya L.) and gandarusa leaves (Justicia gendarussa Burm.f.) are considered medicinal plants that can be used as natural male contraceptives. Papaya seeds contain alkaloids, triterpenoids, saponins, and papain. Meanwhile, the gandarusa leaves contain flavonoids. These compounds have the function of antifertility for men. The purpose of this study was to determine the effect of papaya seeds (Carica papaya L.) ethanol extracts, gandarusa leaves (Justicia gendarussa Burm.f.), and its combination on motility, viability, and morphology of male mice spermatozoa (Mus musculus) most effective decrease concentration on motility, viability, and morphology of male mice spermatozoa (Mus musculus). This research was an experimental study. The samples of this study were 18 male mice with a body weight of 20-30 grams, aged 3-5 months, and were divided into six groups. The treatments given were control, papaya seed ethanol extract, gandarusa leaves ethanol extract, and its combinations to concentrations of P1 Na CMC1%, P2 (papaya seed 100mg/kgW), P3 (gandarusa leaf 50mg/kgW), P4 (papaya seed : gandarusa leaf 50:50 mg/kgW), P5 (papaya seed : gandarusa leaf  50:100 mg/ kgW), P6 (papaya seed : gandarusa leaf 100:50 mg/kgW). The extract was given for 35 days. On the 36th day, the mice were dissected to take their epididymis to observe the spermatozoa's quality (motility, viability, morphology). Those observations used a light microscope. Data were analyzed using one-way ANOVA and LSD post hoc tests. This study resulted differences in P1, P2, P3, P4, P5, and P6 towards motility, viability, and morphology of spermatozoa (p&lt; 0.05). The conclusion of this study showed that both single and combination ethanol extracts of papaya seeds and gandarusa leaves could reduce the motility, viability, and morphology of spermatozoa of male mice, and the effective dosage in reducing motility, viability, and morphology of spermatozoa is P3 gandarusa leaves 50mg/kgW.
Uji Aktivitas Formula Sediaan Masker Gel Peel Off Ekstrak Etanol Buah Patikala (Etlingera eatior (Jack) R.M Smith) terhadap Pertumbuhan Bakteri Penyebab Jerawat Abdul Wahid Suleman; Saparuddin latu; Andi Muh Yagkin Padjalangi; Jangga Jangga
Lumbung Farmasi: Jurnal Ilmu Kefarmasian Vol 5, No 1 (2024): Januari
Publisher : UNIVERSITAS MUHAMMADIYAH MATARAM

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31764/lf.v5i1.14011

Abstract

Buah Patikala memiliki senyawa flavonoid digunakan untuk menghambat mikroba. Tujuan penelitian untukmmengetahui ekstrak buahjpatikala dapat diformulasikan dalam masker peel off  yang secara fisika dan kimia serta untuk mengetahui seberapa  besar konsentrasi dari ekstrak buah patikala yang dapat menghambat bakteri penyebab jerawat. Jenis penelitian ini merupakan eksperimental meliputi evaluasi masker peel off secara fisik dan kimia serta pengujian aktivitas formula masker gel peel off ekstrak etanol buah patikala terhadap zona hambat pada bakteri penyebab jerawat yang terbagi mejadi 5 kelompok. Hasil penelitian menunjukkan bahwa ekstrak etanol buah patikala dapat diformulasikan serta stabil dalam bentuk sediaan masker gel peel off dan memiliki aktivitas antibakteri. Konsentrasi pada formula III merupakan konsentrasi yang memiliki aktivitas antibakteri paling optimal terhadap bakteri Propionibacterium acnes dengan luas zona hambat 9,91±0,18 mm. Konsentrasi pada formula III merupakan konsentrasi yang memiliki aktivitas antibakteri paling optimal terhadap bakteri Staphylococcus epidermidis dengan luas zona hambat 9,25±0,27mm.
Formulasi Sediaan Acne Patch Ekstrak Etanol Daun Coleus scutellarioides L. terhadap Propionibacterium acnes dan Staphylococcus epidermidis Abdul Wahid Suleman; Natasya Virginia; Nasrawati Basir; Sriyanty Sadsyam; Chikita Inaku; Nurfiddin Farid
Indonesian Journal of Medical and Pharmaceutical Science Vol. 5 No. 1 (2026)
Publisher : Sultan Agung Islamic University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30659/ijmps.v5i1.566

Abstract

Background: The increasing prevalence of acne vulgaris and the growing resistance of Propionibacterium acnes and Staphylococcus epidermidis to conventional antibiotics have encouraged the development of safer and more effective natural therapies. This study aimed to formulate and evaluate the physical stability of an acne patch containing ethanolic extract of miana leaves (Coleus scutellarioides L.) and to determine its antibacterial activity against P. acnes and S. epidermidis. Methods: Miana leaves were extracted by maceration using 96% ethanol and formulated into acne patches at concentrations of 0.5%, 1%, and 2% using hydroxypropyl methylcellulose (HPMC) as the film-forming polymer. The formulations were evaluated for organoleptic properties, weight uniformity, pH, thickness, moisture content, and stability through a cycling test. Antibacterial activity was assessed in vitro using the agar diffusion method. Results: All formulations exhibited acceptable physical characteristics and remained stable throughout the cycling test. Statistical analysis revealed significant differences in antibacterial activity among the formulations (p < 0.05). The inhibition zones increased proportionally with extract concentration, indicating a concentration-dependent antibacterial effect. The formulation containing 2% miana leaf extract demonstrated the highest antibacterial activity against both P. acnes and S. epidermidis and showed significantly greater inhibition than the lower concentrations (p < 0.05). Furthermore, this formulation maintained satisfactory physical stability and quality parameters. Conclusion: These findings indicate that the 2% miana leaf extract acne patch is the optimal formulation and has potential as a safe, stable, and effective natural anti-acne product.
Co-Authors A. Nurnadya Arna Andi Muh Yagkin Padjalangi Ardiansyah Habar Ayu Prihandari Besse Yuliana Chikita Inaku Chikita Inaku Farid, Nurfiddin Febrianty Kelmaskossu Herman, Sriyana Irwan Irwan Jangga M. Yogi Riyantama Isjoni Mahmudah, Rifa’atul Mansur Maria Fenesia Fangohoi Miftahul Jannah Muhammad Yusuf Muhammad Yusuf Mustamin, Sharnawati Mutmainnah Siradjuddin Nanik Sulistyani Nasrawati Basir Natasya Virginia Ni Wayan Kamariasih Ningsih Samsy Dhuha Nova Clarita Dama Nurhikmah Nurkhasanah Nurkhasanah Nurmala Sari Nurul Inayah Padjalangi, Andi Muhammad Yaqkin Patti, Seliana Pradila Pratiwi, Rizky Indah Putri, Hardyanti Eka Quthratunnada Ruslan Rizky Indah Pratiwi Rizky Indah Pratiwi, Rizky Indah Rusli Safaruddin Safaruddin Safaruddin Safaruddin Safaruddin, Safaruddin Saparuddin Latu Sari, Putri Indah Silvi Alfitri Sri Rahayu Putri Indra Sri Wahyuningsih Sri Wulan Rini Sriyanty Sadsyam Sriyanty Sadsyam Sulaiman Sulaiman Sulaiman Syamsidar Tahirah Hasan Tenri Ayu Adri Tri Handayani Ummu Kalsum Ummu Kalsum Wahyuni Wahyuni Yanti Puspitasari Yusuf, Muhammad Zahira, Saliza