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All Journal Public Health of Indonesia Jurnal Penelitian Pendidikan IPA (JPPIPA) JPSCR : Journal of Pharmaceutical Science and Clinical Research Jurnal Farmamedika (Pharmamedica Journal) Jurnal Ilmiah Farmasi Farmasyifa Lumbung Farmasi : Jurnal Ilmu Kefarmasian Jurnal Penelitian Farmasi dan Herbal Jurnal Ilmiah Jophus: Journal of Pharmacy UMUS Journal of Pharmaceutical and Health Research Jurnal Kesehatan Tambusai INPHARNMED Journal (Indonesian Pharmacy and Natural Medicine Journal) Proceedings Series on Health & Medical Sciences Medical Sains : Jurnal Ilmiah Kefarmasian Jurnal An-Najat: Jurnal Ilmu Farmasi dan Kesehatan Parapemikir Jurnal Ilmiah Farmasi CERATA Medical Sains : Jurnal Ilmiah Kefarmasian
Abdul Wahid Suleman
Universitas Megarezky
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Dentistry Education Environmental Science Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Nursing Physics Public Health Veterinary

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Phytochemical Constituents and Pharmacological Effects of Baeckea Frutescens: A Review Abdul Wahid Suleman; Nurkhasanah Mahfudh; Nanik Sulistyani
Jurnal Penelitian Pendidikan IPA Vol 11 No 12 (2025): December
Publisher : Postgraduate, University of Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jppipa.v11i12.13476

Abstract

Baeckea frutescens is a medicinal species widely used in traditional practices and known for its rich phytochemical diversity, yet its pharmacological profile remains fragmented across multiple studies. This systematic review aims to integrate current evidence on the phytochemical constituents and pharmacological activities of B. frutescens, focusing on anti-inflammatory, antimicrobial, antioxidant, anticancer, wound-healing, and insecticidal effects. A literature evaluation was conducted using previously compiled research comprising 16 studies from China, Indonesia, Malaysia, and Southeast Asia, covering chemical isolation, essential oil analysis, in vitro assays, in vivo experiments, and computational approaches. The results indicate that B. frutescens contains meroterpenoids, phloroglucinol derivatives, flavonoids, phenolics, and terpenes that collectively contribute to significant modulation of NF-κB, MAPK, TLR4–MyD88, and COX-related pathways. Essential oils and polar extracts exhibit broad antimicrobial and antioxidant activities, while cytotoxic and wound-healing assays demonstrate promising therapeutic potential. Insecticidal studies further highlight ecological relevance through antifeedant and repellent properties. Overall, the review confirms B. frutescens as a pharmacologically versatile species with strong prospects for drug discovery and functional applications. However, further mechanistic and in vivo investigations are needed to strengthen its translational value.
Effect of Papaya Seeds (Carica papaya) and Gandarusa Leaves (Justicia gendarussa) on the Spermatozoa Quality of Male Mice Jangga, Jangga; Suleman, Abdul Wahid; Latu, Saparuddin; Rini, Sri Wulan
JPSCR: Journal of Pharmaceutical Science and Clinical Research Vol 9, No 1 (2024)
Publisher : Universitas Sebelas Maret

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20961/jpscr.v9i1.69885

Abstract

Papaya seeds (Carica papaya L.) and gandarusa leaves (Justicia gendarussa Burm.f.) are considered medicinal plants that can be used as natural male contraceptives. Papaya seeds contain alkaloids, triterpenoids, saponins, and papain. Meanwhile, the gandarusa leaves contain flavonoids. These compounds have the function of antifertility for men. The purpose of this study was to determine the effect of papaya seeds (Carica papaya L.) ethanol extracts, gandarusa leaves (Justicia gendarussa Burm.f.), and its combination on motility, viability, and morphology of male mice spermatozoa (Mus musculus) most effective decrease concentration on motility, viability, and morphology of male mice spermatozoa (Mus musculus). This research was an experimental study. The samples of this study were 18 male mice with a body weight of 20-30 grams, aged 3-5 months, and were divided into six groups. The treatments given were control, papaya seed ethanol extract, gandarusa leaves ethanol extract, and its combinations to concentrations of P1 Na CMC1%, P2 (papaya seed 100mg/kgW), P3 (gandarusa leaf 50mg/kgW), P4 (papaya seed : gandarusa leaf 50:50 mg/kgW), P5 (papaya seed : gandarusa leaf  50:100 mg/ kgW), P6 (papaya seed : gandarusa leaf 100:50 mg/kgW). The extract was given for 35 days. On the 36th day, the mice were dissected to take their epididymis to observe the spermatozoa's quality (motility, viability, morphology). Those observations used a light microscope. Data were analyzed using one-way ANOVA and LSD post hoc tests. This study resulted differences in P1, P2, P3, P4, P5, and P6 towards motility, viability, and morphology of spermatozoa (p< 0.05). The conclusion of this study showed that both single and combination ethanol extracts of papaya seeds and gandarusa leaves could reduce the motility, viability, and morphology of spermatozoa of male mice, and the effective dosage in reducing motility, viability, and morphology of spermatozoa is P3 gandarusa leaves 50mg/kgW.
Co-Authors A. Nurnadya Arna Abda Abda Ardiansyah Habar Besse Yuliana Chikita Inaku Herman, Sriyana Indra, Sri Rahayu Putri Irwan Irwan Jangga Jangga, Jangga M. Yogi Riyantama Isjoni Mahmudah, Rifa’atul Mansur Maria Fenesia Fangohoi Miftahul Jannah Muhammad Yusuf Muhammad Yusuf Mustamin, Sharnawati Nanik Sulistyani Ni Wayan Kamariasih Ningsih Samsy Dhuha Nova Clarita Dama Nurhikmah Nurkhasanah Nurkhasanah Nurmala Sari Nurul Inayah Padjalangi, Andi Muh Yagkin Padjalangi, Andi Muhammad Yaqkin Patti, Seliana Pradila Pratiwi, Rizky Indah Prihandari, Ayu Putri, Hardyanti Eka Rini, Sri Wulan Rizky Indah Pratiwi Rizky Indah Pratiwi, Rizky Indah RR. Ella Evrita Hestiandari Rusli Safaruddin Safaruddin Safaruddin, Safaruddin Saparuddin Latu Sari, Putri Indah Siradjuddin, Mutmainnah Sri Wahyuningsih Sriyanty Sadsyam Syamsidar Tahirah Hasan Tenri Ayu Adri Tri Handayani Ummu Kalsum Wahyuni Wahyuni Yanti Puspitasari Yusuf, Muhammad Zahira, Saliza