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All Journal Public Health of Indonesia Jurnal Penelitian Pendidikan IPA (JPPIPA) JPSCR : Journal of Pharmaceutical Science and Clinical Research Jurnal Farmamedika (Pharmamedica Journal) Jurnal Ilmiah Farmasi Farmasyifa Lumbung Farmasi : Jurnal Ilmu Kefarmasian Jurnal Penelitian Farmasi dan Herbal Jurnal Ilmiah Jophus: Journal of Pharmacy UMUS Journal of Pharmaceutical and Health Research Jurnal Kesehatan Tambusai INPHARNMED Journal (Indonesian Pharmacy and Natural Medicine Journal) Proceedings Series on Health & Medical Sciences Medical Sains : Jurnal Ilmiah Kefarmasian Jurnal An-Najat: Jurnal Ilmu Farmasi dan Kesehatan Parapemikir Jurnal Ilmiah Farmasi CERATA Jurnal Sains, Teknologi dan Kesehatan Medical Sains : Jurnal Ilmiah Kefarmasian
Abdul Wahid Suleman
Universitas Megarezky
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Dentistry Education Engineering Environmental Science Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Nursing Physics Public Health Veterinary

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In vitro Evaluation of Anti-inflammatory Protein-Denaturation Activity of Cashew (Anacardium occidentale Linn) Stem Bark Using a UV–Vis Spectrophotometer Jangga; Wahyuningsih, Sri; Suleman, Abdul Wahid; Sulaiman
Jurnal Penelitian Pendidikan IPA Vol 11 No 10 (2025): October
Publisher : Postgraduate, University of Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jppipa.v11i10.13160

Abstract

Inflammation is a protective response of the body caused by tissue damage due to abnormal physical conditions, harmful chemical compounds, or microbiological agents. The protein denaturation method for anti-inflammatory testing aims to determine whether the ethyl acetate and ethanol–water fractions of cashew (Anacardium occidentale Linn) stem bark exhibit anti-inflammatory activity using the protein denaturation method, and to determine the IC₅₀ values of both fractions. The anti-inflammatory activities of the ethyl acetate and ethanol–water fractions, along with the positive control, were tested using a UV–Vis spectrophotometer at concentrations of 100 ppm, 200 ppm, 400 ppm, 800 ppm, and 1600 ppm. The results showed that the ethyl acetate fraction of cashew stem bark (Anacardium occidentale L.) had an IC₅₀ value of 531.74 µg/mL, the ethanol–water fraction had an IC₅₀ value of 101.31 µg/mL, and the positive control had an IC₅₀ value of –70.85 µg/mL. These findings indicate that the ethanol–water fraction exhibited moderate anti-inflammatory activity, while the ethyl acetate fraction showed weak activity.
Co-Authors A. Nurnadya Arna Ardiansyah Habar Besse Yuliana Chikita Inaku Herman, Sriyana Jangga Jangga, Jangga Mahmudah, Rifa’atul Mansur Maria Fenesia Fangohoi Miftahul Jannah Muhammad Yusuf Mustamin, Sharnawati Najamuddin, Mirfaidah Ni Wayan Kamariasih Ningsih Samsy Dhuha Nova Clarita Dama Nurhikmah Nurmala Sari Nurul Inayah Padjalangi, Andi Muh Yagkin Padjalangi, Andi Muhammad Yaqkin Patti, Seliana Pradila Pratiwi, Elzha Meilya Pratiwi, Rizky Indah Prihandari, Ayu Putri, Hardyanti Eka Rizky Indah Pratiwi Rizky Indah Pratiwi, Rizky Indah RR. Ella Evrita Hestiandari Rusli Safaruddin Safaruddin Safaruddin, Safaruddin Saparuddin Latu Sari, Putri Indah Siradjuddin, Mutmainnah Sri Wahyuningsih Sri Wahyuningsih Sri Wulan Rini Sriyanty Sadsyam Sulaiman Syamsidar Tahirah Hasan Tenri Ayu Adri Tri Handayani Ummu Kalsum Wahid, Hilmiati Wahyuni Wahyuni Yanti Puspitasari Yusuf, Muhammad Zahira, Saliza