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All Journal SAINS MEDIKA : JURNAL KEDOKTERAN DAN KESEHATAN Jurnal Ilmiah Farmasi Media Farmasi : Jurnal Ilmu Farmasi (Journal Of Pharmaceutical Science) Jurnal Ilmu Farmasi dan Farmasi Klinik (Journal of Pharmaceutical Science and Clinical Pharmacy) Majalah Obat Tradisional INDONESIAN JOURNAL OF PHARMACY Pharmascience Majalah Farmaseutik PHARMACY: Jurnal Farmasi Indonesia (Pharmaceutical Journal of Indonesia) Jurnal Farmasi Indonesia JFIOnline CERATA Jurnal Ilmu Farmasi Jurnal Ilmiah Cendekia Eksakta Jurnal Inovasi Teknik Kimia Indonesia Natural Research Pharmaceutical Journal (INRPJ) Infokes : Jurnal Ilmiah Rekam Medis dan Informasi Kesehatan Media Farmasi Indonesia
Mimiek Murrukmihadi
Department Of Pharmaceutical, Faculty Of Pharmacy, Universitas Gadjah Mada Sekip Utara Yogyakarta 55281
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Health Professions Immunology & microbiology Materials Science & Nanotechnology Mechanical Engineering Medicine & Pharmacology Nursing Public Health Veterinary Other

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FORMULASI DAN EVALUASI FISIK SEDIAAN EMULGEL MINYAK KAYU MANIS (Cinnamomum zeylanicum) DAN EFEKTIVITAS SEDIAAN SEBAGAI ANTIFUNGI Candida albicans Wibowo, Danang Novianto; Rahmawati, Nur Laili; Murrukmihadi, Mimiek
CENDEKIA EKSAKTA Vol. 6 No. 2 (2021)
Publisher : Universitas Wahid Hasyim

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31942/ce.v6i2.5529

Abstract

Minyak kayu manis (Cinnamomum zeylanicum) mengandung sinamaldehid dan eugenol sebagai antifungi Candida albicans untuk mengobati kandidiasis oral. Penelitian ini bertujuan untuk mengetahui pengaruh konsentrasi minyak kayu manis terhadap sifat fisik dan aktivitas antifungi Candida albicans dalam emulgel. Minyak kayu manis (Cinnamomum zeylanicum) diformulasikan dalam bentuk emulgel dengan varian konsentrasi F1: 1%, F2: 3%, F3: 5%, F4: 7%, F5: 9%. Formula tersebut diuji sifat fisik dan aktivitas antifungi terhadap Candida albicans menggunakan metode sumuran. Data organoleptis, homogenitas dianalisis secara deskriptif. Viskositas, pH, daya sebar, daya lekat dianalisis dengan korelasi regresi linear. Data diameter daerah hambat dianalisis dengan statistik Kruskall Wallis dilanjutkan Mann Whitney dengan taraf kepercayaan 95%. Kelima formula berwarna putih pekat, bau khas kayu manis, rasa manis khas kayu manis, bentuk semi padat dan homogen. Peningkatan konsentrasi minyak kayu manis meningkatkan pH, viskositas, daya lekat tapi menurunkan daya sebar. Peningkatan konsentrasi minyak kayu manis dalam emulgel mempunyai pengaruh perbedaan yang signifikan terhadap aktivitas antifungi Candida albicans dan minyak kayu manis 5% dalam emulgel mempunyai aktivitas antifungi Candida albicans setara dengan kontrol positif. Nilai diameter daerah hambat yang diperoleh yaitu F1: 12,71 mm, F2: 20,06 mm, F3: 22,11 mm, F4: 22,52 mm, dan F5: 24,37 mm.Kata kunci: emulgel, kayu manis (Cinnamomum zeylanicum), Candida albicans.
The Influence of Polyvinyl Pyrrolidone (PVP) on Piroxicam Absorption with Everted Intestinal SAC Method Prihapsara, Fea; Artanti, Anif Nur; Murrukmihadi, Mimiek
Media Farmasi: Jurnal Ilmu Farmasi Vol. 12 No. 1: Maret 2015
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.12928/mf.v12i1.3028

Abstract

Oral drug absorption was highly influenced by dissolution rate, especially for poorly and insoluble drugs. Piroxicam is a nonsteroidal anti-inflammatory drug that is practically insoluble in water. The oral absorption rate of piroxicam is dependent on its dissolution rate in the GI tract. Polyvinyl Pyrrolidone (PVP) as surfactant can increase drug solubility by means of a micelle forming mechanism. The aim of the study was to know the influence of addition and variation of Polyvinyl Pyrrolidone (PVP) on Piroxicam absorption with everted intestinal sac method.  The  concentration of piroxicam solution was prepared by PVP in  1.0,2.0 and 3.0 % respectively. Crane and Wilson tube containing 75 ml of themucosal fluid was taken at 37 0 C in waterbath. Than, serosal solution of 1.5 mlwas added to intestinal sac by turned upside down and tied to a cannula, then put into the tube containing the mucosal fluid and constantly flowing oxygen gas.Serosal solution of 1 ml were taken every 15 minutes and then diluted with 2 ml of Ba (OH) 2 and 2 ml of ZnSO4 then centrifuge until 25 minute. The absorbant of supernatant was measured by UV spectrophotometer and data analyse wascalculated by one-way ANAVA.  PVP at 1%,2% and 3% increased piroxicamabsorption from the phosphate buffer pH 7.5 compared with negative control.According to P app , the values were 2.52 ± 0.43 cm/minute (negative control), 3.41 ± 2.17 cm/minute (1% PVP), 2.75± 1.14 cm/minute (2% PVP) and 4.77 ± 4.93 cm/minute (3% PVP) respectively. In conclusion. Lower doses of the surfactant (1%, 2%, and 3% PVP) significantly increased absorption of the drug by altering the membrane permeability.  
Co-Authors Ami Afiyati Ami Afiyati, Ami Ana Indrayati Anif Nur Artanti, Anif Nur Aprianto Aprianto Aris Perdana Kusuma Desti Wibowo Dewi Andini K.M. Dewi Andini Kunti Mulangsri, Dewi Andini Kunti Diana Cholida Dias Anita Fajarini Dias Anita Fajarini, Dias Anita Dinar Hesti Permatasari Dinar Hesti Permatasari, Dinar Hesti Elya Zulfa Eni Muaniqoh Fea Prihapsara Fea Prihapsara, Fea Hanum Pramuji Afianti Herman Widjaja Iswandi - Kurniati Pamungkas Kurniati Pamungkas, Kurniati Lutfi Chabib, Lutfi Marchaban . Marchaban Marchaban Marchaban Marchaban Marchaban Marchaban, Marchaban Marchaban, . Marchaban, . Marlyn Dian Laksitorini Mualifah Rifiani Ela Rosita Mutmainah Mutmainah3 Naniek Widyaningrum Nur Laili Nurhayati Nurul Nurul Hidayati PRAISELA RIZDHANIA Prihapsara, Fea Rahmawati, Nur Laili Rani Dewi Pratiwi Rizka Ariani Rizki Ananda Rizki Fajar Roni Ferdian Siti Aisiyah Sri Mulyani Subagus Wahyuono Subagus Wahyuono Subagus Wahyuono Subagus Wahyuono Sudibyo Martono Sudibyo Martono Sudibyo Martono Sudibyo Martono Sugiyono - Sutrisna Khaidir Suwarmi Suwarmi Syarifatun Karunia Ekawati Tegar Bagus Prasetyo Teuku Nanda Saifullah Teuku Nanda Saifullah Tiar Rizki Hayu Tri Utami Handayani Veronica Intani Suherndra Wahyuni Watora Wibowo, Danang Novianto Yogaswara Tawang Gumbara Zein, Halimatus Sa' diyyah