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All Journal Journal of Food and Pharmaceutical Science EKSAKTA: Journal of Sciences and Data Analysis Jurnal Tumbuhan Obat Indonesia Majalah Obat Tradisional INDONESIAN JOURNAL OF PHARMACY Dental Journal (Majalah Kedokteran Gigi) Majalah Farmaseutik Proceeding Biology Education Conference Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Journal of Pharmaceutical and Sciences. Journal of Food and Pharmaceutical Sciences Borneo Journal of Pharmacy
Yosi Bayu Murti
Department Of Pharmaceutical Biology, Faculty Of Pharmacy, Universitas Gadjah Mada, Yogyakarta, Indonesia
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Dentistry Earth & Planetary Sciences Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Neuroscience Nursing Public Health

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Journal : Proceeding Biology Education Conference

 1 
Identifikasi Senyawa Curcumin, Bisdemethoxycurcumin dan Demethoxycurcumin Rimpang Curcuma xanthorrhiza Roxb. dan Curcuma longa L. dengan 1H NMR Erwin Nur Indiarto; Tri Rini Nuringtyas; Yekti Asih Purwestri; Respati Tri Swasono; Yosi Bayu Murti
Proceeding Biology Education Conference: Biology, Science, Enviromental, and Learning Vol 15, No 1 (2018): Proceeding Biology Education Conference
Publisher : Universitas Sebelas Maret

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Abstract

Curcumin and its derivates (Bisdemethoxycurcumin, Demethoxycurcumin) are natural dyes found in Curcuma xanthorrhiza dan Curcuma longa. Parmacologic evidence suggests all three are antioxidant, antiinflamatory, and anticancer. The objective of this research was to identify and measure the intensity of Curcumin compounds, Bisdemethoxycurcumin, and Demethoxycurcumin rhizome C. xanthorrhiza and C. longa by using 1H NMR spectra. Rhizome C.xanthorrhiza and C. longa collected from Wonogiri, Central Java. The rhizomes were dried in the oven at 40 °C and were powdered using a blender. The dried powder sample was extracted using methanol-d4  containing 0.01% TMSP and followed by ultrasonication for 15 minutes. The supernatant was separated from the solution by 10.000 rpm centrifugation for 10 minutes. The supernatant was transferred to NMR tube and analysed by using JEOL 500 MHz NMR. The obtained data were analysed by Mnova 12 software and Simca 14. Results of comparsion of 1H NMR spectra of both rhizomes with reference were identified Curcumin, Bisdemethoxycurcumin, Demethoxycurcumin compounds. The highest intensity all of three compound was found in Curcuma longa and with One way Anova test result obtained p<0,05. The two rhizomes show a good separation on the OPLS-DA scoreplot with Q2 82,1% indicating a good model. The study showed that Curcumin, Bisdemethoxycurcumin, Demethoxycurcumin compounds were found in both rhizomes and had different intensity
Co-Authors Agung Endro Nugroho Akhmad Kharis Nugroho Damiana Nitya Kanistri Damiana Nitya Kanistri Desi Riza Pratiwi Dewi Setyaningsih Dian Mayasari Dina Aryani Dina Aryani, Dina Dyaningtyas Dewi Putri Pamungkas Ema Damayanti Enade Perdana Istyastono Erwin Nur Indiarto Gani, Andayana Puspitasari Hari Purnomo Harsini Harsini Hidayat, Lalu Husnul Illian, Didi Nurhadi Indah Purwantini Indrawan Kurnia Dwinatari Indrawan Kurnia Dwinatari, Indrawan Kurnia Izatunnafis, Izatunnafis Kuswandi Kuswandi Kuswandi Kuswandi Lalita Lisprayatna Lalita Lisprayatna, Lalita Mahfud Alkarim Mahfud Alkarim, Mahfud mufrod mufrod Mufrod Mufrod Muhammad Radifar Mutiara Annisa Nunung Yuniarti Priyasana, I Putu Rafika Sari Rahmawati, Arini Nur Yunia Puspitaningrum Ramadhani, Novia Putri Ratih Anggar Kusumaningtyas Respati Tri Swasono Retno Murwanti Riski, Akhmad Ropiqa, Meri Sanan, Antonius Oenunu Santoso, Bilal Subchan Agus Sekararum Diah Kartikasari Sekararum Diah Kartikasari, Sekararum Diah Shanti Listyawati Sindu Nuranto Sisca Devi Sisca Devi Sismindari Sismindari Siswanto, Soni Siti Sunarintyas Sofa Farida Sofia Mubarika Haryana Sri Budi Barunawati Sudarmanto, B.S. Ari Sudarsono Sudarsono Sudarsono, Sudarsono Suparyono Saleh Sylvia Utami Tunjung Pratiwi T. Nanda Saifullah Sulaiman T. Nanda Saifullah Sulaiman, T. Nanda Saifullah Tamhid, Hady Anshory Tatang Irianti Tivanie, Riza Ayu TN. Saifullah Sulaiman TN. Saifullah Sulaiman, TN. Saifullah Tri Rini Nuringtyas Triana Hertiani Wayan Tunas Artama Yekti Asih Purwestri