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All Journal Jurnal Kedokteran Brawijaya e-Journal Pustaka Kesehatan Dentika Dental Journal Jurnal Pangan dan Agroindustri STOMATOGNATIC- Jurnal Kedokteran Gigi ODONTO Dental Journal Insisiva Dental Journal : Majalah Kedokteran Gigi Insisiva UNEJ e-Proceeding Dental Journal (Majalah Kedokteran Gigi) Jurnal Kedokteran Gigi Universitas Padjadjaran Padjadjaran Journal of Dentistry Journal of Dentomaxillofacial Science Jurnal Kesehatan Komunitas Warta Pengabdian Padjadjaran Journal of Dental Researchers and Students Jurnal Material Kedokteran Gigi Indonesian Journal of Life Sciences Odonto dental journal Jurnal Penelitian The Indonesian Journal of Health Science
Zahreni Hamzah
Bagian Biomedik, Fakultas Kedokteran Gigi, Universitas Jember, Indonesia
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Dentistry Education Health Professions Immunology & microbiology Library & Information Science Materials Science & Nanotechnology Medicine & Pharmacology Nursing Public Health

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Journal : UNEJ e-Proceeding

 1 
THE PROGRESSIVE LOW CHRONIC INFLAMMATION ON ORAL TISSUES IN ELDERLY Zahreni Hamzah; Dyah Indartin; Zahara Meilawaty
UNEJ e-Proceeding Proceeding of 1st International Conference on Medicine and Health Sciences (ICMHS)
Publisher : UPT Penerbitan Universitas Jember

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Aging is a normal process, as inevitable biologicalphenomenon. Generally, this process characterizedby a decrease in the ability of resolution,regeneration, and reparation of cell and tissues, So,those cells and tissues cannot function properly andits will grow up and die.(1) WHO reports that thepopulation of elderly people worldwide increases by1.7% annually, whereas the population of peopleaged ≥ 65 years old increases by 2.5%. WHOclassified the elderly based on their chronologic/biologic state in 4 groups: (1) the middle age ranged45-59 years old, (2) the older/elderly age ranged 60-74 years old, (3) the advanced old age ranged 75-90years old, and (4) the very old age over 90 years old.Generally, elders ≥ 65 years old have healthproblems as effects of aging process. That meansthey need to have a special concern about theirhealth condition include in dental care.(2,3)Low, systemic and progressive chronic inflammationin elderly age is called inflammaging. This conditioncan occur as the effects of injury on cells andtissues.(4,5) There are some factors that cause injuryon cells, such as; hypoxia, chemical materials (toxins,drugs), physical agents (mechanical trauma,temperature, sudden changes in atmosphericpressure, radiation, electrical potency), microbiologyagents (virus, microbes, fungi), immune systemdisorder, genetic disorder, or malnutrition. Whenthe cells got injuries, there are some possibilityreactions on cells and tissues, e.g. retrogressivereaction, progressive reaction; and adaptationreaction. The main cause and the response towardsinflammaging that linked to illness are stillunknown.(6)
[RETRACTED] IMPACT PSYCHOLOGICAL AND PSYCHO-PHYSICAL WORK DISTRESS ON TOOTH MOBILITY IN RAT MODEL (ARTICLE RETRACTED FROM IBSC PROCEEDING) Zahreni Hamzah; Suhartono Taat Putra; Elyana Asnar STP
UNEJ e-Proceeding 2016: Proceeding The 1st International Basic Science Conference
Publisher : UPT Penerbitan Universitas Jember

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Retracted under author request.
ROLE OF CHEMOATTRACTANT CHEMOKINE (SDF-1/CXCR4) IN BONE MARROW NICHE Dyah Indartin Setyowati; Zahreni Hamzah
UNEJ e-Proceeding Proceeding of 1st International Conference on Medicine and Health Sciences (ICMHS)
Publisher : UPT Penerbitan Universitas Jember

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Bone marrow is the pioneer for studying stem cells.The basic concept of stem cells obtained by studyinghematopoietic stem cells. Although how theinteraction of HSCs with the local environmentnecessary for the maintenance of stem cells can notbe fully explained ( Compston, 2002; Iwasaki andSuda., 2010). Studies of HSCs aims to study thehabits of these cells in a population of cellscontained in bone marrow . So far little is knownabout the interaction of the bone marrow niche. Thestudy was conducted using a culture system thatlimited done in a sustainable way to prove theinteraction of the bone marrow niche. From theseresults can then be identified subset of osteoblasts (N-Cadherin + CD 45-) that physically attaches to theHSCs in the BM . ( Tong Yin , 2006)Bone marrow consist of hematopoietic cells arewrapped by the bone structure. Hematopoietic cellsdevelop in the bone cavity and retained in the bonemarrow until they have matured, then released intothe vascular system ( Yin and Li , 2006). Most cells ofhaemopoietic can be found next to the endostealsurface of the bone, which layer is primarilyosteoblasts. Osteoblasts is one type of bone cell thatserves to reform or bone formation. HSCs are stemcells that are known to differentiate into osteoclasts.Osteoclasts are the cells of bone that serves to boneresorption. Their physical proximity betweenosteoblasts and which HSCs are parent cellsosteoclasts, as well as the identification of N -Cadherin / β - Catenin adherent complex betweenthe two prove their relationship or communicationbetween these cells. Osteoblast cells not only play arole in bone formation, but as osteoblast niche inthe bone marrow also, contribute to themaintenance of HSCs that are stem cells osteoclasts(Yin and Li , 2006 ; Tong Yin , 2006 ).There are two main types of stem cells areembryonic and adult stem cells . Pluripotentembryonic stem cells derived from the inner cellmass of blastocysts and has the ability to be a threeembryonic germ layers , namely ectoderm ,endoderm , and mesoderm (Li and Xie , 2005). Atbirth, adult stem cells including GSCs and SSCs willoccupy and live in a special microenvironment,called a niche (Li and Sie., 2005)Niche is different depending on the type of tissue ororgan. Structurally niche supported by the cells andtheir interactions molecular signals that preparedand provided to form a microenvironment for stemcells. Niche hypothesis has actually been describedby Scofield in 1978 ( Li and Sie , 2005; Yin and Li ,2006) . Stem cell niche is supported by manysignaling and adhesion molecules involved in theinteraction of the stem cell niche, accounted diversecharacteristics for each niche function ( figure 1 )that is; SDF -1/CXCR4 , SCF/c - Kit, Jagged/Notch,angiopoietin-1/ Tie2 ( Ang-1/Tie2 ), and Ca2 + -sensing receptor ( Yin and Li, 2006). Most studiesconducted to know and understand the molecularmechanisms of interaction and behavior of stemcells. Understanding the interaction and behavior ofstem cells in the bone marrow niche is veryimportant to understand the eventsosteoclastogenesis, especially how osteoclastprecursor cells can be recruited from niche thenmobile until homing (Kollet et al , 2007). Research isusually conducted in diseases associated with theaccumulation of osteoclasts or osteoclast progenitorcells that causes pathological osteolysis , such as ;benign bone tumors and bone metastases cancer (Kollet et al , 2007; Jennifer , 2009).
ROLE OF REACTIVE OXYGEN SPECIES ON DEVELOPMENTS OF OSTEOCLASTOGENESIS IN AGING Dyah Indartin Setyowati; Zahreni Hamzah; Zahara Meilawaty
UNEJ e-Proceeding 2016: Proceeding The 1st International Basic Science Conference
Publisher : UPT Penerbitan Universitas Jember

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Osteogenesis is a process of development which is perfectly controlled by a number of extrinsic and instrinsic factors that consists of hormones, growth factors, cytokines produced in the bone marrow micro environment, due to process of molecules adhesion that mediate by the interaction of cells and cell-matrix, osteoblasts-specific signaling proteins and transcription factors (TFs). Recently, research explained that adherence osteoclasts on the bone surface and secretion of protons into an extracellular compartment between osteoclasts and bone surface together with the production of Reactive Oxygen Species (ROS) involved in the complex process of bone resorption. Superoxide role in the activation and transcription NF-κB factor is to increase osteoclastogenesis. Furthermore, it is alleged that ROS is involved in both differentiation of osteoclasts and osteoblast cell. Aging and diseases which associated with aging is a result of ROS that cause damage was reported increase with age. This review, which is dedicated to geriatric physicians, geriatric dentistry or gerodontology reviews ROS-related osteoclastogenesis in aging and as the basic of the research to determine benefit of ROS through NADPH oxidase activation in the osteopetrotic case.
COLLABORATION OF NURSES AND DENTISTS TO IMPROVING THE ORAL HEALTH OF THE ELDERLY Zahreni Hamzah; Nadia Kartikasari; Kushariyadi Kushariyadi
UNEJ e-Proceeding 2023: 5th International Agronursing Conference (5th IANC) In Conjunction with 1st International Post
Publisher : UPT Penerbitan Universitas Jember

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Background: The population aged 60 years and over will increase from year to year. Aging does not have to be followed by various diseases if assistance or treatment is done properly and correctly. Currently, dental and oral health has been established as an important risk factor that can cause disease in all body. Aims: The purpose of this article is analyzing the collaboration between dentists and nurses in the elderly community to prevent the emergence of increasingly widespread disease in the elderly. Methods: The search strategy for English and Indonesian studies relevant to the topic was carried out using the ScienceDirect, PubMed, Google Scholar, and Garuda databases limited from 2015 to 2020. The keywords used were “collaboration”, “dentist”, “elderly”, “nurse”. Full text articles were reviewed to select studies that fit the criteria. Inclusion criteria include: many factors could be collaborated in an integrated manner between dentists and nurses for the elderly in order to the elderly could maintain their health. Results: The search results obtained 21 articles. The main principles of collaboration between dentists and nurses that must be fulfilled to maintain the health of the elderly, by a holistic approach accompanied by guidelines, work procedures and management in an integrated manner, such as psychological factors, being friendly, communicating well, suggesting dental care for the elderly according to the indications (advice on the correct way of brushing teeth twice a day and periodical control, cleaning plaque-food residue, wearing dentures, removing calculus) so as not to cause more serious disturbances, digestive disorders, as well as early recognition of abnormalities that may occur in the oral cavity. Conclusions: Collaboration of nurses and dentists in the elderly community can expect to increase the knowledge of the elderly about dental and oral health, which is important to maintain their all health forever.
Co-Authors Adji , Novan Krisno Agustin Wulan Suci Dharmayanti Amandia Dewi Permana Shita Amandia Dewi Permana Shita Ari Tri Wanodyo Ari Tri Wanodyo Handayani Ari Tri Wanodyo Handayani Ari Tri Wanodyo Handayani Arina, Yuliana Mahdiyah Daat Ary TW. Handayani Asyifa Af Ida Haffiz Banun Kusumawardani Daat Arin, Yuliana Mahdiyah Debi Suntari Dessy Rachmawati Didin Erma Indahyani Dominica Diana Siswadi Dwi Prijatmoko Dwi Saputro, Agung Erdiyanto Anindito Dwi Warna Aju Fatmawati Dwita Aryadina Rachmawati Dyah I. Setyowati Dyah Indartin Dyah Indartin Setyowati Dyah Indartin Setyowati Dyah Indartin Setyowati Elfrida M. Agustina Elyana Asnar STP Elyda Akhya Afida Misrohmasari Endang Joewarini Erfin Ramadana Pratama Erna Sulistyani Fitria Nurhabiba Agustine Hafizh, Cinantya Handayani, Ari T.W. Happy Harmono Heru Ernanda Hosea Ferdinan Ida Bagus Narmada Izzata Barid Jevina Sicilia Ahliawan kristianningrum dian Kristianningrum Dian Sofiana Kushariyadi Kushariyadi Kusumadewi, Jihan Tahira Lisa Wahyu Zelda Federika Lutfi Meiga Sari Mala Hayati Mei Syafriadi Melok Aris Wahyukundari, Melok Aris Nadia Kartikasari Ni Made Widia Sasmita Indraswari Niken Probosari Paramudibta Lungit Kuncaraningtyas Piramida, Delyta Prasetyo , Aris Pratama, Armando Hayden Maghriza Prihatiningrum, Berlian Pudji Astuti Pujiana Endah Lestari Purwandhono , Azham Rizki Fitriani, Atmim Rizky Purboningtyas Rondhianto Rondhianto Rothschildi, Dhesyarmani Putri Sari Setyaningsih Setyaningsih, Sari Suhartini Suhartini Suhartini Suhartini Suhartini Suhartini Suhartini Suhartono Taat Putra Swasthi Prasetyarini Tantin Ermawati Tecky Indriana Zahara Meilawati Zahara Meilawaty Zainul Cholid