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All Journal Folia Medica Indonesiana Dental Journal (Majalah Kedokteran Gigi) The Indonesian Biomedical Journal Jurnal Manajemen Kesehatan Yayasan RS.Dr. Soetomo Jurnal Media Analis Kesehatan YARSI Medical Journal INDONESIAN JOURNAL OF MEDICAL LABORATORY SCIENCE AND TECHNOLOGY Biomolecular and Health Science Journal JUXTA: Jurnal Ilmiah Mahasiswa Kedokteran Universitas Airlangga Indian Journal of Forensic Medicine & Toxicology Berkala Penelitian Hayati

Harianto Notopuro

Department Of Biochemistry, School Of Medicine And Tropical Disease Centre Airlangga University, Surabaya.

Author-ID : 331862

Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Dentistry Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Neuroscience Public Health Social Sciences Other

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EFEK MULTI STRAIN PROBIOTIK TERHADAP KADAR LDL-C Rattus norvegicus HIPERLIPIDEMIA Kadeq Novita Prajawanti; Jusak Nugraha; Harianto Notopuro; Amellya Octifani; Yohanes Adrian Kapri Negara
Jurnal Media Analis Kesehatan Vol 14, No 1 (2023): JURNAL MEDIA ANALIS KESEHATAN
Publisher : Poltekkes Kemenkes Pakassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32382/mak.v14i1.3256

Hyperlipidemia is an increase in one or more plasma lipids and the main cause is related to the pattern of food intake. Among the many intestinal microbes, Lactobacillus, Bifidobacterium have been shown to affect the host beneficially by improving the intestinal microbial balance and are therefore categorized as probiotics. The aim of this study was to determine the effect of multi-strain probiotics Lactobacillus rhamnosus and Bifidobacterium bifidum on reducing LDL-C in rat fed HFD 1% per body weight. This True Experimental Research with Pretest-Posttest Design used Rattus norvegicus which was divided into 5 groups each K- (standard feed + tap water), K+ (HFD without probiotics), P1 (HFD + 2mL probiotics), P2 (HFD + 2 .5mL probiotics) and P3 (HFD + 3mL probiotics). The results of the LSD test for LDL cholesterol levels after administration of probiotics, the group that had a significantly different value was in the K- to K+ group with p=0.00; K+ to P1, P2 and P3 with p 0.00 each. Meanwhile, among the treatment groups that were given probiotics, only the P2 to P3 groups showed a significant difference with a p value = 0.037.

Pengaruh Perbedaan Konsentrasi Lactobacillus plantarum Terhadap Perubahan Kadar Kolesterol Total Pada Tikus Putih Widajati, Rahma; Aryati, Aryati; Notopuro, Harianto
Jurnal Manajemen Kesehatan Yayasan RS.Dr. Soetomo Vol 6, No 1 (2020): JMK Yayasan RS.Dr.Soetomo, Pertama 2020
Publisher : STIKES Yayasan RS.Dr.Soetomo

Kebiasaan mengkonsumsi makanan yang mengandung lemak dan gula tinggi akan menyebabkan obesitas, yang pada akhirnya akan menimbulkan sindrom metabolik. Desain penelitian ini menggunakan rancangan penelitian post test only control group, dengan menggunakan sampel rattus norvegicus galur wistar berwarna putih, berjenis kelamin jantan, dewasa berusia 3-4 bulan, dengan berat badan 150-200 gram, dan dengan kondisi fisik sehat yang digunakan sebagai hewan model kolesterol tinggi dengan diberi pakan tinggi lemak, yang kemudian diberi bakteri probiotik Lactobacillus plantarum. Variabel bebas pada penelitian ini adalah Lactobacillus plantarum, sedangkan variabel tergantung adalah kadar kolesterol total dan kolesterol LDL. Pemeriksaan kadar kolesterol total dan kolesterol LDL dengan metode enzimatik kolorimetri dengan prinsip COD-PAP dilakukan pada akhir penelitian. Tujuan penelitian ini adalah untuk mengetahui dosis optimum probiotik yang dapat menurunkan kadar kolesterol tinggi dalam darah. Analisis data menggunakan one way Anova, dimana hasil yang didapat menunjukkan tidak adanya perbedaan yang signifikan pada pemberian bakteri Lactobacillus plantarum dengan konsentrasi 5x10⁸CFU dibandingkan konsentrasi 5x10⁹CFU. Oleh karena itu, pemberian Lactobacillus plantarum dengan konsentrasi sebesar 5x10⁸CFU merupakan dosis optimum yang dapat menurunkan kadar total kolesterol dan LDL kolesterol dalam darah.Kata kunci: Diet Tinggi Lemak, Tikus Putih, Kolesterol Tinggi, Lactobacillus plantarum; Kadar Kolesterol Total.

Effects of Golden Sea Cucumber Extract (Stichopus Hermanii) on Fasting Blood Glucose, Plasma Insulin, and MDA Level of Male Rats (Rattus Norvegicus) Induced with Streptozotocin Prawitasari, Dita Sukmaya; Safitri, Indri; Notopuro, Harianto
Folia Medica Indonesiana Vol. 55 No. 2 (2019): June
Publisher : Universitas Airlangga

Diabetes mellitus (DM) is one of disease that its incidence increases every year worldwide. The condition of DM can cause various complications caused by oxidative stress. Stichopus hermanii (SH) or golden sea cucumber extract contains antioxidant compounds that have been proven to reduce oxidative stress conditions. The purpose of this study was to investigate the effect of Stichopus hermanii extract on condition of diabetes mellitus by looking at changes in fasting blood glucose, plasma insulin, and malondialdehyde levels in animal models of Wistar rats. This study was a laboratory experimental study using Randomized Control Trial Design with Post-test only control group design. Thirty-five male Wistar rats divided into five groups, i.e normal control group, positive control, negative control and two treatment groups with SH extract dose 8.5 and 17 mg / kgBW for 14 days once daily after induction of Streptozotocin at the Biochemistry Laboratory of the Faculty of Medicine, Airlangga University. Fasting blood glucose level was measured by a glucometer, plasma insulin measured by ELISA and MDA level was measured by a spectrophotometer. Data were analyzed statistically by using One Way ANOVA test and Kruskal Wallis. There were significant results of SH extract can reduce fasting blood glucose (Kruskal Wallis, p=0.030) and MDA (Kruskal Wallis, p=0.042) but not in plasma insulin (ANOVA, p=0.130). The lowest MDA level occurs in the K4 group that given SH extract dose 17 mg/kg BW than another experimental group. As the conclusion, this study showed SH extract can decrease fasting blood glucose and oxidative stress in diabetic-induced rats.

Effect of Ethanol Extract of Mangosteen Peel on Serum Malondialdehyde and Leukotriene B4 Levels in Male White Rats (Rattus norvegicus) Wistar Strain Exposed with Electric Cigarette Smoke Santoso, Jemima Lewi; Notopuro, Harianto; Qurnianingsih, Ema
Folia Medica Indonesiana Vol. 56 No. 4 (2020): December
Publisher : Universitas Airlangga

This study aims to analyze the administration of mangosteen peel ethanol extract at different doses can reduce levels of malondialdehyde (MDA) and leukotriene B4 (LTB4) serum in male white rats (Rattus norvegicus) Wistar strains exposed to electric cigarette smoke. Electric cigarette induces mitochondrial ROS production and triggers oxidative stress. Antioxidants are needed by the body if there are many free radicals, for example mangosteen peel. This laboratory experimental study uses a randomized post test only control group design. Thirty male white rats were divided into 5 groups randomly (KK, KR, P1, P2, P3). KK given 0.5% Na-CMC, KR given smoke and 0.5% Na-CMC, P1, P2, P3 given smoke and mangosteen peel ethanol extract 100, 200, 300 mg / kg weight. Data were tested for normality and homogeneity tests. Data distribution was found not normal. Data were tested by Kruskal-Wallis Test and Mann-Whitney. Kruskal-Wallis Test results showed significant differences in MDA and LTB4 levels in each experimental group (KS, KR, P1, P2 and P3), p <0.05. Mann-Whitney test results showed a significant difference in the MDA levels of the KR against P3 and in the LTB4 level of the KR against P2 (p <0.05). The conclusion of the study was the administration of mangosteen peel ethanol extract can reduce MDA and LTB4 levels serum in male white rats (Rattus norvegicus) Wistar strains exposed to electric cigarette smoke.

Co-Authors A Kentjono, Widodo Amellya Octifani Aryati Aryati Awalia Ayesie Natasha Zulka B Notopuro, Paulus Bakhtiar, Arief Chiquita Prahasanti Choirotussanijjah Djajadiman Gatot Ely Rahmatika Nugrahani Endy Novryan Ridwan Ginanjar Sasmito Adi Humairah, Ira I Dewa Gede Ugrasena Indri Safitri Indri Safitri, Indri Jemima Lewi Santoso Joewono Soeroso Juliana Christyaningsih Jusak Nugraha Kadeq Novita Prajawanti Lukitasari, Lina Martono Tri Utomo Mutiarawati, Diah Titik Ponpon Idjradinata Prabowo, Gwenny Ichsan Prawitasari, Dita Sukmaya Purwanta, Marijam Qurnianingsih, Ema Retno Handajani S.Pd. M Kes I Ketut Sudiana . Siti Khaerunnisa SOETJIPTO . Sudarmo, Subijanto Marto Susi Wahyuning Asih Suwandito Suwandito Syafa’ah, Irmi Widajati, Rahma Win Darmanto Wungu, Citrawati Dyah Kencono Yohanes Adrian Kapri Negara Yura Pradiptama Zuhrotul Eka Yulis Anggraeni

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