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Journal : indonesian journal of pharmacy

Synthesis and Preliminary In Vitro Anti-inflammatory Evaluation of Mannich Bases Derivatives of 4’-Methoxy-substituted of Asymmetrical Cyclovalone Analogs Rahmawati, Nur; Hariyanti, Hariyanti; Saputri, Fadlina Chany; Hayun, Hayun
Indonesian Journal of Pharmacy Vol 31 No 1, 2020
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14499/indonesianjpharm31iss1pp35

Abstract

Two of Mannich bases derivatives of 4’-methoxy-substituted of asymmetrical cyclovalone analog (ACA) (2a and 2b) were synthesized. The synthesized compounds and the other two Mannich bases derivatives of 4'-methoxy-substituted ACA (2c and 2d) were evaluated for their in-vitro anti-inflammatory activity preliminary by protein denaturation inhibition method using a final concentration of 1.57 μM. The study found that all the Mannich bases exhibited anti-inflammatory potential with inhibition ranging from 33.17- 42.47%. The activity of 2b (42,47%) and 2d (41.90%) was higher than that of diclofenac sodium (35.27%) and the parent compound 1 (38.16%). As a conclusion,  2b and 2d have a prospect as a potential candidate for an anti-inflammatory agent. Further study should be done using more specific methods.
Co-Authors . Hayun Adia Putra Wirman Aditya Sultan Alda Ria Oktavian Andzar Fikranus Shofa anisa amalia Anisa Amalia Ari Widayanti Ari Widayanti Arry Yanuar Aulia, Cahya Aziz Setiawan Azminah Azminah Cahya Aulia Candra, Ricky Crista Chandra, Ady D. P. Perkasa Devi Wulandari Dewi Susilawati Dewi, Elvira Ratna Dina Pratiwi Ditri Risska Rahmadhani Dwitiyanti Dwitiyanti E Erizal E Erizal E. Mustikarani Erizal Erizal Erizal Erizal Etin Diah Permanasari F. Lukitowati Fadlina Chany Saputri Fajar lukitowati Fatmawati, Sofia Febianti Febianti Firmanto, Johan Dwi Fith Khaira Nursal Fitria Nugrahaeni Fujianti, Fujianti Gantini, Sri Nevi H. Rahmi Hadi Sunaryo Hadi Sunaryo Hanifah Rahmi HANIFAH RAHMI HANIFAH RAHMI I. Lestari Ida Wati Indah Lestari Isra, Rafiq Al Kori Yati Kusmadi Kurmardi Lestari, Pramulani Mulya M Yasin Yunus Merina Merina Muhammad Hanafi Nafi’ah, Khusnun Ni Putu Ermi Hikmawanti Nining Nining, Nining Numlil Khaira Rusdi, Numlil Khaira Nur Azizah Nur Rahmawati Nurhidayah, Sahera Nurkamalia, Nu’aiman Nu’aiman Oktafiani, Erna Pamungkas, Septiana Tri Priyanto Priyanto Priyo Wahyudi R. Z. Apriyani Rahmat, Amalia Rahmayanti, Mice Rina Putri A Rina Putri Ariyanti Rini Prastiwi Ririh Zikriah Rizky Arcinthya Rachmania Rizky Arcinthya Rachmania Salahuddin Salahuddin Sari Nurlaily Sari, Retno Lia Sofiyani, Ratu Amada Sri Nevi Gantini Sri Nevi Gantini Sudirman Sudirman Sulistioso G S Supandi Supandi Syafrika Nurlia Tafriani Sucianti Nesha Tahyatul Bariroh Vesya Putri Viransa Viransa, Vesya Putri Yuniarto, Ari Z Juniarti Zulpahmi Zulpahmi