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Nurmainah Nurmainah
Fakultas Kedokteran Universitas Tanjungpura Pontianak
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Kajian Literatur : Tinjauan Terapi Kardioprotektan untuk Penanganan Kardiotoksisitas Kemoterapi Antrasiklin Sari, Cinantya Meyta; Suprapti, Budi; Nurmainah, Nurmainah
Jurnal Pharmascience Vol 12, No 1 (2025): Jurnal Pharmascience
Publisher : Program Studi Farmasi FMIPA Universitas Lambung Mangkurat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/jps.v12i1.19910

Abstract

Saat ini telah banyak diteliti mengenai beberapa agen farmakologi untuk terapi penanganan kardiotoksisitas antrasiklin. Namun, dibutuhkan kajian lebih lanjut terhadap strategi terapi kardiotoksisitas antrasiklin tersebut dari segi kefarmasian untuk memperkaya referensi sebagai dasar praktek klinis untuk tatalaksana kardiotoksisitas, terutama di negara berkembang. Kajian literatur ini bertujuan mengkaji lebih mendalam terkait kardioprotektan dari aspek mekanisme kerja, karakteristik farmakokinetik, serta dari evidence based medicine yang ada. Kajian literatur secara komprehensif dilakukan berdasarkan penelusuran jurnal ilmiah melalui penelusuran elektronik dengan kata kunci kombinasi “cardioprotective”, “anthracycline”, dan “cardiotoxicity”. Dari seluruh artikel yang diperoleh, didapatkan 39 artikel yang dapat dikaji lebih lanjut, yakni artikel mengenai kardiotoksisitas antrasiklin, serta penelitian dan bukti ilmiah mengenai agen-agen farmakologi yang diteliti bersifat kardioprotektif. Kesimpulan dari tinjauan ini adalah beberapa agen farmakologis telah menunjukkan luaran yang baik pada beberapa parameter kardiotoksisitas, namun penelitian tingkat lanjut dengan skala lebih besar dan waktu  follow up yang lebih lama masih diperlukan terutama dengan sampel domestik agar dapat diperoleh konklusi yang dapat diaplikasikan secara klinis pada masyarakat Indonesia.
Analisis Interaksi Obat pada Pasien Hipertensi di Posyandu Lansia Lembaga Kartini Surya Khatulistiwa Tanjung Hilir Anggraeny, Raine Ardhita; Asseggaf, Syarifah NYRS; Nurmainah, Nurmainah
Wal'afiat Hospital Journal Vol 6 No 1 (2025): Wal'afiat Hospital Journal
Publisher : Rumah Sakit Ibnu Sina, Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33096/whj.v6i1.159

Abstract

Polypharmacy of drugs in elderly hypertensive patients cannot be avoided because the elderly have several diseases other than hypertension. Polypharmacy administration of drugs can increase the potential for drug interactions to occur at a major, moderate or minor level, as well as occur in the pharmacodynamic or pharmacokinetic phase. One way that can be done to reduce these risks is by administering the right medication and minimizing the administration of polypharmacy for hypertensive patients. The research to analyze interactions between drugs, classify antihypertensive drugs, describe the percentage of drug interactions, and the severity of drug interactions given to elderly hypertensive posyandu patients at the Kartini Surya Khatulistiwa Tanjung Hilir Society. Observational with a descriptive model of the cross-sectional study. The sample used in this study is 36 hypertensive patients at the Posyandu Lansia Lembaga Kartini Surya Khatulistiwa Tanjung 2019. This research was conducted from March-April 2021. Samples are selected using Consecutive Sampling (nonprobability sampling). 79 cases interaction drug of hypertension patients in Posyandu Lansia Lembaga Kartini Surya Khatulistiwa Tanjung Hilir Drug interactions that occurred moderate level were 47 cases (59%) and pharmacodynamic stage in 71 cases (90%).
Analisis Interaksi Obat pada Pasien Hipertensi di Posyandu Lansia Lembaga Kartini Surya Khatulistiwa Tanjung Hilir Anggraeny, Raine Ardhita; Asseggaf, Syarifah NYRS; Nurmainah, Nurmainah
Wal'afiat Hospital Journal Vol 6 No 1 (2025): Wal'afiat Hospital Journal
Publisher : Rumah Sakit Ibnu Sina, Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33096/whj.v6i1.159

Abstract

Polypharmacy of drugs in elderly hypertensive patients cannot be avoided because the elderly have several diseases other than hypertension. Polypharmacy administration of drugs can increase the potential for drug interactions to occur at a major, moderate or minor level, as well as occur in the pharmacodynamic or pharmacokinetic phase. One way that can be done to reduce these risks is by administering the right medication and minimizing the administration of polypharmacy for hypertensive patients. The research to analyze interactions between drugs, classify antihypertensive drugs, describe the percentage of drug interactions, and the severity of drug interactions given to elderly hypertensive posyandu patients at the Kartini Surya Khatulistiwa Tanjung Hilir Society. Observational with a descriptive model of the cross-sectional study. The sample used in this study is 36 hypertensive patients at the Posyandu Lansia Lembaga Kartini Surya Khatulistiwa Tanjung 2019. This research was conducted from March-April 2021. Samples are selected using Consecutive Sampling (nonprobability sampling). 79 cases interaction drug of hypertension patients in Posyandu Lansia Lembaga Kartini Surya Khatulistiwa Tanjung Hilir Drug interactions that occurred moderate level were 47 cases (59%) and pharmacodynamic stage in 71 cases (90%).
Peningkatan Pengetahuan Kader PKK melalui Pelatihan Tatalaksana Demam, Gunakan, dan Buang Obat Sirup Demam Anak dengan Tepat Nurmainah, Nurmainah; Novitarini, Poppy; Pramita, Julianti; Balqis, Nur Maharani; Nanmi, Nassya Putri
Jurnal Pengabdian Pada Masyarakat Vol 10 No 2 (2025): Jurnal Pengabdian Pada Masyarakat
Publisher : Universitas Mathla'ul Anwar Banten

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30653/jppm.v10i2.1207

Abstract

Permasalahan yang dihadapi ibu-ibu kader PKK di Desa Rasau Jaya Satu, Kabupaten Kubu Raya bahwa ibu-ibu di desa tersebut masih belum pernah menggunakan termometer dalam pengecekkan suhu tubuh anak demam sebelum diberikan obat. Namun, mereka sering melakukan pengobatan swamedikasi demam dengan membeli obat parasetamol atau ibubrofen yang diketahui dari sosial media atau dari pengalaman ibu-ibu lainnya. Kekeliruan lain yang ditemukan seperti membuang obat sirup dengan tidak benar. Tujuan dari kegiatan Pengabdian Kepada Masyarakat (PKM) ini diharapkan ibu-ibu kader PKK dapat meningkat pengetahuannya dan menjadi agen perubahan bagi masyarakat di desanya dalam menegakkan tatalaksana demam, menggunakan obat sirup, serta membuang sisa obat dan kemasan sirup obat demam anak dengan benar. Metode kegiatan PKM dilakukan dengan mengimplementasikan teori behavioristik dengan pendekatan inkuiri. Kegiatan dilakukan beberapa tahapan, antara lain tahap persiapan, tahap pelaksanaan, dan tahap penilaian. Hasil kegiatan PKM ini diketahui Ibu-ibu kader PKK yang hadir sebanyak 40 orang. Kelompok usia yang terlibat dalam kegiatan ini memiliki rentang usia 30-39 tahun sebanyak 40% dan usia 40-49 tahun sebanyak 37,5%. Setelah dilakukan sosialisasi materi dan pelatihan, kemudian ibu-ibu kader PKK diminta untuk mengisi kuesioner guna mengukur pengetahuannya. Rata-rata tingkat pengetahuannya adalah sangat baik, yaitu 87,5%. Peserta memberikan respons bahwa kegiatan ini sangat bermanfaat (87%) dan bermanfaat (13%). Selain itu, materi yang disampaikan oleh tim PKM sangat mudah diterima (65%), mudah diterima (25%), dan sulit diterima (10%). Kesimpulan dari kegiatan ini bahwa peserta memiliki tingkat pengetahuan yang sangat baik dalam memahami tatalaksana demam, gunakan obat sirup demam anak, serta cara membuang sisa obat dan kemasan botol sirup secara benar setelah mengikuti kegiatan ini. The problem faced by PKK health cadres in Rasau Jaya Satu Village, Kubu Raya Regency is that mothers in the village have never used a thermometer to check the body temperature of children with fever before giving medicine. However, they often self-medicate for fever by buying paracetamol or ibuprofen which they learned from social media or from the experiences of other mothers. Other mistakes found include disposing of syrup medicine incorrectly. The purpose of this Community Service (PKM) activity is that PKK health cadres are expected to increase their knowledge and become agents of change for the community in their village in enforcing fever management, using syrup medicine, and disposing of leftover medicine and children's fever syrup packaging correctly. The PKM activity method is carried out by implementing behaviorist theory with an inquiry approach. The activity is carried out in several stages, including the preparation stage, implementation stage, and assessment stage. The results of this PKM activity were known to the 40 PKK cadre mothers who attended. The age group involved in this activity has an age range of 30-39 years as much as 40% and 40-49 years as much as 37.5%. After the socialization of materials and training, then the PKK cadre mothers were asked to fill out a questionnaire to measure their knowledge. The average level of knowledge was very good, which was 87.5%. Participants responded that this activity was very useful (87%) and useful (13%). In addition, the material presented by the PKM team was very easy to accept (65%), easy to accept (25%), and difficult to accept (10%). The conclusion of this activity was that participants had a very good level of knowledge in understanding fever management, using children's fever syrup, and how to properly dispose of leftover medicine and syrup bottle packaging after participating in this activity.
Gambaran Penggunaan Kontrasepsi Hormonal Yang Berisiko Penyakit Hipertensi Berdasarkan Klasifikasi World Health Organization Gulindari, Natalia Gusta; Nurmainah, Nurmainah; Susanti, Ressi
JURNAL FARMASI GALENIKA Vol 9 No 1 (2022): Jurnal Farmasi Galenika Vol 9 No 1
Publisher : Universitas Bhakti Kencana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.70410/jfg.v9i1.202

Abstract

Pengaturan kehamilan dapat dilakukan menggunakan kontrasepsi. Penggunaan kontrasepsi hormonal seperti pil dan suntik dapat menyebabkan kejadian hipertensi. Tujuan penelitian ini untuk mendeskripsikan penggunaan kontrasepsi hormonal yang berisiko penyakit hipertensi berdasarkan klasifikasi WHO di Puskesmas Pal III Pontianak. Metode penelitian bersifat deskriptif observasional dengan rancangan potong lintang (cross sectional). Pengumpulan data menggunakan data rekam medis akseptor kontrasepsi hormonal periode Januari 2020-Desember 2020. Teknik pengambilan sampel menggunakan purposive sampling dengan jumlah sampel yang memenuhi kriteria inklusi adalah 62 akseptor. Pengolahan data menggunakan Microsoft excel. Hasil penelitian diperoleh sebanyak 20 akseptor kontrasepsi hormonal (32,25%) yang mengalami hipertensi dan 4 akseptor (6,45%) dengan riwayat penyakit hipertensi. Hasil gambaran akseptor kontrasepsi hormonal di Puskesmas Pal III Pontianak yang berisiko penyakit hipertensi menurut klasifikasi WHO berada pada Level A dan Level C. Hasil persentase kejadian hipertensi pada pengguna pil dan suntik adalah sama 50%. Kesimpulan dari penelitian ini adalah terdapat beberapa akseptor dalam penggunaan kontrasepsi hormonal masih ditemukan tidak sesuai dengan rekomendasi yang ditetapkan oleh WHO.
Evaluasi Penggunaan Terapi Benzodiazepin Sebagai Faktor Risiko Jatuh Pada Pasien Geriatri Rawat Inap di Rsud Dr. Soedarso Kalimantan Barat Abbassyyah, Abbassyyah; Nurmainah, Nurmainah; Kurniawan, Hadi
Blantika: Multidisciplinary Journal Vol. 3 No. 10 (2025): Special Issue
Publisher : PT. Publikasiku Academic Solution

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.57096/blantika.v3i10.419

Abstract

Falls are a health problem that is often experienced by the elderly. One of the risk factors for falls is the use of drugs such as benzodiazepines. Benzodiazepines are categorized as high-risk drugs (MFRS score = 3) because they have psychomotor, sedative and muscle relaxation effects. To examine the benzodiazepine class of drugs used by elderly patients by paying attention to action and drug dosage based on the 2022 Benzodiazepine and Z-Drug Safety Guideline. The aim of this study is to describe the percentage of elderly people who use short-acting and long-acting benzodiazepines and evaluate the dosage of benzodiazepine drugs used in accordance with guidelines. This research method uses an observational study type with a descriptive cross-sectional study design. Data collection is retrospective with manual medical record data. The results of the study showed that the percentage of benzodiazepine drug use was 83% of geriatric patients using alprazolam, clobazam 5%, clonazepam 3%, diazepam 3%, midazolam 3%, and a combination of alprazolam and diazepam therapy 3%. The most commonly prescribed drug class was short-acting benzodiazepines compared to long-acting benzodiazepines. The conclusion is that the use of short-acting and long-acting benzodiazepines can be a risk factor for falls in geriatrics. The risk of geriatric falls will increase if benzodiazepines are used in combination with other drugs such as FRM drugs. In this research, the benzodiazepine drug that is widely prescribed is alprazolam.
THE ANALYSIS OF PATIENT CHARACTERISTICS OF COMPLIANCE IN THE USE OF METADONE THERAPY IN THE BANGKONG RIVER REGIONAL MENTAL HEALTH CLINIC OF PONTIANAK IN THE PERIOD OF 2020-2021 Prisilla, Salma; Nurmainah, Nurmainah; Andrie, Mohamad
Journal Pharmacy Of Tanjungpura Vol 1, No 1 (2023): Oktober
Publisher : Universitas Tanjungpura

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Abstract

ABSTRACT  Compliance with Injecting Drug Users (IDUs) in Methadone Maintenance Therapy is crucial during rehabilitation. However, many IDUs still do not comply with methadone therapy. As a result, the patient may once more experience withdrawal symptoms. The purpose of this study was to examine the percentage of patient compliance and the impact of patient's age, education, and occupation on compliance with the use of methadone therapy at Sungai Bangkong Region Psychiatric Hospital, Pontianak. The research method used is observational research with an analytical cohort study design. The data were taken from patient's medical record, which includes the patient's medical record number and patient characteristics such as age, gender, last education, occupation, and the number of days the patient received the drug. The collected medical record data is then analyzed using the Chi-Square analysis method. The results showed that the respondents had a high level of compliance with a percentage of 85.7%. Compliant patients are dominated by patients in the 20-40 age range, with college as their last education, and working as laborers. The results of the Chi-square test analysis showed the impact of age, education, and occupation on compliance, with values of p = 0.462; p=1,000; p=1,000, respectively. This study concludes that characteristics like age, education, and occupation had no impact on patient compliance in undergoing Methadone Maintenance Therapy.  Keywords: Compliance, Injecting Drug Users, Methadone Maintenance Therapy
ANALISIS HUBUNGAN LAMA PENGGUNAAN DAN USIA AKSEPTOR SUNTIK DMPA TERHADAP RISIKO OBESITAS DI PUSKESMAS PERUMNAS II PONTIANAK Nurmainah, Nurmainah; Innas, Syaazaratul Qamelia
Media Farmasi: Jurnal Ilmu Farmasi Vol. 18 No. 2: September 2021
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.12928/mf.v18i2.15903

Abstract

Kontrasepsi suntik adalah obat hormonal yang digunakan untuk mencegah kehamilan  dengan jalan menyuntikkan obat tersebut pada wanita subur. Kontrasepsi hormonal dapat meningkatkan berat badan. Tujuan penelitian ini dilakukan adalah untuk menganalisis hubungan antara lama penggunaan dan usia akseptor terhadap kejadian risiko obesitas. Penelitian ini merupakan penelitian observasional dengan rancangan penelitian potong lintang (cross sectional) bersifat analitik. Populasi dalam penelitian ini adalah seluruh akseptor baru kontrasepsi suntik 3 bulan DMPA di Puskesmas Perumnas II Pontianak pada bulan Januari 2018 hingga Maret 2019. Variabel dari penelitian ini adalah usia, pekerjaan, paritas, dan lama penggunaan. Analisis dilakukan dengan menggunakan analisis chi square.  Teknik pengambilan sampel yang digunakan ialah purposive sampling, dengan sampel sebanyak 81 akseptor. Hasil yang didapatkan ialah sebagian besar akseptor berusia 20-35 tahun, bekerja sebagai ibu rumah tangga dan mempunyai lebih dari 2 anak. Tidak terdapat hubungan antara usia akseptor terhadap kejadian risiko obesitas (p=0,806; OR=1,133; CI 95%= 0,419-3,060). Namun, terdapat hubungan antara lama penggunaan terhadap kejadian risiko obesitas (p=0,001; OR=26,3; CI 95%= 6,828-101,36). Hal tersebut mengindikasikan bahwa semakin lama kontrasepsi suntik digunakan akan meningkatkan kejadian risiko obesitas.
Persistensi Penggunaan Obat Antihipertensi pada Pasien Hipertensi Rawat Jalan Nurmainah, Nurmainah; Ahmad, Ahmad; Dwiprahasto, Iwan
Kesmas Vol. 8, No. 1
Publisher : UI Scholars Hub

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Abstract

Persistensi penggunaan obat antihipertensi pada pasien hipertensi sangat diperlukan mengingat hasil utama terapi hipertensi adalah mencegah kejadian penyakit kardiovaskular seperti infark miokard, dan stroke yang berujung pada kematian. Penelitian ini bertujuan mengetahui pengaruh jenis terapi dan jenis obat antihipertensi terhadap persistensi. Penelitian ini menggunakan desain studi kohort retrospektif dan menggunakan sumber data sekunder pasien hipertensi rawat jalan peserta asuransi kesehatan PT Askes di RSUD Panembahan Senopati Bantul. Metode pengukuran persistensi adalah metode the gaps between refill dengan tenggang waktu pengambilan obat selama 30 hari. Data dianalisis menggunakan uji kai kuadrat, Kaplan-Meier, dan Cox regression. Jumlah subjek yang ikut dalam penelitian ini adalah 304 pasien hipertensi yang menggunakan obat antihipertensi pertama kali (tanggal indeks diagnosis 1 Juli 2007 hingga 31 Desember 2008). Setelah pengamatan 4,5 tahun, hampir separuh subjek yang mendapat monoterapi (57,6%) dan kombinasi terapi (53,8%) tidak persisten menggunakan obat antihipertensi. Ketidakpersistenan penggunaan obat antihipertensi lebih besar pada kelompok monoterapi daripada kelompok kombinasi, tetapi perbedaan tersebut tidak signifikan (RR = 0,94; 95% CI = 0,73 - 1,21). Penggunakan diuretik (85,7%) dan kombinasi obat diuretik + ACE inhibitor (84,6%) cenderung tidak persisten dibandingkan subjek yang menggunakan ACE inhibitor (58,4%). Perbedaan ini bermakna secara statistik (RR = 1,47; 95% CI = 1,05 - 2,01 dan RR = 1,45; 95% CI = 1,10 - 1,91). Persistensi dipengaruhi oleh jenis obat antihipertensi yang digunakan, yaitu ACE inhibitor. Persistence of the use of antihypertensive drugs in hypertensive patients greatly needed. Considering the primary outcome of treatment for hypertension is to reduce or prevent the occurrence of cardiovascular events such as myocardial infarction, stroke resulting in the risk of death. This study aims to determine whether persistence is influenced by the type of treatment or type of antihypertensive drugs. This study was designed with retrospective cohort study using database of prescribing claimed of subjects under health insurance (PT Askes) in Panembahan Senopati hospitals using antihypertensive drugs. Persistency measurement method used is the method of the gaps between refilling. The grace period taking the drug for 30 days. Further data were analyzed using the chi square test, Kaplan-Meier, and Cox regression. This cohort study involving 304 patients using antihypertensive medications first (index diagnosis 1 July 2007 until 31 December 2008). After observation for 4,5 years found almost half of the subjects receive monotherapy (57,6%) or combination therapy (53,8%) are not persistent in the use of antihypertensive medications. Not persistent greater in the monotherapy compare to combination therapy group. However, this difference did not reach significance (RR = 0,94; CI 95% = 0,73 - 1,21). Subject were using a diuretic (85,7%) and ACE inhibitor + diuretic combination (84,6%) tends not to be persistent compare to subject using ACE inhibitors (58,4%). This difference was statistically significant (RR = 1,47; CI 95% = 1,05 - 2,01 and RR = 1,45; CI 95% = 1,10 - 1,91). Overall, persistence is influenced by the type antihypertensive drugs used, the ACE inhibitors.
Analysis of Drug use in Participants of the Kartini Madu II Elderly Posyandu, Kartini Surya Khatulistiwa Institution, East Pontianak Milenia Fara Endira; Syarifah Nurul Yanti R.S.A; Nurmainah, Nurmainah
Jurnal EduHealth Vol. 16 No. 04 (2025): Jurnal EduHealt, Edition October-December , 2025
Publisher : Sean Institute

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Abstract

There is a decline in body abilities and a decline in physiological functions. Increased use of drugs used by the elderly can increase the risk of drug-related problems. This study aims to analyze drug use in the elderly at the Kartini Madu II Elderly Health Post, Kartini Surya Khatulistiwa Institution, Pontianak in 2019. This descriptive analytical study with a cross-sectional design involved 55 elderly patients who met the inclusion criteria. The results showed that the majority of patients were women (87.3%) with the largest age range between 60-69 years (65.4%). The most common complaints were dizziness, itching, and coughing. The most commonly used types of drugs were mefenamic acid, captopril, and paracetamol. This study also found that there were drugs that did not meet the STOPP criteria (diclofenac sodium and CTM) and START (kalk and captopril). The results of this study can be used as a reference to improve the rational use of drugs in the elderly.
Co-Authors ., Nurizawati Abbassyyah, Abbassyyah Achmad Fudholi Achmad Fudholi Afrilla, Dian Ahmad Ahmad Ahmad Fudholi Angelina, Ria Anggareni, Anggareni Anggita, Fransiska Anggraeny, Raine Ardhita Annisa Mutia Yusran Asnawati Asnawati Assegaff, Syarifah Nurul Yanti R S Asseggaf, Syarifah NYRS Balqis, Nur Maharani Budi Suprapti Didik Hasmono Dwi Zulfita Esy Nansy Fradianto, Ikbal Gulindari, Natalia Gusta Hadi Kurniawan, Hadi Hafrizal Riza, Hafrizal Hedaya, Angelina Putri Hermiana, Aida Innas, Syaazaratul Qamelia Iqlima Den Firza Isandora, Yesica Iskandar, Maharani F. Iwan Dwiprahasto Iwan Dwiprahasto Iwan Dwiprahasto Malfirani, Laila Mariani, Luluk Meriska, Nisa Milenia Fara Endira Milenia Kamban Mita Mita, Mita Mohamad Andrie Muktiyani, Sekar Nanmi, Nassya Putri Natalia, Christia Ardhila Nera Umilia Purwanti, Nera Umilia Novitarini, Poppy Nur Anisyah Oi, San Pramita, Julianti Prisilla, Salma Purwanto, Diyna Rusayliya Puspita, Tita Rahmawati, Nadia Ria Angelina Robiyanto Robiyanto, Robiyanto Robiyanto, Robiyanto Ronaldo, Ronaldo Saifudin, I Made Moh. Yanuar Saputra, Pinsensius Boni Sari, Cinantya Meyta Sariyani, Maya Shoma Rizkifani Siti Syabriyantini Sri Wahdaningsih Suharjono, Suharjono Susanti, Ressi Syaazaratul Qamelia Innas Syahab Assegg, Syarifah Nurul Yanti Rizki Syarifah Nurul Yanti R.S.A Ulfa Syafli Nosa Wien Maryati Awdisma Wulandri, Sermia Yuswar, Muhammad Akib