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Pengaruh Pemberian Sinbiotik, Probiotik, dan Prebiotik terhadap Depresi, Stres, dan Mood pada Orang Dewasa: Systematic Review dan Meta-Analisis: Effects of Synbiotic, Probiotic, and Prebiotic Supplementation on Depression, Stress, and Mood in Adults: A Systematic Review and Meta-Analysis Habibi, Nur Ahmad; Gusnedi, Gusnedi; Nindrea, Ricvan Dana; Hasniyati, Rina; Afriza, Renita; Rusydi, Riska; Yuska, Defniwita; Darningsih, Sri; Zulkifli, Zulkifli; Ismanilda, Ismanilda; Handayani, Marni; Utami, Citra Tristi; Umar, Hermita Bus; Dwiyanti, Defriani; Yuniritha, Eva
Amerta Nutrition Vol. 9 No. 1SP (2025): AMERTA NUTRITION SUPPLEMENTARY EDITION Special 5th Amerta Nutrition Conferenc
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/amnt.v9i1SP.2025.420-430

Abstract

Background: Psychobiotics, including probiotics, prebiotics, and synbiotics, have been proposed to improve mental health through modulation of the gut–brain axis. However, findings from randomized controlled trials (RCTs) remain inconsistent, Objectives: To systematically review and synthesize evidence on the effects of probiotics, prebiotics, and synbiotics on depression, stress, and mood in adult populations. Methods: A comprehensive search was conducted in PubMed, yielding 531 articles, of which 14 RCTs met the inclusion criteria. Risk of bias was assessed using the Cochrane Risk of Bias Tool. Meta-analyses were performed using both fixed- and random-effects models in RevMan. The study protocol was registered in PROSPERO (CRD420251103338). Discussions: Ten RCTs (n = 881) assessing depression did not show consistent benefits (SMD = –0.72; 95% CI: –1.42 to –0.01; p-value = 0.05; I² = 96%). Six RCTs (n = 444) evaluating stress also showed non-significant effects (MD = –1.35; 95% CI: –3.70 to 1.01; p-value = 0.26; I² = 73%). Conversely, six RCTs (n = 376) demonstrated significant improvements in mood (MD = 0.73; 95% CI: 0.25 to 1.20; p-value = 0.003; I² = 75%). Meta-regression indicated that larger sample sizes were associated with more consistent improvements in mood (p-value = 0.04). Sensitivity analyses confirmed the stability of the findings, and no evidence of publication bias was detected. Conclusions: Probiotic, prebiotic, and synbiotic supplementation may provide beneficial effects on mood and could serve as a potential nutritional intervention to enhance psychological health. However, effects on depression and stress inconsistent.
ANALISIS PENYEBAB GIZI KURANG PADA BALITA Safitri, Dewi; Safitry, Rusni; Nuliana, Wa; Afriza, Renita
Ensiklopedia Research and Community Service Review Vol 5, No 2 (2026): Vol. 5 No. 2 Februari 2026
Publisher : Lembaga Penelitian dan Penerbitan Hasil Penelitian Ensiklopedia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33559/err.v6i1.3766

Abstract

Malnutrition in toddlers is one of the public health issues that remains a serious concern, especially in developing countries, including Indonesia. Based on data obtained from the Lubuk Buaya Community Health Center during the last three months, from July to August 2025, it is known that malnutrition in toddlers is still high. The purpose of this study is to analyze the causes of malnutrition in toddlers. The research design used in this study was cross-sectional. The research was conducted in the Lubuk Buaya Community Health Center working area. The research was conducted in November 2025. The research population consisted of mothers who had toddlers in the Lubuk Buaya Community Health Center working area. The sample consisted of 70 respondents. The sampling technique used was purposive sampling. The research instrument used a research questionnaire. Data analysis was performed using univariate and bivariate methods. The results showed a relationship between mothers' knowledge (p value: 0.046) and dietary patterns (p value: 0.000) and malnutrition in toddlers. It is recommended that health centers, through health workers and posyandu cadres, make greater efforts to improve educational activities that can increase mothers' knowledge about the importance of providing good nutrition to their toddlers. Keywords: Toddlers, Mother's Knowledge, Diet.