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All Journal Qanun Medika - Medical Journal Faculty of Medicine Muhammadiyah Surabaya Journals of Ners Community Jurnal Respirologi Indonesia Journal Syifa Sciences and Clinical Research (JSSCR) Jurnal Respirasi (JR) JUXTA: Jurnal Ilmiah Mahasiswa Kedokteran Universitas Airlangga Medika Kartika : Jurnal Kedokteran dan Kesehatan JOURNAL OF COMMUNITY MEDICINE AND PUBLIC HEALTH RESEARCH CURRENT INTERNAL MEDICINE RESEARCH AND PRACTICE SURABAYA JOURNAL Indian Journal of Forensic Medicine & Toxicology Mitra Raflesia (Journal of Health Science) Cermin Dunia Kedokteran Asian Journal of Health Research Jurnal Widya Medika
Hasan, Helmia
Department Of Pulmonology And Respiratory Medicine, Faculty Of Medicine, Universitas Airlangga, Surabaya, Indonesia.
Biochemistry, Genetics & Molecular Biology Chemistry Dentistry Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing Public Health Veterinary

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THE COMPARISON OF OXIDATIVE STRESS LEVELS BETWEEN E-CIGARETTE SMOKERS AND CONVENTIONAL SMOKERS IN YOUNG ADULT IN SURABAYA Elisabeth Tri Wahyuni; Helmia Hasan
JURNAL WIDYA MEDIKA Vol. 8 No. 1 (2022): Supplement Juni
Publisher : FAKULTAS KEDOKTERAN UNIVERSITAS KATOLIK WIDYA MANDALA SURABAYA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33508/jwm.v8i1.4026

Abstract

Background: Smoking is one of the leading causes of morbidity and mortality worldwide. Previously, e-cigarettes were considered safe, but later some studies have reported that e-cigarette can increase oxidative stress and induce an inflammatory response. Isoprostane is a biomarker of oxidative stress, which is thought to play a role in the pathogenesis of COPD. The purpose of this study was to determine the level of oxidative stress between e-cigarette and conventional smokers by measuring the isoprostan level in the two group and comparing them. Method: This research is an observational analytic study conducted in Surabaya. Anamnesis, physical examination, chest X-ray, and complete blood were carried out, followed by urine isoprostane. The research subjects were 28 e-cigarrete smokers, 27 conventional smokers, and 14 controls who never smoked. Urine isoprostane levels were measured by the ELISA method using a random urine sample and then corrected with urine creatinine from the same sample. Differences in urine isoprostane levels in the three groups used the Mann-Whitney test. Result: The statistical analysis results showed no significant difference in urine isoprostane levels between e-cigarette and conventional smokers (p = 0.054). The mean and median of urine isoprostane in e-cigarette and conventional smokers tended to be higher than controls. Conclusion: The levels of urine isoprostane for e-cigarette and conventional smokers tended to be higher than controls, but there was no statistically significant difference. It can be concluded that the level of oxidative stress in the two groups did not have significant difference but tended to be higher than controls.
Correlation between Neutrophil-to-Lymphocyte Ratio and Severity of Community-Acquired Pneumonia in Patients Almira, Naufalia Ghina; Hasan, Helmia; Wardhani, Puspa; Hernaningsih, Yetti; Bintoro, Siprianus Ugroseno Yudho; Romadhon, Pradana Zaky
Qanun Medika - Jurnal Kedokteran FK UMSurabaya Vol 9 No 02 (2025): Qanun Medika Vol 09 No 02 July 2025
Publisher : Universitas Muhammadiyah Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30651/jqm.v9i02.25024

Abstract

The high morbidity and mortality rates due to pneumonia in developing countries indicate that a more affordable marker is needed to determine the degree of inflammation in cases of pneumonia infection. The neutrophil-to-lymphocyte ratio (NLR) is a simple indicator used extensively in evaluating the systemic inflammatory response. An observational cross-sectional study of 297 pneumonia patients was conducted using medical records as the source document. The patients’ blood was taken during the hospital admission to obtain neutrophil and lymphocyte values. Meanwhile, the PSI score was used during the hospital admission to assess the severity of the pneumonia. Bivariate analysis using Spearman correlation was used to determine the correlation between NLR and pneumonia severity. The ROC curve was used to determine the cut-off value of NLR to distinguish mild from severe patients. The results of the Spearman correlation test analysis showed that the correlation between the NLR and the pneumonia severity was significantly positive (r = 0.130; p = 0.025). Furthermore, the median NLR value was higher in patients with severe pneumonia than in those with milder pneumonia severity (13.01 vs. 11.79 vs. 6.75). The NLR cut-off value of 9.07 was obtained to differentiate patients with mild severity and those with more severe disease. In conclusion, there is a correlation between the neutrophil-to-lymphocyte ratio and the severity of patients’ pneumonia.
Clinical and Radiological Characteristics of Pneumonia in COVID-19 Patients at First Admission of Dr. Soetomo General Academic Hospital, Surabaya, in June-August 2021 Pradnyandari, Anak Agung Sagung Putri; Hasan, Helmia; Setiawati, Rosy; Effendi, Wiwin Is
JUXTA: Jurnal Ilmiah Mahasiswa Kedokteran Universitas Airlangga Vol. 16 No. 2 (2025): Jurnal Ilmiah Mahasiswa Kedokteran Universitas Airlangga
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/juxta.V16I22025.115-121

Abstract

Highlights: This was the first study that described the radiological features of pneumonia in COVID-19 patients at first admission to Dr. Soetomo General Academic Hospital, Surabaya, during the Delta wave. This study presented the gastrointestinal symptoms of COVID-19 patients with pneumonia.   Abstract Introduction: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) gave rise to the coronavirus disease (COVID-19) pandemic. Pneumonia in COVID-19 can cause acute respiratory distress syndrome (ARDS), which could lead to damage to end organs. This study aimed to describe the clinical and radiological profile of pneumonia in COVID-19 patients at first admission to the emergency department of Dr. Soetomo General Academic Hospital, Surabaya, in June-August 2021. Methods: This was a single-center, descriptive study of COVID-19 patients with pneumonia (n=193) at their first admission to the emergency department of Dr. Soetomo General Academic Hospital, Surabaya, from June to August 2021. The demographic data, pre-existing comorbidities, clinical signs and symptoms, and radiological findings were collected from the electronic medical record and analysed using the International Business Machines Corporation (IBM) Statistical Package for Social Sciences (SPSS) version 26. Results: Out of all the COVID-19 patients included in the study (n=193), most of them were 18-64 years old (86.0%), and the majority were males (50.8%). Of 193 patients, 51.3% had pre-existing comorbidities. Most patients (95.9%) experienced pulmonary symptoms, with shortness of breath being the most common. On chest radiograph, 60.1% patients showed consolidation with central and peripheral predominance (60.6%) and bilateral lung involvement (91.2%). Conclusion: This study presented a description of the clinical and radiological findings in COVID-19 patients with pneumonia. Most of which showed extensive lesions on chest radiograph along with dyspnea, which may suggest that most patients were suffering from late-stage and severe COVID-19 with pneumonia. To confirm this suggestion, further research is needed.
HIGH FLOW NASAL CANUL (HFNC) SEBAGAI TERAPI OKSIGEN PADA KASUS GAGAL NAFAS TIPE 1 Nuswantoro, Yulian; Marhana, Isnin Anang; Hasan, Helmia; Baktiar, Arief
Medika Kartika : Jurnal Kedokteran dan Kesehatan Vol 8 No 3 (2025): Medika Kartika : Jurnal Kedokteran dan Kesehatan
Publisher : Fakultas Kedokteran Universitas Jenderal Achmad Yani

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Penggunaan ventilasi mekanik invasif dapat meningkatkan morbiditas dan mortalitas terkait stres pulmonal dan pneumonia, serta mendorong penggunaan ventilasi non-invasif seperti High Flow Nasal Cannula (HFNC) sebagai terapi oksigen yang efektif pada gagal napas tipe 1. Studi ini bertujuan untuk menganalisis efektivitas HFNC dalam menangani gagal napas akut. Hasil penelitian menunjukkan bahwa HFNC mampu memberikan oksigen dengan konsentrasi tinggi dan aliran gas yang stabil, meningkatkan oksigenasi tanpa menimbulkan efek samping signifikan. HFNC juga terbukti meningkatkan kenyamanan pasien, mengurangi kebutuhan intubasi, dan memperbaiki hasil klinis secara keseluruhan. Kesimpulan dari penelitian ini adalah bahwa HFNC merupakan alternatif yang efektif dan aman dibandingkan dengan ventilasi mekanik invasif untuk pasien dengan gagal napas tipe 1. Kata kunci: gagal napas akut, high flow nasal cannula, terapi oksigen, ventilasi non-invasif DOI : 10.35990/mk.v8n3.p331-343
Profil Pasien Systemic Lupus Erythematosus Dengan Manifestasi Kardiorespirasi Di Rsud Dr Soetomo Periode Januari - Desember 2018 Dwi Amartya Kirana, Putri; Awalia, Awalia; Hasan, Helmia
Journals of Ners Community Vol 13 No 6 (2022): Journals of Ners Community
Publisher : Fakultas Ilmu Kesehatan Universitas Gresik

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55129/jnerscommunity.v13i6.2760

Abstract

Systemic Lupus Erythematosus (SLE) merupakan penyakit inflamasi autoimun kronis sistemik dimana sistem kekebalan tubuh menyerang jaringan dan organ tubuh itu sendiri. Penyebab penyakit autoimun ini belum dapat dijelaskan secara pasti. Manifestasi klinis penyakit SLE begitu beragam dan dapat mengenai berbagai organ tubuh. Beberapa manifestasi klinis pada pasien SLE antara lain yaitu adanya kelainan ada paru dan jantung. Penelitian ini bertujuan untuk mengetahui gambaran profil pasien SLE dengan manifestasi kardiorespirasi yang menjalani rawat inap di RSUD Dr.Soetomo Surabaya. Pengambilan sampel dilakukan dengan teknik total sampling yang berarti semua individu pada populasi yang memenuhi kriteria inklusi merupakan sampel. Jenis penelitian yang digunakan dalam penelitian ini adalah deskriptif dengan menggunakan data sekunder berupa rekam medis. Total sampel yang sesuai dengan kriteria inklusi berjumlah 74 pasien. Pasien didominasi oleh perempuan dengan kelompok usia terbanyak adalah usia 26-45 tahun. Sejumlah 22 pasien dilaporkan meninggal dengan penyebab terbanyak adalah syok sepsis. Manifestasi paru yang ditemukan berupa efusi pleura (30.6%), penumonitis lupus (28.6%), pneumonia (27%), edema paru (11.1%), hipertensi pulmonal (6.3%), tuberkulosis (6.3%), ILD (6.3%). Manifestasi jantung yang ditemukan adalah efusi perikardium (46.7%), insufisiensi katup mitral (30%), insufisiensi katup trikuspid (33.3%), insufisiensi katup pulmonal (6.7%), dilated cardiomypathy (6.7%), dan heart failure (13.3%). Kelainan laboratorium yang ditemukan adalah anemia 66.6%, limfopenia 75.3%, trombositopenia 37%. Terapi yang banyak diberikan berupa methylprednisolon, chloroquin, antibiotik ceftriaxone, dan levofloxacin. Pasien SLE dengan manifestasi kardiorespirasi didominasi oleh perempuan usia produktif. Penyebab kematian pada pasien SLE dengan manifetsasi kardiorespirasi terbanyak adalah akibat syok sepsis.
Unveiling Risk Factors in a Patient with Silicotuberculosis: A Case Report Sadikim, Rahel Yuana; Hasan, Helmia; Hidayat , Agus; Duta, Garinda Alma; Wati, Farah Fatma
Jurnal Respirasi Vol. 11 No. 1 (2025): January 2025
Publisher : Faculty of Medicine Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jr.v11-I.1.2025.62-68

Abstract

Introduction: Silicosis, an occupational lung disease caused by crystalline silica dust, is often complicated by tuberculosis (TB). The epidemiological triad suggests disease results from imbalanced interactions between the host, agent, and environment. Case: A 63-year-old underweight man presented with decreased consciousness after consuming drugs, chronic cough, low-grade fever, weight loss, and lower urinary tract symptoms. He was a smoker, drug abuser, and alcoholic. He had worked as a construction worker for 33 years without personal protective equipment (PPE). The patient lived in substandard housing, and three neighbors had a history of TB. Urine toxicology was positive for amphetamine. Abdominal ultrasound showed prostate enlargement. A chest X-ray showed fibroinfiltrates, cavities, and reticulogranular patterns. A high-kV chest X-ray revealed profusion levels of 1/2 S/S and 1/1 P/P. Contrast chest computed tomography (CT) showed tree-in-bud patterns, reticulogranular patterns, small nodules, and fibrosis. Brain CT was normal. GeneXpert sputum confirmed Mycobacterium tuberculosis (MTB), and bronchoalveolar lavage (BAL) spectrophotometric detected 38.90 ppm silica. He was diagnosed with amphetamine intoxication, benign prostatic hyperplasia, and silicotuberculosis. Haloperidol, tamsulosin, and anti-TB therapy were administered, while silicosis had no specific treatment. He was advised to change job to reduce silica exposure and planned to receive housing renovation assistance from the Health Office of Surabaya. The patient was declared cured after completing six months of TB treatment. Conclusion: The host factors included nutritional status, comorbidity, and personal habits; the agent factor was MTB; and the environmental factors included inadequate ventilation, high housing density, close contact with TB patients, and occupational conditions. A holistic identification of host, agent, and environmental risk factors is essential for understanding the development, prevention, and diagnosis of silicotuberculosis.
Co-Authors Abdul Rahman Bahmid Ahmad Nurdin Almira, Naufalia Ghina Arief Baktiar, Arief Awalia Awalia Awalia, Awalia Bintoro, Siprianus Ugroseno Yudho Bramantono Bramantono, Bramantono Budi Utomo Budi Utomo Chandra, Cecilia Felicia Dedi Kuswandi Devi Ambarwati Duta, Garinda Alma Dwi Amartya Kirana, Putri Effendi, Wiwin Is Elisabeth Tri Wahyuni Garuda Nusantara Putra Utomo Hariani, Lynda HERAWATI, LILIK Hermanto Tri Joewono Heryana, Achmad Yuniari Hidayat , Agus Isnin Anang Marhana Iswinarno Doso Saputro ManikRetno Wahyunitisari Marsha Zahrani Mirza Nur Mazidah Ni Luh Putu Eka Arisanti Nuswantoro, Yulian Pradnyandari, Anak Agung Sagung Putri Pranaya, Azhraa Qinan Putri Dwi Amartya Kirana Putri, Rizki Maulidya Rebekah Setiabudi, Rebekah Rejeki, Purwo Sri Rena Arusita Maranatha Rieza Rizqy Alda Rizki Maulidya Putri Romadhon, Pradana Zaky Sadikim, Rahel Yuana Sakina Salsabilla Gina Rania Samsriyaningsih Handayani Setiawati, Rosy Sulistiawati Sulistiawati Ummah, Fithriyah Cholifatul Wahyuni Hariyanto Wardhani, Puspa Wati, Farah Fatma Yetti Hernaningsih Yuliza