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Efektivitas Plasmaferesis Sebagai Terapi Pada Miastenia Gravis: Sebuah Tinjauan Naratif Azzati, Normaida Baizura; Permana, Hendra; Almurdi, Almurdi; Susanti, Lydia; Alioes, Yustini; Yusri, Elfira
Jurnal Ilmu Kesehatan Indonesia Vol. 6 No. 1 (2025): Maret 2025
Publisher : Fakultas Kedokteran, Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jikesi.v6i1.1390

Abstract

Latar Belakang: Miastenia gravis adalah penyakit neurologi autoimun yang jarang terjadi, namun sangat mempengaruhi kualitas hidup pasien dikarenakan tingkat keparahan yang cukup tinggi. Plasmaferesis digunakan sebagai salah satu pilihan terapi pada kondisi ini. Objektif: Tinjauan Naratif ini bertujuan untuk menilai penelitian terkait efektivitas terapi plasmaferesis terhadap miastenia gravis. Metode: Penelitian ini merupakan tinjauan literatur terhadap 7 artikel penelitian yang dipublikasi pada rentang tahun 2019-2023. Sumber pangkalan data yang digunakan adalah Pubmed, Science Direct, dan ProQuest. Artikel dilakukan penyeleksian berdasarkan kriteria eligibilitas yang telah ditentukan. Hasil: Menurut artikel yang dilakukan tinjauan, diketahui bahwa plasmaferesis dapat memberikan luaran klinis yang baik pada pasien. Plasmaferesis juga mampu meningkatkan kualitas hidup pasien secara signifikan. Kesimpulan: Semua literatur sepakat menyatakan bahwa plasmaferesis efektif digunakan sebagai terapi pada miastenia gravis.
PERBEDAAN HASIL PEMERIKSAAN HEMATOLOGI BERDASARKAN DERAJAT KEPARAHAN PASIEN COVID-19 DI RUMAH SAKIT SEMEN PADANG TAHUN 2021 Puja, Annisa Fitria; Efrida, Efrida; Permana, Hendra; Yulia, Dwi; Welan, Rahmani
EMPIRIS : Jurnal Sains, Teknologi dan Kesehatan Vol. 2 No. 2 (2025): EMPIRIS : Jurnal Sains, Teknologi dan Kesehatan, Juni 2025
Publisher : Lembaga Pendidikan dan Penelitian Manggala Institute

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.62335/empiris.v2i2.1308

Abstract

Objective: To determine differences in the results of hematological examinations based on the severity of COVID-19 patients at Semen Padang Hospital in 2021. Methods: The type of research was observational analytic with a cross-sectional design. We took secondary data from the medical records of COVID-19 patients. A total of 100 patients were included in this study was conducted at Semen Padang Hospital in January-December 2021. Bivariate analysis used a one-way ANOVA with the Kruskal-Wallis alternative. The results are considered as significant if p <0.05. The significance of the parameters was tested using the Post Hoc Scheffe (p<0.05). Results: From 100 patients found the: 60% Male and 40% female, mean age of 51.95 ± 12.82 years, mild COVID-19 patients 36%, moderate 44%, severe 14%, and critical 6%. The mean hematological parameters were within normal limits. Hemoglobin levels (g/dL) of male patients based on severity (mild, moderate, severe, and critical) were 15,02 ± 1,10, 14,20 ± 1,29, 14,14 ± 1,21, 14,50 ± 1,99 respectively (p<0.05); hemoglobin levels (g/dL) of female patients were 13,73 ± 0,94, 12,96 ± 0,76, 14,20 ± 1,27, 12,16 ±0,47 respectively (p<0,05); leukocyte count (/mm3) were 5600, 5950, 6250, 7850 respectively (p>0.05); absolute neutrophil count (103/µL) were 3.51, 3.79, 4.72, 6.56 respectively (p<0.05); absolute lymphocyte count (103/µL) were 1.67±0.60, 1.42±0.44, 1.14±0.44, 1.14±0.59, 1.06±0.65 respectively (p<0.05); eosinophil count (103/µL) were 0.058, 0.057, 0.031, 0.023 respectively (p>0.05); and platelet count (/mm3) were 251,000 ± 61,077, 229,522 ± 59,900, 173,071 ± 57,596, 133,350 ± 44,724, respectively (p<0.05). Conclusion: The conclusion of this study is that there are differences in hemoglobin levels, absolute neutrophils, absolute lymphocytes, and platelet counts between mild, moderate, severe, and critical COVID-19 patients.
Gambaran Fungsi Kognitif pada Pasien Pasca Stroke di Poliklinik RS Otak Dr. Drs. M. Hatta Bukittinggi Tahun 2022 Zaffarsyah, Muhammad Irsyad; Permana, Hendra; Yanis, Amel; Nurhayati, Nurhayati; Mulyana, Roza
Jurnal Ilmu Kesehatan Indonesia Vol. 5 No. 1 (2024): Maret 2024
Publisher : Fakultas Kedokteran, Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jikesi.v5i1.1154

Abstract

Latar belakang: troke merupakan penyakit neurologis yang menyerang otak secara langsung. Stroke menjadi penyebab kematian dan kecacatan nomor dua di dunia. Kecacatan dapat terjadi tidak hanya pada fungsi motorik dan sensorik, tetapi juga dapat terjadi gangguan pada fungsi kognitif yang terjadi akibat adanya perkembangan Cerebral Small Vessel Disease. Penelitian ini bertujuan untuk mengetahui gambaran fungsi kognitif pada pasien pasca stroke di poliklinik neurologi RS Otak Dr. Drs. M. Hatta Bukittinggi berdasarkan karakteristik, fungsi kognitif, dan distribusi frekuensi gangguan fungsi kognitif pada pasien pasca stroke iskemik dan stroke hemoragik. Objektif: Penelitian ini merupakan penelitian deskriptif yang dilakukan di RS Otak Dr. Drs. M. Hatta Bukittinggi pada tahun 2022. Sampel diambil dengan menggunakan teknik consecutive sampling dengan total berjumlah 65 subjek. Sampel penelitian ini adalah pasien pasca stroke di Poliklinik Neurologi RS Otak Dr. Drs. M. Hatta, Bukittinggi. Sampel diambil dengan data primer menggunakan MMSE dan data sekunder dari rekam medis pasien. Hasil: Penelitian ini menunjukan dari 65 sampel didapatkan 53 pasien iskemik dan 12 pasien hemoragik dengan fungsi kognitif normal pasien iskemik 37,7% dan iskemik 33,3%, gangguan kognitif ringan pasien iskemik 37,7% dan pasien hemoragik 33,3%, dan gangguan kognitif berat pasien iskemik 24,5% dan hemoragik 33,3%. Kesimpulan: Penelitian ini mendapati hasil kejadian stroke iskemik lebih banyak daripada stroke hemoragik. Hasil karakteristik pasien pasca stroke ditemukan variatif karena perbedaan tingkat keparahan dan faktor risiko. Ditemukan frekuensi tingkat gangguan fungsi kognitif terbanyak pada pasien tanpa gangguan kognitif dan ringan. Kata kunci: fungsi kognitif, stroke, iskemik, hemoragik, MMSE
Selecting Hormonal Contraceptives in Women Taking Antiepileptic Drugs : Review of Literature and Practical Recommendations Permana, Hendra; Susanti, Restu; Muhammad, Syamel
Andalas Obstetrics And Gynecology Journal Vol. 4 No. 2 (2020)
Publisher : Fakultas Kedokteran Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/aoj.4.2.231-240.2020

Abstract

Contraception is a very important issue in women with epilepsy, since very broad questions taken in applying it to prevent unplanned pregnancy. The choice of contraceptive methods must be related to how the mechanism of action of antiepileptic drugs (AEDs), the contraceptive itself, and both interactions. Hormonal contraception can induce metabolism of AEDs and lead to increasing of seizure frequency, and in the other hand AEDs may decrease the blood levels of hormonal contraception. Therefore, physician must consider the type of contraception being used before prescribing AEDs. Additionally, they should emphasize the interaction between them in counseling, to assure that women with epilepsy have time to decide which type will be best use for them. This challenging matter needs better recommendation for practice, both neurologist and gynecologist.Keywords: antiepileptic drug, contraception, women with epilepsy
Premature Ovarian Failure and Epilepsy Permana, Hendra; Rahmi, Afriyeni Sri; Muhammad, Syamel
Andalas Obstetrics And Gynecology Journal Vol. 5 No. 1 (2021)
Publisher : Fakultas Kedokteran Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/aoj.5.1.1-8.2021

Abstract

Premature ovarian failure (POF) or premature menopause refers to development of amenorrhoea due to cessation of ovarian function before the age of 40 years. The diagnosis is based on elevated FSH levels in menopausal range (usually above 40 IU/l) detected on at least two occasions a few weeks apart. The term “epilepsy” defines a group of disorders characterized by an enduring predisposition of the brain to produce seizures. The hypothalamic-pituitary-ovarian axis regulation is affected by the abnormal neurophysiology of seizures, and the hypothalamic-pituitary-ovarian associated hormones are affected by medications used to treat seizures in women with epilepsy. Ictal and interictal discharges can disrupt the normal activity of brain structures, including the limbic system, amygdala, hypothalamus, and pituitary gland. Management of epilepsy in women requires not only knowledge of epilepsy, but also recognition of the various roles and priorities women have in their lives (education, career development, child rearing, the role as carer within the extended family), and attention to gender-specific issues and their impact on patients’ wellbeing throughout life.Keywords: premature ovarian failure (POF), epilepsy
Polisemi Dalam Media Online Di CNN Arabic Chumairoh, Umama; Permana, Hendra
`A Jamiy : Jurnal Bahasa dan Sastra Arab Vol 12, No 2 (2023): Kajian Bahasa dan Sastra Arab
Publisher : Universitas Muhammadiyah Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31314/ajamiy.12.2.337-346.2023

Abstract

Saat ini, berita yang dipublikasikan melalui media online memiliki banyak keunggulan dibandingkan berita yang dipublikasikan melalui media cetak. Berita dalam media online lebih cepat dan lebih mudah untuk diakses, fleksibilitas dan kapasitasnya yang luas dapat mempengaruhi para pembaca untuk memilih berita yang dipublikasikan melalui media online. Penelitian ini bertujuan untuk, menganalisis, mengatahui, menguraikan dan memahami jenis, makna, dan faktor-faktor yang mempengaruhi terjadinya polisemi dalam bahasa arab yang terdapat pada media online di CNN Arabic. penelitian ini menggunakan kajian kepustakaan dengan metode kualitatif. Melalui penelitian ini peneliti mendeskripsikan fenomena atau gejala kebahasaan yang terdapat bentuk polisemi pada kata atau frasa yang ada pada media online CNN Arabic. Data penelitian ini dikumpulkan dengan teknik catat dengan mencatat potongan kalimat-kalimat di dalam media online CNN Arabic melalui tabel disertai makna, kalimat, dan jenis katanya. Hasil dari penelitian ini menunjukkan bahwa polisemi adalah kata yang mengandung makna lebih dari satu. Dalam media online CNN Arabic terdapat beberapa jenis polisemi. Pembagian polisemi dari hasil analisis yang dilakukan peneliti berdasarkan kelas kata pada media online CNN Arabic diantaranya yakni polisemi kata verba, polisemi kata nomina, dan polisemi kata adjektiva. 
Implementasi Kebijakan Pelayanan Administrasi Terpadu Kecamatan (PATEN) di Kantor Kecamatan Katapang Kabupaten Bandung Permana, Hendra
Jurnal Indonesia Sosial Sains Vol. 3 No. 12 (2022): Jurnal Indonesia Sosial Sains
Publisher : CV. Publikasi Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59141/jiss.v3i12.733

Abstract

The problem studied is the implementation of the policy of the District Integrated Administrative Service (PATEN) at the Katapang District Office, Bandung Regency in the service of making Identity Cards and Family Cards that have not been running optimally. The purpose of the research is to determine the implementation of the policy by using a qualitative approach through descriptive analysis that describes the situation according to the facts that occurred in the research process without manipulation. Analyzed based on four factors that influence the success or failure of implementation, namely communication, resources, disposition, and bureaucratic structure. Informants as data sources include three elements including structural ranks of officials at the Katapang District Office, functional staff serving as operators, representatives from village level government and the general public. The results of the study indicate that the implementation of the District Integrated Administrative Service (PATEN) policy at the Katapang District Office, Bandung Regency in the service of making Identity Cards and Family Cards in general has achieved quite good results. Communication based on aspects or distribution of information through policy socialization has been carried out in accordance with the provisions but has not achieved optimal results, the clarity is quite clear through appeals, announcements through letters and information boards and Whatsapp Group, and consistency covers the entire service process. Resources include aspects of competent human resources at work because they were prepared in advance, financial resources are adequate, facility resources are adequate even though there are some shortcomings and damages, and authority resources are already available based on regional regulations and Regent regulations. Disposition based on the aspect of bureaucratic appointments is in accordance with the needs and incentives in accordance with policy provisions. The bureaucratic structure based on the SOP aspect is already available through the District Head's decision letter and is linked to the Service SOP and the fragmentation is well established.