Garuda - Garba Rujukan Digital

Evaluasi Granul Effervescent dari Berbagai Ekstrak Retty Handayani; Nazmi Syaqib; Aji Najihudin
Parapemikir : Jurnal Ilmiah Farmasi Vol 10, No 1 (2021): Parapemikir : Jurnal Ilmiah Farmasi
Publisher : Pusat Penelitian dan Pengabdian Masyarakat Politeknik Harapan Bersama

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30591/pjif.v10i1.2095

Granul effervescent merupakan suatu produk granul atau serbuk kasar yang didalamnya mengandung obat dalam campuran kering, ketika ditambahkan dengan air, akan bereaksi antara asam dan basa yang membebaskan karbondioksida dan menghasilkan buih sehingga akan memberikan efek yang segar. Review artikel ini dibuat dengan tujuan untuk mereview atau merangkum dan memberikan informasi terkait formulasi dan evaluasi granul effervescent dari berbagai ektrak tumbuhan dengan variasi metode granulasi basah dan granulasi kering. Metode yang digunakan dalam pengumpulan data yaitu melalui instrument pencarian online terbitan Nasional ataupun Internasional. Hasil dari review beberapa artikel ini diketahui perbedaan penggunaan metode menghasilkan evaluasi yang berbeda diantaranya waktu air, waktu larut, kadar air dan kandungan lembab

KARAKTERISASI DAN STUDI PENAPISAN FITOKIMIA DAUN KELOR (Moringa oleifera L.) ASAL GARUT JAWA BARAT: CHARACTERIZATION AND PHYTOCHEMICAL SCREENING STUDY OF MORINGA LEAF (Moringa oleifera L.) FROM GARUT, WEST JAVA Aji Najihudin; Siti Hindun; Nopi Rantika; Ghina Magfiroh; Dani Sujana
Medical Sains : Jurnal Ilmiah Kefarmasian Vol 8 No 2 (2023)
Publisher : Sekolah Tinggi Farmasi Muhammadiyah Cirebon

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37874/ms.v8i2.761

Tanaman kelor (Moringa oleifera L.) digunakan oleh masyarakat sebagai obat tradisional dan diyakini memiliki potensi untuk mengatasi malnutrisi serta mencegah dan menyembuhkan berbagai penyakit. Sebagai calon bahan baku obat, karakteristik merupakan langkah awal untuk mengetahui mutu dari simpilia, sehingga hasilnya dapat dijadikan acuan pengembangan penelitian selanjutnya. Tujuan dari karakteristik simplisa dalam upaya pemenuhan persyaratan dan menjamin konsistensi mutu untuk memenuhi standar yang telah ditetapkan sebagai bahan baku obat tradisional. Penelitian ini melaporkan bahwa serbuk simplisia daun kelor memiliki nilai kadar air 4,0%, kadar abu total 6,47%, kadar abu larut air 1,69%, kadar abu tidak larut asam 0,73%, kadar sari larut air 38%, kadar sari larut etanol 18% dan susut pengeringan 6,5%. Rendemen ekstrak yang diperoleh adalah 13,58%, sedangkan hasil penapisan fitokimia dari simplisia dan ekstrak daun kelor menunjukkan hasil yang konsisten antara kandungan alkaloid, flavonoid, tanin dan kuinon, akan tetapi saponin dan steroid/triterpenoid justru tidak terdeteksi setelah perlakuan ekstraksi. Jenis dan konsentrasi fitokimia pada tanaman sumber berbeda-beda tergantung faktor internal dan eksternal seperti jenis tanaman, varietas, tanah, dan lingkungan tumbuh (luas, ketinggian, dan musim). Saponin diklasifikasikan sebagai saponin steroid atau triterpenoid tergantung pada sifat aglikon, yang dikenal sebagai sapogenin. Selama ekstraksi, saponin dapat terhidrolisis dan terdegradasi, sehingga harus sangat berhati-hati selama ekstraksi. Selain itu, struktur kimia saponin dapat berubah selama penyimpanan atau pengolahan. Ikatan antara rantai gula dan aglikon serta antara gugus gula dapat dihidrolisis dengan perlakuan asam atau basa, dihidrolisis atau diubah oleh enzim/mikroorganisme, mengarah pada pembentukan aglikon, prosapogenin (saponin yang dihidrolisis sebagian) dan residu gula...

ACTIVITY TEST OF RED BETEL LEAF ETHANOL EXTRACT (Piper crocatum Ruiz & Pav) AS AN ACTIVE INGREDIENT IN SUNSCREEN PREPARATIONS Siti Hindun; Nopi Rantika; Aji Najihudin; Nurul Auliasari; Winna Khoerunisa
Medical Sains : Jurnal Ilmiah Kefarmasian Vol 9 No 2 (2024)
Publisher : Sekolah Tinggi Farmasi Muhammadiyah Cirebon

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37874/ms.v9i2.1007

Skin that is continuously exposed to sunlight can cause a reduction in the structure and elasticity of the skin and other bad effects, so it is necessary to have a skin protective agent, one of which is using sunscreen preparations. In the cosmetics sector, making products from natural ingredients is more profitable. They have a good tolerance for the skin because they do not cause severe irritation to sensitive skin. This research aims to determine the activity of red betel leaf ethanol extract as a sunscreen by looking at the SPF (Sun Protection Factor) value. The determination of the SPF value of red betel leaf ethanol extract was carried out in vitro using UV-Vis spectrophotometers at a wavelength range of 290 – 320 nm. Phytochemical testing is carried out to determine the content of chemical compounds that play a role in sunscreen activity. The research results show that the SPF values obtained from concentrations of 100, 200, 300, 400, 500, and 600 ppm, respectively, are 8.486 (extra-protection), 10,849 (maximum protection), 13,709 (maximum protection), 17.1 (ultra protection), 22 (ultra protection) and 25 (ultra protection). Based on the results of phytochemical tests, the ethanol extract of red betel leaves positively contains phenolics, flavonoids, alkaloids, tannins, saponins, steroids, and/or terpenoids. Keywords: Red betel leaves (Piper crocatum Ruiz &Pav), Sunscreen, SPF, In-Vitro, Ultra-protection

FORMULATION OF RED BETEL LEAF EXTRACT LOTION (Piper crocatum Ruiz & Pav) AS SUNSCREEN Rantika, Nopi; Hindun, Siti; Najihudin, Aji; Auliasari, Nurul; Khoerunisa, Winna; Sopiah, Siti
Jurnal Ilmiah Farmako Bahari Vol 15, No 2 (2024): Jurnal Ilmiah Farmako Bahari
Publisher : Faculty of Mathematic and Natural Science, Garut University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52434/jifb.v15i2.3253

Betel leaf is a natural ingredient that people use as a traditional medicine. One of the ingredients found in red betel leaves is a phenolic compound in the form of flavonoids, a photoprotective substance that can be used as protection from UV radiation. Sunscreen is a cosmetic preparation that can protect the skin from UV radiation and reduce the amount of radiation harmful to the skin. This study aimed to formulate a lotion preparation from red betel leaf extract that has activity as a sunscreen. Red betel leaf (Piper crocatum Ruiz & Pav) was extracted using the maceration method. Preparation formulations were made with variations of red betel leaf ethanol extract in each formula, namely with concentrations of 0.04% (F1), 0.05% (F2), 0.06% (F3), and base control (F0). The activity of sunscreen lotion extract is based on the Sun Protection Factor (SPF) value using UV-VIS spectrophotometry at wavelengths of 290–320 nm using the Mansur equation. The results of the SPF value of the lotion are F1 of 13.48, F2 of 16.71, and F3 of 18.7. The evaluation of the lotion results obtained a light green lotion with M/A emulsion type that met the requirements, including homogeneity, pH, spreadability, viscosity, centrifugation test, and freeze and thaw test. Research results show that betel leaf extract lotion is physically stable and has a high SPF value, so it has the potential to be a sunscreen.

ANTI-ACNE FACIAL WASH FORMULATION FROM RED BETEL LEAF EXTRACT (PIPER CROCATUM RUIZ & PAV) Hindun, Siti; Gazzali, Amirah Mohd; Najihudin, Aji; Hamdani, Siva; Rantika, Nopi; Azizah, Winanda Nur
Jurnal Ilmiah Farmako Bahari Vol 15, No 1 (2024): Jurnal Ilmiah Farmako Bahari
Publisher : Faculty of Mathematic and Natural Science, Garut University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52434/jifb.v15i1.3259

Acne can be caused by dust, sweat, and dirt that stick to the skin, forming blackheads. When blackheads become infected with bacteria, inflammation can occur. Therefore, it is essential to maintain good skin hygiene. One way to do this is by using natural ingredients with antibacterial properties. Red betel leaf is known to have antibacterial activity. This study aims to create a facial wash using red betel leaf extract that exhibits antibacterial properties against Propionibacterium acnes. The red betel leaf was extracted using the maceration method. Antibacterial testing was conducted against Propionibacterium acnes bacteria using the suitable diffusion method with a combination of red betel leaf extract at 10%, 15%, and 20%. The study found that facial wash products containing extract concentrations of 10%, 15%, and 20% demonstrated good physical stability, meeting the requirements of SNI-19-4380-1996 for pH, viscosity, specific gravity, and foam height. Additionally, the products showed potent antibacterial activity against Propionibacterium acnes bacteria, with inhibition zones of 29.0 mm, 32.6 mm, and 35.3 mm for the 10%, 15%, and 20% concentrations, respectively.

FORMULATION OF RED BETEL LEAF EXTRACT LOTION (Piper crocatum Ruiz & Pav) AS SUNSCREEN Rantika, Nopi; Hindun, Siti; Najihudin, Aji; Auliasari, Nurul; Khoerunisa, Winna; Sopiah, Siti
Jurnal Ilmiah Farmako Bahari Vol 15 No 2 (2024): Jurnal Ilmiah Farmako Bahari
Publisher : Faculty of Mathematic and Natural Science, Garut University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52434/jifb.v15i2.3253

Betel leaf is a natural ingredient that people use as a traditional medicine. One of the ingredients found in red betel leaves is a phenolic compound in the form of flavonoids, a photoprotective substance that can be used as protection from UV radiation. Sunscreen is a cosmetic preparation that can protect the skin from UV radiation and reduce the amount of radiation harmful to the skin. This study aimed to formulate a lotion preparation from red betel leaf extract that has activity as a sunscreen. Red betel leaf (Piper crocatum Ruiz & Pav) was extracted using the maceration method. Preparation formulations were made with variations of red betel leaf ethanol extract in each formula, namely with concentrations of 0.04% (F1), 0.05% (F2), 0.06% (F3), and base control (F0). The activity of sunscreen lotion extract is based on the Sun Protection Factor (SPF) value using UV-VIS spectrophotometry at wavelengths of 290–320 nm using the Mansur equation. The results of the SPF value of the lotion are F1 of 13.48, F2 of 16.71, and F3 of 18.7. The evaluation of the lotion results obtained a light green lotion with M/A emulsion type that met the requirements, including homogeneity, pH, spreadability, viscosity, centrifugation test, and freeze and thaw test. Research results show that betel leaf extract lotion is physically stable and has a high SPF value, so it has the potential to be a sunscreen.

FORMULASI DAN KARAKTERISASI NANOPARTIKEL α- MANGOSTIN DENGAN VARIASI KITOSAN-TPP SEBAGAI POLIMER Auliasari Nurul; Azzahra Rizki Fatimah; Najihudin Aji
Pharmacoscript Vol. 7 No. 2 (2024): Pharmacoscript
Publisher : Lembaga Penelitian dan Pengabdian Masyarakat, Universitas Perjuangan Tasikmalaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36423/pharmacoscript.v7i2.1660

Tanaman manggis mengandung senyawa α-Mangostin yang merupakan senyawa turunan dari senyawa Xanton. α-Mangostin memiliki banyak aktivitas salah satunya adalah antibakteri. Kekurangan senyawa α-Mangostin yaitu stabilitas yang kurang baik, karakteristik yang sensitif dan mudah teroksidasi. Sehingga untuk mengatasi permasalahan tersebut dibuatlah sistem penghantaran nanopartikel dengan menggunakan variasi kitosan dan TPP sebagai polimer. Tujuan dari penelitian ini adalah untuk melakukan formulasi dan karakterisasi nanopartikel α-Mangostin dari kulit buah manggis dengan variasi kitosan-TPP sebagai polimer dan menentukan formula terbaik dari nanopartikel α-Mangostin dengan variasi kitosan-TPP sebagai polimer. Pada penelitian ini dilakukan formulasi nanopartikel kosong dengan variasi kitosan yaitu F1, F2 dan F3 adalah 1,4 mg/mL; 2,8 mg/mL, dan 5,6 mg/mL. Kemudian α-Mangostin diformulasikan kedalam nanopartikel dengan variasi konsentrasi diantaranya F1, F2 dan F3 adalah 0,0125 mg/mL; 0,0250 mg/mL; dan 0,0500 mg/mL menggunakan metode gelasi ionik. Selanjutnya, nanopartikel dievaluasi meliputi ukuran partikel, indeks polidispersitas dan efisiensi enkapsulasi. Formula terbaik nanopartikel yang dihasilkan yaitu pada F1 dengan konsentrasi kitosan 1,4 mg/mL; TPP 1,47 mg/mL; dan α-Mangostin 0,0125 mg/mL dengan ukuran partikel yaitu 813 nm ± 0,818 dan indeks polidispersitas 0,604 ± 0,004 serta efisiensi enkapsulasi sebesar 94,565% ± 0,563. Hal ini menunjukkan bahwa isolat α-Mangostin berhasil terenkapsulasi dalam sistem pembawa nanopartikel dan diharapkan mampu meningkatkan ketersediaan hayati obat.

Selective Determination of Tetracycline in Broiler Chicken Meat by Molecularly Imprinted Polymer Suryana, Shendi; Najihudin, Aji; Elivania, Salma; Suherman, Meillia
Indonesian Journal of Pharmaceutical Science and Technology Vol 12 (2025): Vol. 12 Suppl. 2 (2025)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/ijpst.v12i0.58889

Tetracycline (TC) residues in poultry meat products can create antibiotic resistance in humans who consume them. Hence, sensitive analytical procedures to evaluate the quantities of tetracycline residues are required to assess the safety of these products for consumption. The study aimed to develop a sorbent using molecular imprinting technology to analyze tetracycline in chicken broiler meat products. The study used several tests and computational techniques to increase the effectiveness of screening for the best MIP systems. According to the bond energybased computational analysis, methacrylate acid (MAA) was the best functional monomer at a TC-to-MAA molar ratio of 1:6. The mixture of methanol and chloroform yielded the greatest Ka. The Job plot showed that a TC-to-MAA-molar ratio of 1:6 was best for synthesizing imprinted polymer in the mixture of methanol and chloroform. We generated MIPs using two alternative production methods: bulk (MIP1) and precipitation (MIP2). Adsorption capacity results revealed that MIP1 matches well with the Langmuir model, whereas MIP2 fits better with the Freundlich. MIP1 application produced recovery rates of 82,74±4.1% and MIP2 results of 92.14±3.2% for TC in spike-chicken meat. The outcomes of the selectivity test also demonstrated that MIP2 is superior to MIP1 and can recover TC from spiked chicken meat while coexisting with another antibiotic drug. The study’s findings indicate that MIP2 helps determine TC in spike chicken meat.

Peningkatan Perilaku Hidup Bersih dan Sehat (PHBS) Di Madrasah Tsanawiyah Persatuan Islam 99 Rancabango Melalui Workshop Pembuatan Sabun Najihudin, Aji; Auliasari, Nurul; Hindun, Siti; Rantika, Nopi; Amalia, Nur; Fadhlillah, Faizah Min
Jurnal Pengabdian Masyarakat Farmasi : Pharmacare Society Vol 4, No 3 (2025)
Publisher : State University of Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37905/phar.soc.v4i3.33782

Perilaku hidup bersih dan sehat (PHBS) merupakan suatu praktik tentang perilaku seseorang dengan cara memperhatikan kebersihan, kesehatan, dan berperilaku sehat untuk meningkatkan derajat kesehatan. Tujuan dari kegiatan pengabdian kepada masyarakat ini adalah memberikan workshop kepada siswa dan guru Madrasah Tsanawih (MTS) Pesantren Persatuan Isalam (Persis) 99 Rancabango mengenai cara pembuatan sabun batang, sabun cuci tangan dan sabun cuci piring secara sederhana. Metode yang digunakan pada kegiatan ini yaitu melakukan pre-test mengenai mengenai perilaku hidup bersih dan sehat yang terkolerasi dengan berbagai aktivitas di pesantren, workshop pembuatan sabun batang, sabun cuci piring dan sabun cuci tangan oleh peserta kegiatan pengabdian, pemberian produk hasil workshop kepada peserta dan post-test. Selanjutnya dilakukan pengisian kuisioner tingkat kepuasan siswa dan guru terhadap kegiatan workshop, pemberian sertifikat, dan evaluasi. Kegiatan dilakukan pelatihan pembuatan produk kebersihan yang umum digunakan di rumah tangga, bahan dasar sabun yang digukan diantaranya adalah Natrium lauril sulfat, Natrim sulfat, amphitol, Natrium EDTA, pewarna, pewangi dan air. Dari kegiatan berlangung peserta mendapatkan pengalaman membuat dan mengolah produk pembersih sehingga dapat digunakan sebagai bagian produk dalam meningkatkan perilaku hidup bersih dan sehat hasil evaluasi menunjukkan ada peningkatan pengetahuan siswa dan guru mengenai perilaku hidup bersih dan sehat yang dapat dilihat dari hasil evaluasi pre-test dan pos-test yaitu dari 82% menjadi 90% yang artinya adanya peningkatan sebesar 8%, dan untuk hasil kuesioner kepuasan siswa dan guru terhadap workshop pembuatan sabun yang diberikan yaitu menyatakan 99% siswa dan guru puas terhadap workshop yang diberikan.

ANTI-ACNE FACIAL WASH FORMULATION FROM RED BETEL LEAF EXTRACT (PIPER CROCATUM RUIZ & PAV) Hindun, Siti; Gazzali, Amirah Mohd; Najihudin, Aji; Hamdani, Siva; Rantika, Nopi; Azizah, Winanda Nur
Jurnal Ilmiah Farmako Bahari Vol 15 No 1 (2024): Jurnal Ilmiah Farmako Bahari
Publisher : Faculty of Mathematic and Natural Science, Garut University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52434/jifb.v15i1.3259

Acne can be caused by dust, sweat, and dirt that stick to the skin, forming blackheads. When blackheads become infected with bacteria, inflammation can occur. Therefore, it is essential to maintain good skin hygiene. One way to do this is by using natural ingredients with antibacterial properties. Red betel leaf is known to have antibacterial activity. This study aims to create a facial wash using red betel leaf extract that exhibits antibacterial properties against Propionibacterium acnes. The red betel leaf was extracted using the maceration method. Antibacterial testing was conducted against Propionibacterium acnes bacteria using the suitable diffusion method with a combination of red betel leaf extract at 10%, 15%, and 20%. The study found that facial wash products containing extract concentrations of 10%, 15%, and 20% demonstrated good physical stability, meeting the requirements of SNI-19-4380-1996 for pH, viscosity, specific gravity, and foam height. Additionally, the products showed potent antibacterial activity against Propionibacterium acnes bacteria, with inhibition zones of 29.0 mm, 32.6 mm, and 35.3 mm for the 10%, 15%, and 20% concentrations, respectively.

Title

Found 38 Documents
Search

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Title Search

Found 38 Documents Search

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Title

Found 38 Documents
Search