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Immune response in IGF-1 and growth parameters among infected children Ardianah, Eva; Widjaja, Nur Aisiyah; Indriani, Diah; Melaniani, Soenarnatalina; Kuntoro; Wibowo, Arief; Notobroto, Hari Basuki; Purnomo, Windhu; Indawati, Rachmah; Saputro, Sigit Ari; Santoso, Febrina Mustika; Puspitasari, Ria; Pebriaini, Prisma Andita; Nurfidaus, Yasmine; Irawan, Roedi; Hidayat, Boerhan; Hidayati, Siti Nurul; Hanindita, Meta Herdiana
BKM Public Health and Community Medicine Vol 41 No 08 (2025)
Publisher : Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/bkm.v41i08.18379

Abstract

Purpose: Infections in children can affect weight gain and linear growth by influencing metabolism and nutrition. Chronic inflammation results in growth failure mediated by pro-inflammatory cytokines and poor nutritional intake, which affects the GH/IGF-1 axis. This study aimed to investigate the impact of the inflammatory response on children's anthropometry, particularly HAZ, and the role of IGF-1. Methods: An observational study with a cross-sectional design was conducted from September 2021 to July 2022. The study involved children diagnosed with infections. The subjects had undergone a physical and laboratory investigation, which included a thorax photo, urine culture, Mantoux test, and complete blood test in a hospital setting. A complete medical history was obtained from the pediatrician. Results: The prevalence of undernutrition was 37.33%; the prevalence of underweight/severely underweight, stunted/severely stunted, and wasted/severely wasted was 25.33%, 30.66%, and 14.67% respectively. Stunted/severely stunted was more prevalent in subjects under 2 years old, compared to subjects more than 2 years old (22/41 vs. 7/34, p=0.014). SEM analysis revealed that the inflammatory response affected IGF-1 levels (r=0.850, p=0.000), while IGF-1 affected body composition (r=0.245, p=0.025), and then affected HAZ (r=1.000, p=0.000). The effect of IGF-1 on HAZ appears to be indirect, acting through body composition. Parental height has a weak, albeit significant, effect on body composition (r=0.101, p=0.025) and HAZ (r=0.192, p=0.040). Univariate analysis revealed strong correlations between IL-6 and IL-10 and IGF-1 (r=0.870, p=0.000 and 0.876, p=0.000, respectively). In contrast, parental height showed a correlation with HAZ/LAZ (r=0.319, p=0.000). Maternal height was correlated positively with WAZ (r=0.320, p=0.044). Conclusion: The prevalence of stunting among children under two years of age indicates that early childhood constitutes a critical period for intervention in growth and development. Inflammatory response has been demonstrated to influence IGF-1 levels in children. The role of IGF-1 on HAZ was mediated by body composition.
Faktor-Faktor Yang Berhubungan Dengan Kejadian Kekurangan Energi Kronis Pada Wanita Hamil di Indonesia Rahayu, Almirah Nareswari; Purnomo, Windhu
Jurnal Promotif Preventif Vol 7 No 3 (2024): Juni 2024: JURNAL PROMOTIF PREVENTIF
Publisher : Fakultas Kesehatan Masyarakat Universitas Pancasakti

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47650/jpp.v7i3.1325

Abstract

Kekurangan Energi Kronis (KEK) merupakan kondisi kekurangan makanan yang berlangsung menahun (kronis) yang dapat menyebabkan gangguan kesehatan pada ibu. Prevalensi KEK pada wanita hamil di Indonesia tahun 2023 mencapai 16,9%. Penelitian ini bertujuan untuk mengidentifikasi faktor yang berhubungan dengan kejadian KEK pada ibu hamil di Indonesia menggunakan data SKI 2023. Penelitian ini menggunakan metode kuantitatif dengan desain cross sectional study. Populasi pada penelitian ini adalah seluruh wanita hamil usia 10-49 tahun sebanyak 70.916, sampel pada penelitian ini diambil menggunakan teknik proportionate starified random sampling sebanyak 4.854. Hasil penelitian dianalisis menggunakan uji kendall’s tau untuk mengetahui nilai p. Hasil penelitian menunjukkan terdapat hubungan antara faktor usia (p=0,009) dan faktor status ekonomi (p=0,050) dengan kejadian KEK pada ibu hamil, tidak terdapat hubungan antara faktor pendidikan (p=0,091) dengan kejadian KEK. Kesimpulan penelitian ini adalah wanita hamil dengan status ekonomi yang rendah dan usia yang terlalu muda berisiko mengalami KEK.
Faktor Pemilihan Metode Kontrasepsi Jangka Panjang pada Akseptor KB: Studi di Wilayah Kerja Puskesmas Sukabumi Kota Probolinggo Sari, Karinda Permata; Purnomo, Windhu
Viva Medika Vol 16 No 3 (2023)
Publisher : Universitas Harapan Bangsa Purwokerto

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35960/vm.v16i3.1100

Abstract

The program to increase the use of LARC is the main focus of the family planning program in preventing the adverse effects of the population explosion by adjusting the time, spacing and number of pregnancies for couples of childbearing age and reducing the Maternal Mortality Rate (MMR). The coverage of KB LARC acceptors in the Working Area of ​​the Sukabumi Health Center is only 15.5% or below the national target (25.9%). This study aims to analyze factors related to the selection of MKJP for family planning acceptors in the working area of ​​the Sukabumi Health Center, Probolinggo City in 2023 with a quantitative case-control design study with a retrospective approach then use simple random sampling from the study population of 1,980 family planning acceptors and 88 samples comprising 44 LARC FP acceptors and 44 Non-LARC FP acceptors. Primary data was obtained by distributing questionnaires and then univariate and bivariate analysis was performed using the chi-square test. The results of the study mentioned age (p=0.001), number of children (p=0.002), employment status (p=0.018), knowledge (p=0.003), attitude (p=0.033), spousal support (p=0.030) and role health workers (p=0.000) had a relationship. In contrast, an education level (p=0.089) had no association with the selection of LARC acceptors in the Working Area of ​​the Sukabumi Health Center.
Hubungan ASI Eksklusif dengan Perkembangan Balita yang Memiliki Riwayat Berat Badan Lahir Rendah (BBLR) di Puskesmas Tanah Kali Kedinding Surabaya Kumala, Hasniyah Rizka; Purnomo, Windhu
Media Gizi Kesmas Vol 8 No 2 (2019): MEDIA GIZI KESMAS (DECEMBER 2019)
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/mgk.v8i2.2019.33-39

Abstract

Latar Belakang: Bayi dengan berat badan lahir rendah (BBLR) atau bayi yang lahir <2500g, memilikiperkembangan cenderung lebih lambat dibandingkan anak yang lahir dengan berat badan normal.Pada kasus BBLR sangat jarang diberikan ASI secara eksklusif karena keinginan ibu untukmenaikkan berat badan bayi secara cepat, sehingga diberikan makanan tambahan selain ASI. Balitadengan riwayat BBLR sangat beresiko mengalami gangguan tumbuh kembang.Tujuan: Tujuan Penelitian ini adalah menganalisis apakah ada hubungan antara ASI ekslusif denganperkembangan balita dengan riwayat BBLR di Puskesmas Tanah Kali Kedinding Kota Surabaya.Metode: Jenis penelitian analitik observasional yang bersifat cross sectional. Populasi ibu yangmemiliki bayi usia 12-36 bulan dengan riwayat Berat Badan Lahir Rendah sebanyak 34 responden,menggunakan tehnik simple random sampling ditemukan besar sampel 32 responden. Variabelindependen ASI eksklusif, variabel dependen pertumbuhan. Pengumpulan data menggunakankuesioner dan uji statistic menggunakan spearman.Hasil: Hasil penelitian menunjukkan bahwa dari penghitungan menggunakan uji spearman diperolehp=0, 000 yang berarti ada hubungan yang signifikan antara ASI eksklusif dengan perkembangan padabalita dengan riwayat BBLR.Kesimpulan: Kesimpulan dari penelitian ini semakin bayi diberi ASI eksklusif maka perkembanganbalita akan semakin baik.ABSTRACTBackground: Babies with Low Birth Weight or babies born ≤2500gr, having a development of tend tobe slower than children born with normal weight. In the case LBW was given exclusive breastfeedingrarely because the mother want to raised the baby weight quickly, so given extra food other thanbreastfeeding. The growth of toddler with LBW history is very at risk of growth disorder.Objectives: The purpose of this study was to analyze the relationship between exclusivebreastfeeding with development of toddlers who had LBW history in Puskesmas Tanah Kali KedindingSurabaya The population involved the mother with a baby 12-36 months of age with a history of lowbirth weight as much as 34, respondents using simple technique random sampling found big 32respondents.Methods: This research using cross sectional approach. The independent variable, exclusive breastmilk the dependent variable growth and development. The collection of data using a questionnaire andtest it statistic use spearman correlation.Results: The results p value of test spearman p=0.000 which means significant exists correlationbetween breastfeeding exclusively with development.Conclusion: The conclusion this study, the more babies are given exclusive breastfeeding, the betterthe toddler's development will be.
Co-Authors Adelia Dwi Pratiwi Afif Nurul Hidayati Agus Sulistyono Ardianah, Eva Arief Wibowo Astik Umiyah A`im Matun Nadhiroh Bambang Trijanto Bambang Trijanto, Bambang Bangun Cahyo Utomo Boerhan Hidayat Boerhan Hidayat, Boerhan Budi Santoso Chatarina Umbul Wahyuni Christine Ohee Desiansi Merlinda Niga Diah Indriani Dias Lidiana A.S Dina Dewi Anggraini Dina Dewi Anggraini Diyah Herowati Djazuly Chalidyanto Eddy Rahardjo Efri Tri Ardianto Eka Mawang Susanti Eka Nasrur Maulana Endang Retnowati Endang Retnowati Frieska Piesesha Galuh Pradian Yanuaringsih Gede Danu Widarta Hanindita, Meta Herdiana Hari Basuki Notobroto HERAWATI, LILIK Hermanto Tri Joewono Heru Santoso Wahito Nugroho Hikma Rafiah Nadjib Ilham Ikhtiar Irwan A. Hi. Mustafa Irwanto, Irwanto Iswari Hariastuti Karinda Permata Sari Kumala, Hasniyah Rizka KUNTORO Laksana, Muhammad Ardian Cahya Lestari Basoeki Lila Tri Harjana Lutfiya, Indah Maemonah, Maemonah Mardiyono Mardiyono Marisca Mega Widya Puspa Ningrum Merryana Adriani Mohamad Nurdin Zuhri Najakhatus Sa’adah Najib, Hikmah Rafiah Nila Kurniasari Ningtyas, Amalia Dwi Niniek Lely Pratiwi Nur Aisiyah Widjaja, Nur Aisiyah Nurfidaus, Yasmine Nurwasis Nurwasis Nyoman Anita Damayanti Pebriaini, Prisma Andita Piesesha, Frieska Rachmah Indawati Rachmat Hargono Rahayu, Almirah Nareswari Rehatta, Nancy Margarita Ria Puspitasari Roedi Irawan Royke Tony Kalalo Santi Martini Santoso, Febrina Mustika Sarah Christiawan Sari, Karinda Permata Shrimarti Rukmini Devy Sigit Ari Saputro Sinawan Sinawan Sinawan Sinawan, Sinawan SITI NURUL HIDAYATI Soenarnatalina Meilanani Soenarnatalina Melaniani Suhatno Susanti, Eka Mawang Teguh Prawono Sabat Teguh Prawono Sabat, Teguh Prawono Tri Ratna Ariestini Tumbelaka, Reyner Valiant Udin Kurniawan Aziz Uktutias, Sendy Ayu Mitra Wandera Ahmad Religia Widjiati Widjiati Yanuaringsih, Galuh Pradian Yuly Sulistyorini