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Journal : Science and Technology Indonesia

Anti-Inflammatory Activity and Phytochemical Profile from the Leaves of the Mangrove Sonneratia caseolaris (L.) Engl. for Future Drug Discovery Rozirwan; Ade Siswanto; Nadila Nur Khotimah; Redho Yoga Nugroho; Wike Ayu Eka Putri; Fauziyah; Rezi Apri; Hartoni
Science and Technology Indonesia Vol. 9 No. 2 (2024): April
Publisher : Research Center of Inorganic Materials and Coordination Complexes, FMIPA Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26554/sti.2024.9.2.502-516

Abstract

The increasing demand for effective and natural anti-inflammatory agents prompts an investigation into the properties of Sonneratia caseolaris (L.) Engl., a plant traditionally used in medicine. This study aimed to explore the ability of S. caseolaris leaves extract to inhibit inflammation and accelerate wound healing. S. caseolaris leaves were collected from Tanjung Api-Api area, Banyuasin, South Sumatra. The method involved carrageenan induction in rat paws as an inflammatory model. The results showed that the most effective dose was found in the group with a dose of 150 mg/kg BW measured using a digital caliper and plethysmometer. The qualitative phytochemical test contain alkaloids, steroids, flavonoids, and phenols. The results GC-MS analysis were thought to contain aldehydes, glucosinolates, coumarins, esters, terpenoids, alcohols, lipids, tocopherols, and steroids. Due to their diverse range of mechanisms of action, coumarins show significant promise in mitigating inflammation and hold potential for treating inflammatory conditions. This study provides new insights related to the potential of S. caseolaris as a source of natural anti-inflammatory agents, supporting public comprehension regarding the utilization of traditional herbal remedies.
Copper and Lead Contamination in Sediment and Benthic Ecosystems of Sembilang National Park’s Coastal Region, South Sumatra Rozirwan; Ananta, Dio Alif; Khotimah, Nadila Nur; Putri, Wike Ayu Eka; Fauziyah; Dianysah, Gusti; Siregar, Yusni Ikhwan; Ramses; Isnaini; Melki; Aryawati, Riris; Agustriani, Fitri; Nugroho, Redho Yoga
Science and Technology Indonesia Vol. 10 No. 3 (2025): July
Publisher : Research Center of Inorganic Materials and Coordination Complexes, FMIPA Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26554/sti.2025.10.3.866-876

Abstract

Littoral zone often face environmental pressure due to anthropogenic activities, which can impact the quality of their ecosystem. This study analyzes the concentrations of copper (Cu) and lead (Pb) in sediments and benthic (Anadara granosa and Cerithidea cingulata). Sampling procedures were implemented during September 2022 across the aquatic habitats of Sembilang National Park, in South Sumatra Province, using the purposive sampling method. Sediment grain size and substrate type were analyzed using Shepard’s triangle. Metal detection using a spectrophotometric method based on atomic absorption. The results showed that the sediment fraction mostly consisted of clay, ranging from 92.03% to 94%. Cu concentrations in the sediment ranged from 5.01±0.017 to 5.71±0 mg/kg, while Pb concentrations ranged from 10.5±0.195 to 11.51±0.395 mg/kg. In the benthic, Cu concentrations ranged from 0.0037±0.00005773 to 0.0147±0.00000346 mg/kg, and Pb concentrations ranged from 0.0001±0.000227 to 0.005±0 mg/kg. According to the statistical evaluation testing via independent sample t-test showed that heavy metals differed significantly (p <0.05) between sediment and benthic compartments. These results show that the environmental quality in Sembilang National Park is still comparatively well maintained and within current quality requirements, despite certain activities that have the potential to pollute the environment. To guarantee the long-term viability of this area, it is advised that environmental quality be frequently monitored as a mitigation action.
Co-Authors Ade Siswanto Akdhia Besta Sari Amelia Fitriani, Amelia Ananta, Dio Alif Andrian Saputra Andrian Saputra Ani Haryati, Ani Anna Ida Sunaryo Purwiyanto Anna Ida Sunaryo Purwiyanto Anna Ida Sunaryo Purwiyanto Anna Ida Sunaryo Purwiyanto Anna Ida Sunaryo Purwiyanto Anna Ida Sunaryo Purwiyanto Annisa Agustina Kurnia Putri Apon Zaenal Mustopa Aranxa, Virly Barus, Beta Susanto Berliana Iksy Della Beta Susanto Barus Beta Susanto Barus Che Abd Rahim Mohamed De Karo, Fransiskus Dianysah, Gusti Dietriech Geoffrey Bengen Dika Ardila Elyakim Sitorus Etty Riani Fajri, M. Awaluddin FAUZIYAH Fauziyah Fauziyah Fauziyah Fauziyah Fauziyah Fauziyah Fauziyah Fauziyah Fauziyah Fikriyya, Nabela Fitri Agustriani Fitri Meiriyani Gusri, Ariqoh Athallah Gusti Diansyah Gusti Diansyah Gusti Diansyah Gusti Diansyah Gusti Diansyah Harahap, Diny Novita Sari Hartoni Hartoni Hartoni HEDI INDRA JANUAR Heron Surbakti Ida Riyanti Indra Yustian Isnaini Isnaini . Isnaini Isnaini Khotimah, Nadila Nur Kurniawan, Mardian Candra Latupeirissa, Cherokee Mikha-El Lestari, Ning Intan Lidya Grace Lidya Grace Lilik Maslukah M. Andrian Putra Pratama M. Awaluddin Fajri M. Hendri M. Yosi Prasetyo Mardian Candra Kurniawan Mei Ida Susanti Meiriyani, Fitri Meiyerani, Jeni Melki Melki , Melki Melki Melki Melki Melki Melki Moh. Muhaemin Moh. Muhaemin Mohamed, Che Abd Rahim Muhammad Hendri Muhammad Hendri Muhtadi Muhtadi Muhtadi Nadila Nur Khotimah Nadila Nur Khotimah Nidia Nova Riena Ningsih, Ellis Nurjuliasti Novi Anggraini Novi Angraini Novitasari, Tri Ayu Prihatiningsih, Isnaini Rahmad Purnama Rahmad Purnama, Rahmad Raihan, Muhammad Ramadhian, M. Zalfa Ramses Redho Yoga Nugroho Rezi Apri Ria Ariana Riena, Nidia Nova Riris Aryawati Rozirwan . RR. Ella Evrita Hestiandari Santeri, Tiara Sarno . Siddik, Judistira Sitorus, Rijal Suai Batul Aslamiah Tengku Zia Ulqodry Tengku Zia Ulqodry Tjahjo Winanto, Tjahjo Tri Prartono Wahyudi Wahyudi Widiya Nopita Sari Winarta, Yoga Yuanita Windusari Yulianto Suteja Yundari, Yundari Yusni Ikhwan Siregar