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All Journal Alchemy : Journal of Chemistry Biology, Medicine, & Natural Product Chemistry KOVALEN: Jurnal Riset Kimia Jurnal Ilmiah Universitas Batanghari Jambi Martabe : Jurnal Pengabdian Kepada Masyarakat Molekul: Jurnal Ilmiah Kimia ALKIMIA : Jurnal Ilmu Kimia dan Terapan Jurnal Inovasi Farmasi Indonesia Abdimas Galuh: Jurnal Pengabdian Kepada Masyarakat Jurnal Abdimas Ilmiah Citra Bakti (JAICB) Jurnal Bioteknologi & Biosains Indonesia (JBBI) Khidmah Nusantara Jurnal Bioteknologi & Biosains Indonesia
Datin An Nisa Sukmawati
Department Of Pharmacy, Faculty Of Healthy Sciences, University Of Kadiri, Kediri-East Java 64115, Indonesia
Agriculture, Biological Sciences & Forestry Arts Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Civil Engineering, Building, Construction & Architecture Computer Science & IT Decision Sciences, Operations Research & Management Economics, Econometrics & Finance Education Energy Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Mathematics Medicine & Pharmacology Nursing Physics Public Health Social Sciences

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Analisis Tingkat Pengetahuan dan Perilaku Swamedikasi Obat Analgesik di Apotek Sumber Urip Jaya: Analysis of Knowledge Level and Self-Medication Behavior of Analgesic Drugs at Sumber Urip Jaya Pharmacy, Kediri Probosiwi , Neni; Ilmi , Tsamrotul; Laili, Nur Fahma; saristiana, yuneka; Sukmawati, Datin An Nisa
Jurnal Inovasi Farmasi Indonesia (JAFI) Vol. 6 No. 1 (2024): Volume 6, No.1, Desember 2024
Publisher : Universitas Kadiri

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30737/jafi.v6i1.6487

Abstract

Swamedikasi merupakan tindakan dalam memilih dan menggunakan obat tanpa resep dokter untuk mengatasi masalah kesehatan atau gejala tertentu yang dirasakan. Tujuan penelitian ini untuk analisis tingkat pengetahuan dan perilaku swamedikasi obat analgesik di Apotek Sumber Urip Jaya. Sampel yang digunakan pada penelitian ini sebanyak 105 responden. Instrumen penelitian berupa kuesioner pengetahuan yang terdiri dari 10 pertanyaan domain kepercayaan swamedikasi, 3 pertanyaan cara mendapatkan obat, 3 pertanyaan cara menggunakan obat, 3 pertanyaan cara penyimpanan obat, dan kuesioner perilaku swamedikasi sebanyak 10 pertanyaan. Penelitian ini dilakukan pada bulan Maret – Mei dan dilakukan di Apotek Sumber Urip Jaya. Analisis data menggunakan SPSS versi 16.0 dengan menggunakan uji chisquare. Hasil penelitian menunjukkan  sebagian besar berusia 36-45 tahun, dengan pendidikan terakhir SMA  dan berprofesi sebagai wiraswasta, mayoritas responden pada indikator kepercayaan swamedikasi (91,42%), cara mendapatkan obat (85,71%), cara penyimpanan obat (86,67%). Nilai signifikansi 0,000 yang artinya terdapat hubungan yang signifikan antara tingkat pengetahuan dan perilaku swamedikasi di apotek Sumber Urip Jaya
Formulasi Dan Uji Antibakteri Porphyromonas Gingivalis Sediaan Gargarisma Ekstrak Daun Pacar Air (Impatiens Balsamina L.): Formulation And Antibacterial Test Porphyromonas Gingivalis Of Gargarisma Extract Water Henna Leaves (Impatiens Balsamina L. Yuniarto, Prayoga Fery; Sukmawati, Datin An Nisa; Lambert, Maringan; Witaning, Leny; hidayah, lailatul; Virginia, Vivi
Jurnal Inovasi Farmasi Indonesia (JAFI) Vol. 6 No. 2 (2025): Volume 6, No.2 Juni 2025
Publisher : Universitas Kadiri

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30737/jafi.v6i2.6525

Abstract

Porphyromonas gingivalis is one of the anaerobic gram-negative bacteria that causes dental and oral health problems that will cause periodontal disease, especially chronic periodontitis. Water henna leaf (Impatiens balsamina L) is one of the plants can be used as an antibacterial drug. This study aims to determine the antibacterial activity of the formulation of Gargarisma leaf extract of henna water against Porphyromonas gingivalis bacteria. The method used in the antibacterial activity test is the diffusion method. The ethanol extract of henna leaf ethanol extract was tested, namely organoleptic test, homogeneity test, pH test and viscosity test. Then proceed with data analysis with One Way ANOVA. This study used 3 formulas with different extract concentrations of 10%, 15%, and 20%, positive control (Chlorhexidine Gluconate), and negative control (aquades). The results of the antibacterial activity test of gargarisma preparations obtained that the average inhibition zone at 10% concentration was 10.97 mm, 15% concentration was 12.02 mm, 20% concentration was 13.76 mm, positive control was 17.9 mm, and aquadest negative control did not show any antibacterial activity.
Profil Terapi dan Evaluasi Peresepan Pasien Covid-19 Rawat Jalan Di RS Wafa Husada Malang: Therapy Profile and Prescription Evaluation for Covid-19 Out Patients at Wafa Husada Hospital Malang Ilmi , Tsamrotul; Probosiwi , Neni; Sukmawati, Datin An Nisa; Nurkamah, Siti; Lestari, Sri; Tandela, Tantik
Jurnal Inovasi Farmasi Indonesia (JAFI) Vol. 6 No. 2 (2025): Volume 6, No.2 Juni 2025
Publisher : Universitas Kadiri

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30737/jafi.v6i2.6529

Abstract

Treatment of COVID-19 patients is differentiated based on the degree of symptoms. The purpose of this study was to determine the therapeutic profile and appropriateness of prescriptions for outpatient COVID-19 at Wava Husada Hospital for the period January–July 202, based on the COVID-19 Management Protocol Book, Edition 2, 2021 and the Hospital Formulary. The research method was a retrospective descriptive observational study with a purposive sampling technique. The research instruments were medical records from SIMRS and patient prescriptions. The results showed that most patients were male (53%), aged 18-44 years (60%). The treatment profile of COVID-19 patients with asymptomatic and mild symptoms, according to therapeutic class, were vitamins (40.3%), cough and cold (12.7%), antipyretic analgesics (9.1%), supplements (8.2%), and macrolide antibiotics (7.6%). The most common types of drugs were vitamin C 500 mg non-acidic (11.8%), vitamin E 400 IU (9.8%) and vitamin D 5000 IU (8.1%). The prescription compliance is 92% of drugs according to the COVID-19 Management Protocol Book Ed. 2 of 2021 and the rationality compliance is 79%. The prescription compliance according to the Hospital Formulary has been fulfilled 100%.
ANALYSIS OF KIDNEY HISTOPATHOLOGY IN SEPSIS MODEL OF MICE (MUS MUSCULUS) WITH PREVENTIVE TREATMENT OF LEAF EXTRACT FROM 'DAUN KENTUT' PLANT (PAEDERIA FOETIDA L.) AGAINST ESCHERICHIA COLI INFECTION Savitri, Lisa; Kasimo, Elfred Rinaldo; Krissanjaya, Rochmad; Sukmawati, Datin An Nisa; Juwita, Syntia Tanu; Kholis, Akbar Nur; Mosse1, Yosep
Jurnal Bioteknologi & Biosains Indonesia (JBBI) Vol. 10 No. 2 (2023)
Publisher : BRIN - Badan Riset dan Inovasi Nasional

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55981/jbbi.2023.2946

Abstract

Sepsis is a critical health concern characterized by organ dysfunction due to uncontrolled host reactions to infections. The prevalence of microorganisms causing sepsis varies, with Gram-positive bacteria and fungal sepsis gaining significance. Sepsis often leads to acute kidney injury (AKI), and its association with sepsis is known as sepsis-associated AKI (SA-AKI). The "Daun Kentut" plant, known for its diverse bioactive compounds, has shown potential in combating inflammation and oxidative stress. In this study, histopathological changes in mouse kidneys induced by Escherichia coli were investigated. Hemorrhage was the primary change observed. Dehydration caused by E. coli infection potentially led to kidney injury through hormonal responses. The plant extract's anti-inflammatory potential, attributed to compounds like saponins and flavonoids, was also explored. The study emphasizes the need for understanding sepsis-related kidney damage and suggests possible preventive strategies using natural compounds.
THE ANTI-APOPTOTIC POTENTIAL OF Paederia foetida L. LEAF EXTRACT THROUGH THE DOWNREGULATION OF CASPASE-3 EXPRESSION IN AN ESCHERICHIA COLI-INDUCED SEPSIS MICE MODEL Savitri, Lisa; Krissanjaya, Rochmad; Juwita, Syntia Tanu; Sukmawati, Datin An Nisa; Probosiwi, Neni; Laili, Nur Fahma; Ilmi, Tsamrotul; Prasetyawan, Fendy
Jurnal Bioteknologi & Biosains Indonesia (JBBI) Vol. 11 No. 2 (2024)
Publisher : BRIN - Badan Riset dan Inovasi Nasional

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55981/jbbi.2024.8235

Abstract

Sepsis is a life-threatening condition characterized by an abnormal immune response to infection, leading to high mortality rates in intensive care units (ICUs) worldwide. Caspase-3, a crucial enzyme in the apoptosis pathway, plays a significant role in sep-sis-related cellular damage. This study investigates the anti-apoptotic potential of Paederia foetida L. leaf extract by examining its effect on Caspase-3 expression in an Escherichia coli-induced sepsis mice model. Male Balb/c mice were divided into six groups, including positive control, negative control, and treatment groups receiving varying doses of the extract (100 mg/kgBW, 300 mg/kgBW, and 500 mg/kgBW). Caspase-3 expression in the spleen was measured after 24 hours of treatment. The results demonstrated a significant reduction in Caspase-3 expression, particularly in the group treated with 500 mg/kgBW of the extract, indicating its anti-apoptotic effect. These findings suggest that P. foetida leaf extract may serve as a potential therapeutic agent for reducing cell apoptosis in sepsis, warranting further investigation into its mechanisms and clinical pharmacological field.
Optimasi Formulasi Sediaan Balsem Ekstrak Belimbing Wuluh (Averrhoa Bilimbi L.): Formulation Optimization of Starfruit Extract Balm Preparation (Averrhoa Bilimbi L.) Rosyida, Firdania Firdaus; Mustika, Silvia Wahyu; Jaroh, Assolychathu; Remanti, Etis; Kristijono, Ary; Sukmawati, Datin An Nisa
Jurnal Inovasi Farmasi Indonesia (JAFI) Vol. 7 No. 1 (2025): Volume 7 No 1 2025
Publisher : Universitas Kadiri

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30737/jafi.v7i1.7039

Abstract

Balsem merupakan bentuk sediaan farmasi yang bermanfaat sebgai bahan pereda nyeri. Belimbing wuluh secara Konvesional dapat dimanfaatkan untuk mengatasi pembengkakan, karena mengandung terdapat kandungan senyawa flavonoid, tanin, saponin dan akaloid sebagai anti inflamasi. Senyawa ini memiliki kemampuan untuk menghambat enzim pro-inflamasi, seperti siklooksigenase (COX) dan lipoksigenase (LOX). Tujuan penelitian ini adalah optimasi formulasi sediaan balsem ekstrak blimbing wuluh dengan konsentrasi ekstrak 2% dengan bahan tambahan seperti paraffin solidum (12 %), menthol (1 %), methil salisilat (10 %), vaselin album (ad 100%), dan champora sebagai variasi formulasi dengan konsentrasi F1=6% F2=7% F3=8%.  Didapatkan hasil evaluasi fisik sediaan balsem ekstrak belimbing wuluh formula 2 (F2) memiliki nilai tertinggi pada hampir seluruh parameter fitokimia, yaitu flavonoid sebesar 58,1 ± 2,0 mg, tanin 28,3 ± 1,2 mg/g, saponin 3,83 ± 0,15%, serta alkaloid 2,08 ± 0,10 mg/g. Daya sebar F2 sebesar 7,58 ± 0,20 cm, daya lekat. Nilai pH F2 yaitu 5,80 ± 0,06, dan pH F2 yaitu 5,80 ± 0,06, menandakan bahwa F2 memiliki kandungan senyawa aktif paling optimal.
Aktivitas Antioksidan, Kadar Flavonoid, dan Fenolik Total Cangkang Kerang Mutiara (Pinctada maxima): Antioxidant Activity, Flavonoid Content, and Total Phenolics of Pearl (Pinctada maxima) Clam Shells Ngibad, Khoirul; Muadifah, Afidatul; Sukmawati, Datin An Nisa
KOVALEN: Jurnal Riset Kimia Vol. 9 No. 1 (2023): April Edition
Publisher : Chemistry Department, Mathematics and Natural Science Faculty, Tadulako University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22487/kovalen.2023.v9.i1.16281

Abstract

Antioxidant compounds are able to dampen or ward off free radicals. Living things including pearl mussels (Pinctada maxima) can produce secondary metabolite compounds (phenolics, alkaloids, and terpenoids). There have been no studies on the antioxidant potential, flavonoid content, and total phenolics of pearl clam shells. This study aimed to determine the antioxidant potential of pearl clam shell ethanol extract (EECKM) in vitro using the DPPH method. In addition, it aims to determine the total flavonoid and phenolic levels of EECKM. The powder of pearl mussel shells is soaked with ethanol and the filtrate is concentrated until a concentrated extract is obtained. Flavonoid and phenolic levels from EECKM were measured using a UV-Vis spectrophotometer. Measurement of antioxidant activity using the DPPH method. EECKM has a yield of 1.73%, flavonoid levels of 0 mg QE/g, and total phenolics of 4.8 mg GAE/g. The extract has the highest antioxidant activity for a concentration of 100 mg / L with a percent value of DPPH radical inhibition of 67.1%.
Co-Authors Ana Retnowati Anis Akhwan Dhafin Antika, Ayu Rindi Antoro, Ester Lianawati Arifani Siswidiasari Arifani Siswidiasari Ate, Chrispianus Christian Bin Abd Kadir, Mujtahid Dhony Hermanto Eka Wahyuningtiyas Elfred Rinaldo Kasimo Elfred Rinaldo Kasimo, Elfred Rinaldo Elok Kamilah Hayati Elsa Mahardika Putri Ester Lianawati Antoro Fendy Prasetyawan Firdania Firdaus Rosyida Freitas, João Gregório Ida Septika Wulansari Jaroh, Assolychathu Juan Vega Mahardhika Juwita, Syntia Tanu Kadir, Mujtahid Bin Abd Kholis, Akbar Nur Kristijono, Ary Lailatul Hidayah Laili, Nur Fahma Lambert, Maringan Mosse1, Yosep Muadifah, Afidatul Mujtahid Bin Abd Kadir Mujtahid Bin Abd Khadir Mujtahid Bin Abd. Kadir Mustika, Silvia Wahyu Muti'ah, Roihatul Neni Probosiwi Ngibad, Khoirul Nimas Ayu Rahardini Nur Fahma Laili Nurkamah, Siti Nurul Ismillayli Okky Intan Mawarni Ornai, Andre Mario Sequeira Alves Prayoga Fery Yuniarto prayoga fery yuniarto Probosiwi , Neni Putri Larasati, Julyana Remanti, Etis Rochmad Kris Sanjaya Rochmad Krissanjaya savitri, Lisa Sembiring, Yulia Shara Sri Haryuni Sri Lestari Sulistyowati , Yuni Syntia Tanu Juwita Syntia Tanu Juwita Tandela, Tantik Tsamrotul Ilmi Virginia, Vivi Winartiana Witaning, Leny Wulansari, Ida Septika Yosep Mosse Yuneka Saristiana Yuniar, Arlita Wulan Yuniarto, Prayoga Fery