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All Journal Alchemy : Journal of Chemistry Biology, Medicine, & Natural Product Chemistry Jurnal Ilmiah Universitas Batanghari Jambi Martabe : Jurnal Pengabdian Kepada Masyarakat Molekul: Jurnal Ilmiah Kimia ALKIMIA : Jurnal Ilmu Kimia dan Terapan Jurnal Inovasi Farmasi Indonesia Abdimas Galuh: Jurnal Pengabdian Kepada Masyarakat Jurnal Abdimas Ilmiah Citra Bakti (JAICB) Jurnal Bioteknologi & Biosains Indonesia (JBBI) Khidmah Nusantara Jurnal Bioteknologi & Biosains Indonesia
Datin An Nisa Sukmawati
Department Of Pharmacy, Faculty Of Healthy Sciences, University Of Kadiri, Kediri-East Java 64115, Indonesia
Agriculture, Biological Sciences & Forestry Arts Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Civil Engineering, Building, Construction & Architecture Computer Science & IT Decision Sciences, Operations Research & Management Economics, Econometrics & Finance Education Energy Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Mathematics Medicine & Pharmacology Nursing Physics Public Health Social Sciences

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Formulasi Dan Uji Antibakteri Porphyromonas Gingivalis Sediaan Gargarisma Ekstrak Daun Pacar Air (Impatiens Balsamina L.): Formulation And Antibacterial Test Porphyromonas Gingivalis Of Gargarisma Extract Water Henna Leaves (Impatiens Balsamina L. Yuniarto, Prayoga Fery; Sukmawati, Datin An Nisa; Lambert, Maringan; Witaning, Leny; hidayah, lailatul; Virginia, Vivi
Jurnal Inovasi Farmasi Indonesia (JAFI) Vol. 6 No. 2 (2025): Volume 6, No.2 Juni 2025
Publisher : Universitas Kadiri

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30737/jafi.v6i2.6525

Abstract

Porphyromonas gingivalis is one of the anaerobic gram-negative bacteria that causes dental and oral health problems that will cause periodontal disease, especially chronic periodontitis. Water henna leaf (Impatiens balsamina L) is one of the plants can be used as an antibacterial drug. This study aims to determine the antibacterial activity of the formulation of Gargarisma leaf extract of henna water against Porphyromonas gingivalis bacteria. The method used in the antibacterial activity test is the diffusion method. The ethanol extract of henna leaf ethanol extract was tested, namely organoleptic test, homogeneity test, pH test and viscosity test. Then proceed with data analysis with One Way ANOVA. This study used 3 formulas with different extract concentrations of 10%, 15%, and 20%, positive control (Chlorhexidine Gluconate), and negative control (aquades). The results of the antibacterial activity test of gargarisma preparations obtained that the average inhibition zone at 10% concentration was 10.97 mm, 15% concentration was 12.02 mm, 20% concentration was 13.76 mm, positive control was 17.9 mm, and aquadest negative control did not show any antibacterial activity.
Profil Terapi dan Evaluasi Peresepan Pasien Covid-19 Rawat Jalan Di RS Wafa Husada Malang: Therapy Profile and Prescription Evaluation for Covid-19 Out Patients at Wafa Husada Hospital Malang Ilmi , Tsamrotul; Probosiwi , Neni; Sukmawati, Datin An Nisa; Nurkamah, Siti; Lestari, Sri; Tandela, Tantik
Jurnal Inovasi Farmasi Indonesia (JAFI) Vol. 6 No. 2 (2025): Volume 6, No.2 Juni 2025
Publisher : Universitas Kadiri

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30737/jafi.v6i2.6529

Abstract

Treatment of COVID-19 patients is differentiated based on the degree of symptoms. The purpose of this study was to determine the therapeutic profile and appropriateness of prescriptions for outpatient COVID-19 at Wava Husada Hospital for the period January–July 202, based on the COVID-19 Management Protocol Book, Edition 2, 2021 and the Hospital Formulary. The research method was a retrospective descriptive observational study with a purposive sampling technique. The research instruments were medical records from SIMRS and patient prescriptions. The results showed that most patients were male (53%), aged 18-44 years (60%). The treatment profile of COVID-19 patients with asymptomatic and mild symptoms, according to therapeutic class, were vitamins (40.3%), cough and cold (12.7%), antipyretic analgesics (9.1%), supplements (8.2%), and macrolide antibiotics (7.6%). The most common types of drugs were vitamin C 500 mg non-acidic (11.8%), vitamin E 400 IU (9.8%) and vitamin D 5000 IU (8.1%). The prescription compliance is 92% of drugs according to the COVID-19 Management Protocol Book Ed. 2 of 2021 and the rationality compliance is 79%. The prescription compliance according to the Hospital Formulary has been fulfilled 100%.
ANALYSIS OF KIDNEY HISTOPATHOLOGY IN SEPSIS MODEL OF MICE (MUS MUSCULUS) WITH PREVENTIVE TREATMENT OF LEAF EXTRACT FROM 'DAUN KENTUT' PLANT (PAEDERIA FOETIDA L.) AGAINST ESCHERICHIA COLI INFECTION Savitri, Lisa; Kasimo, Elfred Rinaldo; Krissanjaya, Rochmad; Sukmawati, Datin An Nisa; Juwita, Syntia Tanu; Kholis, Akbar Nur; Mosse1, Yosep
Jurnal Bioteknologi & Biosains Indonesia (JBBI) Vol. 10 No. 2 (2023)
Publisher : BRIN - Badan Riset dan Inovasi Nasional

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55981/jbbi.2023.2946

Abstract

Sepsis is a critical health concern characterized by organ dysfunction due to uncontrolled host reactions to infections. The prevalence of microorganisms causing sepsis varies, with Gram-positive bacteria and fungal sepsis gaining significance. Sepsis often leads to acute kidney injury (AKI), and its association with sepsis is known as sepsis-associated AKI (SA-AKI). The "Daun Kentut" plant, known for its diverse bioactive compounds, has shown potential in combating inflammation and oxidative stress. In this study, histopathological changes in mouse kidneys induced by Escherichia coli were investigated. Hemorrhage was the primary change observed. Dehydration caused by E. coli infection potentially led to kidney injury through hormonal responses. The plant extract's anti-inflammatory potential, attributed to compounds like saponins and flavonoids, was also explored. The study emphasizes the need for understanding sepsis-related kidney damage and suggests possible preventive strategies using natural compounds.
THE ANTI-APOPTOTIC POTENTIAL OF Paederia foetida L. LEAF EXTRACT THROUGH THE DOWNREGULATION OF CASPASE-3 EXPRESSION IN AN ESCHERICHIA COLI-INDUCED SEPSIS MICE MODEL Savitri, Lisa; Krissanjaya, Rochmad; Juwita, Syntia Tanu; Sukmawati, Datin An Nisa; Probosiwi, Neni; Laili, Nur Fahma; Ilmi, Tsamrotul; Prasetyawan, Fendy
Jurnal Bioteknologi & Biosains Indonesia (JBBI) Vol. 11 No. 2 (2024)
Publisher : BRIN - Badan Riset dan Inovasi Nasional

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55981/jbbi.2024.8235

Abstract

Sepsis is a life-threatening condition characterized by an abnormal immune response to infection, leading to high mortality rates in intensive care units (ICUs) worldwide. Caspase-3, a crucial enzyme in the apoptosis pathway, plays a significant role in sep-sis-related cellular damage. This study investigates the anti-apoptotic potential of Paederia foetida L. leaf extract by examining its effect on Caspase-3 expression in an Escherichia coli-induced sepsis mice model. Male Balb/c mice were divided into six groups, including positive control, negative control, and treatment groups receiving varying doses of the extract (100 mg/kgBW, 300 mg/kgBW, and 500 mg/kgBW). Caspase-3 expression in the spleen was measured after 24 hours of treatment. The results demonstrated a significant reduction in Caspase-3 expression, particularly in the group treated with 500 mg/kgBW of the extract, indicating its anti-apoptotic effect. These findings suggest that P. foetida leaf extract may serve as a potential therapeutic agent for reducing cell apoptosis in sepsis, warranting further investigation into its mechanisms and clinical pharmacological field.
Edukasi Peluang Dan Tantangan Terkini Pharmacist Dengan Distruksi di Industri Farmasi Fendy Prasetyawan; Mujtahid Bin Abd Kadir; Nur Fahma Laili; Prayoga Fery Yuniarto; Datin An Nisa Sukmawati; Arifani Siswidiasari; Neni Probosiwi; Tsamrotul Ilmi; Elsa Mahardika Putri; Yuneka Saristiana; Okky Intan Mawarni; Winartiana; Nimas Ayu Rahardini; Anis Akhwan Dhafin
Khidmah Nusantara Vol. 1 No. 1 (2024): Agustus 2024
Publisher : CV.RIZANIA MEDIA PRATAMA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.69533/ghy9th25

Abstract

Tingkat pengangguran yang meningkat setiap tahunnya membuat masyarakat mencari sumber informasi dengan tujuan memperoleh dan mendapatkan lapangan pekerjaan, yang dapat dicapai dengan menempuh pendidikan perguruan tinggi. Jurusan farmasi merupakan jurusan yang banyak diminati karena memiliki prospek yang biak kedepannya dan salah satu jurusan populer. Seorang farmasis dapat bekerja disektor industri, indonesia memiliki sebanyak 230 industri farmasi. Dengan jumlah industri yang banyak sehingga industri farmasi membutuhkan banyak tenaga kerja, terutama tenaga farmasi yang profesional. Selain peluang kerja di indsutri farmasi namun di era industri 4.0 ini tantangan yang dihadapi semakin besar, sehingga farmasis harus meningkatkan pengetahuan untuk mengimbangi teknologi yang terus maju. Oleh karena itu diperukan pengetahuan untuk meningkat wawasan terkait indutri farmasi.Tujuan dari kegiatan pengabdian masyarakat ini adalah untuk mendorong mahasiswa farmasi agar dapat bekerja di industri farmasi dan memberikan gambaran tentang industri farmasi. Kegiatan pengabdian ini dilakukan di gedung AULA FIK Universitas Kadiri hari sabtu, 20 April 2024. Hasil kegiatan menunjukkan bahwa peserta antusias mengikuti acara, terlihat dari keikutsertaan mereka dalam mengikuti acara dari awal hingga akhir dan mengajukan pertanyaan selama sesi kuliah pakar berlangsung.Oleh karena itu, kegiatan pengabdian masyarakat ini dinilai berpotensi membantu menginspirasi, mendorong dan informasi bagi mahasiswa farmasi untuk berkarir di industri farmasi.
Optimasi Formulasi Sediaan Balsem Ekstrak Belimbing Wuluh (Averrhoa Bilimbi L.): Formulation Optimization of Starfruit Extract Balm Preparation (Averrhoa Bilimbi L.) Firdania Firdaus Rosyida; Silvia Wahyu Mustika; Assolychathu Jaroh; Etis Remanti; Ary Kristijono; Datin An Nisa Sukmawati
Jurnal Inovasi Farmasi Indonesia (JAFI) Vol. 7 No. 1 (2025): Volume 7 No 1 2025
Publisher : Universitas Kadiri

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30737/jafi.v7i1.7039

Abstract

Balsem merupakan bentuk sediaan farmasi yang bermanfaat sebgai bahan pereda nyeri. Belimbing wuluh secara Konvesional dapat dimanfaatkan untuk mengatasi pembengkakan, karena mengandung terdapat kandungan senyawa flavonoid, tanin, saponin dan akaloid sebagai anti inflamasi. Senyawa ini memiliki kemampuan untuk menghambat enzim pro-inflamasi, seperti siklooksigenase (COX) dan lipoksigenase (LOX). Tujuan penelitian ini adalah optimasi formulasi sediaan balsem ekstrak blimbing wuluh dengan konsentrasi ekstrak 2% dengan bahan tambahan seperti paraffin solidum (12 %), menthol (1 %), methil salisilat (10 %), vaselin album (ad 100%), dan champora sebagai variasi formulasi dengan konsentrasi F1=6% F2=7% F3=8%.  Didapatkan hasil evaluasi fisik sediaan balsem ekstrak belimbing wuluh formula 2 (F2) memiliki nilai tertinggi pada hampir seluruh parameter fitokimia, yaitu flavonoid sebesar 58,1 ± 2,0 mg, tanin 28,3 ± 1,2 mg/g, saponin 3,83 ± 0,15%, serta alkaloid 2,08 ± 0,10 mg/g. Daya sebar F2 sebesar 7,58 ± 0,20 cm, daya lekat. Nilai pH F2 yaitu 5,80 ± 0,06, dan pH F2 yaitu 5,80 ± 0,06, menandakan bahwa F2 memiliki kandungan senyawa aktif paling optimal.
Kadar Fenolik, Flavonoid Total dan Aktivitas Antioksidan Ekstrak Etanol Daun Calathea Silver Plate: Total of Phenolic, Flavonoid Content and Antioxidant Activity of Calathea Silver Plate Leaves Extract Datin An Nisa Sukmawati; Lisa Savitri; Firdania Firdaus Rosyida; Khoirul Ngibad; Hanifah Delima Nuardani
Jurnal Inovasi Farmasi Indonesia (JAFI) Vol. 7 No. 1 (2025): Volume 7 No 1 2025
Publisher : Universitas Kadiri

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30737/jafi.v7i1.7316

Abstract

Daun Calatea Silver Plate (CSP) merupakan tanaman hias yang memiliki karakteristik daun berwarna ungu pada bagian atasnya dan perak pada bagian bawahnya yang mengindikasikan adanya potensi bioaktivitas sebagai antioksidan. Sehingga, tujuan penelitian ini adalah untuk mengetahui dan menganalisis kadar fenolik, flavonoid total dan mengukur aktivitas antioksidan ekstrak etanol CSP. Uji kadar fenolik total menggunakan metode folin-ciocalteu dengan menggunakan asam galat sebagai senyawa standar. Sedangkan untuk uji kadar flavonoid total menggunakan metode kolorimetri dengan menggunakan AlCl3 dan senyawa kuersetin sebagai standar. Untuk uji aktivitas antioksidan menggunakan metode DPPH dan ABTS. Adapun hasil dari penelitian ini adalah ekstrak CSP mengandung senyawa fenolik dengan kadar 203,89 mg GEA/g, senyawa flavonoid dengan kadar 446 mg QE/g, memiliki aktivitas antioksidan dengan nilai IC50  75,78±2,1 terhadap DPPH dan nilai IC50 87,75±3,0 terhadap ABTS. Berdasarkan hasil tersebut dapat disimpulkan bahwa ekstrak CSP memiliki potensi sebagai antioksidan alami.
Studi In Silico Senyawa Daun Sambung Nyawa (Gynura procumbens (Lour.) Merr.) terhadap HER2 dan EGFR sebagai Antikanker Payudara: In Silico Study of (Gynura procumbens (Lour.) Merr.) Compounds Against HER2 and EGFR as Breast Anticancer Mohammad Firdaus Alshol; Datin An Nisa Sukmawati; Novyananda Salmasfattah; Fendy Prasetyawan; Anis Akhwan Dhafin
Jurnal Inovasi Farmasi Indonesia (JAFI) Vol. 7 No. 2 (2026): Volume 7 Nomor 2, Juni 2026
Publisher : Universitas Kadiri

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30737/jafi.v7i2.7723

Abstract

Kanker payudara adalah neoplasma ganas dengan karakteristik biologis yang beragam sehingga mmerlukan terapi spesifik. Pendekatan komputasi, seperti penambatan molekuler, simulasi dinamika molekuler, dan prediksi ADMET, banyak digunakan untuk mengidentifikasi kandidat obat antikanker secara efisien. Studi ini bertujuan untuk menghasilkan senyawa bioaktif potensial dari Daun Sambung Nyawa (Gynura procumbens (Lour.) Merr.) terhadap protein target HER2 dan EGFR sebagai kandidat obat kanker payudara. Penambatan molekuler dilakukan menggunakan AutoDock 4.0. Senyawa dengan energi terendah kemudian dianalisis melalui simulasi dinamika molekuler menggunakan YASARA dan sifat farmakokinetik dan toksisitasnya diprediksi berdasarkan parameter ADMET. Hasil menunjukkan bahwa beberapa senyawa memiliki afinitas pengikatan yang baik terhadap HER2 dan EGFR dan membentuk kompleks yang stabil berdasarkan nilai RMSD dan RMSF. Prediksi ADMET menunjukkan profil yang mendukung pengembangan lebih lanjut sebagai kandidat obat kanker payudara oral.
Co-Authors Ana Retnowati Anis Akhwan Dhafin Antika, Ayu Rindi Antoro, Ester Lianawati Arifani Siswidiasari Ary Kristijono Assolychathu Jaroh Ate, Chrispianus Christian Bin Abd Kadir, Mujtahid Dhony Hermanto Eka Wahyuningtiyas Elfred Rinaldo Kasimo Elfred Rinaldo Kasimo, Elfred Rinaldo Elok Kamilah Hayati Elsa Mahardika Putri Ester Lianawati Antoro Etis Remanti Fendy Prasetyawan Firdania Firdaus Rosyida Freitas, João Gregório Hanifah Delima Nuardani Ida Septika Wulansari Juan Vega Mahardhika Juwita, Syntia Tanu Kadir, Mujtahid Bin Abd Khoirul Ngibad Kholis, Akbar Nur Lailatul Hidayah Laili, Nur Fahma Lambert, Maringan Lisa Savitri Mohammad Firdaus Alshol Mosse1, Yosep Muadifah, Afidatul Mujtahid Bin Abd Khadir Mujtahid Bin Abd. Kadir Muti'ah, Roihatul Neni Probosiwi Ngibad, Khoirul Nimas Ayu Rahardini Novyananda Salmasfattah Nur Fahma Laili Nurkamah, Siti Nurul Ismillayli Okky Intan Mawarni Ornai, Andre Mario Sequeira Alves prayoga fery yuniarto Probosiwi , Neni Putri Larasati, Julyana Rochmad Kris Sanjaya Rochmad Krissanjaya Sembiring, Yulia Shara Silvia Wahyu Mustika Sri Haryuni Sulistyowati , Yuni Syntia Tanu Juwita Syntia Tanu Juwita Tandela, Tantik Tsamrotul Ilmi Virginia, Vivi Winartiana Witaning, Leny Wulansari, Ida Septika Yosep Mosse Yuneka Saristiana Yuniar, Arlita Wulan Yuniarto, Prayoga Fery