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All Journal Hemera Zoa Media Veteriner Jurnal Veteriner Jurnal Riset Veteriner Indonesia (Journal of The Indonesian Veterinary Research) Community Development Journal: Jurnal Pengabdian Masyarakat Jurnal Layanan Masyarakat (Journal of Public Service) Jurnal Pengabdian Masyarakat Medika
Dwi Kesuma Sari
Study Program Of Veterinary Medicine, Faculty Of Medicine, Hasanuddin University, Jl. Perintis Kemerdekaan Km. 10, Makassar, 90245, South Sulawesi, Indonesia
Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Decision Sciences, Operations Research & Management Economics, Econometrics & Finance Education Environmental Science Health Professions Medicine & Pharmacology Public Health Social Sciences Veterinary Other

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Journal : Jurnal Veteriner

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Ultrastructural and Immunohistochemical Studies of Transplanted Canine Lung Carcinoma Cell to Severe Combined Immunodeficiency Mice (STUDI ULTRASTRUKTUR DAN IMUNOHISTOKIMIA TRANSPLANTASI SEL KANKER PARU-PARU ANJING PADA MENCIT SEVERE COMBINED IMMUNODEFF Dwi Kesuma Sari; Bambang Pontjo Priosoeryanto; Dewi Ratih Agungpriyono; Ryoji Yamaguchi; Kazuyuki Uchida; Susumu Tateyama
Jurnal Veteriner Vol 14 No 4 (2013)
Publisher : Faculty of Veterinary Medicine, Udayana University and Published in collaboration with the Indonesia Veterinarian Association

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Abstract

Primary lung cancers, or tumors originating in the lung, are relatively uncommon in dogs. The objectiveof this study was to describe the canine lung carcinoma that serially transplanted into severe combinedimmunodeficiency (SCID) mice, in order to established cell line from this tumor cell.  Morphology andcharacteristic of this canine lung carcinoma in SCID mice by histopathological and ultrastructuralexaminations with metastatic lesion in lung were also examined.  Histopathologically, the tumor masswere consisted of cuboidal to columnar cells with papillary pattern, uniform in size, the nuclei were oftenvariable in size, and some cells have vacuole on their cytoplasms.  Glandular forms were predominant withlobulated pattern, ductal pattern with papillary injected into tube-like structure were also encountered.Mitotic figures commonly found with inflammatory reaction were sometimes present in the interstitiumand lumen gland.  Ultrastructural analysis of the tumor cells showed round to oval cells with one or moreprominent nucleoli.  The cells possessed numerous mitochondria, smooth endoplasmic reticulum, andindividual cells which were interconnected via desmosomes.  Tonofilament characterize by long cytoplasmicmaterial was encountered.  Positive reaction of the round to oval tumor cells to anti keratin antibodyconfirmed that their epithelial cell nature.  Lung metastatic lesions were found in SCID mice aftertransplantation and this phenomenon indicated that canine lung carcinoma is tumorigenic to SCID mice.
Co-Authors A. Magfira Satya Apada A. MUH. ICHLASUL AKMAL Abdul Halim, Musdalifah Abdul Wahid Jamaluddin Adryani Ris Adyatma Muhammad Nur Alni, Nurul Istiana Amriani, Rini Andi Magfira Satya Apada Andini, Nurul Sulfi Annita Vury Nurjunitar Aras, Irwin Arif, Makruf Arsyad, M Aryadi Astri Caturutami Sjahid Azzahra, Nabila Azzuhdi, Faiz Adlan Bahmid, Nur Alif Bambang Pontjo Priosoeryanto Baso Yusuf Cangara, Husni Dedy Rendrawan Dewi Mutisari Dewi Ratih Agungpriyono Dian Anugrah Dian Fatmawati DIDIK IMAM SAKIRIN Dini Marmansari Djabir, Yulia Yusrini Erdi Purwanto Erning Ertami Anton Fachira Ulfa Makmur Fatimah Mappanyompa Fatmawati, Dian Fedri Rell Ferra Indrawati Fika Yuliza Purba Gilang, Gilang Ramadhan Hartarto Akhmad Hendra Wibawa Ilham Akbar Rahman IRFAN IDRIS Irfan Idris Irfan Idris Irma Andriani Ismartoyo (Ismartoyo) Kazuyuki Uchida Ketut Adnyane Mudite Khusnul Yakin Kusumaningrum, Arsyinta Retno Lellah Rahim Magfira Satya Mufidatul Asmi Muflihanah Muh. Nasrum Massi MUHAMMAD DIRGA GIFARDI Muhammad Fadhil Shalih Muhammad Fadhlullah Mursalim Muhammad Hatta Muhammad Muflih Nur Muhammad Syukur Hamdan Muhammad Zulfadhillah Sinusi Musdalifah Natsir, Sartini Novi Susanty Nurlaila Fitriani Nurlina Nurmauliah Syaharuddin Pratiwi, Hamria Purba, Fika Yuliza Ramadhan K., Muhammad Zoel Vitra Rarasmika, Ainun Rasdiyanah Rasdyanah Rasdyanah Ratna Romi Mesra Ryoji Yamaguchi Sartini Natsir Savitri Novelina Sitti Mughniati Sri Deniati Srihadi Agungpriyono Suanti Supri Susumu Tateyama Tutik Wresdiyati Wahyuni Wahyuni WAODE SANTA MONICA Yulia Yusrini Djabir Zahrani, Putri Dyah