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All Journal Proceedings of Annual International Conference Syiah Kuala University - Life Sciences & Engineering Chapter Majalah Kedokteran Bandung Althea Medical Journal The Journal of Pure and Applied Chemistry Research Dental Journal (Majalah Kedokteran Gigi) The Indonesian Biomedical Journal Sari Pediatri Paediatrica Indonesiana Journal of Maternal and Child Health The International Journal of Tropical Veterinary and Biomedical Research Unnes Journal of Public Health

Budi Setiabudiawan

Departemen Ilmu Kesehatan Anak Fakultas Kedokteran Universitas Padjadjaran/Rumah Sakit Dr. Hasan Sadikin Bandung

Author-ID : 376422

Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Dentistry Engineering Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Public Health Veterinary Other

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Infeksi Gigi Sebagai Faktor Pencetus Terbanyak Henoch-Schonlein Purpura dengan Keterlibatan Ginjal Budi Setiabudiawan; Reni Ghrahani; Gartika Sapartini; Minerva Riani Kadir
Sari Pediatri Vol 14, No 6 (2013)
Publisher : Badan Penerbit Ikatan Dokter Anak Indonesia (BP-IDAI)

Latar belakang.Henoch Schonlein purpura (HSP) dengan keterlibatan ginjal memiliki prognosis yang lebih buruk, dan infeksi gigi merupakan faktor risiko terbanyak terjadinya HSP dengan keterlibatan ginjal. Tujuan.Menganalisis hubungan antara riwayat infeksi gigi dan terjadinya HSP dengan keterlibatan ginjal pada anak.Metode.Penelitian retrospektif dengan rancangan potong lintang terhadap 146 anak yang didiagnosis HSP berdasarkan kriteria American College of Rheumatology(ACR) sertaEuropean League Against Rheumatism(EULAR), Pediatric Rheumatology International Trials Organization(PRINTO), dan Pediatric Rheumatology European Society(PRESS). Penelitian dilakukan di Divisi Alergi-imunologi Departemen Ilmu Kesehatan Anak Rumah Sakit Hasan Sadikin Bandung, periode Januari 2006âˆ’ Desember 2012. Data pasien diambil dari rekam medis dan dianalisis menggunakan uji Chi square.Hasil.Didapatkan 146 anak dengan HSP, 93(63,7%) laki-laki dan 53(36,3%) perempuan dengan rasio 1,8:1. Rerata usia pasien 8,05Â±2,9 tahun. Sembilan puluh dua pasien (63%) diduga mengalami infeksi sebagai pencetus terjadinya HSP. Didapatkan 41 pasien HSP dengan keterlibatan ginjal (28%), yaitu proteinuria 6 (14,6%), hematuria 9 (22,0%), serta proteinuria dan hematuria 26 (63,4%) Infeksi gigi merupakan faktor pencetus terbanyak dibandingkan dengan faktor pencetus lainnya pada HSP dengan keterlibatan ginjal, yaitu 25 pasien (61%) dengan p=0,025; Odd ratio(OR) 2,7 (1,1â€“6,4) dengan interval kepercayaan 95%.Kesimpulan. Anak dengan riwayat infeksi gigi memiliki risiko tinggi untuk terjadi HSP dengan keterlibatan ginjal.

Relapsing Polychondritis pada Anak Budi Setiabudiawan; Sinta Boesoerie; Reni Ghrahani DM; Gartika Sapartini; Diana Rosifah
Sari Pediatri Vol 12, No 1 (2010)
Publisher : Badan Penerbit Ikatan Dokter Anak Indonesia (BP-IDAI)

Relapsing polychondritis (RP) adalah penyakit autoimun yang jarang terjadi. Penyakit RP ditandai denganinflamasi jaringan kartilago berulang dan berpotensi untuk terjadi kerusakan progresif pada jaringan tersebut.Terutama menyerang dewasa pada dekade ke-4 atau ke-5 dengan usia rata-rata 51 tahun, hanya sedikit kasusyang dilaporkan pada anak. Patogenesis RP diduga akibat terbentuknya autoantibodi terhadap komponenkartilago terutama kolagen tipe II, sehingga menimbulkan suatu proses inflamasi dan mekanisme selularyang melibatkan pelepasan enzim lisosom dengan hasil akhir berupa penghancuran kartilago. Dilaporkanseorang anak laki-laki, usia 12 tahun dengan keluhan utama sesak napas disertai suara mengorok sejak satubulan sebelum masuk rumah sakit. Pada pemeriksaan didapatkan saddle nose deformity, peningkatan LED(40/125 mm/jam), uji ANA positif dengan pola nuklear, penyempitan kolom udara dalam laring dan faringpada foto soft tissue leher, dan adanya laringotrakeomalasia pada trakeoskopi. Pasien didiagnosis denganrelapsing polychondritis dan mendapat prednison 2 mg/kgBB/hari. Ditambahkan obat imunosupresanmetotreksat karena respons yang kurang baik terhadap steroid. Keadaan klinis pasien membaik setelahmendapat terapi kombinasi.

A Validated Ultra Performance Liquid Chromatography Method for Quantification of Metformin in Human Plasma Vycke Yunivita Kusumah Dewi; Atu Purnama Dewi; Budi Setiabudiawan; Edhyana Sahiratmadja; Triana Nurul Meirina; Harold Eka Atmaja; Rovina Ruslami
The Journal of Pure and Applied Chemistry Research Vol 7, No 3 (2018): Edition September-December 2018
Publisher : Chemistry Department, The University of Brawijaya

Metformin is oral hypoglycemic or blood sugar-lowering drug which is used for the first- line drug in the treatment of diabetes mellitus type 2. This study presented the validated Ultra Performance Liquid Chromatography UltraViolet (UPLC-UV) method for the determination of metformin in human plasma. Metformin levels were measured using UPLC with a UV detector and liquid-liquid extraction method. Separation was carried out on an Acquity UPLC HSS T3 100mm × 2.1mm i.d. column (1.8μm particle size) using gradient elution of acetonitrile and phosphate buffer 0.02 M (0.6 mL/min) as mobile phase at 30°C. The analyte was monitored at 236 nm. No endogenous substances were found to interfere with the peaks of drug and internal standard. The value of percent deviation and the coefficient variation obtained respectively less than the percentage set in the FDA guidelines. The linearity factor values were more than 0.997 and LOD was 0.01µg/mL. UPLC with UV detector is able to analyze metformin in a short time with good precision and accuracy which is useful for bioequivalence and bioavailability studies.

The association between fever in the first year of life and atopy in children with or without family history of atopic disease Susy P. Wihadi; Budi Setiabudiawan; Cissy B. Kartasasmita
Paediatrica Indonesiana Vol 47 No 2 (2007): March 2007
Publisher : Indonesian Pediatric Society

Background The role of repeated infection in early life in thedevelopment of childhood atopy is still controversy. Fever in thefirst year of life which is frequently associated with infections mightdecrease atopy.Objective The aim of this study was to investigate the associationbetween fever in the first year of life and atopy in children.Methods This was an observational clinical epidemiology studyperformed at Puskesmas Garuda, Padasuka, and Babakan Sari,Bandung, from January to March 2006. From 749 children, werandomly chose 150 subjects each from group with and withoutfamily history of atopic disease. Skin prick test and measurementof total serum immunoglobulin (Ig) E were performed on eachchildren. Atopy was defined as the skin prick test result waspositive to >1 allergen. The number of fever episodes in the firstyear of life was based on parents report. The relationship betweenfever and atopy was analyzed using Mantel Haenszel.Results From 284 subjects, atopy was found in 28.2% of children,of which 32.4% with and 23.9% without a family history of atopicdisease. Generally there was no significant association betweenfever and atopy. There was only decreased odds ratio withincreased fever episodes and trend analysis showed this decreasewas significant (P=0.01). The significant association betweenfever and atopy were found only in group without family historyof atopic disease (P=0.03, OR=0.43, CI 95% 0.18;1.01).Conclusion There is a relationship between fever and atopy inchildren without family history of atopic disease.

The association between duration of breastfeeding and atopy in children with or without family history of atopic disease Riana Novy; Budi Setiabudiawan; Cissy B. Kartasasmita
Paediatrica Indonesiana Vol 47 No 4 (2007): July 2007
Publisher : Indonesian Pediatric Society

Background Atopic diseases (AD) are the most common chronicdiseases in childhood, and their incidence has a tendency to increaserecently. Tendency to have atopy could be triggered by many factorsoriginated in early life, including time of breastfeeding cessation.Objective To determine the association between exclusive andduration of breastfeeding and atopy in children with or withoutfamily history of atopic disease.Methods This was an observational clinical epidemiology studyperformed at Babakansari, Padasuka, Garuda Primary Health CareCenter in Bandung from January to March 2006. One hundredfifty of 749 children were randomized from group with and withoutfamily history of AD. They underwent skin prick tests and totalserum IgE level analysis. Atopy was defined as a positive skinprick test to any of the eight allergens tested. History of exclusiveand duration of breastfeeding was obtained from their parents.Significance tests for contingency tables were on the basis of x 2test for association odds ratio with 95% confidence interval.Results Atopy was found in 28.2% of children, of whom 32.4% withand 23.9% without family history of AD. Children exclusivelybreastfed exhibited a reduced risk of atopy (5.8% v 35.3%, OR=0.11,95%CI= 0.03;0.34, P<0.001). The difference of atopy was stronglysignificant between children who had exclusive breastfeeding andthose without exclusive breastfeeding whether or not the subjectshad family history of AD (P<0.001). There was a highly significantrisk reduction for atopy related to prolonged breastfeeding (=6months) (OR=0.37, 95%CI = 0.19 to 0.72, P=0.001). Thedifference of atopy was strongly significant between children whohad prolonged breastfeeding and short breastfeeding duration whetheror not the subjects had family history of AD (P<0.001)Conclusions Exclusive and prolonged breastfeeding decrease atopyin children with as well as without family history of AD.

Relationship between atopic manifestations, family history of atopic disease and cord blood IgE levels in children Tisnasari Hafsah; Myrna Soepriadi; Budi Setiabudiawan; Herry Garna
Paediatrica Indonesiana Vol 47 No 6 (2007): November 2007
Publisher : Indonesian Pediatric Society

Background The incidence of atopic disease tends to increaseover the past few decades and its morbidity interferes with thequality of life and health. Prediction of the disease is importantfor early prevention.Objective To evaluate the relationship between atopicmanifestations, family history (FH) of atopic disease and cordblood IgE (CB-IgE) levels.Methods We conducted an analytic observational study withcohort retrospective design on children with an average age of 3years whose CB-IgE had been measured at delivery inKiaracondong Primary Health Care during Octoberâ€“December2004. Manifestations of atopic disease were recorded using ISAACquestionaire for allergy. Chi-square, Mann-Whitney test, andlogistic regression analysis were used for analysis.Results Cord blood IgE was measured on 124 children after birth.Only 94 children (76%) fulfilled the inclusion criteria. Atopicdisease was found in 17 children (18%), consisting of 8 childrenwith atopic dermatitis, 4 with allergic rhinitis, and 5 suffered fromboth. There were significant differences in the mean value of CB-IgE (Z M-W =4.60; P<0.001) and FH (x 2 =19.059; P<0.001)between atopic and non atopic children. Cut off point of the CB-IgE concentration was 1.4 IU/mL (77.7%). The highest probabilityfor atopic manifestations was found in children who had highCB-IgE and positive FH (P=45%). Relative risk of children withhigh CB-IgE level in positive FH group was 3.636 (95% CI0.943;14.016).Conclusion CB-IgE level and family history of atopic disease arerisk factors for the development of atopic manifestation.

The association between onset, frequency, duration of seizure and IQ level in epileptic children Yulia Yulia; Sjarif Hidayat Effendi; Budi Setiabudiawan
Paediatrica Indonesiana Vol 49 No 3 (2009): May 2009
Publisher : Indonesian Pediatric Society

Background Epilepsy is a common neurological disorder found inall races and age groups. Epilepsy becomes a serious problem when occurs during the child's critical development period. It is known that onset, frequency, and duration of seizures are associated with IQ level. Therefore, intelligent assessment is important to determine prognostic and holistic management.Objective To determine the association between onset, frequency, duration of seizure and IQ level in epileptic children.Methods This cross sectional study was carried out at theDepartment of Child Health, Hasan Sadikin Hospital, Bandung,Indonesia from October to December 2007. The subjects wereepileptic children aged 4-16 years old being treated with valproicacid. Statistic analysis was done using logistic regression analysis, OR and RR, with 95% confidence interval.Results There were 90 subjects with epilepsy (46 males). Twentysubjects (22%) showed onset of seizures at < 18 months old; these subjects had 3.08 higher risk for having a low IQ level (score <90) compared to those with seizure onset at~ 18 months old (P=0.003). Sixty subjects (67%) had a seizure frequency of> 10 times annually; they had 1.68 higher risk of having a low IQcompared to those with seizure frequency< 10 times (P=0.430).Seven subjects (28.0%) had seizures of> 10 minutes; they had 1.17 higher risk of having a low IQ compared to those with seizures of < 10 minutes (P=0.706).Conclusion Onset of seizures at < 18 months old is significantlyassociated with low IQ level, while frequency and durationof seizure have no significant association with lower IQ level.

Association between serum vitamin D level and tuberculosis in children Ahmad Zaeni Syafii; Abdurachman Sukadi; Budi Setiabudiawan
Paediatrica Indonesiana Vol 48 No 6 (2008): November 2008
Publisher : Indonesian Pediatric Society

Background A possible association between vitamin 0 andtuberculosis has been described. In adult, vitamin 0 is consideredto have a role in protecting tuberculosis. On the other hand,tuberculosis infection can decrease serum vitamin 0 level.Objective To find out the difference between serum vitamin 0level in children with and without tuberculosis, and to find theassociation of serum vitamin 0 level with tuberculosis.Methods A cross sectional study was conducted in Cibabat Hospital,Ban dung from July to October 2007. We selected children :S 14years, diagnosed as tuberculosis, and had positive response aftertwo month treatment; for control we selected randomly siblingsor neighbors who didn't have tuberculosis. We excluded childrenwith liver abnormalities and immunocompromized children.Mann-Whitney test and OR method with 95% confidence intervalwas used to analyze the data.Results Thirty-nine children with tuberculosis (21 boys, 18 girls)and 39 children without tuberculosis (19 boys, 20 girls) as wereenrolled. Mean serum vitamin 0 level of children with and withoutTB were 4 7 (SO 25) pmol/L and 125 (SO 3 7) pmol/L, respectively(P=O.OOl). All children without tuberculosis had normal vitamin0 level while of those with tuberculosis, 14 children had normallevel and 25 children were deficient (corrected OR: 139, 95%CI8 to 238).Conclusion Serum vitamin 0 level is low in children withtuberculosis.

Association between immunization coverage and atopy in children with or without family history of atopic disease Isabella Riandani; Budi Setiabudiawan; Cissy B. Kartasasmita
Paediatrica Indonesiana Vol 48 No 6 (2008): November 2008
Publisher : Indonesian Pediatric Society

Background Atopic diseases are determined by the interactionbetween genetic and environmental factors. The possible effectsof immunization, as one of environmental factors, on atopy remaina matter of controversy.Objective We conducted an observational clinical epidemiologyto find out the protective effect of high vaccination coverage toatopy in children.Methods During January through March 2006, 150 of749 childrenat Garuda, Padasuka, and Babakan Sari Primary Health Care inBandung were randomized from group with and without familyhistory of atopic disease. Atopy derived from skin prick test andtotal serum lgE was evaluated. Atopy was defined as a positiveskin test to any of the eight allergens tested. The immunizationswere recorded from Kartu Menuju Sehat (KMS). Statistical analysesincluded Chi square to compare prevalence, independent T-testand Mann-Whitney to compare mean.Results Atopy was found in 28.2% of284 subjects, of which 32.4%with and 23.9% without a family history of atopic disease. Themedian of total serum lgE level was higher in children with familyhistory of atopic disease and in atopy children. Children weregrouped according to total dose of basic immunizations (0-17 and2: 18) based on Program Pengembangan Imunisasi (PPI). There wasnonsignificant association between total doses of immunizationand atopy. Even though no statistically significant, the cumulativeimmunization doses were inversely related to the median of totalserum IgE level.Conclusions The immunization coverage has not decreased atopyrisk.

Correlation between obesity with atopy and family history of atopy in children Putria Rayani Apandi; Budi Setiabudiawan; Abdurachman Sukadi
Paediatrica Indonesiana Vol 51 No 4 (2011): July 2011
Publisher : Indonesian Pediatric Society

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14238/pi51.4.2011.227-33

Background The prevalence of childhood obesity and atopy has increased in recent decades. Research on links between obesity and atopy has shown varied results. Few previous studies have reported on the significance of family history of atopic disease in children.Objective To determine correlation between obesity with atopy and family history of atopic disease in children.Methods This cross-sectional study was conducted from April to September 2010 in the Pediatric Allergy-Immunology subdivision, Hasan Sadikin Hospital. Children aged 6âˆ’11 years were divided into four groups of 40 each: obese subjects with and without family history of atopic disease, and normal weight subjects with and without family history of atopic disease. Skin prick test was performed to determine which subjects had atopy. Chi-square test was used to analyze mutual independence, and partial Chi-square test was used to analyze correlation of obesity to atopy and family history of atopic disease in children. Environmental factors, type of childbirth, and pregnancy history were also analyzed as risk factors for atopy.Results Of 80 obese children with and without family history of atopic disease, 40 (100%) and 38 (95%), respectively, were atopic. Of 80 normal weight children with and without family history of atopic disease, 39 (98%) and 9 (23%), respectively, were atopic. Thus atopy was observed in 126 subjects, while the remaining 34 subjects were non-atopic. Partial test showed a correlation between obesity with atopy and family history of atopic disease (P < 0.001). There were no significant differences in risk factors for atopy by group.Conclusion Obesity correlates with atopy and family history of atopic disease in children.

Co-Authors Abdurachman Sukadi Abdurachman Sukadi Ahmad Zaeni Syafii Alex Chairulfatah Ambrosius Purba Anang Endaryanto Andhika T. Hutapea Andri Firdaus Ani Melani Maskoen Arini Setiawati Asep Aziz Asopari Asri Arum Sari Atu Purnama Dewi Ayu Alia Aziz, Muhammad Alamsyah Bakhtiar Bakhtiar Basrowi, Ray Wagiu Benny Hasan Purwara Budi Handono Cissy B. Kartasasmita Cissy B. Kartasasmita Citra Amelinda Dedi Rachmadi Diana Rosifah Diet Sadiah Rustama Dikdik Kurnia Dilantika, Charisma Dina Muktiarti, Dina Dita Lasendra Djatnika Setiabudi Dwi Prasetyo Edhyana Sahiratmadja Edhyana Sahiratmadja Elza Noviani Endang Sutedja Erny Rachmawati Triwardhani Fedri Ruluwedrata Rinawan Gaga Irawan Nugraha Gartika Sapartini Harold Eka Atmaja Harry Raspati Hendra Dian Adhita Henni Djuhaeni Herry Garna Hesti Puspasari Ida Parwati Ika Agus Rini Irma Ruslina Defi Irman Permana Irna Sufiawati Isabella Riandani Johanes C. Mose Johanes C. Mose Johannes Cornelius Mose Johannes Hudyono Juandy Jo Jusuf Sulaeman Effendi Kartjito, Melissa Stephanie Keri Lestari Ketut Dewi Kumara Wati Kuswandewi Mutyara Laniyati Hamijoyo, Laniyati Lelani Reniarti M. Thaufiq S. Boesoirie, M. Thaufiq S. Mahesa Suryanagara Melati Sudiro Melva Louisa Mieke H. Satari Minerva Riani Kadir Mohamad Yanuar Anggara Myrna Soepriadi Nur Melani Sari Perdana, Nanan Surya Putria Rayani Putria Rayani Apandi Raden Tina Dewi Judistiani Rahmat Gunadi Reni Ghrahani Reni Ghrahani Reni Ghrahani Reni Ghrahani Reni Ghrahani DM Riana Novy RINI SUNDARI RINI SUNDARI, RINI Rovina Ruslami, Rovina Saputri, R. Ayu Hardianti Sasfia Candrianita Sefty Mariany Samosir Setyorini Irianti Sheba, Shiane Hanako Sinta Boesoerie Sitorus, Nova Sjarif Hidayat Effendi Sofie R. Krisnadi Sumadiono Sumadiono Sunjaya, Deni K. Surapsari, Juwalita Susy P. Wihadi Sylvia Rachmayati Teti Madiadipoera Tetty Yuniati Tetty Yuniati Thaufiq S. Boesoirie Tisnasari Hafsah Triana Nurul Meirina Triatmaja, Dendy Vitriana Vitriana Vycke Yunivita Kusumah Dewi Weninggalih, Endah Yulia Yulia Zakiudin Munasir Zulfan M. Alibasyah

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