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All Journal Medical Journal of Indonesia Damianus Journal of Medicine Indonesian Journal of Cancer The New Ropanasuri Journal of Surgery Generics: Journal of Research in Pharmacy Generics : Journal of Research in Pharmacy
Rianto Setiabudy
Department of Pharmacology, Faculty of Medicine, Universitas Indonesia, Jakarta
Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Education Health Professions Immunology & microbiology Medicine & Pharmacology Public Health

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Journal : Indonesian Journal of Cancer

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Survei Pengetahuan Dokter Spesialis terhadap Penggunaan Opiat pada Tatalaksana Nyeri Kanker di Rumah Sakit Pemerintah, Jakarta, 2017 INDRAYANI, LENNY; SETIABUDY, RIANTO; SOETIKNO, VIVIAN; IRAWAN, COSPHIADY
Indonesian Journal of Cancer Vol 11, No 4 (2017): October- December 2017
Publisher : Indonesian Journal of Cancer

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (1097.236 KB)

Abstract

Treatment of cancer pain often requires opioids, and morphine is a gold standard in the management of severe cancer pain. Inadequate knowledge of cancer pain management causes opioid usage is not optimal. Indonesia is one of the countries with very low opioid consumption. The purpose of this study was to find out the physician’s knowledge about the management of cancer pain in choosing opioid, administration, doses, side effects, addiction and factors of opioid that barrier in pain management. This cross-sectional study was conducted in General Hospital Jakarta and a Private Hospital in Tangerang. Inclusion criteria were medical specialist who treating cancer pain. This study used questionnaires that filled out by respondents and confidential. Score of adequate knowledge was ≥ 70, and to assess the relationship between knowledge of opioid use with specialization analyzed by Chi-square test and Fisher’s exact if Chi-square requirement is not fulfilled. Statistical analysis was performed by SPSS version 20. From a total of 146 distributed questionnaires, we received 103 questionnaires (70,5%). In this study, the majority of respondents (69,9%) had inadequate knowledge. The highest rate (70,55) was found in the choosing opioid section, while the lowest rate (49,5) was found in the opioid side effects section. There is no significant relationship between physician knowledge on opioid usage and specialization (P= 0,355). Government regulation is major obstacle to opioid use, followed by lack of training, drug availability and knowledge of side effects ABSTRAK Penatalaksanaan nyeri kanker sering kali membutuhkan opiat dengan morfin sebagai gold standard menurut panduan WHO analgesic step ladder . Pengetahuan penalaksanaan nyeri kanker yang kurang menyebabkan penggunaan opiat yang tidak optimal. Indonesia merupakan salah satu negara dengan konsumsi opiat yang sangat rendah. Tujuan studi ini adalah untuk mengetahui pengetahuan dokter mengenai penanganan nyeri kanker dalam pemilihan opiat, cara pemberian, dosis, efek samping, dan adanya adiksi, serta faktor-faktor yang menjadi penghambat pada penanganan nyeri kanker. Desain penelitian ini merupakan survei potong lintang ( cross sectional ) yang dilakukan terhadap dokter spesialis yang menangani nyeri kanker di Rumah Sakit Umum Pemerintah Jakarta dan salah satu rumah sakit swasta di Tangerang. Penelitian ini menggunakan kuesioner yang diisi responden dan bersifat rahasia. Pengetahuan dianggap baik bila nilai ≥ 70. Sedangkan untuk menilai hubungan antara pengetahuan tentang penggunaan opiat dengan bidang spesialisasi dokter dianalisis dengan uji Chi-square . Hasil statistik dianalisis dengan menggunakan SPSS versi 20. Dari total 146 kuesioner yang didistribusikan, didapatkan 103 kuesioner (70,5%) yang direspons. Pada penelitian ini, mayoritas responden (69,9%) mempunyai pengetahuan yang tidak adekuat. Rerata tertinggi didapatkan pada bagian pemilihan opiat 70,55; sedangkan rerata terendah didapatkan pada bagian efek samping opiat, yaitu 47,56. Tidak terdapat hubungan bermakna antara pengetahuan dokter tentang penggunaan opiat dengan bidang spesialisasi (P= KORESPONDENSI: Lenny Indrayani Departemen Farmakologi dan Terapeutik, Universitas Indonesia. Email: lenny3ma@gmail.com Indonesian Journal of Cancer Vol. 11, No. 4 October - December 2017160 0,355). Regulasi pemerintah merupakan penghambat utama pada penggunaan opiat, disusul dengan kurangnya pelatihan, ketersediaan obat dan pengetahuan tentang efek samping.
Evaluation of Kidney Injury Molecule-1 (KIM-1) and Neutrophil Gelatinase-Associated Lipocalin (NGAL) Urinary Levels for Detecting Kidney Dysfunction in Patients With Nasopharyngeal Cancer Treated With Cisplatin-Based Treatment Rejeki, Marliana Sri; Arozal, Wawaimuli; Setiabudy, Rianto; Atmakusuma, Djumhana
Indonesian Journal of Cancer Vol 12, No 2 (2018): April-June
Publisher : National Cancer Center - Dharmais Cancer Hospital

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (951.677 KB) | DOI: 10.33371/ijoc.v12i2.581

Abstract

Background: Cisplatin has a potency of causing nephrotoxicity. Serum BUN and creatinine levels have been well-known for detecting kidney dysfunction; while KIM-1 and NGAL urine levels are relatively new measurements. The study was aimed to evaluate urinary KIM-1 and NGAL level to detect kidney dysfunction in patients with advanced stage NPC who received cisplatin-based chemotherapy.Methods: The study was a cohort-prospective study with 3 subject groups, i.e. patients who had never received and who had received 75-100 mg/m2 cisplatin-based chemotherapy as well as those who had never received 40 mg/m2 cisplatin-based chemotherapy. The levels of urinary KIM-1, NGAL and serum level of BUN and creatinine were measured before and after receiving cisplatin. Statistical analyses were ANOVA, Pearson, Spearman, Kolmogorov-Smirnov test and SPSS version 22.0.Result: There was a significant difference of delta BUN level (p=0.0001) and delta urinary NGAL level (p = 0.025) before and after treatment in all three groups; while delta KIM-1 level showed no significant difference in all three groups (p=0.275). Cisplatin may cause accumulated nephrotoxicity, which has dose-dependent manner.Conclusion: Measuring urinary NGAL level can detect an early stage of kidney dysfunction; however, it still cannot replace the role of BUN. Measurement of urinary KIM-1 level cannot detect kidney dysfunction.
Co-Authors Adi K Aman, Adi K Agus Setiyono Ahmad Sulaeman Akmal Taher Ali Baziad Ali Sulaiman Alida Harahap Arini Setiawati Aru W Sudoyo Ascobat, Purwantyastuti Bernardus Philippi Beti E. E Dewi, Beti E. E Cleopas Martin Rumende Cosphiadi Irawan Daldiyono H Dalima A.W. Astrawinata Dewi Muliaty Diani Kartini Djajadiman Gatot Djumhana Atmakusuma, Djumhana Frans D. Suyatna Gayatri, Anggi Harry Isbagio Harry Isbagyo, Harry Haryana, Sofia M Hidayati, Anggi Puspa Nur Husniah Th-Akib I Dewa Gede Ugrasena Imam Effendi Indra Kusuma INDRAYANI, LENNY Inge A. Kristanti Instiaty, Instiaty Irawan Yusuf Iwan Darmansjah Jason Sriwijaya Johannes Hudiono Jusman, Sri W Kato, Mitsuyasu Laurentius A. Lesmana Lina Lasminingrum Lisnawati Rachmadi Madoka Takeuchi Marulam M. Panggabean Masahiro Takeuchi Melva Louisa Muchtaruddin Mansyur Murdani Abdullah Murti Andriastuti, Murti Nafrialdi Nafrialdi Nurul Akbar Nuzirwan Acang Nyoman Kertia Primariadewi Rustamadji Priyono, Harim Puteri, Meidi U. Putri, Pingkan Permata Rahajuningsih Dharma Rejeki, Marliana Sri Restuti, Ratna Dwi Riadi Wirawan Rikarni Rikarni Robby Zulkarnain Saukani Gumay Septelia I. Wanandi Sjaifoellah Noer Soehartati Gondowiardjo Sonar S. Panigoro Suyanto Sidik Tambunan L Tambunan, Tambunan L Toar J.M. Lalisang Unggul Budihusodo Vera Yuwono Vivian Soetikno Wardhani, Bantari W.K. Watanabe, Yukihide Wawaimuli Arozal Wibowo, Suryo Anggoro Kusumo Yefta Moenadjat Zita Arieselia