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Arum Setiawan
Jurusan Biologi FMIPA, Universitas Sriwijaya
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Journal : Science and Technology Indonesia

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Antioxidant and Antibacterial Activity of Endophytic Fungi Isolated from Fruit of Sungkai (Peronema canescens) Oktiansyah, Rian; Widjajanti, Hary; Setiawan, Arum; Elfita
Science and Technology Indonesia Vol. 9 No. 1 (2024): January
Publisher : Research Center of Inorganic Materials and Coordination Complexes, FMIPA Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26554/sti.2024.9.1.17-27

Abstract

Peronema canescens, often known as sungkai, is widely used and can be found all around Indonesia. The public believes that the leaves may reduce fever and strengthen the immune system. However, the effectiveness of sungkai fruit has not been thoroughly investigated. In this research, we looked at endophytic fungus extracts from sungkai fruit’s that have antioxidant and antibacterial properties. The study’s results will serve as the foundation for further investigation into the development of potential natural chemicals with antioxidant and antibacterial properties. Morphologically, the endophytic fungi isolated from sungkai fruit were identified. The antioxidant and antibacterial properties of endophytic fungal extracts were studied using the DPPH technique and the paper disk diffusion method. By employing molecular identification and column chromatography to separate the active compounds, the most likely endophytic fungal isolates were found based on the results of the bioactivity tests. Using 1D NMR spectroscopic methods, the chemical’s structure was determined, and the results were compared to NMR data for the same compound published in the literature. Fruit of sungkai had 8 strains of endophytic fungus (RBH1-RBH8). Strong antibacterial and very strong antioxidant activity were shown by the RBH5 isolate (IC50 < 20 μg/mL). Pythium periplocum was determined to be the RBH5 isolate based on molecular testing. Pure chemical compound extracted from RBH5 isolates shown highly potent and potent antibacterial and antioxidant effects. The chemical compound was identified by spectroscopy as 3-hydroxy-4(hydroxy(4-hydroxyphenyl)methyl)-γ-butyrolactone. The results of this study serve as the foundation for developing compounds as pharmaceutical raw materials via further research phases.
Combination Effect of Extracts and Pure Compounds of Endophytic Fungi Isolated from Sungkai (Peronema canescens) Leaves on Antioxidant Activity Elfita; Oktiansyah, Rian; Mardiyanto; Setiawan, Arum; Widjajanti, Hary
Science and Technology Indonesia Vol. 9 No. 1 (2024): January
Publisher : Research Center of Inorganic Materials and Coordination Complexes, FMIPA Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26554/sti.2024.9.1.69-76

Abstract

Endophytic fungi extracts have various biological and pharmacological activities as natural antioxidants which have the potential to be developed in the pharmaceutical. Drugs made from natural substances frequently work best when they are present in large quantities. This may result in unfavorable side effects from using more of one substance at a time. This limitation can be overcome by using a combination of the extracts/pure compounds that allow synergistic interactions with strong antioxidant properties at fairly low concentrations. The purpose of this research was to determine the combined effect of endophytic fungi extracts and its pure compounds on their antioxidant activity. This research was initiated by rejuvenating eight selected endophytic fungal isolates from Sungkai leaves and morphological characterization was carried out. Each fungus was cultivated in PDB medium for 4 weeks under statistical conditions. Ethyl acetate was used to extract the endophytic fungi’s liquid culture, which was then evaporated. Each endophytic fungal extract (PD1-PD8) and their five pure compounds were tested for antioxidant activity by the DPPH method. Then a combination of two and three extracts was carried out with a ratio of 1:1. The results show that the interaction of the mixture of endophytic fungi extracts and their pure compounds can be classified as synergistic (combined effect of the extracts > individual effects), additive (combined effect of the extracts = individual effect), and nothing is antagonistic (combined effect of the extracts < individual effects). The best combination in this study was PD4+PD5+PD6 (1:1:1) which could be used as a formula for further research into in vivo immunostimulant tests. Another conclusion from this research is that the pure compounds contained in the extracts have lower antioxidant activity than the extracts and do not have a synergistic effect on the combination.
Co-Authors Aetin, Entin Nur Affandi, Azhar Kholiq Aini, Intan Nurul Alexander Alexander, Alexander Anita Desiani Aprilia, Ina Aprillia, Ina Aprillia, Ina Arfan Abrar Aurora, Dhea Apriano Cahyaningrum, Putri Chandra Irsan Dahelmi Dahelmi Denny Noberio, Denny Dewi Imelda Roesma Djong Hon Tjong Doni Setiawan Ekowati, Indah Agustina Elfita Elfita Elfita Elvi Sunarsih Enggar Patriono, Enggar Harmoko Harmoko, Harmoko Hary Widjajanti Indra Yustian Indrianti, Winda Indriati, Winda Irmeilyana Istriati Istriati, Istriati Istriyati Istriyati Kadarisman, Reza Kurniawati, Alfia Rahma Kusuma, Shinta Kusuma, Shinta Laila Hanum Mammed Sagi Mardiyanto Muhammad Gunawan Muhammad Iqbal Muhammad Iqbal Muharni Muharni Nadya Rahmania, Nadya Ngudiantoro . Novitrie, Ayu Oktaberi, Redi Oktiansyah, Rian Oktora Dwi Putranti Pragustiandi, Guntur Pratiwi, Putri Rizki Prima, Bayu Rio Firman Saputra, Rio Firman Ryan Hidayat, Ryan Safri, Adios Salni Samitra, Dian Sepriyaningsih, Sepriyaningsih Sri Indra Maiyanti Syaifullah Syaifullah Syarifah Syarifah, Syarifah Wenny Saptalisa, Wenny Widjajanty, Hary Widya Asmara Widya Ismara, Widya Wilson Novarino Wiwik Handayani Yuanita Windusari Yundari, Yundari Zubaidah R, Zubaidah Zulkifli Dahlan