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All Journal Jurnal Sains dan Seni ITS Jurnal Kedokteran Brawijaya Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Jurnal Kesehatan Reproduksi The Indonesian Biomedical Journal Universa Medicina Qanun Medika - Medical Journal Faculty of Medicine Muhammadiyah Surabaya Indonesian Journal of Obstetrics and Gynecology (Majalah Obstetri dan Ginekologi Indonesia) Andalas obstetrics and gynecology journal Jurnal Mnemonic Placentum: Jurnal Ilmiah Kesehatan dan Aplikasinya Narra J Folia Medica Indonesiana International Journal of Computing Science and Applied Mathematics-IJCSAM

Soetrisno Soetrisno

Institut Teknologi Sepuluh Nopember

Author-ID : 384357

Arts Humanities Biochemistry, Genetics & Molecular Biology Computer Science & IT Health Professions Immunology & microbiology Mathematics Medicine & Pharmacology Neuroscience Nursing Public Health

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Implementasi Algoritma Genetika untuk Optimalisasi Random Forest dalam Proses Klasifikasi Penerimaan Tenaga Kerja Baru : Studi Kasus PT.XYZ Laras Binarwati; Imam Mukhlash; Soetrisno Soetrisno
Jurnal Sains dan Seni ITS Vol 6, No 2 (2017)
Publisher : Lembaga Penelitian dan Pengabdian Kepada Masyarakat (LPPM), ITS

Kualitas sumber daya manusia sangat penting bagi suatu perusahaan untuk mempertahankan keunggulan kompetitifnya agar mampu bersaing dengan perusahaan lainnya maupun untuk meningkatan kualitas dari perusahaan itu sendiri. Oleh karena itu, menggali pola penerimaan tenaga kerja baru sangat diperlukan. Pada penelitian ini, metode random forest digunakan untuk menggali pola penerimaan tenaga kerja baru. Adapun algoritma genetika (GA) digunakan untuk mengoptimalkan akurasi berdasarkan pola yang didapat. Hasil pengujian program ini menunjukkan keakuratan pola yang dihasilkan oleh random forest yang dioptimalkan dengan algoritma genetika lebih tinggi dengan hasil keakuratan berkisar antara 91%-95% dibanding dengan hanya menggunakan random forest saja yang hanya berkisar 40-95%.

SIMULATOR EKSEKUSI INSTRUKSI PADA SISTEM KOMPUTER VIRTUAL Soetrisno, Soetrisno
Jurnal Mnemonic Vol 2 No 1 (2019): Mnemonic Vol. 2 No. 1
Publisher : Teknik Informatika, Institut Teknologi Nasional malang

Sistem komputer modern saat ini semakin canggih dan mudah digunakan karena kompleksitas perangkat keras, dan piranti lunak, semakin tersembunyi dari pengguna. Sehingga, untuk memahami bagaimana sebuah komputer melakukan eksekusi instruksi yang dilakukan oleh mikroprosesor tidak secara mudah dilakukan. Salah satu solusinya adalah dalam bentuk piranti lunak simulator, atau emulator, suatu mikroprosesor tertentu. Penulis merancang dan membuat piranti lunak sistem komputer virtual, terdiri dari mikroprosesor virtual, dan memori virtual. Mikroprosesor virtual dirancang dan dibuat mulai dari rancangan instruction set, dengan format ukuran instruksi yang seragam 32 bits, menyediakan 16 register berukuran 32 bits. Memori virtual yang dibuat pada simulator sebesar 32 kilo bytes. Sistem komputer yang dibuat memungkinkan lebih dari satu program berada di memori, dan mikroprosesor dapat menjalankan program-program yang ada di memori tersebut, meskipun masih dieksekusi secara sekuensial. Satu program dikerjakan hingga selesai, dilanjutkan program berikutnya. Dalam simulator ini, program dapat ditulis menggunakan bahasa mesin berdasarkan rancangan instruction set yang ada, atau program ditulis berupa pseudocode yang akan dikompilasi oleh piranti lunak compiler yang telah dibuat. Menggunakan compiler ini dapat diperlihatkan hasil translasi dari pseudocode ke kode dalam bahasa assembly, juga dalam bahasa mesin, dan serta status register, maupun memori, dari tiap instruksi yang dieksekusi.

Correlation between circulating fibrosis biomarkers with left atrial function and left atrial volume index in rheumatic mitral stenosis Asrial, An A.; Reviono, Reviono; Soetrisno, Soetrisno; Setianto, Budi Y.; Widyaningsih, Vitri; Nurwati, Ida; Wasita, Brian; Pudjiastuti, Anggit
Narra J Vol. 4 No. 1 (2024): April 2024
Publisher : Narra Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52225/narra.v4i1.293

Mitral stenosis is the most common rheumatic heart disease (RHD) disorder worldwide, including in Indonesia. This pathological condition causes left atrial pressure, leading to left atrial fibrosis that affects the structure and function of the left atrial as well as the clinical condition. The aim of this study was to assess the correlation between circulating fibrosis biomarkers with net atrioventricular compliance (Cn) as a parameter of left atrial function, and left atrial volume index (LAVI) as a parameter left atrium structure of changes. A cross-sectional study was conducted at Panti Rahayu Hospital and Permata Bunda Hospital, Purwodadi, Central Java, with a total of 40 RHD patients with severe mitral stenosis. The ELISA was used to measure the levels of carboxy-terminal propeptide of type I procollagen (PICP), matrix metalloproteinase I (MMP-1), tissue inhibitor matrix metalloproteinase 1 (TIMP-1), and transforming growth factor-β1 (TGF-β1). The left atrial function was assessed by measuring Cn, and the LAVI parameters were measured to assess left atrium structure/size. The mean levels of circulating fibrosis biomarkers were as follows: PICP 153.96±89.12 ng/mL; MMP-1 1.44±2.12 ng/mL; MMP-1/TIMP-1 ratio 0.38±0.54 and TGF-β1 2.66±1.96 pg/mL. From the echocardiographic evaluation, the mean Cn was 5.24±1.93 mL/mmHg and the mean LAVI was 152.55±79.36 mL/m2. There were significant correlation between MMP-1 and MMP-1/TIMP-1 ratio with Cn (r=0.345 and r=0.333, respectively; both had p<0.05). PICP and TGF-β1 biomarkers did not significantly correlate with Cn (p>0.05). Meanwhile, none of the biomarkers had a significant correlation with LAVI (p>0.05). This study highlights that MMP-1 and MMP-1/TIMP-1 ratio are potentially to be used as markers to determine the Cn in RHD patients with severe mitral stenosis. However, further studies with a higher sample size are needed to confirm this finding.

Aerobic exercise improves spatial memory in a rat model of meningitis Zaidah, Lailatuz; Soetrisno, Soetrisno; Purwanto, Bambang; Kristiyanto, Agus; Wasita, Brian; Widyaningsih, Vitri
Narra J Vol. 4 No. 3 (2024): December 2024
Publisher : Narra Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52225/narra.v4i3.977

Infections of the nervous system, such as acute bacterial meningitis, pose serious health problems that require immediate intervention. In experimental animals, exposure to lipopolysaccharide (LPS) is used to induce meningitis. Aside from drug intervention to reduce inflammation in meningitis, aerobic exercise helps to maintain the regulatory mechanisms of brain homeostasis through anti-inflammatory mechanisms. The aim of this study was to evaluate the effect of aerobic exercise on malondialdehyde (MDA), nuclear factor-kappa B (NF-κB), insulin-like growth factor 1 (IGF-1), endothelial nitric oxide synthase (eNOS), brain-derived neurotrophic factor (BDNF), apoptosis, and spatial memory. A four-week experimental study was conducted using 18 rats, which were randomly divided into three different groups (six rats per group): healthy rats as negative controls (non-meningitis), a treatment group treated with antibiotic treatment (meningitis group), and a third group (aerobic exercise group) treated with antibiotics and aerobic exercise following LPS-induced meningitis. Data were analyzed using a one-way analysis of variance (ANOVA) test, and the comparison between groups used the Bonferroni post-hoc test. The results showed that aerobic exercise significantly reduced MDA (p<0.001), NF-κB (p=0.035), and apoptosis (p=0.020) while increasing the serum levels of IGF-1 (p<0.001), eNOS (p=0.011), and BDNF (p=0.001) levels. Improvement in spatial memory was significant in the aerobic exercise group (p<0.001). This study suggested that aerobic exercise could be a promising adjunct therapy in meningitis management strategies, particularly due to its effect on improving spatial memory. Further clinical trials are needed to confirm these findings for clinical use.

Impacts of Phyllanthus niruri extract on biomarker levels, macrophage count, and lesion area in an endometriotic rat model Wulandari, Eka T.; Soetrisno, Soetrisno; Purwanto, Bambang; Reviono, Reviono; Wasita, Brian; Laqif, Abdurrahman
Narra J Vol. 4 No. 3 (2024): December 2024
Publisher : Narra Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52225/narra.v4i3.1002

Endometriosis is a gynecological disorder characterized by chronic inflammation, anatomical changes, prolonged pain, and infertility. On the other hand, Phyllanthus niruri is recognized for its pharmacological effects, which might be beneficial in managing endometriosis. The aim of the study was to investigate the pharmacological effects of P. niruri as a potential therapy for endometriosis by using an animal model. An experimental laboratory study with randomized, controlled trial, pre-test, and post-test design using 40 female Wistar rats (Rattus norvegicus) was conducted at the Integrated Research and Testing Laboratory (LPPT) of Universitas Gadjah Mada, Yogyakarta, Indonesia, from February to June 2023. Endometriosis was induced in female Wistar rats by suturing a 0.5 cm2 flap from the uterine horn to the peritoneal cavity. Changes in serum interleukin 1β (IL-1β), malondialdehyde (MDA), and matrix metalloproteinase 9 (MMP-9), before and after the treatment, were analyzed using enzyme-linked immunosorbent assay. Hematoxylin and eosin (HE) staining were used to evaluate lesion size and macrophage quantity. The results suggested that the P. niruri extract with a dose of 196 mg/200 g body weight (BW) could significantly attenuate serum IL-1β (p=0.004), MMP-9 (p=0.021), and MDA (p=0.021). Rats receiving the P. niruri extract (196 mg/200 g BW) had significantly higher macrophage counts (p=0.003), but similar lesion area (p=0.093) as compared with the negative control. In conclusion, P. niruri demonstrated promising therapeutical effects on endometriosis by modulating IL-1β, MDA, and MMP-9 levels, although the effect was not pronounced on macrophage counts and lesion area.

Evaluating autologous peritoneum grafting for enhanced healing of bile duct injuries: A preliminary data from an animal study Nugroho, Anung N.; Mudigdo, Ambar; Soetrisno, Soetrisno; Yarso, Kristanto Y.; Nurwati, Ida; Indarto, Dono; Pamungkasari, Eti P.
Narra J Vol. 5 No. 1 (2025): April 2025
Publisher : Narra Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52225/narra.v5i1.1873

Increased incidence of laparoscopic cholecystectomy-related bile duct injuries (BDIs), combined with its risk of serious complications and mortality, highlights the need for a more effective repair technique. Although the use of autologous graft in BDI repair has been promoted, the role of autologous parietal peritoneum remains underexplored. The aim of this study was to evaluate the effect of autologous parietal peritoneum grafts in rabbit models of partial BDI, emphasizing its effect on the expression of cluster of differentiation 68 (CD68) and transforming growth factor-β (TGF-β). An experimental post-test-only design was employed, using 27 male New Zealand rabbits (Oryctolagus cuniculus) aged 8–10 months. The rabbits were allocated into three groups: control (primary closure), autologous parietal peritoneum graft, and autologous gallbladder graft. Partial BDI measuring 15×5 mm were surgically created and repaired according to group assignments. The expression of CD68 and TGF-β were measured via enzyme-linked immunosorbent assay (ELISA), while the anastomosis was pathologically examined through hematoxylin and eosin (H&E) staining on days 3, 7, and 14 post-surgery. Statistical analysis was performed using analysis of variance (ANOVA) followed by Bonferroni post hoc tests. No statistically significant difference was observed in the expression of CD68 or TGF-β among the three treatment groups on days 3, 7, and 14 post-surgery, indicating that the effects of autologous parietal peritoneum graft were comparable to the control and the autologous gallbladder graft in promoting wound healing. Fibroblast density on day 3 was significantly lower in the parietal peritoneum group (p=0.040), reflecting delayed recruitment, but normalized by day 14, indicating successful integration and remodeling. The study highlights the potential role of autologous parietal peritoneum grafts for BDI.

Propolis effectiveness on the reduction of blood glucose level and improvement of body weight in diabetic model's rat Meida, Nur Shani; Purwanto, Bambang; Wasita, Brian; Indrakila, Senyum; Soetrisno, Soetrisno
Qanun Medika - Jurnal Kedokteran FK UMSurabaya Vol 8 No 01 (2024): Qanun Medika Vol 08 No 01 January 2024
Publisher : Universitas Muhammadiyah Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30651/jqm.v8i01.18617

Propolis is an herbal medicinal plant that contains caffeic acid phenethyl ester. This natural polyphenol compound acts as an antioxidant and can reduce blood glucose levels and increase body weight. This study aims to determine the effectiveness of Gunung Lawu propolis in lowering blood glucose levels and increasing body weight in diabetic rats. The Wistar rats were induced with STZ 45 mg/kg BW and nicotinamide 110 mg/kg BW as diabetic model rats. Research subjects were taken randomly and divided into five groups: (1) Normal, (2) DM with no propolis, (3) DM 14 days + propolis 100 mg/kg BW/day (P1), (4) DM 14 days + Propolis 200 mg/kg BW/day (P2), and (5) DM 0 day + Propolis 200 mg/kg BW/day (P3). Propolis extract was given orally once a day for 14 consecutive days (in groups 3 and 4) and 28 consecutive days (in group 5). Blood glucose levels in the treatment group (P1, P2, and P3) decreased significantly (P1: 115.28 ± 4.7 mg/dL; P2: 98.36 ± 4.8 mg/dL; and P3: 87.36 ± 4, 2 mg/dL) compared with that in the DM group (272.07 ± 3.9 mg/dL). The body weight of the treatment group (P1, P2, and P3) increased significantly (P1: 180.60 ± 5.7 g; P2: 180.60 ± 4.2 g; and P3: 208.00 ± 5.1 gr) compared with that in the DM group (160.00 ± 3.2 gr). In conclusion, Propolis is effective in reducing blood glucose levels and improving (increasing) body weight in diabetic model rats.

OMPHE-VIA (Obedient Male Partner in Health-Education and Engagement for Visual Inspection with Acetic Acid Examination) Model Was Solution to Save Cervical Cancer Ferry, Ferdinal; Machmud, RIzanda; Soetrisno, Soetrisno; Bachtiar, Adang
Andalas Obstetrics And Gynecology Journal Vol. 7 No. 1 (2023)
Publisher : Fakultas Kedokteran Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/aoj.7.1.286-294.2023

Background: VIAÂ screening is very suitable for developing countries such as Indonesia, because the technique is easy, simple, low cost/cheap, high sensitivity, fast and accurate for early detection of cervical cancer. The coverage of early detection in Indonesia is <5% so that many cases of cervical cancer are found to be at an advanced stage and often cause death in women.Methods: This study uses a mix-method study approach with a sequential exploratory approach. The research was carried out sequentially with qualitative methods first (interviews and FGDs), then continued with quantitative methods. In this study, the sampling technique used was multi-stage random sampling in 7 selected sub-districts.Results: The variable perception of vulnerability with a good perception of vulnerability have a 2.64 times greater risk of carrying out an VIA examination. In multivariate modeling, knowledge is the most dominant variable because it has the largest POR of 6.3, which means the N-Gain value is in the medium category with a fairly effective interpretation of the effectiveness of the module, namely an increase in knowledge of 63.86% after being given education using the OMPHE-VIA module.Â Conclusion: Based on the implementation of the OMPHE-VIA module, it was found that there was an increase in the average value of knowledge, before and after the education was given. It was also found that there was a significant difference in knowledge, andÂ husband's support,Â construct between before and after the education was given using the OMPHE-VIA module.

The Influence of Psychocurative on Cortisol Level, Anxiety, and Quality of Life in Advanced Stage Cervical Cancer Patients Soetrisno, Soetrisno; Mulyani, Sri; Nurinasari, Hafi; Nurinasari, Hafi; Budi, Erindra
Folia Medica Indonesiana Vol. 55, No. 3
Publisher : Folia Medica Indonesiana

Show Abstract | Download Original | Original Source | Check in Google Scholar

Every year, there are 500.000 new cases and more than 250.000 deaths caused by cervical cancerworldwide. Cervical cancer patients faced physical and psychological problems several times that it activate stress mechanism such as hypothalamus-pituitary-adrenal (HPA) axis. These recurrent activations caused HPA axis disruption and adverse clinical effects. Several symptoms of endocrine stress response are the change of circadian cortisol rhythm. Cortisol is known as a stress hormone that involves an organism's response to stress and anxiety that influence the quality of life. This research aims to analyze the differences among serum cortisol level, anxiety, and quality of life in cervical cancer patients before and after psychocurative intervention in obstetrics and gynecology wards and polyclinic in RSUD Dr. Moewardi Surakarta. This research is an experimental double-blind randomized controlled clinical trial pre-test post-test group design study. The subjects were advance stage (IIB-IV)cervical cancer patients. The subjects were randomly chosen into fifteen subjects that given standard therapy and psychocurative, while the other fifteen subjects as a control only got standard therapy. Data were obtained from measurement of serum cortisol level, anxiety questionnaire DASS 42 and WHO quality of life questionnaire. Data were analyzed using SPSS 21 using difference test. The difference mean test result of cortisol serum level, anxiety, quality of life from the controlled group and uncontrolled group showed a significant difference (p < 0.05). In conclusion, psychocurative is significant to reduce cortisol level, anxiety, and improve the quality of life in advanced stage cervical cancer patients.

The effect of recombinant vascular endothelial growth factor 121 on nitride oxide level in mice (mus musculus) model of preeclampsia Soetrisno, Soetrisno; Isharyadi, Isharyadi; Sulistyowati, Sri
Folia Medica Indonesiana Vol. 53, No. 3
Publisher : Folia Medica Indonesiana

Show Abstract | Download Original | Original Source | Check in Google Scholar

Preeclampsia is a multifactorial syndrome in pregnancy whose cause is still unknown. Several proangiogenic and antiangiogenic mediators such as Vascular Endothelial Growth Factor (VEGF) and Nitrite Oxide (NO) play important roles in preventing preeclampsia. VEGF can increase NO level that lowers maternal blood pressure, improves endothelial function and reduces placental hypoxia in preeclampsia. Recombinant VEGF 121 is expected to be an option in the prevention and treatment of preeclampsia. This experimental study used mice (Mus musculus) as the model. The objective of this study was to observe the effect of recombinant VEGF 121 in increasing the level of nitric oxide in mice (Mus musculus) model of preeclampsia. This was an experimental analytical study with Randomized Control Trial (RCT) design. The study enrolled 27 pregnant mice (Mus musculus) which met the restriction criteria divided into 3 groups. The first group (K1) were 9 normal pregnant mice. The second group (K2) were 9 pregnant mice of preeclampsia model without treatment. The third group (K3) were 9 pregnant mice of preeclampsia model receiving recombinant VEGF 121 therapy. The independent variable was the administration of recombinant VEGF 121 and the dependent variable was the serum NO level. Statistical analysis was performed by using anova statistics. NO level in the first group (K1) was 1.746±0.347, with minimum value of 1.00 µM, and maximum value of 2.28 µM, CI (1.479-2.013). NO level in second group (K2) was 1.167±0.380, with minimum value of 0.64 µM, and maximum value of 1.94 µM, CI (0.875-1.460). NO level in the third group (K3) was 2.164±0.556, with minimum value of 1.56 µM, and maximum value of 5.96 µM, CI (1.842-2.486). With anova statistical test, there were significant differences between K1 group and K2 group (p value=0.004<0.05), K1 group and K3 group (p value=0.000<0.05) as well as K2 group and K3 group (p value=0.029<0.05). In conclusion, Recombinant VEGF 121 increased the level of nitric oxide in mice (Mus musculus) model of preeclampsia significantly.

Co-Authors Abd. Rasyid Syamsuri Adang Bachtiar Adang Muhammad Gugun, Adang Muhammad Agus Kristiyanto Ambar Mudigdo Annang Giri Moelyo Anwar Sandi Wibowo, Anwar Sandi Asrial, An A. Bambang Eko Wiyono, Bambang Eko Bambang Purwanto Brahmana, Ivanna Beru Brian Wasita Budi, Erindra Cahyanto, Erindra Budi Didon Muhammad Trimulya Donny Irawan, Donny Dono Indarto Dwi Ratna Sulistyaningrum Eddy Tiro Eka Tri Wulandari, Eka Tri Eric Edwin Yuliantara Eti Poncorini Pamungkasari Fadhlan Septianto Eka Putra Faris, Abdul Ferry, Ferdinal Hari Wujoso Harsono Salimo Ida Nurwati Imam Mukhlash Isharyadi, Isharyadi Isi Bifawa’idati John Arianto Sondakh, John Arianto Kurniawan, Hendro Laqif, Abdurahman Laqif, Abdurrahman Laras Binarwati Mappaware, Nasrudin Andi Mohammad Hakimi Mohammad Isa Irawan MULYOTO PANGESTU Nasrudin, Muhamad Nizar Hero K, Nizar Hero Nugroho, Anung N. Nugroho, Muhammad Anggit Nur Shani Meida Nurinasari, Hafi Ova Emilia Pamungkasari, Eti P. Pratiwi, Laurita Laras Pudjiastuti, Anggit Rabrageri, Alberthzon Kris Silo Rahmah Rahmah Reviono Reviono Rifdy Fachry Risanto Siswosudarmo Risya Cilmiaty, Risya Rita Cempaka Rizanda Machmud Senyum Indrakila Setianto, Budi Y. Shahab, Muhammad Luthfi Siti Maesaroh Siti Munawaroh Soerjo Hadijono Sri Lestariningsih Sri Mulyani Sri Sulistyowati Sulistyawati, Sri Sulistyawati, Sri Supriyadi H Respati Supriyadi Hari Respati Suryoningrat, Dewanto Syamsiar, Syamsiar Titin J. Ambarwati Tjiang, Rubin Enhui Tonang Dwi Ardyanto Trimulya, Didon M Uki Retno Budihastuti Umar Malinta Vitri Widyaningsih Wulandari, Eka T. Yarso, Kristanto Y. Yusup Subagio Zaidah, Lailatuz Zulfa Afiq Fikriya

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