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All Journal Jurnal Sains dan Seni ITS Jurnal Kedokteran Brawijaya Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Jurnal Kesehatan Reproduksi Folia Medica Indonesiana Universa Medicina International Journal of Computing Science and Applied Mathematics Indonesian Journal of Obstetrics and Gynecology (Majalah Obstetri dan Ginekologi Indonesia) Jurnal Mnemonic Narra J Physical Therapy Journal of Indonesia Jurnal Kesehatan Masyarakat
Soetrisno Soetrisno
Institut Teknologi Sepuluh Nopember
Arts Humanities Biochemistry, Genetics & Molecular Biology Computer Science & IT Education Health Professions Immunology & microbiology Mathematics Medicine & Pharmacology Neuroscience Nursing Public Health Other

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Effects of aerobic exercise and high-intensity interval training on muscle damage in an overtraining rat model Syetiawinanda, Amriansyah; Doewes, Muchsin; Purwanto, Bambang; Soetrisno, Soetrisno; Kristiyanto, Agus; Pamungkasari, Eti Poncorini
Physical Therapy Journal of Indonesia Vol. 6 No. 1 (2025): January-June 2025
Publisher : Universitas Udayana dan Diaspora Taipei Medical University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51559/ptji.v6i1.297

Abstract

Background: Overtraining is commonly associated with elevated oxidative stress, inflammatory responses, and structural damage to muscle fibers, all of which contribute to a decline in physical performance. This study aimed to assess the impact of aerobic exercise on biomarkers including malondialdehyde (MDA), interleukin-6 (IL-6), caspase-3, nitric oxide (NO), superoxide dismutase (SOD), as well as the integrity of the sarcolemma. Methods: A six-week experimental study was conducted using 24 rats, which were randomly divided into three groups (n = 8 per group): a negative control group (no treatment), an aerobic exercise group, and a high-intensity interval training (HIIT) group. The levels of biochemical markers, including malondialdehyde (MDA), interleukin-6 (IL-6), nitric oxide (NO), and superoxide dismutase (SOD), were measured using the enzyme-linked immunosorbent assay (ELISA) technique. Additionally, the expression of caspase-3 was determined through immunohistochemical (IHC) analysis. Muscle tissue damage was evaluated by means of histopathological examination. The data were analyzed using a one-way analysis of variance (ANOVA), followed by the Mann-Whitney post hoc test to assess differences between groups. Results: The findings indicated that aerobic exercise did not result in a statistically significant reduction in malondialdehyde (MDA) (p = 0.833), interleukin-6 (IL-6) (p = 0.800), nitric oxide (NO) (p = 0.791), or superoxide dismutase (SOD) (p = 0.520) levels. Nevertheless, the aerobic exercise group exhibited a significantly lower expression of caspase-3 compared to the other groups (p = 0.023). Furthermore, aerobic exercise was associated with a significant reduction in muscle tissue damage (p = 0.001). Conclusion: The findings of this study indicate that both aerobic exercise and high-intensity interval training (HIIT) have the potential to be utilized as therapeutic approaches for mitigating exercise-induced muscle damage, primarily through their positive influence on sarcolemma stability. However, additional clinical investigations are necessary to confirm these results and establish their relevance for clinical implementation.
The effects of overtraining protocol on markers of oxidative stress and inflammation Syetiawinanda, Amriansyah; Doewes, Muchsin; Purwanto, Bambang; Soetrisno, Soetrisno; Kristiyanto, Agus; Pamungkasari, Eti Poncorini
Physical Therapy Journal of Indonesia Vol. 6 No. 2 (2025): Inpress July-December 2025
Publisher : Universitas Udayana dan Diaspora Taipei Medical University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51559/ptji.v6i2.304

Abstract

Background: Overtraining can elevate reactive oxygen species (ROS), suppress endogenous antioxidant activity, and trigger systemic inflammation. Monitoring oxidative stress and inflammation is essential to prevent muscle damage. This study aimed to examine the effects of an overtraining protocol on oxidative stress and inflammatory markers MDA, IL-6, NO, and SOD in male Wistar rats. Methods: The experimental was conducted over two weeks using male Wistar rats at the Bioscience Institute Laboratory, Universitas Brawijaya, Malang, Indonesia as a preliminary study. Three rats were examined to assess the effects of overtraining on MDA, IL-6, NO, and SOD levels. Observations were made one day after overtraining protocol for the intervention group value (KP) and six weeks after overtraining for the control group value (K1). Results: Three male rats underwent an overtraining protocol, and blood samples were collected one day post-overtraining (KP) to assess MDA, IL-6, NO, and SOD levels. The mean values at KP were MDA: 370.3 ± 10.3, IL-6: 5.9 ± 0.7, NO: 61.0 ± 8.4, and SOD: 0.05 ± 0.03. At six weeks post-overtraining (K1), MDA (192.8 ± 10.3), IL-6 (3.3 ± 1.9), and NO (41.7 ± 21.6) levels were lower, while SOD (0.3 ± 0.2) was higher compared to KP. Conclusion: Overtraining can elevate ROS and inflammatory responses, as indicated by increased MDA, IL-6 levels, and NO, along with reduced SOD expression.
In Silico and In Vitro Approach of Preeclampsia Prophylaxis from Water of Kalianda Kopyor Fitriana, Fitriana; Soetrisno, Soetrisno; Sulistyowati, Sri; Indarto, Dono
Jurnal Kesehatan Masyarakat Vol. 21 No. 1 (2025)
Publisher : Universitas Negeri Semarang in collaboration with Ikatan Ahli Kesehatan Masyarakat Indonesia (IAKMI Tingkat Pusat) and Jejaring Nasional Pendidikan Kesehatan (JNPK)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15294/kemas.v21i1.3468

Abstract

Preeclampsia (PE) stands as a prominent cause of maternal mortality in developing nations, yet a standardized therapy for PE has not been established. Some pregnant women in Lampung have consumed the water of young kopyor coconut fruit from the Kalianda variety (WKK), although its therapeutic effects remain unexplored. This study aimed to investigate WKK phytochemicals through in vitro and silico analyses. Liquid Chromatography-Mass Spectrometry (LCMS) was employed for phytochemical analysis, while an in silico study involved Autodock, Autodock Tools, Autodock Vina, Biovia Discovery Studio 2020, and Open Babel GUI, alongside pharmacokinetics prediction using the pkCSM strategy. The study assessed the inhibitory potential of WKK on Gentiatibetine and curcumenolacto C, targeting the PE ACE2 receptor (1R24) through molecular docking with the 3D structure. Post-docking analysis, including binding affinities, hydrophobic interactions, and pharmacokinetic predictions, was conducted. WKK exhibited relatively low binding affinities for Gentiatibetine (-4.86 kcal/mol), curcumenolactone C (-2.96 kcal/mol), and aspirin (-5.12 kcal/mol). Multiple hydrophobic interactions were observed, such as Van der Waals, Salt Bridge, Conventional Hydrogen Bond, Alkyl, 162, and Lys 129. The receptor IR displayed a high bond-free energy, like aspirin docked with the same gene receptor. Pharmacokinetics predictions indicated that WKK possesses a favorable profile. In conclusion, WKK phytochemicals demonstrated a notable docking score comparable to aspirin, suggesting its potential for preventive therapy use.
Co-Authors Abd. Rasyid Syamsuri Adang Muhammad Gugun, Adang Muhammad Agus Kristiyanto Ambar Mudigdo Anwar Sandi Wibowo, Anwar Sandi Asrial, An A. Bambang Eko Wiyono, Bambang Eko Bambang Purwanto Brian Wasita Cahyanto, Erindra Budi Didon Muhammad Trimulya Donny Irawan, Donny Dono Indarto Eddy Tiro Eric Edwin Yuliantara Eti Poncorini Pamungkasari Fadhlan Septianto Eka Putra Faris, Abdul Fitriana Fitriana Hari Wujoso Harsono Salimo Ida Nurwati Imam Mukhlash Isharyadi, Isharyadi John Arianto Sondakh, John Arianto Kurniawan, Hendro Laqif, Abdurahman Laqif, Abdurrahman Laras Binarwati Mappaware, Nasrudin Andi Mohammad Hakimi Mohammad Isa Irawan Muchsin Doewes Nasrudin, Muhamad Nizar Hero K, Nizar Hero Nugroho, Anung N. Nurinasari, Hafi Ova Emilia Pamungkasari, Eti P. Pudjiastuti, Anggit Rabrageri, Alberthzon Kris Silo Rahmah Rahmah Reviono Reviono Rifdy Fachry Risanto Siswosudarmo Risya Cilmiaty, Risya Setianto, Budi Y. Shahab, Muhammad Luthfi Slamet Riyanto Soerjo Hadijono Sri Sulistyowati Sulistyawati, Sri Sulistyawati, Sri Supriyadi H Respati Supriyadi Hari Respati Suryoningrat, Dewanto Syetiawinanda, Amriansyah Titin J. Ambarwati Tjiang, Rubin Enhui Tonang Dwi Ardyanto Trimulya, Didon M Umar Malinta Vitri Widyaningsih Wulandari, Eka T. Yarso, Kristanto Y. Yusup Subagio Zaidah, Lailatuz Zulfa Afiq Fikriya