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The impacts of stimulation in protracted labor to cortisol levels and incidence of post-partum blues Soetrisno, Soetrisno; Respati, Supriyadi Hari; Sulistyowati, Sri; Kurniawan, Hendro
Folia Medica Indonesiana Vol. 53, No. 1
Publisher : Folia Medica Indonesiana

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Abstract

Delivery, induction, stimulation, cesarean section with the aid of a vacuum extraction, for example, can reduce maternal confidence on the smooth delivery process, as well as improve postpartum stress. These stressors stimulate the HPA axis (hypothalamus-pituitary-adrenal), so that the adrenal cortex produces more cortisol hormone, it can increase postpartum blues. The objective of this study was to analyze the effect of delivery stimulation on protracted labor on cortisol levels and the occurrence of postpartum baby blues. This was an experimental study of non-randomized post-test control group. The subject of the study 30 patients in labor taken consecutive sampling, divided into 2 groups (normal delivery and stimulation) each group consist of 15 patients. In stimulation delivery group, it is examined of cortisol serum levels after five days and then continued for postpartum blues occurrence measurement. Statistical analysis using t-test for differences in levels of cortisol and chi square for analyzing the effect on the occurrence of post-partum blues (a=0.05). Mean level of cortisol in delivery stimulation group is 40.29 ± 5.58, in normal delivery is 33.59 ± 11.17, with p=0.047, meaning there are significant differences both study groups. Stimulation delivery increases the occurrence of post-partum blues 5.50 times compared to normal delivery (OR=5.50 and p=0.028). Mean cortisol levels on post-partum blues higher at 42.90 ± 6.97 compared to no post-partum blues 30.14 ± 6.66, p=0:00, which means there are significant differences both groups. In conclusion, there was significant relationship between stimulation in protrated labor that increases cortisol serum level and post partum blues incidence.
Expression of human leukocyte antigen-e and natural killer cells in intra uterine fetal death Sulistyowati, Sri; Nugroho, Muhammad Anggit; Respati, Supriyadi Hari; Soetrisno, Soetrisno
Folia Medica Indonesiana Vol. 53, No. 4
Publisher : Folia Medica Indonesiana

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Abstract

Intra Uterine Fetal Death (IUFD) is one contributor to infant mortality. Human Leukocyte Antigen-E (HLA-E) and Natural Killer Cells (NK cells) are believed to play an important role towards IUFD associated with immune maladaptation. This study aimed to determine the expression of HLA-E and NK cells on trophoblast on IUFD and normal pregnancy. The study used cross sectional approach undertaken at Department of Obstetrics and Gynecology, Dr. Moewardi Hospital, Surakarta, networking hospitals, and Anatomic Pathology Laboratory of Faculty of Medicine, Sebelas Maret University. The number of samples were 32 subjects consisting of 16 subjects with normal pregnancy and 16 subjects with IUFD. The expression of HLA-E and NK cells on trophoblast of subjects who met the inclusion and exclusion criteria were examined using immunohistochemistry method and t-test statistical analysis. The mean value of HLA-E expression in the trophoblast of IUFD group was 17.30±6.69, in normal pregnancy was 57.06±32.04, with p=0.00 (p<0.05). The mean value of NK cell expression in trophoblast in IUFD group was 78.62±36.43, in normal pregnancy was 19.87±6.43, with p=0.00 (p<0.05). This study concluded that the expression of HLA-E was lower and NK cells wass higher in IUFD compared to those in normal pregnancy.
Effect of cognitive behavioral therapy for serotonin level, depression score and quality of life in cervical cancer patients Soetrisno, Soetrisno; Sulistyowati, Sri; Respati, Supriyadi Hari; Nasrudin, Muhamad
Folia Medica Indonesiana Vol. 52, No. 3
Publisher : Folia Medica Indonesiana

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Abstract

Cervical cancer is the most common cause of death among gynaecological neoplasms. Management of advanced cervical cancer currently has not been able to improve the prognosis. Standard intervention therapy, chemotherapy and radiotherapy, as well as the emerging pain could lead to psychological stress till depression, thus reduce patients' quality of life. CBT for psychological stress and depression is expected to improve the fruitfulness of standard therapy. Serotonin is a neurotransmitter which plays a role in the patophysiology of depression. The aim of this study is to analyze the effect of cognitive behavioral therapy on serotonin level, depression score and quality of life in advanced cervical cancer patient with experimental quasi pre and post test design methods. The samples are 15 subjects in both intervention and control groups. Intervention group was given CBT and standard therapy, while control group was given standard therapy only. Study was held in Department of Obstetric and Gynecologic Dr. Moewardi Hospital Surakarta and Prodia Laboratory, in January to March 2015. Independent variable was advanced cervical cancer patients underwent CBT intervention and dependent variables were serotonin level, depression score and quality of life score. The result, serotonin level and quality of life scores were higher after intervention compared with control, (219.43±33,42 vs 89.57±23.23) and (85.13±14.62 vs 41.86±7.24), respectively. Depression score was lower after intervention than without CBT intervention (11.20±4.94 vs 17.00±4.86) and statistically significant (p < 0.05). So, there were effects of cognitive behavioural therapy on serotonin level, depression score and quality of life score in cervical cancer patients and were statistically significant.
Texture-Based Woven Image Classification using Fuzzy C-Means Algorithm Soetrisno Soetrisno; Dwi Ratna Sulistyaningrum; Isi Bifawa’idati
(IJCSAM) International Journal of Computing Science and Applied Mathematics Vol. 8 No. 1 (2022)
Publisher : LPPM Institut Teknologi Sepuluh Nopember

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Abstract

There are a lot of texture-based image data stored in the storage media Internet. Most of these data portray the cultural fabric texture results from a State. Because of the many variants of the existing texture, the data need to be easily accessible through the Internet. Moreover, the area of origin of weaving the surface is easily known. Therefore, it is necessary to develop a classification system based on woven image data. The texture of the image data stored in a database on the Internet can be grouped/clustered well, making it easy to access. This study examines a texture-based woven image classification using fuzzy c-means algorithm. This method combines extraction methods Gabor filter, fuzzy c-means algorithm and Euclid distance similarity measure. An experiment was done using the system as many as 60 woven images from Bali, NTT and Central Java areas, each taken as many as 25 images weaving. The test results stated that testing using the test images taken from the images in the database generates a 100% accuracy rate, and testing using test images taken from outside the database produces an accuracy rate of 94%.
A Genetic Algorithm with Best Combination Operator for the Traveling Salesman Problem Muhammad Luthfi Shahab; Titin J. Ambarwati; Soetrisno Soetrisno; Mohammad Isa Irawan
(IJCSAM) International Journal of Computing Science and Applied Mathematics Vol. 5 No. 2 (2019)
Publisher : LPPM Institut Teknologi Sepuluh Nopember

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Abstract

In this research, we propose a genetic algorithm with best combination operator (BC(x,y)O) for the traveling salesman problem. The idea of best combination operator is to find the best combination of some disjoint sub-solutions (also the reverse of sub-solutions) from some known solutions. We use BC(2,1)O together with a genetic algorithm. The proposed genetic algorithm uses the swap mutation operator and elitism replacement with filtration for faster computational time. We compare the performances of GA (genetic algorithm without BC(2,1)O), IABC(2,1)O (iterative approach of BC(2,1)O), and GABC(2,1)O (genetic algorithm with BC(2,1)O). We have tested GA, IABC(2,1)O, and GABC(2,1)O three times and pick the best solution on 50 problems from TSPLIB. From those 50 problems, the average of the accuracy from GA, IABC(2,1)O, and GABC(2,1)O are 65.12%, 94.21%, and 99.82% respectively.
Mahkota Dewa (Phaleria macrocarpa) Fruit Extract Decrease Malondialdehyde, Tumor Necrosis Factor-α, and Caspase 3 Levels May Improve Infertility in Endometriosis Mice Brahmana, Ivanna Beru; Soetrisno, Soetrisno; Purwanto, Bambang; Pamungkasari, Eti Poncorini; Wasita, Brian; Budihastuti, Uki Retno; Pangestu, Mulyoto; Cempaka, Rita; Lestariningsih, Sri; Wulandari, Eka Tri; Maesaroh, Siti
The Indonesian Biomedical Journal Vol 18, No 2 (2026)
Publisher : The Prodia Education and Research Institute (PERI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18585/inabj.v18i2.2736

Abstract

BACKGROUND: Endometriosis, which often causes infertility, is characterized by a complex interplay between oxidative stress, inflammatory response, and apoptosis. Currently, the most effective therapy used for endometriosis is hormonal treatments, however it has many common side effects. Therefore, it is necessary to explore alternative treatments for endometriosis, including herbal ingredients. Phaleria macrocarpa fruit contains flavonoids with strong antioxidant and anti-inflammatory properties which have potency to improve fertility in endometriosis cases. However, assessments of whether P. macrocarpa might have any effect on oxidative stress, inflammatory response, and apoptosis in relation to endometriosis are still limited. This study was conducted to identify the effect of P. macrocarpa fruit ethanol extract (PMFEE) in improving infertility by assessing oxidative stress, inflammatory response, and apoptosis parameters in endometriosis mice model.METHODS: Female Balb/C mice were endometriosis-induced, and treated either with 6.5 µg/day Letrozole, 7.5 mg/kgBW/day PMFEE, or 15 mg/kgBW/day PMFEE for 14 days. Heatlhy mice were also included as control. Mice were necropsied, then the uterus and fat tissue around the uterus was collected. Malondialdehyde (MDA) as oxidative stress marker, tumor necrosis factor (TNF)-α as inflammatory marker, and Caspase-3 as apoptosis marker were assessed using enzyme-linked immunosorbent assay (ELISA).RESULTS: In uterus, MDA and TNF-α levels were significantly different among all groups (p<0.05). PMFEE both at 7.5 and 15 mg/kgBW/day lowered MDA and TNF-α compared to the healthy mice and mice receiving Letrozol. Meanwhile, Caspase-3 levels were quite indifferent among groups, showing that PMFEE was able to maintain the Caspase-3 levels in the endometriosis-induced mice.CONCLUSION: PMFEE reduces the MDA and TNF-α, also maintains Caspase-3 levels in the uterus of endometriosis-induced mice, suggesting it might have potential to improve fertility in endometriosis mice.KEYWORDS: Phaleria macrocarpa, endometriosis, infertility, MDA, TNF-α, Caspase-3
Hyperemesis Gravidarum and Maternal Age under 20 Years: A Cross Sectional Study Munawaroh, Siti; Pratiwi, Laurita Laras; Soetrisno, Soetrisno
Placentum: Jurnal Ilmiah Kesehatan dan Aplikasinya Vol 10, No 3 (2022): Special Issue
Publisher : Program Studi Kebidanan Fakultas Kedokteran Universitas Sebelas Maret

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20961/placentum.v10i3.56917

Abstract

Background: Nausea and vomiting during pregnancy are common. When this happens excessively and interferes with activities, it is also called hyperemesis gravidarum. This situation can be detrimental to the mother and fetus, such as nutritional deficiencies, dehydration, electrolyte disturbances, weight loss during pregnancy, and an increased risk of childbirth, premature birth, and low birth weight. Many factors can cause the occurrence of hyperemesis gravidarum, one of which is the age of the mother under 20 years. This study aims to determine the relationship between hyperemesis gravidarum with maternal age under 20 years.Method: a cross-sectional study with a fixed disease sampling method. Subjects were divided into two groups, there were 50 pregnant women with hyperemesis gravidarum and 50 pregnant women without hyperemesis gravidarum. This research was conducted in Dr. Moewardi Hospital, Surakarta. The independent variable being the mother's age under 20 years old and the dependent variable being hyperemesis gravidarum. The Fisher's Exact test was used to evaluate the data in SPSS. The participants in this study were 100 pregnant women,Result:12 of whom were under 20 and 88 of whom were between 20 and 35. The Fischer's Exact test yielded a p-value of 0.03, indicating that maternal age < 20 was related to hyperemesis gravidarum. Hyperemesis gravidarum is more common and has a higher risk in pregnant women under the age of 20.Conclusion: There is a link between maternal age and the occurrence of hyperemesis gravidarum among women under the age of 20.
THE EFFECT OF PROGRESSIVE MUSCLE RELAXATION TO MENTAL HEALTH ON ADOLESCENT Indrakila, Senyum; Cahyanto, Erindra Budi; Soetrisno, Soetrisno; Moelyo, Annang Giri; Nurinasari, Hafi
Placentum: Jurnal Ilmiah Kesehatan dan Aplikasinya Vol 10, No 1 (2022): February
Publisher : Program Studi Kebidanan Fakultas Kedokteran Universitas Sebelas Maret

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20961/placentum.v10i1.53155

Abstract

Background: During the covid-19 pandemic, there are changes in living habits that must be faced by everyone, including teenagers. Adolescents in orphanages in adjustment experience stress, depression and sleep disturbances that can affect the quality of life. For this reason, progressive muscle relaxation efforts can be used as a way to improve adolescent mental health.Methods: This type of research is an analitic observational. This research was conducted at the Marhdatillah Sukoharjo Orphanage, Central Java. The subjects in this study were 42 people living in the Mardhatillah orphanage which divided into control group (27 people) and intervention group (15 people). In both the control group and the intervention group, mental health assessments were carried out twice. In the intervention group, prior to the second mental health assessment, a progressive muscle relaxation intervention was performed. Data was collected using the Strengths and Difficulties Questionnaire (SDQ) and intervention. Analyzed by independent t-test with SPSS 21.Results: The results of the independent t test were significant (p=0.042). The control group consisted of 27 subjects with a mean post-test SDQ score of 23.8 (abnormal) and post-test 13.22 (borderline). The intervention group consisted of 15 subjects with a mean SDQ score of 22.2 pre-test (abnormal) and 9.40 post-test (normal).Conclusion: Progressive muscle relaxation can improve mental health in adolescents who live in the Mardhatillah orphanage, Sukoharjo, Central Java. 
Co-Authors Abd. Rasyid Syamsuri Adang Bachtiar Adang Muhammad Gugun, Adang Muhammad Agus Kristiyanto Ambar Mudigdo Annang Giri Moelyo Anwar Sandi Wibowo, Anwar Sandi Asrial, An A. Bambang Eko Wiyono, Bambang Eko Bambang Purwanto Brahmana, Ivanna Beru Brian Wasita Budi, Erindra Cahyanto, Erindra Budi Didon Muhammad Trimulya Donny Irawan, Donny Dono Indarto Dwi Ratna Sulistyaningrum Eddy Tiro Eka Tri Wulandari, Eka Tri Eric Edwin Yuliantara Eti Poncorini Pamungkasari Fadhlan Septianto Eka Putra Faris, Abdul Ferry, Ferdinal Hari Wujoso Harsono Salimo Ida Nurwati Imam Mukhlash Isharyadi, Isharyadi Isi Bifawa’idati John Arianto Sondakh, John Arianto Kurniawan, Hendro Laqif, Abdurahman Laqif, Abdurrahman Laras Binarwati Mappaware, Nasrudin Andi Mohammad Hakimi Mohammad Isa Irawan MULYOTO PANGESTU Nasrudin, Muhamad Nizar Hero K, Nizar Hero Nugroho, Anung N. Nugroho, Muhammad Anggit Nur Shani Meida Nurinasari, Hafi Ova Emilia Pamungkasari, Eti P. Pratiwi, Laurita Laras Pudjiastuti, Anggit Rabrageri, Alberthzon Kris Silo Rahmah Rahmah Reviono Reviono Rifdy Fachry Risanto Siswosudarmo Risya Cilmiaty, Risya Rita Cempaka Rizanda Machmud Senyum Indrakila Setianto, Budi Y. Shahab, Muhammad Luthfi Siti Maesaroh Siti Munawaroh Soerjo Hadijono Sri Lestariningsih Sri Mulyani Sri Sulistyowati Sulistyawati, Sri Sulistyawati, Sri Supriyadi H Respati Supriyadi Hari Respati Suryoningrat, Dewanto Syamsiar, Syamsiar Titin J. Ambarwati Tjiang, Rubin Enhui Tonang Dwi Ardyanto Trimulya, Didon M Uki Retno Budihastuti Umar Malinta Vitri Widyaningsih Wulandari, Eka T. Yarso, Kristanto Y. Yusup Subagio Zaidah, Lailatuz Zulfa Afiq Fikriya