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All Journal International Journal of Evaluation and Research in Education (IJERE) Medicina Buletin Udayana Mengabdi INDONESIAN JOURNAL OF BIOMEDICAL SCIENCES E-Jurnal Medika Udayana MPI (Media Pharmaceutica Indonesiana) JURNAL MANAJEMEN DAN PELAYANAN FARMASI (Journal of Management and Pharmacy Practice) Jurnal Epidemiologi Kesehatan Komunitas ISM (Intisari Sains Medis) : Jurnal Kedokteran Jurnal Riset Hesti Medan Akper Kesdam I/BB Medan Bioscientia Medicina : Journal of Biomedicine and Translational Research Jurnal Ners Jurnal Ilmiah Medicamento Bioscientia Medicina : Journal of Biomedicine and Translational Research Jurnal Farmasi Indonesia Kartika : Jurnal Ilmiah Farmasi
Desak Ketut Ernawati
Departemen Farmakologi, Fakultas Kedokteran, Universitas Udayana
Biochemistry, Genetics & Molecular Biology Chemistry Education Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences

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Hubungan antara Tingkat Pengetahuan dan Penggunaan Obat Tradisional dan Suplemen untuk Memelihara Daya Tahan Tubuh selama Masa Pandemi COVID-19 pada Mahasiswa Fakultas Kedokteran Universitas Udayana Ivana, Jocelyn; Ernawati, Desak Ketut; Satriyasa, Bagus Komang; Alit Widhiartini, Ida Ayu
E-Jurnal Medika Udayana Vol 11 No 7 (2022): E-Jurnal Medika Udayana
Publisher : Universitas Udayana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24843/MU.2022.V11.i7.P10

Abstract

Ketika COVID-19 pertama kali muncul, semua orang berusaha mencari cara untuk mencegah diri agar tidak terinfeksi. Salah satu caranya adalah dengan meningkatkan daya tahan tubuh melalui obat tradisional dan suplemen. Tujuan dari penelitian ini adalah untuk mengetahui apakah ada hubungan antara tingkat pengetahuan dan penggunaan obat tradisional dan suplemen tersebut. Penelitian cross-sectional ini menggunakan simple random sampling untuk mengambil sampelnya. Setelah semua data terkumpul, maka data diolah dengan uji regresi untuk mengetahui apakah penggunaan obat tradisional dan suplemen memiliki korelasi dengan variabel lain seperti angkatan, jenis kelamin, tingkat pengetahuan tentang COVID-19, tingkat pengetahuan tentang obat tradisional, dan tingkat pengetahuan tentang suplemen. Hasil penelitian menemukan terdapat beberapa variabel yang memiliki korelasi seperti tingkat pengetahuan terhadap COVID-19 mempengaruhi penggunaan meniran (p value = 0.001, Exp = 0.117), jenis kelamin (p value = 0.037, Exp = 1.679) dan angkatan 2019 (p value = 0.048, Exp = 1.778) mempengaruhi penggunaan kunyit, tingkat pengetahuan terhadap COVID-19 mempengaruhi penggunaan temulawak (p value = 0.031, Exp = 0.392), serta jenis kelamin (p value = 0.046, Exp = 2.077) dan tingkat pengetahuan terhadap COVID (p value = 0.001, Exp = 4.401) mempengaruhi Vitamin C. Jahe merupakan obat tradisional yang paling banyak digunakan (45,6%) sedangkan Vitamin C merupakan suplemen yang paling banyak digunakan responden (89,5%).
UJI EFEKTIVITAS EKSTRAK ETANOL DAUN UBI JALAR UNGU (Ipomoea batatas L.) TERHADAP PERTUMBUHAN BAKTERI METHICILLIN-RESISTANT STAPHYLOCOCCUS AUREUS ATCC 3351 SECARA IN VITRO Pandansari, Ni Wayan Bunga; Ernawati, Desak Ketut; Widhiartini, Ida Ayu Alit
E-Jurnal Medika Udayana Vol 11 No 7 (2022): E-Jurnal Medika Udayana
Publisher : Universitas Udayana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24843/MU.2022.V11.i7.P18

Abstract

ABSTRAK Daun0ubi0jalar0ungu mengandung senyawa aktif gflavonoid, tfenol, ktanin, dan bsaponin yang dinyatakan memiliki aktivitasdantibakteri. Kandungan senyawa aktif ini potensial dikembangkan sebagai antibakteri Methicillin-Resistant Staphylococcus aureus (MRSA). Pengembangan antibakteri alternatif dari bahan alam diperlukan untuk penanganan infeksi nosokomial. Penelitian eksperimental ini dilakukan untuk membuktikan adanya aktivitaspantibakterihekstrakjetanol0daun0ubi0jalar0ungu terhadap bakteri penyebab infeksi nosokomial dengan menggunakan bakteri standar MRSA ATCC 3351 secara in vitro. Desainlpenelitian merupakanppostutestponlyecontrolkgroup.jAktivitaspantibakterijekstrak etanol daunfubiljalarrungu diuji dengan metode difusilagar (disc diffusion) terhadap ekstrak etanol yang diperoleh dari proses maserasi daun ubi jalar ungu yang dikeringkan dan daun segar pada berbagai konsentrasi bertingkat. Aktifitas antibakteri dinilai berdasarkan pengukuran luas diameter zona hambat yang dihasilkan setelah perlakuan esktrak terhadap kultur bakteri dalam media agar plate. Hasil penelitian menunjukkan tidak adanya daya hambat pada ekstrak segar namun, pada ekstrak kering terdapat daya hambat terhadap bakteri MRSA ATCC 3351. Diameterlzonaihambat yang terbentuk pada kelompok konsentrasi 20%, 40%, dan 80% secara berurutan adalah 6,9 mm, 10mm, dan 11mm. Untuk mengetahui adanya efek perlakuan, dilakukan analisis terhadap Uji Kruskal-Walis. Uji Mann-Whitney menunjukkanjadanya perbedaankyang bermakna padajsetiap kelompok yang dibandingkan, kecuali pada ekstrak 10%. Pada penelitian ini dapat disimpulkan bahwa ekstrak etanol 96% daun ubi jalar ungu kering (Ipomoea batatas L.) memiliki aktivitas antibakteri terhadap MRSA ATCC 3351. Sedangkan pada ekstrak etanol 96% daun ubi jalar ungu segar (Ipomoea batats L.) tidak memiliki daya hambat terhadap pertumbuhan bakteri MRSA. Kata Kunci: Daun ubi jalar ungu (Ipomoea batatas L.), zona hambat, MRSA
Uji Aktivitas Anti-Inflamasi Ekstrak Kulit Terong Ungu (Solanum melongena L.) Terhadap Tikus Putih Galur Wistar (Rattus norvegicus) Yang Diinduksi Karagenan Heryanto, Jessica Diva; Dewi, Ni Wayan Sucindra; Ernawati, Desak Ketut
E-Jurnal Medika Udayana Vol 13 No 4 (2024): E-Jurnal Medika Udayana
Publisher : Universitas Udayana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24843/MU.2024.V13.i04.P03

Abstract

Inflammation is the human body’s defense to prevent tissue damage due to different kinds of factors. The purple eggplant peel (Solanum melongena L.) may have the potential to have anti-inflammatory properties due to containing nasunin, which is a phenolic, flavonoid anthocyanin substance by inhibiting cyclooxygenase pathway. This research was done to prove the anti-inflammatory effect of purple eggplant peel extract in rats. The research method was conducted by true experimental post-test only control-group design. 25 rats were divided into 5 groups with different treatments which are: positive control, negative control, purple eggplant peel extract with a dose of 0,3 mg/gBW, 6 mg/gBW and 0,9 mg/gBW. The data measured was the decrease of edema volume induced by carrageenan at hours-0 1, 2, 3, 4, 5, and 6. Data analysis was performed at the 4th hour using ANOVA and post-hoc LSD tests. The results of the study found that there were significant differences between the negative control group and the positive control group and the entire treatment group. The conclusion of this study was that purple eggplant peel extract had anti-inflammatory activity with the best effectiveness at a dose of 0,9 mg/gBW.
Potensi Bunga Telang (Clitoria ternatea L.) terhadap Sindrom Metabolik Rupadani, Ni Luh Desy; Ernawati, Desak Ketut; Trapika, I.G.M.G. Surya Candra
Jurnal Riset Hesti Medan Vol 9, No 1 (2024): Edisi Juni
Publisher : Akademi Keperawatan Kesdam I/Bukit Barisan Medan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.34008/jurhesti.v9i1.324

Abstract

Sedentary lifestyle such as consuming fast food, fatty foods, smoking and rarely doing physical activity are triggers for metabolic syndrome. Metabolic syndrome is a collection of risk factors for metabolic and cardiovascular disease consisting of dyslipidemia, obesity, hypertension and insulin resistance. The presence of metabolic syndrome will lead to a doubled risk of cardiovascular disease compared to patients without metabolic syndrome. Cardiovascular disease is the leading cause of death worldwide. One of the plants that has benefits for preventing and treating metabolic syndrome is telang (Clitoria ternatea L.). Almost all parts of the telang plant can be used for preventive and medicinal therapies, but the most commonly used part of the plant is the flower. Telang flowers are known to have antiobesity, antidiabetic, antioxidant and other activities. Telang flowers have chemical compound components in the form of flavonoids, alkaloids, tannins, saponins, phenolic acids and terpenoids.
Analisis Kebutuhan Formulasi Kebijakan Program Pengembangan Karier Apoteker Non Aparatur Sipil Negara Pratita, Rasta Naya; Bachtiar, Adang; Ernawati, Desak Ketut
JFIOnline | Print ISSN 1412-1107 | e-ISSN 2355-696X Vol. 15 No. 2 (2023): Jurnal Farmasi Indonesia
Publisher : Pengurus Pusat Ikatan Apoteker Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35617/jfionline.v15i2.152

Abstract

The level of public health is determined by the quality of public health services, as stated by WHO, the quantity of health personnel contributing as much as 80% of the success in health services. According to Undang-Undang No 36/2014 regarding Health Worker article1, health works improvement is directed to improve the quality and career of health worker. One of the current problems for health worker is the career path / career improvement. There is still no regulation regarding health worker’s career development aside from health civil worker, especially for pharmacist, that also suffer from the lack of synchronization of the career development program between the one from the government and the one from the pharmacist organization. Qualitative method is used in the research of the process of formulating the related regulations and stakeholder analysis. Primary data is acquired by doing in-depth interview with chosen informant, and literature research is used as secondary data. The result shows that all the interviewed stakeholders are supporting and committing in the Pharmacist’s career development program. Pharmacist organization along with the government are of two of the most important actors regarding the implementation of this program. The competency certification and specialization education program are expected to be the right options for the pharmacist career development program. On the other side, the interaction, advocacy and communication process between the stakeholders in pharmacist organization and the government still need improvement, and there are many of the pharmacist itself that not aware of the career development program. Therefore improvement in stakeholder’s coordination and communication is a must.
FOLFOX vs. FOLFIRI in Colorectal Adenocarcinoma: A Retrospective Study of Treatment Patterns, Side Effects, and Treatment Response Putu Ananda Sutiksna Mulya; Bagus Komang Satriyasa; Ni Wayan Sucindra Dewi; Desak Ketut Ernawati
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 9 No. 3 (2025): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v9i3.1221

Abstract

Background: Colorectal adenocarcinoma (CRC) is a prevalent malignancy with a high recurrence rate, necessitating multimodal treatment strategies. Chemotherapy regimens like FOLFOX (folinic acid, fluorouracil, oxaliplatin) and FOLFIRI (folinic acid, fluorouracil, irinotecan) are crucial components of this approach. This study aimed to analyze treatment patterns, side effects, and treatment response of FOLFOX and FOLFIRI in a real-world cohort of CRC patients. Methods: A retrospective observational study was conducted on CRC patients who received FOLFOX or FOLFIRI between January 2020 and December 2023. Data on demographics, disease stage, chemotherapy regimen, side effects, comorbidities, and treatment response were collected from electronic medical records. Results: A total of 146 patients were included. The majority were male (57.5%) with a mean of age 58.4 years. Most tumors were located in the rectum and sigmoid (75.3%), with over 50% of patients presenting with stage IV disease. FOLFIRI was the most common regimen (45.9%), followed by FOLFOX (36.3%). Common side effects included nausea, vomiting, decreased appetite, and hair loss. Hypertension was the most prevalent comorbidity. A total of 79.5% of patients were alive after chemotherapy. Conclusion: This study provides insights into the real-world treatment patterns and outcomes of FOLFOX and FOLFIRI in CRC patients. The choice of regimen appears to be influenced by factors such as disease stage and patient characteristics. Further research is needed to compare the efficacy and safety of these regimens and identify optimal treatment strategies for specific patient subgroups.
Profil Pengunaan Opioid untuk Mengelola Nyeri di Rumah Sakit Negeri di Bali Ernawati, Desak Ketut; Widatama, Agata
Jurnal Ilmiah Medicamento Vol 11 No 1 (2025): Jurnal Ilmiah Medicamento
Publisher : Fakultas Farmasi Universitas Mahasaraswati Denpasar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36733/medicamento.v11i1.10105

Abstract

Opioids are the mainstay of pain management, particularly in chronic pain-related and nonrelated cancer. Studies have shown that the number of opioids used globally varies. It was used excessively in some parts, while in others, it was underused. Little study is known on how opioids are used in Indonesia. This study aimed to identify indications of opioids prescribed and types of opioids used, as well as assess the nature of opioid therapy as pain management for chronic and non-related cancer. This retrospective study was conducted in a public hospital in Bali, Indonesia. Data was collected from all inpatients who received opioids in the hospital from 2018 to 2020. Patients’ age, gender, as well as opioid information such as types of opioids and used for treatment for cancer or non-cancer patients, were pooled and analyzed descriptively. This study found that fentanyl injection was the most opioid prescribed by anesthesiologists as preoperative medications. Opioids were prescribed mostly for non-cancer patients, and limited opioids were prescribed for cancer patients. Future research is required to evaluate factors that influence opioid prescriptions in hospitals.
Pengaruh Ekstrak Etanol Kubis Ungu terhadap Kadar Malondialdehida, Superoksida Dismutase dan Derajat Steatosis Hati pada Tikus Model NAFLD Dewi, Ni Made Gita Kusuma; Sugiritama, I Wayan; Widianti, I Gusti Ayu; Wardana, I Nyoman Gede; Ernawati, Desak Ketut; Mayura, I Putu Bayu
Jurnal Ners Vol. 9 No. 2 (2025): APRIL 2025
Publisher : Universitas Pahlawan Tuanku Tambusai

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/jn.v9i2.43013

Abstract

Non-Alcoholic Fatty Liver Disease (NAFLD) adalah gangguan hati kronis yang ditandai dengan akumulasi lemak berlebih dalam hepatosit dan berkaitan dengan sindrom metabolik. Stres oksidatif berperan dalam progresi NAFLD, dengan kadar malondialdehida (MDA) dan aktivitas superoksida dismutase (SOD) sebagai biomarker. Kubis ungu (Brassica oleracea var. capitata L.) memiliki kandungan antosianin tinggi yang bersifat antioksidan, namun efek hepatoprotektifnya terhadap NAFLD masih perlu diteliti lebih lanjut. Penelitian ini bertujuan untuk mengevaluasi efek hepatoprotektif ekstrak etanol kubis ungu terhadap kadar MDA dan SOD serta derajat steatosis hati pada tikus Wistar jantan yang diinduksi dengan diet tinggi lemak dan karbon tetraklorida (CCl₄). Studi ini menggunakan desain post-test only control group dengan empat kelompok: kontrol negatif dan tiga kelompok perlakuan yang menerima ekstrak etanol kubis ungu dengan dosis 100 mg/kg BB, 200 mg/kg BB, dan 400 mg/kg BB. Analisis menggunakan ANOVA dan uji post-hoc Tukey HSD menunjukkan bahwa ekstrak kubis ungu secara signifikan mencegah peningkatan kadar MDA (p < 0,05), mencegah penurunan aktivitas SOD (p < 0,05), serta mencegah peningkatan derajat steatosis, dengan dosis paling efektif 200 mg/kg BB. Hasil ini menunjukkan bahwa ekstrak etanol kubis ungu memiliki efek hepatoprotektif dan berpotensi sebagai agen terapeutik alami untuk pencegahan NAFLD.
FOLFOX vs. FOLFIRI in Colorectal Adenocarcinoma: A Retrospective Study of Treatment Patterns, Side Effects, and Treatment Response Putu Ananda Sutiksna Mulya; Bagus Komang Satriyasa; Ni Wayan Sucindra Dewi; Desak Ketut Ernawati
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 9 No. 3 (2025): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v9i3.1221

Abstract

Background: Colorectal adenocarcinoma (CRC) is a prevalent malignancy with a high recurrence rate, necessitating multimodal treatment strategies. Chemotherapy regimens like FOLFOX (folinic acid, fluorouracil, oxaliplatin) and FOLFIRI (folinic acid, fluorouracil, irinotecan) are crucial components of this approach. This study aimed to analyze treatment patterns, side effects, and treatment response of FOLFOX and FOLFIRI in a real-world cohort of CRC patients. Methods: A retrospective observational study was conducted on CRC patients who received FOLFOX or FOLFIRI between January 2020 and December 2023. Data on demographics, disease stage, chemotherapy regimen, side effects, comorbidities, and treatment response were collected from electronic medical records. Results: A total of 146 patients were included. The majority were male (57.5%) with a mean of age 58.4 years. Most tumors were located in the rectum and sigmoid (75.3%), with over 50% of patients presenting with stage IV disease. FOLFIRI was the most common regimen (45.9%), followed by FOLFOX (36.3%). Common side effects included nausea, vomiting, decreased appetite, and hair loss. Hypertension was the most prevalent comorbidity. A total of 79.5% of patients were alive after chemotherapy. Conclusion: This study provides insights into the real-world treatment patterns and outcomes of FOLFOX and FOLFIRI in CRC patients. The choice of regimen appears to be influenced by factors such as disease stage and patient characteristics. Further research is needed to compare the efficacy and safety of these regimens and identify optimal treatment strategies for specific patient subgroups.
Co-Authors A.N. Mahendra A.W. Indrayani Adang Bachtiar Adioka I G. M. Agung Nova Mahendra Agung Wiwiek Indrayani Bagus Komang Satriyasa Bruce Sunderland Bruce Sunderland Cokorda Bagus Jaya Lesmana Cokorda Istri Dyah Yustika Dewi Desak Gede Vicsilia Mahambara Gita Desak Ketut Indrasari Utami Desak Nyoman Puriani Dewa Ayu Agung Maya Gayatri Dewa Ayu Putu Sri Ista Dewanti Dewi, Ni Made Gita Kusuma Dewi, Ni Wayan Sucindra Dinda Anggita Meiwita Sari Heryanto, Jessica Diva Hughes, Jeff I Gusti Ayu Artini I Gusti Ayu Eka Arirahmayanti I Kadek Dwi Putra Diatmika I Made Jawi I Nyoman Gede Wardana I Putu Bayu Mayura, I Putu Bayu I Wayan Sugiritama I Wayan Sumardika I Wayan Weta I.A.A. Widhiartini I.G. Wiranatha I.G.A. Artini I.G.M. Aman I.G.M.G.S.C. Trapika Ivana, Jocelyn Jeff Hughes Jeff Hughes Ketut Agus Adrianta Lee, Ya Ping N.W. Tianing N.W.S. Dewi Nabila Putri Rachmawati Ni Ketut Sri Diniari Ni Luh Suriani Ni Wayan Mutiara Warmasari Ni Wayan Sucindra Dewi Ni Wayan Sucindra Dewi Pandansari, Ni Wayan Bunga Pratita, Rasta Naya Putu Ananda Sutiksna Mulya Putu Resika Melarosa Rupadani, Ni Luh Desy Sunderland, Bruce syahida, iin kurnia Trapika, I.G.M.G. Surya Candra Widana K Widatama, Agata Widianti, I Gusti Ayu Ya Ping Lee Ya Ping Lee