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Journal : Jurnal Medik Veteriner

Evaluation of Acute Dermal Toxicity of Hibiscus Leaves as Simplicial Ointment on Albino Rats Saputra, Made Gede Adi Surya; Sudira, I Wayan; Samsuri, Samsuri; Merdana, I Made; Dharmayudha, Anak Agung Gde Oka; Sudisma, I Gusti Ngurah
Jurnal Medik Veteriner Vol. 6 No. 2 (2023): October
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jmv.vol6.iss2.2023.216-229

Abstract

Hibiscus is a plant that has been shown to contain substances that may be used as sunscreen to protect the skin from UV radiation. In terms of their potential as sunscreens, flavonoids, tannins, and quinone chemicals are crucial because they are antioxidants that can reduce the negative effects of UV radiation and boost photoprotective activity. This study aimed to investigate the acute dermal toxicity potential of hibiscus leaves simplicial ointment 40% on female albino rats. The evaluation method refered to The OECD Guideline for Testing of Chemicals – No. Test: 402, Acute Dermal Toxicity-Fixed Doses Procedure. Based on the Globally Harmonized System compared to this study reported that acute dermal median lethal dose (LD50) was > 2000 mg/kg. It can be concluded that hibiscus leaves simplicial ointment 40% has safe to apply topically and doesn't produce acute skin toxicity.
Co-Authors A.A.G.J. Wardita Adnyana, Ida Bagus Nararya Primastana Aida Lousie Tenden Rompis An'nisafitri Lutviana Anak Agung Gde Jaya Wardhita, Anak Agung Gde Jaya Anak Agung Gde Oka Dharmayudha Anak Agung Sagung Kendran Anak Agung Sagung Kendran Bendelin Melda Loekali Deo Lauda Putra Diana, Kadek Leni Martha Dondin Sajuthi DWI SURYANTO Erika Erika Grace Tabitha Tenggi Olihta Simatupang Gunanti . I Gede Soma I Gusti Agung Arta Putra I Gusti Agung Ayu Suartini I Gusti Agung Gede Putra Pemayun I Gusti Made Krisna Erawan I Gusti Ngurah Bagus Trilaksana I K. SUATHA I Ketut Anom Dada I Ketut Berata I Ketut Suada I Made Agus Adnyana I Made Merdana I Made Sukada i Nengah Wandia I NYOMAN MANTIK ASTAWA I Nyoman Suarsana I Nyoman Suartha I Nyoman Sulabda I Putu Gede Yudhi Arjentinia I Putu Juli Sukariada I Wayan Gorda I Wayan Gorda I Wayan Suardana I Wayan Sudira I Wayan Wirata I Wayan Wirata I.G.A.G.P. Pemayun I.H. Utama I.K.A. Dada I.W. Batan I.W. Gorda Ida Bagus Komang Ardana Ida Bagus Ngurah Swacita Ida Bagus Windia Adnyana Jusniari, Ni Luh Kadek Ratih Kadek Karang Agustina Luh Dewi Anggreni Luh Komang Ayu Puteri Priharyanthi Luh Made Sudimartini M.D. Rudyanto Made Gede Adi Surya Saputra Made Sandy Widhi Raharja Marliani, Ni Kadek Mokhamad Fakhrul Ulum, Mokhamad Monica, Mia Nur Liliana Putri Prihatiningsih Prasetyo, Catur Putra, I Gede Putu Alit Anggara Putu Ayu Sisyawati Putriningsih Rahmiati, Nur Ilmi Riki Siswandi Rosita, Indah Rosni Lumban Gaol Rozalina, Irma Samsuri Samsuri Samsuri, Samsuri Samsuri Samuel, Josia Sasmita, Debbie Aprillia Yona Setyo Widodo Sholichah, Sholichah Sukma, Ni Ketut Ayu Mega Sultan, Nurul Fadillah T. Sari Nindia Tjok Gde Oka Pemayun Tjokorda Sari Nindhia Vivi Indrawati