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All Journal Syntax Literate: Jurnal Ilmiah Indonesia Proceedings of the International Conference on Applied Science and Health Global Health Management Journal Tunas Medika Jurnal Kedokteran & Kesehatan InaBHS (Indonesian Journal of Biomedicine and Health Science)
Donny Nauphar
Fakultas Kedokteran Unswagati
Humanities Biochemistry, Genetics & Molecular Biology Education Environmental Science Health Professions Law, Crime, Criminology & Criminal Justice Medicine & Pharmacology Nursing Public Health Social Sciences Other

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COMPARISON OF EFFECTIVENESS BETWEEN CELERY JUICE (Apium graveolens L.) AND 2% MICONAZOLE TOWARDS THE GROWTH OF Malassezia furfur Ronaa Hammada; Witri Pratiwi; Shofa Nur Fauzah; Donny Nauphar; Amanah Amanah
Proceedings of the International Conference on Applied Science and Health No. 3 (2018)
Publisher : Yayasan Aliansi Cendekiawan Indonesia Thailand (Indonesian Scholars' Alliance)

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Introduction: Pityriasis versicolor is caused by the fungi Malassezia furfur with a worldwide prevalence of 50%, including tropical countries, second only to dermatitis in Indonesia. Pityriasis versicolor is difficult to treat and requires long-term treatment. The disease has high recurrence risk and may cause drug resistance. 2% Miconazole is known to have long-term side effects; therefore, alternative treatment is needed. Several studies suggested that celery (Apium graveolens L.) contains active substances with anti-fungal properties. This paper aims to investigate the comparison of effectiveness between celery juice and 2% Miconazole towards the growth of Malassezia furfur. Methods: This is an in-vitro experimental study with post-test only control group design. The subjects were split into 5 groups which were given celery juice in 10% DMSO with the concentration of 10%, 20%, 30%, 40%, and 50%. A negative control group was given only 10% DMSO and the positive control group was given 2% Miconazole. The data were then analyzed using Kruskall-Wallis followed by Mann-Whitney test. Results: The Kruskall-Wallis test showed all concentration of celery juice had antifungal effect with p=0.000 (p<0.05) and were effective in inhibiting the growth of Malassezia furfur. The Mann-Whitney test showed that the 50% celery concentration was as effective as 2% Miconazole in inhibiting the growth of Malassezia furfur (p=0.495). Conclusion: Celery juice (Apium graveolens L.) was effective in inhibiting the growth of Malassezia furfur with 50% concentration as the most effective concentration. 
ANTENATAL CARE (ANC) VISIT FREQUENCY IN THE THIRD TRIMESTER AND PRETERM EVENTS IN PUSKESMAS PONDOH AND JUNTINYUAT IN INDRAMAYU REGENCY BETWEEN 2014-2016 Elinda Ameliana; Donny Nauphar; Ruri Eka Maryam
Proceedings of the International Conference on Applied Science and Health No. 3 (2018)
Publisher : Yayasan Aliansi Cendekiawan Indonesia Thailand (Indonesian Scholars' Alliance)

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Background: World Health Organization (WHO) estimates that 15 million babies are born preterm every year and this number continues to increase. Several risk factors for preterm are identified as mother’s lifestyle such as smoking, malnutrition, weight gain during pregnancy, and drug use or other factors such as socioeconomic status. In 2015, WHO reported more than 300.000 women died from pregnancy-related causes and 2.6 million babies were still born worldwide with half occurring during the third trimester. Antenatal Care (ANC) in the third semester aims to identify fetal position and identify complication during pregnancy and screen for pre-eclampsia, infection of the reproductive organs and urinary tract, and plan for delivery. The ANC in the third semester is crucial in keeping pregnant mother healthy throught pregnancy and delivery. Aim: To find out the relationship between third trimester Antenatal Care (ANC) visit frequency and preterm birth event at Puskesmas Pondoh and Juntinyuat in Indramayu regency between 2014-2016. Methods: This was observational analytic study with cross-sectional approach. The sampling technique in this research was done by total sampling with 100 respondens. Data were collected from maternal cohort book and control card of pregnant women. The data were analyzed using Chi-square test and Prevalence Ratio. Results: This study found that the proportion of pregnant mothers with insufficient third trimester ANC was 38% and the number of mothers delivering preterm baby was 32%. Statistical analysis showed that there was a statistical significance between third trimester ANC visit frequency and preterm labor with p=0,000 (p<0,05) and women with insufficient ANC visit have 40 times higher risk of preterm baby compared to mothers who has sufficient ANC visit (PR=40,60; CI95%=11.699-140.8862) in Puskesmas Pondoh and Juntinyuat Indramayu District 2014-2016. Conclusion: Having less than 4 ANC visit in the third trimester may increase the risk of delivering preterm babies. Pregnant women are advised to do ante natal care monthly of a minimum 4 times during the third trimester. 
EFFECT OF PHYSICAL ACTIVITY AND FAST FOOD CONSUMPTION FREQUENCY ON OVERWEIGHT LEVEL AMONG HIGH SCHOOL ADOLESCENT Lita Harlianti; Witri Pratiwi; Donny Nauphar; Eni Suhaeni
Proceedings of the International Conference on Applied Science and Health No. 3 (2018)
Publisher : Yayasan Aliansi Cendekiawan Indonesia Thailand (Indonesian Scholars' Alliance)

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Background: Obesity was believed to be one of the risk factors of degenerative diseases, such as diabetes mellitus, hypertension, and coronary heart disease. Obesity occurred gradually that started with overweight. Risk factors for overweight are lack of physical activity, and consumption of high caloric fatty food which may cause accumulation of fats inside the body. This research aims to examine the effect of physical activity and fast food consumption frequency on overweight level among high school adolescent in Cirebon. Methods: It was a cross-sectional study conducted among 262 high school students aged 15-17 years using stratified random sampling. Results: The result based on Spearman correlation test showed negative correlation between physical activity and overweight level with p= 0,001 (p< 0,05) and correlation coefficient of -0,627. There was positive correlation between consumption fast food frequency with overweight with p=0,037 (p=0,05) and correlation coefficient of 0,423. Conclusions: Physical activity and fast food consumption frequency have effects on overweight level in high school adolescent in Cirebon. 
THE EFFECT OF ORALLY ADMINISTERED CATFISH (Clarias gariepinus) SKIN AND MEAT ON EPITHELIALIZATION THICKNESS AND COLLAGEN DENSITY IN INCISION WOUND OF WISTAR RAT (Rattus norvegicus) Muhammad Irsyad Baihaqi; Muhammad Duddy Satrianugraha; Tiar M Pratamawati; Donny Nauphar
Proceedings of the International Conference on Applied Science and Health No. 4 (2019)
Publisher : Yayasan Aliansi Cendekiawan Indonesia Thailand (Indonesian Scholars' Alliance)

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Background: Alternative medicine using animal is still rare whereas Indonesia have a lot of potential natural resources. Catfish is easily found animal in Indonesia and is common consumed as nutriment sources contains albumin, amino acid and fatty acids which plays an essential role of wound healing process. This study will determine effect of orally administered catfish (Clarias gariepinus) skin and meat on epithelialization thickness and collagen density in incision wound of white male rat (Rattus norvegicus).Methods: This experimental post-test only group design used 30 white male rat (Rattus norvegicus), that randomly divided into 4 tratment goup and one control group. The treatment group was given 12,5 mg/g W, 25 mg/g W, 37,5 mg/g W and 50 mg/g W dose of catfish (Clarias gariepinus) skin and meat flour, in the other hand the contol group were given aquades. Non-parametric analyses using Kruscall-Wallis and Mann Whitney test were used to compare epithelization thickness and collagen density.Result: The comparison results of epithelialization thickness between group C with TGI, C with TG2, C with TG3 and C with TG4 showed significant differences (p<0.05). TG4 was the thickest of all groups. Significant differences were also observed in collagen density result between C with TGI, C with TG2, C with TG3 and C with TG4 (p <0,05) TG4 showed the highest density of all groups.Conclusion: Catfish (Clarias gariepinus) skin and meat flour with 50 mg/200g W dose is effective for wound healing and increasing epithelial thickness and collagen density in Wistar rat (Rattus norvegicus) incision wounds.
EFFECTIVENESS OF ORALLY USE TILAPIA (Oreochromis niloticus) ON WOUND LENGTH AND FIBROBLAST DENSITY ON INCISION WOUND OF WISTAR RAT (Rattus norvegicus) Sayyidah Vina Syauqia; A Fariz Malvi Zamzam Zein; Tiar M Pratamawati; Donny Nauphar
Proceedings of the International Conference on Applied Science and Health No. 4 (2019)
Publisher : Yayasan Aliansi Cendekiawan Indonesia Thailand (Indonesian Scholars' Alliance)

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Background: The incidence of a wound in Indonesia has increased from 7.5 percent in 2007 to 8.2 percent in 2013 according to Riskesdas. Wound care that widely used is povidone-iodine, but in case, it has a toxic effect on healthy cells around the wound. The albumin, amino acids, and fatty acids in Tilapia  (Oreochromis niloticus) are the potential substances to accelerate the wound healing process. This study aims to investigate the efficacy of Tilapia (Oreochromis niloticus) on wound length and fibroblast density on the incision wound of Wistar rat (Rattus norvegicus).Methods: The study was conducted in the Food and Nutrition PAU Laboratory and Pathology Anatomy Laboratory of Universitas Gadjah Mada, Yogyakarta. This post-test only control group design experimental study used 30 male white rats that randomly divided into five groups, i.e. control group K, and treatment group P1, P2, P3 and P4 that were each given Tilapia with a dose of 12.5 mg/200gBW, 25 mg/200gBW, 37.5 mg/200gBW dan 50 mg/200gBW. The length of the wound was measured by a ruler each day. The rats were terminated on the 10th day to obtain wound tissue for H&E stained histopathological sections to observe fibroblast density. One Way ANOVA, Tamhane, Kruskal-Wallis and Mann Whitney tests were used to compare the wound length and fibroblasts density.Results: Incision wounds in this study showed the best wound healing on the 10th day. Based on the theory, on the 10th day, a proliferation and remodeling phase occurs. There is an effect of giving Tilapia (Oreochromis niloticus) orally at a different dose. Tilapia at dose 37.5mg/200gBW is more effective compared with the dose of 12.5mg/200gBW, 25mg/200gBW, and 50mg/200gBW to accelerate wound healing for wound length and fibroblast density in Wistar rat (Rattus norvegicus).Conclusion: Consuming Tilapia (Oreochromis niloticus) could be a new alternative for wound healing treatment. The antimicrobial ability of Tilapia should be analyzed.
EFFECTIVENESS OF ORALLY USE CATFISH (Clarias gariepinus) SKIN AND MEAT ON WOUND LENGTH AND FIBROBLAST DENSITY IN INCISION WOUND OF WISTAR RAT (Rattus norvegicus) Sri Utami Fauziah; Risnandya Primanagara; Tiar M Pratamawati; Donny Nauphar
Proceedings of the International Conference on Applied Science and Health No. 4 (2019)
Publisher : Yayasan Aliansi Cendekiawan Indonesia Thailand (Indonesian Scholars' Alliance)

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Background: Treatment for wounds that are currently often given is use povidone-iodine. But, this antiseptics also kills fibroblast tissue which is useful for forming new tissue. One of the other ways to treatment for wounds is use catfish. The contents found in catfish (Clarias gariepinus) is albumin which is a globular protein that is useful in the formation of body tissues, such as postoperative wounds and burns. This study aims to determine the effect of skin and meat of catfish (Clarias gariepinus) on wound length and fibroblast density in incision wounds of Wistar rat (Rattus norvegicus).Methodology: This study is an experimental study with Post Test Only Control Group Design using Wistar rats which are divided into five groups. The control group (aquadest) and treatment groups 1, 2, 3 and 4 are given the skin and meat of catfish (Clarias gariepinus) orally at a dose of 12.5 mg / 200 g BW, 25 mg / 200 g BW, 37.5 mg / 200 g BW, and 50 mg / 200 g BW. After 10 days, the rats are killed to take the wound tissue for histological preparations to observe fibroblast density. Then, it is analyzed by ANOVA test or the alternative.Results: There is an effect of giving catfish skin and meat (Clarias gariepinus) orally at different dose. The administration of catfish skin and meat (Clarias gariepinus) at a dose of 37.5 mg / 200 g BW and 50 mg / 200 g BW is better than other doses assessed from wound length and fibroblast density in Wistar rat incision wounds (Rattus norvegicus).Conclusion: The use of catfish for wound healing can be applied. This method can reduce wound length and increase fibroblast density at certain doses.
The International Conferences on Applied Science and Health (ICASH): Efforts and Commitments in Translating Research Results into Policy and Practices, for a Better Society Dyah Anantalia Widyastari; Doni Marisi Sinaga; Canggih Puspo Wibowo; Pamuko Aditya Rahman; Hafizh Muhammad Noor; Dimas Sondang Irawan; Tiara Fatmarizka; Dwina Gustia Diary; I Gusti Ngurah Edi Putra; Maretalinia Maretalinia; Marina Ayu Viniriani; Monita Destiwi; Galih Albarra Shidiq; Ivana Aprilia Pratiwi; Made Dian Shanti Kusuma; Ni Wayan Kesari Dharmapatni; Mahendrawan Nugraha Aji Pratama; Ary Norsaputra; Andi Pancanugraha; Febrian Hendra Kurniawan; Wahyu Manggala Putra; Rifqi Abdul Fattah; Puput Kusumawardani Moehas; Ricky Alexander Samosir; Andang Adi Fitria Hananto; I Gusti Ngurah Agastya; Taufik Eko Susilo; Pichpisith Pierre Vejvisithsakul; Donny Nauphar; Ariestya Indah Permata Sari; Andrew John Macnab
GHMJ (Global Health Management Journal) Vol. 3 No. 3 (2019)
Publisher : Yayasan Aliansi Cendekiawan Indonesia Thailand (Indonesian Scholars' Alliance)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35898/ghmj-33451

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The International Conferences on Applied Science and Health (ICASH): Efforts and Commitments in Translating Research Results into Policy and Practices, for a Better Society Dyah Anantalia Widyastari; Doni Marisi Sinaga; Canggih Puspo Wibowo; Pamuko Aditya Rahman; Hafizh Muhammad Noor; Dimas Sondang; Tiara Fatmarizka; Dwina Gustia Diary; I Gusti Ngurah Edi Putra; Maretalinia; Marina Ayu Viniriani; Monita Destiwi; Galih Albarra Shidiq; Ivana Aprilia Pratiwi; Made Dian Shanti Kusuma; Ni Wayan Kesari Dharmapatni; Mahendrawan Nugraha Aji Pratama; Ary Norsaputra; Andi Pancanugraha; Febrian Hendra Kurniawan; Wahyu Manggala Putra; Rifqi Abdul Fattah; Puput Kusumawardani Moehas; Ricky Alexander Samosir; Andang Adi Fitria Hananto; I Gusti Ngurah Agastya; Taufik Eko Susilo; Pichpisith Pierre Vejvisithsakul; Donny Nauphar; Ariestya Indah Permata Sari; Andrew John Macnab
GHMJ (Global Health Management Journal) Vol. 3 No. 3 (2019)
Publisher : Yayasan Aliansi Cendekiawan Indonesia Thailand (Indonesian Scholars' Alliance)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35898/ghmj-33580

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TNF-α -308 G/A Gene Polymorphism as a Risk Factor for Pulmonary Tuberculosis in Cirebon, Indonesia Oktaviyati, Nurfithria; Pratamawati, Tiar Masykuroh; Nauphar, Donny
GHMJ (Global Health Management Journal) Vol. 8 No. 1s (2025): Special Issues
Publisher : Yayasan Aliansi Cendekiawan Indonesia Thailand (Indonesian Scholars' Alliance)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35898/ghmj-81s1159

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Background: Mycobacterium tuberculosis, the causative agent of pulmonary tuberculosis, spreads via droplets. The TNF-α-308 G/A gene polymorphism is one of the host genetic variables that may affect an individual's vulnerability to the disease. However, this polymorphism has not been studied in Cirebon. Aims: To analyze the TNF-α -308 G/A gene polymorphism as a risk factor for the occurrence of pulmonary tuberculosis in Cirebon. Methods: A total of 64 participants joined part in an analytical observational study using a case-control design at the Biomolecular and Genetics Laboratory, Faculty of Medicine, Universitas Swadaya Gunung Jati, Indonesia. DNA extraction from blood samples, ARMS-PCR genotyping, and 1.5% electrophoresis gel visualization were all part of the data gathering process. The chi-square test was used to analyze the data. This study including inclusion criteria, exclusion criteria, and sample control for the research. Results: According to the study, there is no link between Cirebon's risk of pulmonary tuberculosis and the polymorphism in the TNF-α-308 G/A gene (OR = 0.462; P > 0.05). However, the study shown a protective factors which means that individuals with the TNF-α -308 G/A gene polymorphism have a lower risk of developing pulmonary tuberculosis compared to those without the polymorphism. Conclusion: The TNF-α-308 G/A gene variant is not associated with an increased risk of pulmonary tuberculosis in the Cirebon community.
Potassium Inwardly Rectifying Channel Subfamily J Member 11 (KCNJ11) RS5219 Gene Polymorphism as a Risk Factor for Type 2 Diabetes Mellitus in Indonesia: A Case Control Study Putri, Annisa Septiani Putri; Pratamawati, Tiar Masykuroh; Nauphar, Donny
GHMJ (Global Health Management Journal) Vol. 8 No. 1s (2025): Special Issues
Publisher : Yayasan Aliansi Cendekiawan Indonesia Thailand (Indonesian Scholars' Alliance)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35898/ghmj-81s1160

Abstract

Background: Diabetes Mellitus (DM) is a chronic metabolic disease caused by the failure of the pancreas to produce the hormone insulin or ineffective use of the hormone insulin. It is estimated that 537 million adults aged 20-79 years worldwide suffer from DM. Genetics is one of the risk factors involved in the pathophysiology of type 2 DM. The KCNJ11 gene encodes the Kir6.2 protein that is responsible for adenosine triphosphate-sensitive potassium ion channels (kATP) synthesis in pancreatic beta cells plasma membrane. Aims: This study aims to examine the KCNJ11 rs5219 gene polymorphism as a risk factor for type 2 diabetes mellitus in Cirebon population. Methods: This case control study involved 29 cases of type 2 diabetes mellitus and 29 healthy controls with purposive sampling technique. Sample data was obtained through the examination of blood sugar, DNA extraction, PCR-RFLP with Eco24I restriction enzyme, then visualization of the results with Gel Electrophoresis. Results: The frequency of G allele was found more in the case group (70%) while the frequency of A allele was found more in the control group (38%). The frequency of heterozygous GA genotype was found more in the control group (48.3%) and the frequency of homozygous mutant AA genotype was more in the case group (17.2%) compared to the control group (13.8%). Chi-Square Test results obtained p-value 0.115, OR value 2.318. Conclusion: This study showed no significant association between Potassium Inwardly Rectifying Channel Subfamily J Member 11 (KCNJ11) rs5219 gene polymorphism and the incidence of Type 2 Diabetes Mellitus in Cirebon population.
Co-Authors A Fariz Malvi Zamzam Zein Agastya, I Gusti Ngurah Akbarahma, Ikrama Akrom, Akrom amanah amanah Amanah Amanah Ameliana, Elinda Anak Agung Istri Sri Wiadnyani Andang Adi Fitria Hananto Andi Pancanugraha Andrew John Macnab Annida Maharani Ariestya Indah Permata Sari Ary Norsaputra Baihaqi, Muhammad Irsyad Brajadenta, Gara Samara Canggih Puspo Wibowo Catur Setiya Sulistiyana Destiwi, Monita Diary, Dwina Gustia Dimas Sondang Dimas Sondang Irawan Doni Marisi Sinaga Doni Marisi Sinaga, Doni Marisi Dwina Gustia Diary Dyah Anantalia Widyastari Dyah Anantalia Widyastari Elinda Ameliana Eni Suhaeni Fattah, Rifqi Abdul Fauzah, Shofa Nur Fauziah, Sri Utami Febrian Hendra Kurniawan Galih Albarra Shidiq Galih Albarra Shidiq Hadyanto Lim Hafizh Muhammad Noor Hammada, Ronaa Hananto, Andang Adi Fitria Harlianti, Lita Hendry Gunawan, Hendry Henny Erina Saurmauli Ompusunggu Husna, Nazaul I Gusti Ngurah Agastya I Gusti Ngurah Edi Putra Ivana Aprilia Pratiwi Jamhari Jamhari Juwita -, Juwita Kurniawan, Febrian Hendra Kuswara, Hasna Nurazizah Lita Harlianti Macnab, Andrew John Made Dian Shanti Kusuma Maharani, Annida Mahendrawan Nugraha Aji Pratama Maretalinia Maretalinia Maretalinia Maretalinia, Maretalinia Marina Ayu Viniriani Maryam, Ruri Eka Moehas, Puput Kusumawardani Monita Destiwi Muhammad Irsyad Baihaqi Ni Wayan Kesari Dharmapatni Noor, Hafizh Muhammad Norsaputra, Ary Oktaviyati, Nurfithria Ompusunggu, Henny E.S. Pamuko Aditya Rahman Pancanugraha, Andi Pardede, Sumondang M. Pichpisith Pierre Vejvisithsakul Pradana, Muhammad Firyal Pratama, Mahendrawan Nugraha Aji Pratamawati, Tiar M Pratamawati, Tiar Masykuroh Pratiwi, Ivana Aprilia Puput Kusumawardani Moehas Putra, I Gusti Ngurah Edi Putra, Wahyu Manggala Putri, Annisa Septiani Putri Rahman, Pamuko Aditya Ricky Alexander Samosir Rifqi Abdul Fattah Risnandya Primanagara Ronaa Hammada Ruri Eka Maryam Sadji, Angel Angriani Elma Budai Samosir, Ricky Alexander Sari, Ariestya Indah Permata Satrianugraha, Muhammad Duddy Sayyidah Vina Syauqia Shofa Nur Fauzah Sri Utami Fauziah Syauqia, Sayyidah Vina Tiar M Pratamawati Tiara Fatmarizka Vejvisithsakul, Pichpisith Pierre Viniriani, Marina Ayu Wahyu Manggala Putra Wibowo, Canggih Puspo Witri Pratiwi Witri Pratiwi Yahwardiah Siregar Yuny Hafitry Zein, A Fariz Malvi Zamzam Zein, Ahmad Fariz Malvi Zam Zam