Claim Missing Document
Check
Articles

Found 38 Documents
Search

EFFECTIVENESS OF ORALLY USE CATFISH (Clarias gariepinus) SKIN AND MEAT ON WOUND LENGTH AND FIBROBLAST DENSITY IN INCISION WOUND OF WISTAR RAT (Rattus norvegicus) Sri Utami Fauziah; Risnandya Primanagara; Tiar M. Pratamawati; Donny Nauphar
Proceedings of the International Conference on Applied Science and Health No. 4 (2019)
Publisher : Yayasan Aliansi Cendekiawan Indonesia Thailand (Indonesian Scholars' Alliance)

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Background: Treatment for wounds that are currently often given is use povidone-iodine. But, this antiseptics also kills fibroblast tissue which is useful for forming new tissue. One of the other ways to treatment for wounds is use catfish. The contents found in catfish (Clarias gariepinus) is albumin which is a globular protein that is useful in the formation of body tissues, such as postoperative wounds and burns. This study aims to determine the effect of skin and meat of catfish (Clarias gariepinus) on wound length and fibroblast density in incision wounds of Wistar rat (Rattus norvegicus). Methodology: This study is an experimental study with Post Test Only Control Group Design using Wistar rats which are divided into five groups. The control group (aquadest) and treatment groups 1, 2, 3 and 4 are given the skin and meat of catfish (Clarias gariepinus) orally at a dose of 12.5 mg / 200 g BW, 25 mg / 200 g BW, 37.5 mg / 200 g BW, and 50 mg / 200 g BW. After 10 days, the rats are killed to take the wound tissue for histological preparations to observe fibroblast density. Then, it is analyzed by ANOVA test or the alternative. Results: There is an effect of giving catfish skin and meat (Clarias gariepinus) orally at different dose. The administration of catfish skin and meat (Clarias gariepinus) at a dose of 37.5 mg / 200 g BW and 50 mg / 200 g BW is better than other doses assessed from wound length and fibroblast density in Wistar rat incision wounds (Rattus norvegicus). Conclusion: The use of catfish for wound healing can be applied. This method can reduce wound length and increase fibroblast density at certain doses. Keywords: Fibroblasts, incision wounds, catfish, Clarias gariepinus, wound healing
CHANGING COSMETIC BRANDS INCREASE RISK OF FREQUENCY AND DEGREE OF ACNE VULGARIS IN FEMALE UNDERGRADUATE STUDENTS Annida P Maharani; Witri Pratiwi; Donny Nauphar
Proceedings of the International Conference on Applied Science and Health No. 3 (2018)
Publisher : Yayasan Aliansi Cendekiawan Indonesia Thailand (Indonesian Scholars' Alliance)

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Background: Acne vulgaris is a skin disease caused by chronic inflammation of the follicular pilosebacea marked by the presence of blackheads, papules, pustules, nodules, and cysts in place of healthy skin. One of the risk factors for Acne vulgaris is changing cosmetic brands which may contain comedogenic and acnegenic ingredients. The aim of this study is to find out the relationship of changing cosmetic brands and the prevalence of Acne vulgaris in female undergraduates. Methods: This was an observational study with cross sectional design. The subjects were 344 female undergraduates who used two out of four types of cosmetics, recruited by total sampling. Data were analyzed to see the relationship of changing cosmetic brands with the degree and the frequency of acne. Results: Based on Spearman correlation test, changing cosmetic brands has a strong positive correlation (r2= 0.762) with the degree of acne and a mild positive correlation (r2=0.461) with acne frequency. Chi-square test showed statistical significance (p<0.05) between changing cosmetic brands and the degree and frequency of acne. Subjects who frequently changes cosmetics has a 66 times higher risk of having bad acne (PR= 66.994; CI 95% = 32.099–139.320) and 8 times higher risk of having more frequent acne (PR= 8.432; CI 95% = 4.969-14.308) compared to subjects that do not frequently change cosmetics. Conclusion: Changing cosmetic brands increased the risk for both the degree of acne and the frequency of acne.
COMPARISON OF EFFECTIVENESS BETWEEN CELERY JUICE (Apium graveolens L.) AND 2% MICONAZOLE TOWARDS THE GROWTH OF Malassezia furfur Ronaa Hammada; Witri Pratiwi; Shofa Nur Fauzah; Donny Nauphar; Amanah Amanah
Proceedings of the International Conference on Applied Science and Health No. 3 (2018)
Publisher : Yayasan Aliansi Cendekiawan Indonesia Thailand (Indonesian Scholars' Alliance)

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Introduction: Pityriasis versicolor is caused by the fungi Malassezia furfur with a worldwide prevalence of 50%, including tropical countries, second only to dermatitis in Indonesia. Pityriasis versicolor is difficult to treat and requires long-term treatment. The disease has high recurrence risk and may cause drug resistance. 2% Miconazole is known to have long-term side effects; therefore, alternative treatment is needed. Several studies suggested that celery (Apium graveolens L.) contains active substances with anti-fungal properties. This paper aims to investigate the comparison of effectiveness between celery juice and 2% Miconazole towards the growth of Malassezia furfur. Methods: This is an in-vitro experimental study with post-test only control group design. The subjects were split into 5 groups which were given celery juice in 10% DMSO with the concentration of 10%, 20%, 30%, 40%, and 50%. A negative control group was given only 10% DMSO and the positive control group was given 2% Miconazole. The data were then analyzed using Kruskall-Wallis followed by Mann-Whitney test. Results: The Kruskall-Wallis test showed all concentration of celery juice had antifungal effect with p=0.000 (p<0.05) and were effective in inhibiting the growth of Malassezia furfur. The Mann-Whitney test showed that the 50% celery concentration was as effective as 2% Miconazole in inhibiting the growth of Malassezia furfur (p=0.495). Conclusion: Celery juice (Apium graveolens L.) was effective in inhibiting the growth of Malassezia furfur with 50% concentration as the most effective concentration.
ANTENATAL CARE (ANC) VISIT FREQUENCY IN THE THIRD TRIMESTER AND PRETERM EVENTS IN PUSKESMAS PONDOH AND JUNTINYUAT IN INDRAMAYU REGENCY BETWEEN 2014-2016 Elinda Ameliana; Donny Nauphar; Ruri Eka Maryam
Proceedings of the International Conference on Applied Science and Health No. 3 (2018)
Publisher : Yayasan Aliansi Cendekiawan Indonesia Thailand (Indonesian Scholars' Alliance)

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Background: World Health Organization (WHO) estimates that 15 million babies are born preterm every year and this number continues to increase. Several risk factors for preterm are identified as mother’s lifestyle such as smoking, malnutrition, weight gain during pregnancy, and drug use or other factors such as socioeconomic status. In 2015, WHO reported more than 300.000 women died from pregnancy-related causes and 2.6 million babies were still born worldwide with half occurring during the third trimester. Antenatal Care (ANC) in the third semester aims to identify fetal position and identify complication during pregnancy and screen for pre-eclampsia, infection of the reproductive organs and urinary tract, and plan for delivery. The ANC in the third semester is crucial in keeping pregnant mother healthy throught pregnancy and delivery. Aim: To find out the relationship between third trimester Antenatal Care (ANC) visit frequency and preterm birth event at Puskesmas Pondoh and Juntinyuat in Indramayu regency between 2014-2016. Methods: This was observational analytic study with cross-sectional approach. The sampling technique in this research was done by total sampling with 100 respondens. Data were collected from maternal cohort book and control card of pregnant women. The data were analyzed using Chi-square test and Prevalence Ratio. Results: This study found that the proportion of pregnant mothers with insufficient third trimester ANC was 38% and the number of mothers delivering preterm baby was 32%. Statistical analysis showed that there was a statistical significance between third trimester ANC visit frequency and preterm labor with p=0,000 (p<0,05) and women with insufficient ANC visit have 40 times higher risk of preterm baby compared to mothers who has sufficient ANC visit (PR=40,60; CI95%=11.699-140.8862) in Puskesmas Pondoh and Juntinyuat Indramayu District 2014-2016. Conclusion: Having less than 4 ANC visit in the third trimester may increase the risk of delivering preterm babies. Pregnant women are advised to do ante natal care monthly of a minimum 4 times during the third trimester.
EFFECT OF PHYSICAL ACTIVITY AND FAST FOOD CONSUMPTION FREQUENCY ON OVERWEIGHT LEVEL AMONG HIGH SCHOOL ADOLESCENT Lita Harlianti; Witri Pratiwi; Donny Nauphar; Eni Suhaeni
Proceedings of the International Conference on Applied Science and Health No. 3 (2018)
Publisher : Yayasan Aliansi Cendekiawan Indonesia Thailand (Indonesian Scholars' Alliance)

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Background: Obesity was believed to be one of the risk factors of degenerative diseases, such as diabetes mellitus, hypertension, and coronary heart disease. Obesity occurred gradually that started with overweight. Risk factors for overweight are lack of physical activity, and consumption of high caloric fatty food which may cause accumulation of fats inside the body. This research aims to examine the effect of physical activity and fast food consumption frequency on overweight level among high school adolescent in Cirebon. Methods: It was a cross-sectional study conducted among 262 high school students aged 15-17 years using stratified random sampling. Results: The result based on Spearman correlation test showed negative correlation between physical activity and overweight level with p= 0,001 (p< 0,05) and correlation coefficient of -0,627. There was positive correlation between consumption fast food frequency with overweight with p=0,037 (p=0,05) and correlation coefficient of 0,423. Conclusions: Physical activity and fast food consumption frequency have effects on overweight level in high school adolescent in Cirebon.
The Association Between the Pattern of Electronic Cigarette Smoking and Gastroesophageal Reflux Ahmad Fariz Malvi Zamzam Zein; Donny Nauphar; Uswatun Khasanah; Tiar M Pratamawati; Rama S Brajawikalpa; Eka Ayuningtyas; Alif Hamzah
The Indonesian Journal of Gastroenterology, Hepatology, and Digestive Endoscopy Vol 22, No 1 (2021): VOLUME 22, NUMBER 1, April 2021
Publisher : The Indonesian Society for Digestive Endoscopy

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (433.581 KB) | DOI: 10.24871/221202116-20

Abstract

Background: This study was aimed to investigate the proportion of gastroesophageal reflux (GER) among electronic cigarette (e-cig) smokers and its association with the pattern of e-cig smoking.Method: This cross-sectional study underwent among e-cig smokers community in Cirebon City, Jawa Barat, ranged from March to August 2020. Subjects were enrolled through consecutive sampling method. The data collection used survey containing the pattern of e-cig smoking and GER. The pattern of e-cig smoking included the duration of e-cig smoking and the amount of e-cig smoking. Gastroesophageal reflux consisted of GER-related symptoms (heartburn, regurgitation, and nocturnal symptom) and gastroesophageal reflux disease (GERD). GERD was defined as GERD questionnaire score cut-off 8. Data analysis used chi square test. This study has been approved by The Medical Research Ethics Committee, Faculty of Medicine, Universitas Swadaya Gunung Jati.Results: There were 273 respondents in this study. The proportion of heartburn was 6.6%, 10.3% for regurgitation, 3.7% for nocturnal symptom, and 5.5% for GERD. There was no association between duration of e-cig smoking and heartburn (p 0.681), regurgitation (p 0.568), nocturnal symptom (p 0.764), and GERD (p 0.113). There was no association between amount of e-cig smoking and heartburn (p 0.062), regurgitation (p 0.770), nocturnal symptom (p 0.985), and GERD (p 0.605).Conclusion: There was relatively low proportion of GER among e-cig smokers. There was no association between the pattern of e-cig smoking and GER in this study.
TNF-α -308 G/A Gene Polymorphism as a Risk Factor for Pulmonary Tuberculosis in Cirebon, Indonesia Oktaviyati, Nurfithria; Pratamawati, Tiar Masykuroh; Nauphar, Donny
GHMJ (Global Health Management Journal) Vol. 8 No. 1s (2025): Special Issues
Publisher : Yayasan Aliansi Cendekiawan Indonesia Thailand (Indonesian Scholars' Alliance)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35898/ghmj-81s1159

Abstract

Background: Mycobacterium tuberculosis, the causative agent of pulmonary tuberculosis, spreads via droplets. The TNF-α-308 G/A gene polymorphism is one of the host genetic variables that may affect an individual's vulnerability to the disease. However, this polymorphism has not been studied in Cirebon. Aims: To analyze the TNF-α -308 G/A gene polymorphism as a risk factor for the occurrence of pulmonary tuberculosis in Cirebon. Methods: A total of 64 participants joined part in an analytical observational study using a case-control design at the Biomolecular and Genetics Laboratory, Faculty of Medicine, Universitas Swadaya Gunung Jati, Indonesia. DNA extraction from blood samples, ARMS-PCR genotyping, and 1.5% electrophoresis gel visualization were all part of the data gathering process. The chi-square test was used to analyze the data. This study including inclusion criteria, exclusion criteria, and sample control for the research. Results: According to the study, there is no link between Cirebon's risk of pulmonary tuberculosis and the polymorphism in the TNF-α-308 G/A gene (OR = 0.462; P > 0.05). However, the study shown a protective factors which means that individuals with the TNF-α -308 G/A gene polymorphism have a lower risk of developing pulmonary tuberculosis compared to those without the polymorphism. Conclusion: The TNF-α-308 G/A gene variant is not associated with an increased risk of pulmonary tuberculosis in the Cirebon community.
Potassium Inwardly Rectifying Channel Subfamily J Member 11 (KCNJ11) RS5219 Gene Polymorphism as a Risk Factor for Type 2 Diabetes Mellitus in Indonesia: A Case Control Study Putri, Annisa Septiani Putri; Pratamawati, Tiar Masykuroh; Nauphar, Donny
GHMJ (Global Health Management Journal) Vol. 8 No. 1s (2025): Special Issues
Publisher : Yayasan Aliansi Cendekiawan Indonesia Thailand (Indonesian Scholars' Alliance)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35898/ghmj-81s1160

Abstract

Background: Diabetes Mellitus (DM) is a chronic metabolic disease caused by the failure of the pancreas to produce the hormone insulin or ineffective use of the hormone insulin. It is estimated that 537 million adults aged 20-79 years worldwide suffer from DM. Genetics is one of the risk factors involved in the pathophysiology of type 2 DM. The KCNJ11 gene encodes the Kir6.2 protein that is responsible for adenosine triphosphate-sensitive potassium ion channels (kATP) synthesis in pancreatic beta cells plasma membrane. Aims: This study aims to examine the KCNJ11 rs5219 gene polymorphism as a risk factor for type 2 diabetes mellitus in Cirebon population. Methods: This case control study involved 29 cases of type 2 diabetes mellitus and 29 healthy controls with purposive sampling technique. Sample data was obtained through the examination of blood sugar, DNA extraction, PCR-RFLP with Eco24I restriction enzyme, then visualization of the results with Gel Electrophoresis. Results: The frequency of G allele was found more in the case group (70%) while the frequency of A allele was found more in the control group (38%). The frequency of heterozygous GA genotype was found more in the control group (48.3%) and the frequency of homozygous mutant AA genotype was more in the case group (17.2%) compared to the control group (13.8%). Chi-Square Test results obtained p-value 0.115, OR value 2.318. Conclusion: This study showed no significant association between Potassium Inwardly Rectifying Channel Subfamily J Member 11 (KCNJ11) rs5219 gene polymorphism and the incidence of Type 2 Diabetes Mellitus in Cirebon population.
Angiotensin Converting Enzyme 2 (ACE2) G8790A Gene Polymorphism as a Risk Factor for Essential Hypertension Husna, Nazaul; Nauphar, Donny; Pratamawati, Tiar Masykuroh
GHMJ (Global Health Management Journal) Vol. 8 No. 2s (2025): Special Issues
Publisher : Yayasan Aliansi Cendekiawan Indonesia Thailand (Indonesian Scholars' Alliance)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35898/ghmj-82s1231

Abstract

Background: Globally, the number of people with hypertension has doubled, from 650 million to 1.3 billion. The World Health Organization reported that hypertension is responsible for more than 10 million deaths every year. Essential hypertension is a multifactorial condition with genetics as one of the factors. Genome-Wide Association Study has identified several genes associated with hypertension, one of which is the Angiotensin Converting Enzyme 2 (ACE2) gene. Essential hypertension may be predisposed to by the G8790A polymorphism of the ACE2 gene, which is hypothesized to interfere with the normal function of the Renin Angiotensin System (RAS). Aims: The purpose of this study is to determine whether the ACE2 G8790A gene polymorphism in Cirebon, West Java, Indonesia, is associated with an increased risk of essential hypertension. Methods: This is a case-control study conducted at the Talun Health Center, Cirebon Regency, April-August 2024, involving 30 essential hypertensive patients and 30 healthy controls. The study population comprised adults aged 30 to 72 years. Data was obtained through the examination of blood pressure, DNA extraction, PCR-RFLP with ALUI restriction enzyme, and then visualization of the results with Gel Electrophoresis. The Chi-Square Test technique and the Odds Ratio (OR) computation were used to analyze the data. Results: The G allele was higher in the case group 33 (55%), while the A allele was higher in the control group 34 (56.7%). The statistical analysis showed that there was no significant link between the ACE2 G8790A gene variation and essential hypertension, with a p-value of 0.592 (p > 0.05) (OR = 0.750; CI = 0.262–2.151). Conclusion: The ACE2 gene G8790A polymorphism and the rate of hypertension in Cirebon, West Java, were not significantly correlated. Further research is required on a larger scale to investigate the effects of gene combinations or interactions with other locus genes on essential hypertension.
Efektivitas Virtual Reality Upper Motoric Training Terhadap Pemulihan Fungsi Motorik Atas Pada Pasien Stroke Pradana, Muhammad Firyal; Gunawan, Hendry; Nauphar, Donny
Syntax Literate Jurnal Ilmiah Indonesia
Publisher : Syntax Corporation

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36418/syntax-literate.v10i9.61582

Abstract

Latar Belakang: Stroke merupakan penyebab utama disabilitas jangka panjang dengan gangguan fungsi motorik atas yang signifikan, sehingga mengganggu aktivitas harian pasien. Rehabilitasi dengan metode konvensional memiliki keterbatasan dalam hal keterlibatan pasien dan efektivitas jangka panjang. Inovasi terapi menggunakan Virtual Reality Upper Motoric Training (VRUMT) telah berkembang sebagai pendekatan alternatif yang interaktif dan menarik dalam pemulihan motorik pasca stroke. Tujuan: Mengetahui efektivitas Virtual Reality Upper Motoric Training terhadap pemulihan fungsi motorik atas pada pasien stroke di RSU Universitas Muhammadiyah Cirebon. Metode: Penelitian ini menggunakan desain kuasi-eksperimental dengan pendekatan pre-test post-test with nonequivalent control group. Sampel sebanyak 20 pasien stroke yang dibagi menjadi kelompok intervensi (VRUMT) dan kelompok kontrol (fisioterapi konvensional). Penilaian fungsi motorik atas dilakukan menggunakan instrumen Fugl-Meyer Assessment Upper Extremity (FMA-UE) sebelum dan sesudah intervensi. Hasil: Kelompok intervensi menunjukkan peningkatan signifikan skor FMA-UE dibandingkan kelompok kontrol. Hasil uji statistik bivariat menunjukkan nilai signifikansi (p < 0,05), menandakan bahwa Virtual Reality Upper Motoric Training efektif dalam meningkatkan fungsi motorik atas pasien stroke. Simpulan: Virtual Reality Upper Motoric Training terbukti efektif dalam meningkatkan pemulihan fungsi motorik atas pada pasien stroke, dan dapat dipertimbangkan sebagai terapi alternatif yang inovatif dan menarik dalam program rehabilitasi stroke.
Co-Authors A Fariz Malvi Zamzam Zein Agastya, I Gusti Ngurah Ahmad Fariz Malvi Z Zein Akbarahma, Ikrama Alif Hamzah amanah amanah Amanah Amanah Amanah Amanah Ameliana, Elinda Anak Agung Istri Sri Wiadnyani Andang Adi Fitria Hananto Andi Pancanugraha Andrew John Macnab Annida Maharani Annida P Maharani Ariestya Indah Permata Sari Ary Norsaputra Baihaqi, Muhammad Irsyad Canggih Puspo Wibowo Catur Setiya Sulistiyana Destiwi, Monita Diary, Dwina Gustia Dimas Sondang Dimas Sondang Irawan Doni Marisi Sinaga Doni Marisi Sinaga, Doni Marisi Dwina Gustia Diary Dyah Anantalia Widyastari Dyah Anantalia Widyastari Edhyana Sahiratmadja Eka Ayuningtyas Elinda Ameliana Elinda Ameliana Eni Suhaeni Fattah, Rifqi Abdul Fauzaan Azhar Rizqulloh Fauzah, Shofa Nur Fauziah, Sri Utami Febrian Hendra Kurniawan Ferdian Muhammad Rafsandani Galih Albarra Shidiq Galih Albarra Shidiq Gara Samara Brajadenta Hadyanto Lim Hafizh Muhammad Noor Hammada, Ronaa Hananto, Andang Adi Fitria Harlianti, Lita Hendry Gunawan, Hendry Henny Erina Saurmauli Ompusunggu Husna, Nazaul I Gusti Ngurah Agastya I Gusti Ngurah Edi Putra Indriani Silvia Ivana Aprilia Pratiwi Jamhari Jamhari Juwita -, Juwita Kurniawan, Febrian Hendra Kuswara, Hasna Nurazizah Leonardo Lubis Lita Harlianti Lita Harlianti Macnab, Andrew John Made Dian Shanti Kusuma Maharani, Annida Mahendrawan Nugraha Aji Pratama Maretalinia Maretalinia Maretalinia Maretalinia, Maretalinia Marina Ayu Viniriani Maryam, Ruri Eka Moehas, Puput Kusumawardani Monita Destiwi Muhammad Ajmalunnas Muhammad Irsyad Baihaqi Muhammad Irsyad Baihaqi Ni Wayan Kesari Dharmapatni Noor, Hafizh Muhammad Norsaputra, Ary Oktaviyati, Nurfithria Ompusunggu, Henny E.S. Pamuko Aditya Rahman Pancanugraha, Andi Pardede, Sumondang M. Pichpisith Pierre Vejvisithsakul Pradana, Muhammad Firyal Pratama, Mahendrawan Nugraha Aji Pratamawati, Tiar M Pratamawati, Tiar Masykuroh Pratiwi, Ivana Aprilia Puput Kusumawardani Moehas Putra, I Gusti Ngurah Edi Putra, Wahyu Manggala Putri, Annisa Septiani Putri Rahman, Pamuko Aditya Rama S Brajawikalpa Ricky Alexander Samosir Rifqi Abdul Fattah Risnandya Primanagara Ronaa Hammada Ronaa Hammada Ruri Eka Maryam Ruri Eka Maryam Mulyaningsih Sadji, Angel Angriani Elma Budai Samosir, Ricky Alexander Satrianugraha, Muhammad Duddy Sayyidah Vina Syauqia Sayyidah Vina Syauqia Shofa Nur Fauzah Shofa Nur Fauzah Sri Utami Fauziah Sri Utami Fauziah Syauqia, Sayyidah Vina Tiar M Pratamawati Tiar Masykuroh Pratamawati Tiar Masykuroh Pratamawati Tiar Masykuroh Pratamawati Tiara Fatmarizka Uswatun Khasanah Vejvisithsakul, Pichpisith Pierre Viniriani, Marina Ayu Wahyu Manggala Putra Warih Kuncoro Mukti Wibowo, Canggih Puspo Widiyatmiko Arifin Putro Witri Pratiwi Witri Pratiwi Yahwardiah Siregar Yuni Susanti Pratiwi Yuny Hafitry Zein, A Fariz Malvi Zamzam Zein, Ahmad Fariz Malvi Zam Zam