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Journal : JURNAL BIOLOGI INDONESIA

Kajian Pakan Bersumber Energi Tinggi pada Pembentukkan Monyet Obes Oktarina, Ria; Mansjoer, Sri Supraptini; Astuti, Dewi Apri; Suparto, Irma Herawati; Sajuthi, Dondin
JURNAL BIOLOGI INDONESIA Vol 6, No 3 (2010): JURNAL BIOLOGI INDONESIA
Publisher : Perhimpunan Biologi Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (72.126 KB) | DOI: 10.14203/jbi.v6i3.3145

Abstract

ABSTRACTHigh Energy Diet to Develop Obese Animal Model in Cynomolgus Monkeys (Macacafascicularis). Obesity is a primary predisposition for diseases such as metabolic syndrome(insulin resistance, blood lipid abnormality, and hypertension), type 2 diabetes, andcardiovascular disease. The effort to overcome obesity is needed by understanding thedevelopment of obesity. Therefore, it is urgent to carry out preclinical trials by using an obeseanimal model however it is still limited. The objective of this research was to study the effect ofhigh energy diet with animal fat and soluble carbohydrate to produce obese cynomolgusmonkeys (Macaca fascicularis). Animals used in this study were 15 adult males dividedequally into three treatment groups and were given diets for 4 months. The 3 groups were 1)receiving diet A consists of beef tallow without egg yolk; 2) receiving diet B consists of beeftallow and egg yolk, (energy 4,207 cal/g, fat 19.62%, and starch 60.34% in both first two diet) 3)receiving diet C consists of monkey chow as control (energy 4,330 cal/g, fat 5.55%, and starch51.38%). Measurement were taken every four weeks for body weight, crown rump length, hipdiameter, abdominal skin thickness, body mass index (BMI), nutrient consumption anddigestibility. Results showed that animals received diet B had significant increase in bodyweight and BMI at week 4 and 8. Hip diameter and abdominal skin thickness were significantstarting at week 4 in animals receiving diet with egg yolk (p<0.05) compared to the other twogroups. Protein consumption and digestibility in group with diet A and B was lower (p<0.05)compared to control animals. However, digestibility for dry matter, fat, starch and energy wereabout 90%, meaning that the rations were considered adequate in developing obese monkey.The diet formula containing tallow and egg yolk increased body weight based on BMI criteriaabove 25 kg/m2.Key words: obesity, cynomolgus, egg yolk, body mass index, digestibility
KAJIAN PAKAN BERSUMBER ENERGI TINGGI PADA PEMBENTUKKAN MONYET OBES Oktarina, Ria; Mansjoer, Sri Supraptini; Astuti, Dewi Apri; Suparto, Irma Herawati; Sajuthi, Dondin
JURNAL BIOLOGI INDONESIA Vol 6, No 3 (2010): JURNAL BIOLOGI INDONESIA
Publisher : Perhimpunan Biologi Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14203/jbi.v6i3.3145

Abstract

ABSTRACTHigh Energy Diet to Develop Obese Animal Model in Cynomolgus Monkeys (Macacafascicularis). Obesity is a primary predisposition for diseases such as metabolic syndrome(insulin resistance, blood lipid abnormality, and hypertension), type 2 diabetes, andcardiovascular disease. The effort to overcome obesity is needed by understanding thedevelopment of obesity. Therefore, it is urgent to carry out preclinical trials by using an obeseanimal model however it is still limited. The objective of this research was to study the effect ofhigh energy diet with animal fat and soluble carbohydrate to produce obese cynomolgusmonkeys (Macaca fascicularis). Animals used in this study were 15 adult males dividedequally into three treatment groups and were given diets for 4 months. The 3 groups were 1)receiving diet A consists of beef tallow without egg yolk; 2) receiving diet B consists of beeftallow and egg yolk, (energy 4,207 cal/g, fat 19.62%, and starch 60.34% in both first two diet) 3)receiving diet C consists of monkey chow as control (energy 4,330 cal/g, fat 5.55%, and starch51.38%). Measurement were taken every four weeks for body weight, crown rump length, hipdiameter, abdominal skin thickness, body mass index (BMI), nutrient consumption anddigestibility. Results showed that animals received diet B had significant increase in bodyweight and BMI at week 4 and 8. Hip diameter and abdominal skin thickness were significantstarting at week 4 in animals receiving diet with egg yolk (p<0.05) compared to the other twogroups. Protein consumption and digestibility in group with diet A and B was lower (p<0.05)compared to control animals. However, digestibility for dry matter, fat, starch and energy wereabout 90%, meaning that the rations were considered adequate in developing obese monkey.The diet formula containing tallow and egg yolk increased body weight based on BMI criteriaabove 25 kg/m2.Key words: obesity, cynomolgus, egg yolk, body mass index, digestibility
Co-Authors . NURHAIMI-HARIS . Permanawati Adi Winarto Agus Harsoyo Agus Malik Ibrahim Alfa A Perdana Alzamori, Winda Amalia Yunita Amelia Marzanti Amrina Rosyada Andi Nursanti Ani Suryani Suryani Annisa Dewi, Fitriya Nur Arief Boediono Auliatifani, Reza Auliya Ilmiawati Baiq NM Utami Bella Fitri Rahmantika Cece Sumantri Cecep Abdurohman Putra Charlena Chonny Damayanti Chusnul Choliq Chusnul Choliq Daniel Putra Oktavianus Laia Dede R. Adawiyah Dedy Duryadi Solihin DEWI APRI ASTUTI Dewi, Fitriya Nur Annisa Dewi, Tri Isyani Tungga Diah Iskandriati Dondin Sajuthi Dudi Tohir Dwi Ramadhani Ekowati Handharyani Era Rahmi Eti Rohaeti Ferian A Setiyoko Fiqa Annisa Rakhmatika Fitriah Sari Fransiska Rungkat Zakaria Gina, Safira Gregory K. Wilkerson Gustan Pari Gustan Pari Harrold Halilintar MR Subu Taopan Huda Shalahudin Darusman I Nengah Budiarsa I NENGAH BUDIARSA Ibrahim, Agus Malik Ida Ayu Putu Sri Widnyani Iin Indriawati Iin Kurnia Hasan Basri Irmanida Batubara J. Mark Cline Khaydanur Khaydanur Khaydanur, Khaydanur Laela Wulansari Latifah Kosim Darusman Lilis Nurhadijah Lis Rosmanah Luthfiana, Widya M. Rafi Manasye Erlangga Mohamad Rafi Mohamad Rafi Mohamad Rafi Munawaroh, Fauziyatul Nengsih, Nunuk Kurniati Noviyan Darmawan Nunuk Kurniati Nengsih Nur Inayatullah Nurhadijah, Lilis Nurul Siti AYUNINGTIAS PAMUNGKAS, DIAH DARU Perdana, Alfa A Permanawati Permanawati PERMANAWATI, PERMANAWATI Pijoh, Deyv Purnomo, Tsania Firqin Rachmitasari Noviana Rachmitasari Noviana Rahmagiarti, Cintera Rakhmatika, Fiqa Annisa Reno Fitri Hasrini Retno Wulansari Reza Auliatifani Ria Oktarina Riska Widya Aprianti Rizki Aulia Ansari Rudi Heryanto SATRIYAS ILYAS Sela Septima Mariya Septaningsih, Dewi Anggraini Septi Iriani Setiyoko, Ferian A Silmi Mariya SILMI MARIYA Silmi Mariya Silmi Mariya Silmi Mariya Silmi Mariya Sri Rahmatul Laila Sri Supraptini Mansjoer Subu Taopan, Harrold Halilintar MR Sulistiyani Sulistiyani, Sulistiyani SUMINAR SETIATI ACHMADI Teja Kisnanto Tetty Kemala Tri Isyani Tungga Dewi Tsania Firqin Purnomo Ummah, Isna Mustafiatul Utami, Baiq NM Uus Saepuloh Uus Saepuloh Veby Tri Yani Veby Tri Yani Wasmen Manalu Widyawati Widyawati Widyawati Widyawati Wildayati, Wildayati Wina Yulianti Wisaeni Intannia Wisnu Ananta Kusuma Wulan Tri Wahyuni Wulansari, Laela Yessie Widya Sari Yoga Yuniadi Yuliana Yuni Cahya Endrawati Yusuf Ryadi Zuraida Zuraida Zuraida