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All Journal HAYATI Journal of Biosciences Jurnal Teknologi Dan Industri Pangan ACTA VETERINARIA INDONESIANA Jurnal Primatologi Indonesia Journal of Tropical Life Science : International Journal of Theoretical, Experimental, and Applied Life Sciences Jurnal Veteriner Jurnal Bios Logos JURNAL KIMIA SAINS DAN APLIKASI Jurnal Sains dan Teknologi Nuklir Indonesia (Indonesian Journal of Nuclear Science and Technology) IPTEK Journal of Proceedings Series Jurnal Penelitian Hasil Hutan agriTECH Majalah Obat Tradisional JURNAL BIOLOGI INDONESIA Science and Technology Indonesia Al-Kimia Acta Pharmaciae Indonesia : Acta Pharm Indo Indonesian Journal of Chemistry Menara Perkebunan Jurnal Jamu Indonesia Jurnal Penelitian Hasil Hutan ZOOTEC Jurnal Kedokteran Hewan al Kimiya : Jurnal Ilmu Kimia dan Terapan Indonesian Journal of Jamu Jurnal Penelitian Hasil Hutan
Irma Herawati Suparto
Department Of Chemistry FMIPA IPB University, IPB Campus, Dramaga, Bogor, 16680, Indonesia
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Decision Sciences, Operations Research & Management Earth & Planetary Sciences Energy Engineering Environmental Science Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Materials Science & Nanotechnology Mechanical Engineering Medicine & Pharmacology Physics Public Health Veterinary Other

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Journal : Jurnal Veteriner

 1 
Penurunan Kadar Gula Darah pada Monyet Ekor Panjang Obes dengan Pemberian Nikotin Dosis Rendah (DECRESE IN BLOOD SUGAR LEVEL IN LONG TAILED OBESE MACAQUES GIVING WITH LOW DOSE NICOTINE) Chusnul Choliq; Dondin Sajuthi; Irma Herawati Suparto; Dewi Apri Astuti; Retno Wulansari
Jurnal Veteriner Vol 14 No 2 (2013)
Publisher : Faculty of Veterinary Medicine, Udayana University and Published in collaboration with the Indonesia Veterinarian Association

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Abstract

The aim of the study was to evaluate the role of low dose nicotine on the profile of blood glucose and  â-cell of pancreatic islets.  Fourteen adult (aged 6 – 8 years) male cynomolgus monkeys grouped based ontheir Body Mass Index (BMI) into preobese (BMI=23.65 – 25.00) and obese (BMI e” 26.00) were used inthis study. Subsequently animals were grouped into four:  (i) preobese monkeys with nicotine (pOb+), (ii)obese monkeys with nicotine (Ob+), (iii) preobese monkeys without nicotine (pOb-), and (iv) obese monkeyswithout nicotine (Ob-). Animals in the nicotine groups were fed with high fat diet mixed with nicotine dose0.5–0.75mg/kg body weight/day for three months and the others were fed Monkey Chow® only as thecontrol group. Blood samples were collected every month for glucose analysis and necropsy was performedat the end of study. Pancreas tissues were processed histologically and stained using  immunohistochemicalmethod. The results showed that the blood glucose either preobese (28.37%) or  obese (33.72%) animals inthe nicotine groups significantly decrease (p<0.05) during the study period in comparison to the controlgroup.  Based on brown color intensity of granules cytoplasm of insulin producing cells or immunoreactiveâ-cells, it is shown that the cells of animals in the non nicotine group were more reactive than those in thenicotine groups. In conclusion, there was positive effect of low dose nicotine in maintaining the bloodglucose level in normal range by stimulation of islet cells proliferation to maintain the production ofinsulin in the pancreatic islet.
Co-Authors . NURHAIMI-HARIS . Permanawati Adi Winarto Agus Harsoyo Agus Malik Ibrahim Alfa A Perdana Alzamori, Winda Amalia Yunita Amelia Marzanti Amrina Rosyada Andi Nursanti Ani Suryani Suryani Annisa Dewi, Fitriya Nur Arief Boediono Auliatifani, Reza Auliya Ilmiawati Baiq NM Utami Bella Fitri Rahmantika Cece Sumantri Cecep Abdurohman Putra Charlena Chonny Damayanti Chusnul Choliq Chusnul Choliq Daniel Putra Oktavianus Laia Dede R. Adawiyah Dedy Duryadi Solihin DEWI APRI ASTUTI Dewi, Fitriya Nur Annisa Dewi, Tri Isyani Tungga Diah Iskandriati Dondin Sajuthi Dudi Tohir Dwi Ramadhani Ekowati Handharyani Era Rahmi Eti Rohaeti Ferian A Setiyoko Fiqa Annisa Rakhmatika Fitriah Sari Fransiska Rungkat Zakaria Gina, Safira Gregory K. Wilkerson Gustan Pari Gustan Pari Harrold Halilintar MR Subu Taopan Huda Shalahudin Darusman I Nengah Budiarsa I NENGAH BUDIARSA Ibrahim, Agus Malik Ida Ayu Putu Sri Widnyani Iin Indriawati Iin Kurnia Hasan Basri Irmanida Batubara J. Mark Cline Khaydanur Khaydanur Khaydanur, Khaydanur Laela Wulansari Latifah Kosim Darusman Lilis Nurhadijah Lis Rosmanah Luthfiana, Widya M. Rafi Manasye Erlangga Mohamad Rafi Mohamad Rafi Mohamad Rafi Munawaroh, Fauziyatul Nengsih, Nunuk Kurniati Noviyan Darmawan Nunuk Kurniati Nengsih Nur Inayatullah Nurhadijah, Lilis Nurul Siti AYUNINGTIAS PAMUNGKAS, DIAH DARU Perdana, Alfa A Permanawati Permanawati PERMANAWATI, PERMANAWATI Pijoh, Deyv Purnomo, Tsania Firqin Rachmitasari Noviana Rachmitasari Noviana Rahmagiarti, Cintera Rakhmatika, Fiqa Annisa Reno Fitri Hasrini Retno Wulansari Reza Auliatifani Ria Oktarina Riska Widya Aprianti Rizki Aulia Ansari Rudi Heryanto SATRIYAS ILYAS Sela Septima Mariya Septaningsih, Dewi Anggraini Septi Iriani Setiyoko, Ferian A Silmi Mariya Silmi Mariya SILMI MARIYA Silmi Mariya Silmi Mariya Silmi Mariya Sri Rahmatul Laila Sri Supraptini Mansjoer Subu Taopan, Harrold Halilintar MR Sulistiyani Sulistiyani, Sulistiyani SUMINAR SETIATI ACHMADI Teja Kisnanto Tetty Kemala Tri Isyani Tungga Dewi Tsania Firqin Purnomo Ummah, Isna Mustafiatul Utami, Baiq NM Uus Saepuloh Uus Saepuloh Veby Tri Yani Veby Tri Yani Wasmen Manalu Widyawati Widyawati Widyawati Widyawati Wildayati, Wildayati Wina Yulianti Wisaeni Intannia Wisnu Ananta Kusuma Wulan Tri Wahyuni Wulansari, Laela Yessie Widya Sari Yoga Yuniadi Yuliana Yuni Cahya Endrawati Yusuf Ryadi Zuraida Zuraida Zuraida