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Journal : Universa Medicina

Home humidity increased risk of tuberculosis in children living with adult active tuberculosis cases Lestari, Pudji; Sustini, Florentina; Endaryanto, Anang; Asih, Retno
Universa Medicina Vol 30, No 3 (2011)
Publisher : Faculty of Medicine, Trisakti University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/UnivMed.2011.v30.138-145

Abstract

Indonesia is one of the countries with the largest number of tuberculosis (TB) cases in the world. Environmental factors play significant roles in infection and disease development in children living with adult active TB cases. The aim of this study was to explore the environmental factors affecting TB risk in children, including humidity and number of people living in the same house with the children.  Using a cross-sectional study design, children living with active TB adults for at least 8 weeks were recruited. The subjects underwent clinical examination, tuberculin skin test (TST) and radiological investigations. Home visits were conducted three times daily, namely in the morning, at midday, and in the evening, to measure humidity by digital hygrometer and to observe home conditions. Of 56 index cases living with active TB adults in an urban low socio-economic setting, 64 contact TB children were recruited. These children were classified as class I with negative TST and no clinical signs, class II with positive TST and no clinical signs, and class III with both positive TST and clinical signs. There were 32 (50%) class I, 10 (15.6%) class II and 22 (34.3%) class III children. However, a sub-sample of 43 showed positive results for Mtb 16S rRNA, indicating that all children were infected. The humidity cut-off point was set at 75%, p=0.04 and EP 2.09 (CI= 1.32-3.29), signifying that children living in houses with a humidity higher than 75%, were twice more likely to be tuberculin positive. Environmental conditions playing a role in disease development were humidity and number of people living in the house.
Co-Authors Adisti Kristianingrum Agung Dwi Wahyu Widodo Ahmad Taufik Alecia Fransiska Khorianto Alit Armini, Ni Ketut Anang Endaryanto Andreas Woitila Sukur Andri Danika Anisah Machmudah Aranda, Biembee Nayoan Cosa Ari Sutjahjo, Ari Arisyna Arisyna Arjuna, Sansan Rollens Atiah Atiah Bella Agustina Andreani Bella Patricia Simanjorang Benevitto, Axel Budi Utomo Cahyani, Ni Putu Novi Christian Jaya Sumarto Putra Christin Setiawan Citra Dewi Maharani Dana Parama Julius Dewa Ayu Liona Dewi Dewi, Dewa Ayu Liona Dian Perdana Fitri Mandasari Doddy M. Soebadi Dwi Puspitasari Dwi Susanti Dyah Priyatini Eka Mishbahatul Mar'ah Has Ekaristy, Mergivia Elicia Vincensa Ernawati, Titiek Farah Vizah Fathmawati Fathmawati Felicia Margaret Firda Iragama Freddy Kurniawan Grace Alverina Grace, Paulina Holy Hamdani, Delincia Hardiono Hardiono, Hardiono Heny Arwati Hidajat, Boerhan I Dewa Gede Pangestu Banu Ananta Ilya Krisnana, Ilya Inez Anabela Suprijadi Suprijadi Inge Wattimena Inge Wattimena Inge Wattimena Irwina Angelia Silvanasari Isabel Nauli Anggia Pangaribuan Ivita Tahta Murbarani Jasinda Dwiranti Joni Haryanto Jose Giovanny Julio Cesar Adhyaksa de Fatima Juniastuti Juniastuti Kevin Alexander Danuseputro Khairul Bariyah, Khairul Komang Yoga Suryawan Lathifah Nurul Fajri Leonardo Adi Wibowo Lukas Slamet Rihadi Lukas Slamet Rihadi Misbakhul Munir Miza Nisrinah Muhdi, Nalini Nabila Fitri Ariyati Nindya Amalia Biharjo Putri Nirmala Kusumaningrum Sunaryo Nirwana Mila Safitri Niswa Salamung Paul Jhosua Dayoh Pawana, I Putu Alit Prastiya Indra Gunawan Pudji Lestari Puspitasari, Dyan Eka Raharja, Davin Rahma Isti Kusyadi Retno Ardanari Agustin Retno Ardanari Agustin, Retno Ardanari Retno Asih, Retno Ricky Stefanus Tanuy Rihadi, Lukas Slamet Rizalanda, Sofyan Rizalanda, Sofyan Robertus Saldi Cundawan Ronald Pratama Adiwinoto Sagung Putri Maharani Salvador Benedictus Borromeu Sancha Melarisa Hilarius Setiadi, Rocky Shallen Angelia Wijaya Silva, Theodora Emanuella da Sincihu, Yudhiakuari Soebadi, Doddy Moesbadianto Sri Subekti Stefanny Ckaudia Centis Da Lopez Steven Wijono Subagyo Yotopranoto Sudibyo, Devi Ariani Sumomba, Yordani Sundari Indah Wiyasihati Susilo, Dwi Hari TANGGO, EDDY HERMAN Theresia Arum Hanitani Titik Ernawati Usman Hadi Valerie Grecia Willianto, Vincentius Michael Winarjo, Givenchy Angela Yosephine Valentine Surya Yudhiakuaru Sincihu Yudistira .. Zanuba Qottrun Nada