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All Journal Majalah Kedokteran Bandung Jurnal Kesehatan Masyarakat Nexus Kedokteran Komunitas Nexus Kedokteran Klinik Universa Medicina Indonesian Journal of Medicine Jurnal Respirologi Indonesia Jurnal Biomedika Jurnal Peduli Masyarakat Cermin Dunia Kedokteran International Journal of Public Health Excellence (IJPHE) Jurnal Masyarakat Madani Indonesia Jurnal Ilmiah Pengabdian Masyarakat Bidang Kesehatan
Yusup Subagio Sutanto
Faculty of Medicine, Sebelas Maret University
Humanities Biochemistry, Genetics & Molecular Biology Computer Science & IT Dentistry Education Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Medicine & Pharmacology Nursing Public Health Social Sciences Other

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Sensitivity and specificity of cell block method of transthoracic fine needle aspiration in diagnosis of lung cancer Sutanto, Yusup Subagio; Santi, Nur; Wasita, Brian; Rima, Ana; Kurniawan, Hendra
Universa Medicina Vol. 40 No. 2 (2021)
Publisher : Faculty of Medicine, Universitas Trisakti

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/UnivMed.2021.v40.133-140

Abstract

BackgroundLung cancer is still the main cause of cancer deaths. The high lung cancer mortality rate is caused by a diagnosis factor or therapy selection. The cell block cytology technique using fine needle aspiration (FNA) samples can provide immunocytochemical material that plays an important role in the differential diagnosis of lung cancer subtypes and in determining immunotherapy administration. This study aimed to determine the sensitivity and specificity of transthoracic FNA (TTFNA) cell block cytology in comparison with bronchial washing smears and TTFNA smears in diagnosing lung cancer. MethodsThis was a cross-sectional diagnostic study involving 26 subjects. All subjects had undergone bronchial washing and CT scan-guided fine needle aspiration followed by cell block preparation. Both direct FNA smears and cell blocks are useful in the diagnostic work-up of patients. Comparative statistical analysis of TTFNA cell block versus bronchial washing smear and TTFNA smear cytology was carried out using the McNemar test. ResultsLung cancer was found in 15 patients (57.7%) using the TTFNA cell block technique. The sensitivity and specificity of the TTFNA cell block technique were 85.7% and 75%, respectively. There was no difference in the positivity value between TTFNA cell block technique of bronchial wash smear technique, and TTFNA smear on lung cancer diagnosis (p>0.05). ConclusionsTransthoracic fine-needle aspiration in combination with the cell block technique has good sensitivity and specificity. The TTFNA can be used for immunocytochemical examinations in lung cancer diagnosis and therapy. This approach is valuable for providing individualized treatment and prognostic evaluations.
Hubungan Kategori Level Xpert MTB/RIF dengan Waktu Konversi Kultur Sputum Pasien TB Resisten Obat (TB RO) -, Samuel; Apridasari, Jatu; -, Reviono; Sutanto, Yusup Subagio; -, Harsini
Cermin Dunia Kedokteran Vol 47, No 11 (2020): Infeksi
Publisher : PT. Kalbe Farma Tbk.

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (199.822 KB) | DOI: 10.55175/cdk.v47i11.1194

Abstract

Penanganan TB yang tidak tepat dan tidak sesuai standar dapat menimbulkan masalah TB resisten obat (TB RO). Penelitian ini bertujuan mengetahui hubungan antara kategori level hasil Xpert MTB/RIF dengan waktu konversi kultur sputum pasien TB RO. Data berasal dari rekam medik mulai bulan September 2012 sampai dengan bulan Oktober 2015; didapatkan 198 pasien TB RO, 112 laki-laki (56,6%) dan 86 perempuan (43,4%).Usia rerata 38,87 ± 12,41 tahun. Seluruh pasien TB RO merupakan pasien TB paru dengan memiliki riwayat pengobatan OAT kategori 1. Hasil pemeriksaan Xpert MTB/RIF menunjukkan sebagian besar pasien TB RO berada pada kategori low (43,9%). Konversi kultur terbanyak pada minggu ke empat sampai ke delapan pengobatan sebesar 59,1%. Tidak ada perbedaan bermakna antara kategori Xpert MTB/RIF dengan waktu konversi kultur sputum pasien TB RO (CI 95%, p = 0,572). Tidak ada korelasi bermakna antara kategori level gene X-pert dengan waktu konversi kultur sputum pasien TB RO (CI 95%, r = 0,061, p = 0,392).Inadequate TB management can cause the emergence of drug resistant tuberculosis. This study is to determine the correlation between Xpert MTB/RIF levels category with sputum culture conversion time in drug resistant tuberculosis patients. This retrospective cohort study was conducted in PMDT clinic at Dr. Moewardi General Public Hospital, Surakarta from September 2012 until October 2015. The respondents were 198 drug resistant tuberculosis patients; 112 males (56.6%) and 86 females (43.4%), mean age 38.87 ± 12.41 years old. All were pulmonary TB patients with category 1 anti-TB treatment. The Xpert MTB/RIF levels were mostly low category (43.9%).Culture conversion showed that 59.1% had conversion between the fourth and eighth week of drug resistant tuberculosis treatment. No statistically significant difference between Xpert MTB/FIR level category and sputum culture conversion time (CI 95%, p = 0.572). No statistically significant correlation between Xpert MTB/RIF level category and sputum culture conversion time (CI 95%, r = 0.061, p = 0.392).
The Effectiveness of Anti-Inflammatory Cream Galenic Preparations Based on Snail Seromucoid, Durian Peel Extract Polysaccharides and Chitosan in the Wound Healing Process (In Vivo) Harti, Agnes Sri; Sutanto, Yusup Subagio; Agustin, Wahyu Rima; Putriningrum, Rahajeng; Irdianty, Mellia Silvy; Saelan, Saelan; Ardiani, Nurul Devi
International Journal of Public Health Excellence (IJPHE) Vol. 3 No. 2 (2024): January-May
Publisher : PT Inovasi Pratama Internasional

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55299/ijphe.v3i2.876

Abstract

Development of galenic preparation formulations that can be used to make anti-inflammatory cream preparations. Snail seromucoid contains glycoproteins, mannose carbohydrates, glucose, N-acetyl muramic acid and the α-1 globulin-oromucoid fraction which functions as a bioimmunostimulator. Durian peel (Durio zibethinus L.) contains a polar polysaccharide polymer compound such as D-galacturonic acid which has anti-microbial properties. Chitosan is a polymer compound resulting from derivatization of chitin which has antimicrobial polycationic properties; biodegradable, and biocompatible with animal body tissue. The aim of the research was to examine the effectiveness of a galenic anti-inflammatory cream preparation based on snail seromucoid, durian skin extract, and chitosan for healing acute and chronic wounds in vivo. The research method is experimental research, namely the effectiveness of anti-inflammatory galenic cream preparations made from snail seromucoid, durian peel extract and chitosan on various types of wounds in vivo. Analysis of observation data using the one way anova test. A galenic preparation based on a combination of 2% snail seromucoid, 2% durian peel extract polysaccharide and 2% chitosan ratio 1:1:1 is effective in the healing process based on the formation of granulation tissue thickness in incision injuries, hot objects injuries, second degree burns and ulcers. diabetes. The bioformulation galenic preparation of 2% snail seromucoid, 2% polysaccharide of durian peel extract; 2% chitosan and their combination with ratio 1:1:1 is effective as an anti-inflammatory galenic cream preparation so that it can be applied for healing chronic wounds, acute wounds and diabetic ulcers.
The Potential and Effectiveness of Snail Seromucoid and Chitosan as Bioimmunostimulators Harti, Agnes Sri; Sutanto, Yusup Subagio; Puspawati, Nony
Biomedika Vol 15 No 2 (2022): Jurnal Biomedika
Publisher : Fakultas Ilmu Kesehatan Universitas Setia Budi Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31001/biomedika.v15i2.1448

Abstract

The host's cellular immune response plays an important role in the process of eliminating microorganisms that cause infection. Substances that can stimulate an increase in the immune response are called immunostimulators. Snail seromucoid contains bioactive compounds such as glycans, peptides, glycopeptides and chondroitin sulfate. Chitosan as an antimicrobial agent can be used in the biomedical field because chitosan has a number of hydroxyl groups (OH) and amine groups (NH2). The research objective was to determine the potency and effectiveness of snail seromucoid and chitosan as bioimmunostimulators. The research method is based on laboratory experimental results with the research stages, namely the analysis of the effectiveness of seromucoid and chitosan on lymphocyte proliferation. The results of the one way ANOVA analysis showed a p value of 0.000 so that there was a significant effect between the treatment groups, namely the effect of giving chitosan 65 ug/ml; snail mucus 65 ug/mL and a combination of chitosan (65 ug/mL) and snail mucus (65 ug/mL) ratio of 1:1, can increase lymphocyte proliferation optimally. This shows that snail mucus, chitosan and their combination in a 1:1 ratio are effective as BRM (Biological Response Modifier). It is hoped that the contribution of the results of this study can be further developed in the bioformulation of snail seromucoid preparations and chitosan as therapeutic agents for infectious diseases, including Acute Respiratory Distress Syndrome (ARDS), Tuberculosis and other diseases.
Differences in White Blood Cells, Neutrophil-to-Lymphocyte Ratio, Tumor Necrosis Factor-α based on Procalcitonin Level in Community-Acquired Pneumonia Patients Sutanto, Yusup Subagio; Apriningsih, Hendrastutik; Syaikhu, Akhmad; Siregar, Sihsusetyaningtyas Tiominar
Jurnal Respirologi Indonesia Vol 44, No 3 (2024)
Publisher : Perhimpunan Dokter Paru Indonesia (PDPI)/The Indonesian Society of Respirology (ISR)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36497/jri.v44i3.632

Abstract

Background: Community-acquired pneumonia (CAP) is a respiratory infectious disease caused by bacteria, viruses, or fungi. Procalcitonin (PCT) levels will rise, especially in bacterial infection. PCT examination in CAP can help to confirm the diagnosis and anticipate complications. CAP is diagnosed by symptoms, vital signs, laboratory tests, and radiographic investigations. Inflammatory biomarkers are required for predicting causative microorganisms, guiding antibiotic therapy, and determining severity. The purpose of this study is to compare NLR, WBC, and TNF-α levels in CAP patients dependent on PCT level.Methods: This was an analytical cross-sectional study involving 43 CAP patients admitted to Universitas Sebelas Maret (UNS) Hospital and Moewardi Regional General Hospital Surakarta between February and March 2023. Patients were separated into two groups based on PCT levels: those with levels ≤0.12 ng/mL and >0.12 ng/mL. All patients provided a blood sample for NLR, WBC, TNF-α, and PCT testing. The independent t-test and Mann-Whitney tests were performed for statistical analysis of two unpaired groups, and the Chi-square or Fisher exact test was utilized for ordinal categorical data. If the value of P<0.05, the result is statistically significant.Results: NLR and TNF-α levels were higher in the PCT group >0.12 ng/mL and statistically significant with a value of P=0.001. WBC levels in the PCT group >0.12 ng/mL were higher, but the difference was not statistically significant (P=0.096).Conclusion: The NLR value, WBC, and TNF-α levels were found to be higher in the group with PCT >0.12 ng/mL. 
Serum Matrix Metalloproteinase 9 Level, Blood Absolute Neutrophil Count in Correlation with Diffusion Capacity and Exercise Capacity of Stable Chronic Obstructive Pulmonary Disease Patients at Universitas Sebelas Maret Hospital Lestari, Anggraini Dwi; Apriningsih, Hendrastutik; Reviono, Reviono; Sutanto, Yusup Subagio; Setijadi, Ana Rima
Jurnal Respirologi Indonesia Vol 44, No 3 (2024)
Publisher : Perhimpunan Dokter Paru Indonesia (PDPI)/The Indonesian Society of Respirology (ISR)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36497/jri.v44i3.400

Abstract

Background: Chronic obstructive pulmonary disease (COPD) is the leading cause of morbidity and mortality worldwide. Exposure to cigarette smoke activates alveolar macrophages producing neutrophils and proteases such as MMP-9 and NE that damage the extracellular matrix triggering emphysema as well as spill over into the systemic circulation. This study aimed to determine the correlation of serum MMP-9 level and blood absolute neutrophil count with diffusion capacity and exercise capacity of stable COPD patients.Methods: A cross-sectional observational study was conducted in stable COPD patients visiting the pulmonary outpatient clinic of Universitas Sebelas Maret (UNS) Hospital in October 2022. Consecutive sampling was applied for sample collection. We assessed diffusion capacity and exercise capacity with the DLCO method and 6MWT, respectively. We examined serum MMP-9 level and blood absolute neutrophil count. All data were statistically analyzed with SPSS 22.0 and P<0.05 was considered significant.Results: Thirty stable COPD patients were included in the study comprising 19 males (63.3%), and 11 females (36.7%). With a mean age of 61.90±9.99. Serum MMP-9 level did not correlate with either diffusion capacity and blood absolute neutrophil count (P=0.898 and P=0.589, respectively). However, serum MMP-9 level had a significant correlation with exercise capacity (P=0.014). There was no correlation between blood absolute neutrophil count with diffusion capacity and exercise capacity (P=0.0281 and P=0.592, respectively). Diffusion capacity related to exercise capacity (P=0.001).Conclusion: Serum MMP-9 level is not related to diffusion capacity, but it is related to exercise capacity. Blood absolute neutrophil count is not related to diffusion capacity or exercise capacity. Serum MMP-9 level is not associated with blood absolute neutrophil count. Diffusion capacity is related to exercise capacity. 
Differences in Interleukin-6 Levels, Neutrophil Levels, and Length of Hospitalization in Pneumonia Patients with and without Garlic Supplementation (Allium sativum) Irawan, Yogie; Harsini, Harsini; Sutanto, Yusup Subagio
Jurnal Respirologi Indonesia Vol 44, No 3 (2024)
Publisher : Perhimpunan Dokter Paru Indonesia (PDPI)/The Indonesian Society of Respirology (ISR)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36497/jri.v44i3.396

Abstract

bacteria, viruses, fungi, or parasites, with high mortality and morbidity rates. The examination of IL-6 and neutrophils helps in diagnosis as a marker of inflammation, a predictor of mortality and morbidity, and is useful in evaluating the outcome of treatment. Garlic and its organosulfur content possess anti-inflammatory activity that has the potential to be used as additional therapy in pneumonia patients.Methods: A clinical study with a pretest-posttest quasi-experimental design was conducted on pneumonia patients who were hospitalized at Dr. Moewardi General Hospital, Surakarta from August to October 2022 by consecutive sampling. The treatment group (n=20) received standard therapy plus 3.5 mg of garlic capsules per day for 6 days, while the control group (n=20) received standard therapy. Levels of IL-6 and neutrophil were calculated on the first and sixth days, while the length of hospitalization was calculated from when the patient was admitted until discharge.Results: There was a significant IL-6 difference in the treatment group (P=0.027) and a neutrophil difference in the treatment group (P=0.025) compared to the control group, but there was no significant difference (P=0.876) in the length of stay in the treatment group compared to the control group.Conclusion: Giving garlic as a supplemental therapy to pneumonia patients could significantly reduce IL-6 and neutrophil levels.
Effectiveness of Guided Imagery to %FEV1, Absolut Neutrophil, Anxiety, and Quality of Life in Stable Chronic Obstructive Pulmonary Disease (COPD) Patient Herlina, Liana; Sutanto, Yusup Subagio; Nugroho, I.G.B Indro; Harsini, Harsini; Prasetya, Windu
Jurnal Respirologi Indonesia Vol 44, No 4 (2024)
Publisher : Perhimpunan Dokter Paru Indonesia (PDPI)/The Indonesian Society of Respirology (ISR)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36497/jri.v44i4.387

Abstract

Background: Chronic obstructive pulmonary disease (COPD) is a leading factor in morbidity and mortality worldwide associated with excessive chronic inflammatory response. Guided imagery is a relaxation technique to achieve the desired positive outcome. This study analyzed the effectiveness of guided imagery in stable COPD patients on the value of % FEV1, absolute neutrophils, anxiety, and the standard of living in those with steady COPD.Methods: Experimental analytic research with quasi-experimental, pretest and post-test design. Subjects were outpatient stable COPD patients at the pulmonary polyclinic of UNS Surakarta Hospital in January-June 2022. Subjects were divided into guided imagery intervention groups for 4 weeks and controls. Subjects were then examined for %FEV1 by spirometry, absolute neutrophils, Taylor Minnesota Anxiety Scale (TMAS) questionnaire, and St. George Respiratory Questionnaire (SGRQ) quality of life questionnaire, and re-evaluated after four weeks.Results: There were 32 research subjects. The findings demonstrated that the therapy group did not endure a significant increase in the mean value of %FEV1 (P=0.617). Meanwhile, the mean value of %FEV1 significantly decreased in the control group (P=0.025), given that the control group's value of % FEV1 fell. In contrast, the treatment group's increased, even if the difference was not statistically significant, the use of guided imagery could effectively halt the decline in %FEV1 value. Compared to the control group (P=0.014), the TMAS anxiety score was lower in the treatment group (P≤0.001). The overall SGRQ score (quality of life) considerably decreased in the treatment group (P≤0.001) while significantly increasing in the control group (P=0.014). Absolute neutrophils were found in both the treatment group and the control group (P=0.642; P=0.224, respectively). Absolute neutrophil blood levels in the treatment and control groups did not differ significantly.Conclusion: Guided imagery is effective on %FEV1 values, anxiety, and quality of life in stable COPD patients but not against absolute neutrophils.
Synbiotic Soygurt Tempe Extract as A Functional Beverage Harti, Agnes Sri; Irdianty, Mellia Silvy; Muhlishoh, Arwin; Sutanto, Yusup Subagio
International Journal of Public Health Excellence (IJPHE) Vol. 4 No. 1 (2024): June-December
Publisher : PT Inovasi Pratama Internasional

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55299/ijphe.v4i1.1124

Abstract

Synbiotic tempeh extract soyghurt is a Krenova (creative and innovative) food product because it is novelty and unique as healthy and safe food, functional food, fun for diet and one for all. The result of probiotic fermentation of Lactic Acid Bacteria (LAB) and based on synbiotic tempeh extract (rice bran and chitosan) which has multifunctional anti-hyperglycemia and anti-hypercholesterolemia properties. Research objective: to analyze the effectiveness of synbiotic tempeh soyghurt as a functional drink. The research method analyzes the nutritional content and quality of synbiotic tempeh soygurt products which refer to SNI 7552:2009 concerning flavored fermented milk. Data analysis used bivariate and multivariate Anova tests. The Hedonic test results showed a semi-solid texture, white color, synbiotic tempeh extract aroma, sour taste in the formulation with the addition of 15% skim milk, 1% chitosan, 1:1 ratio LAB starter mix and 5% inoculum. The results of physical chemical and mycobiological quality tests show that the synbiotic tempeh extract meets the quality test as a functional drink.
Hilirisasi Produk Krenova Krim Galenik untuk Perawatan Luka bagi Praktisi Kesehatan Harti, Agnes Sri; Sutanto, Yusup Subagio; Agustin, Wahyu Rima; Irdianty, Mellia Silvy; Saelan, Saelan
Jurnal Peduli Masyarakat Vol 6 No 4 (2024): Jurnal Peduli Masyarakat: Desember 2024
Publisher : Global Health Science Group

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37287/jpm.v6i4.4425

Abstract

Penerapan hasil riset civitas akademika Universitas Kusuma Husada Surakarta terkait eksplorasi potensi bahan alam dan pengembangan teknologi formulasi sediaan farmasi berbasis bahan galenik bioimunostimulator perlu dioptimalkan untuk menunjang efektivitas terapi perawatan luka kronis. Tujuan kegiatan sesuai paradigma kegiatan pengabdian pada masyarakat melalui fasilitasi Program Inovokasi Universitas Kusuma Husada Surakarta tahun 2024 adalah diseminasi dan implementasi sediaan galenik sebagai produk krenova berbasis knowledge based economy yang siap dihilirisasi dan dikomersialisasi secara profesional; mandiri serta berkelanjutan. Metode kegiatan meliputi transfer knowledge workshop manajemen perawatan luka manajement perawatan luka kepada 30 orang praktisi atau perawat mandiri dan webinar kolaborasi internasional antara Universitas Kusuma Husada Surakarta dan Instituto Ciencias Da Saude (ICS) Timor Leste tentang kuliah pakar manajemen perawatan luka antara yang diikuti oleh 325 peserta aktif secara online. Diseminasi dan implementasi produk krenova civitas akademika UKH Surakarta sediaan galenik seromukoid bekicot, ekstrak kulit durian dan atau kitosan sebagai healthy and safety product untuk wound healing melalui kolaborasi link and match antara UKH Surakarta dengan mitra industry herbal, bidang layanan kesehatan yaitu praktisi mandiri, home care, ataupun unit layanan kesehatan lain guna mendukung tercapainya hilirisasi produk krenova krim galenik antiinflamasi dan mendukung suksesnya program Pemerintah dalam penanggulangan perawatan luka kronis di Indonesia.
Co-Authors -, Harsini -, Reviono . Reviono Adhiputri, Artrien Agnes Sri Harti Agnes Sri Harti Akhmad Syaikhu Ana Rima Ana Rima Setijadi Apridasari, Jatu Apriningsih, Hendrastutik Ari Natalia Probandari Arwin Muhlishoh Atmojo, Anang Purwoko Avamira Rosita Pranoto Bambang Abdul Syukur Bhisma Murti Brian Wasita Caesaria Sarah Selleca Dhani Redhono, Dhani Jatu Aphridasari Leli Saptawati Lestari, Anggraini Dwi Maria Dewi Caetline marwoto marwoto Mellia Silvy Irdianty, Mellia Silvy Mochammad Imron Awalludin Murti, Paulus Wisnu Kuncoro Nony Puspawati Nugroho, I.G.B Indro Nurul Devi Ardiani, Nurul Devi Putranto, Wachid R, Sari Apriliana Rahajeng Putriningrum Reviono Reviono Saelan, Saelan Samuel - Santi, Nur Sebayang, Pribadi M Septiawan, Debree Sigit, Indarto Siregar, Sihsusetyaningtyas Tiominar Soetejo, FX Sri Haryati Subandrio, Subandrio SURYAWATI, BETTY Sutanto, Magdalena Sutanto, Magdalena Sutanto Wahyu Rima Agustin Wahyuningsih Safitri, Wahyuningsih Wati, Martha Ratna Widyasanti, Diana Windu Prasetya Yogie Irawan Yundari, Yundari