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All Journal Majalah Kedokteran Bandung Jurnal Kesehatan Masyarakat Nexus Kedokteran Komunitas Nexus Kedokteran Klinik Universa Medicina Indonesian Journal of Medicine Jurnal Respirologi Indonesia Jurnal Biomedika Jurnal Peduli Masyarakat Respiratory Science Cermin Dunia Kedokteran International Journal of Public Health Excellence (IJPHE) Jurnal Masyarakat Madani Indonesia Jurnal Ilmiah Pengabdian Masyarakat Bidang Kesehatan
Yusup Subagio Sutanto
Faculty of Medicine, Sebelas Maret University
Humanities Biochemistry, Genetics & Molecular Biology Computer Science & IT Dentistry Education Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Medicine & Pharmacology Nursing Public Health Social Sciences Other

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Diseminasi Produk Krenova Krim Galenik Anti Inflamasi melalui Program Kemitraan Masyarakat Agustin, Wahyu Rima; Harti, Agnes Sri; Sutanto, Yusup Subagio; Safitri, Wahyuningsih; Saelan, Saelan
Jurnal Peduli Masyarakat Vol 6 No 4 (2024): Jurnal Peduli Masyarakat: Desember 2024
Publisher : Global Health Science Group

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37287/jpm.v6i4.4426

Abstract

Prototipe sediaan krim galenik ekstrak kulit durian dan kitosan sebagai produk kesehatan krenova berbasis senyawa bioaktif alami anti inflamasi yang efektif, aman, halal dan ekonomis untuk perawatan luka kronis; berwawasan knowledge based economy, product safety dan product hygiene yang siap dihilirisasi dan dikomersialisasi secara professional, mandiri, berkelanjutan. Tingginya kasus luka kronis disebabkan paradigma yang masih ada di masyarakat maka tujuan kegiatan pengabdian masyarakat yaitu pendidikan kesehatan bagi masyarakat dan diseminasi produk krenova krim galenic anti inflamasi melalui program kemitraan masyarakat. Pelaksanaan kegiatan PKM UKH Surakarta melibatkan tim pelaksana yaitu 10 dosen dan 12 mahasiswa bersama 9 kader serta 30 orang masyarakat Posyandu Cempaka Desa Wonorejo, Gondangrejo Kabupaten Karanganyar yang mendapat respon dan antusias dari masyarakat melalui peran serta dan keterlibatan aktif sesi diskusi dan tanya jawab. Diseminasi produk krenova sediaan galenic anti inflamasi untuk perawatan luka yang dilakukan secara berkelanjutan, tuntas dan bermakna melalui program kemitraan masyarakat mendukung tercapainya target hilirisasi produk kesehatan kreova yang bermanfaat bagi masyarakat guna mendukung permasalahan terapi luka kronis khususnya Posyandu Cempaka Desa Wonorejo, Kec. Gondangrejo, Kabupaten Karanganyar.
The Agreement of Immunoglobulin Gamma Release Assay (IGRA)/ T-SPOT Tuberculosis and Tuberculin Skin Test to Detect Latent TB Infection in Diabetes Mellitus Patients Reviono, Reviono; Sutanto, Yusup Subagio; Harsini, Harsini; Saptawati, Leli; Marwoto, Marwoto; Suryawati, Betty; Redhono, Dhani; Sebayang, Pribadi M
Indonesian Journal of Medicine Vol. 6 No. 3 (2021)
Publisher : Masters Program in Public Health, Universitas Sebelas Maret, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (33.167 KB)

Abstract

Background: WHO identifies diabetes mellitus (DM) as a neglected risk factor for tuberculosis (TB). Currently, there is no gold standard test for latent TB infection (LTBI). Centers for Disease Control and Prevention (CDC) recommends using Tuberculin Skin Test (TST) and Immunoglobulin Gamma Release Assay (IGRA) to diagnose LTBI. TST is an LTBI classic diagnostic tool that has low sensitivity and specificity. But it is still preferred in diagnosing LTBI due to its lower price, and more health facilities can perform the examination compared to IGRA (T-SPOT.TB). The study aimed to measure the agreement of TST and T-SPOT.TB testing in detecting LBTI in DM and the correlation of HbA1c with TST and T-SPOT.TB.Subjects and Method: Subjects were DM patients who underwent TST and T-SPOT.TB testing. If the results of TST and T-SPOT.TB was positive, the test would be continued with Xpert MTB/RIF microbiological testing. TST used PPD RT23 2TU. T-SPOT.TB was performed toward peripheral blood mononuclear cells. The degree of agreement between TST and T-SPOT.TB testing was calculated using the Test of Agreement (Kappa Cohen). The degree of correlation between the two variables was calculated by using Pearson correlation.Results: The selected 30 study subjects with DM undergoing antidiabetic therapy showed 6 (20%) detected LTBI and 24 (80%) without LTBI using TST and T-SPOT.TB test. There was a substantial agreement level between TST and T-SPOT.TB testing in detecting LTBI among diabetes mellitus patients undergoing anti-diabetic therapy with kappa value= 0.62 (p<0.001). HbA1c increased T-SPOT (r= 0.07; p= 0.716) and TST (r= 0.11; p= 0.956).Conclusion: TST testing may substitute T-SPOT.TB to detect LTBI among diabetes patients undergoing antidiabetic therapy.Keywords: latent tuberculosis infection, diabetes mellitus, TST, Immunoglobulin Gamma Release Assay (IGRA), T-SPOT.TBCorrespondence: Reviono. Department of Pulmonology and Medical Respiratory, Faculty of Medicine, Universitas Sebelas Maret/ Dr. Moewardi Hospital, Surakarta, Indonesia. Email: reviono@staff.uns.ac.id.Indonesian Journal of Medicine (2021), 06(03): 298-306https://doi.­org/10.26911­/theijmed.2021.06.03.07
The Impact of the COVID-19 Pandemic on the Resistance Level of Mycobacterium Tuberculosis in Suspected Tuberculosis Patients at the Surakarta Central General Hospital Sutanto, Yusup Subagio; Sutanto, Magdalena; Harti, Agnes Sri
Indonesian Journal of Medicine Vol. 7 No. 1 (2022)
Publisher : Masters Program in Public Health, Universitas Sebelas Maret, Indonesia

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Abstract

Background: Analysis of the impact of the Covid-19 pandemic on the resistance level of Mycobacterium tuberculosis (MTb) isolates to Anti Tuberculosis Drugs (ATD) needs to be carried out considering the level of MTB resistance is an important factor in the occurrence of Multidrug-Resistant TB (MDR-TB) in Indonesia. The purpose of the study was to analyze the impact of the Covid-19 pandemic on the level of resistance of MTb isolates of patients with suspected TB in Surakarta.Subjects and Method: This research is a quantitative descriptive study with a retrospective Cohort based on the medical record data of suspected TB patients  at Surakarta Central General Hospital in 2020 – 2021. The sampling technique was random sampling with a total of 200 samples each year. Data analysis used the SPSS 21 program.Results: Characteristics of respondents with suspected TB patients who visited the Surakarta Central General Hospital in 2020 and 2021, mostly in men and occurring in productive ages 36-55 years. The most effective type of ATD against MTb isolates is Rifampicin with a mean rank of 6.00 and a p=0.035. While Ethambutol is ineffective as an ATD with a mean rank of 58.00 and a p<0.001. The results of the Wilcoxon test analysis showed  there was a significant difference in the level of resistance or sensitivity of MTb isolates in 2020 and 2021 with a p-value=0.000.Conclusion: There is a significant effect of the impact of the Covid-19 pandemic on the level of resistance or sensitivity of MTb isolates of patients with suspected TB in the Surakarta area in 2020 and 2021.Keywords: pandemic, Covid-19, resistance, MTb isolates, ATDCorrespondence: Yusup Subagio Sutanto. Department of Pulmonology and Respiratory Medicine, Faculty of Medicine, Universitas Sebelas Maret. Jl. Ir. Sutami 36A, Surakarta 57126, Central Java, Indonesia. Email: yusupsubagiosutanto@gmail.com. Mobile: +62811284165.Indonesian Journal of Medicine (2022), 07(01): 28-38https://doi.org/10.26911/theijmed.2022.07.01.04
Edukasi Kesehatan dan Implementasi Produk Krenova Krim Galenik Untuk Perawatan Luka Melalui Optimalisasi Pemberdayaan Kemitraan Masyarakat Harti, Agnes Sri; Syukur, Bambang Abdul; Sutanto, Yusup Subagio; Puspawati, Nony
Jurnal Masyarakat Madani Indonesia Vol. 4 No. 3 (2025): Agustus
Publisher : Alesha Media Digital

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59025/5m5ga075

Abstract

Penerapan hasil riset civitas akademika Universitas Kusuma Husada Surakarta terkait eksplorasi potensi bahan alam dan pengembangn teknologi formulasi sediaan galenik berbasis bahan alam perlu dioptimalkan untuk menunjang efektivitas terapi perawatan luka. Produk krenova krim galenik untuk perawatan luka berbasi seromukoid bekicot 1%, ekstrak kulit durian 1% dan kitosan 1%, telah terdaftar Paten Sederhana No. S00202214385 dan No. S00202010479. Tingginya kasus luka kronis disebabkan paradigma yang masih ada di masyarakat khususnya di Posyandu RW 16 Ceplukan, Desa Wonorejo, memberikan gambaran perlunya dilakukan edukasi kesehatan bagi masyarakat terkait permasalahan perawatan luka. Tujuan kegiatan melakukan edukasi kesehatan dan implementasi produk krenova untuk perawatan luka berbasis knowledge based economy, healthy and safety product melalui optimalisasi pemberdayaan kemitraan masyarakat. Metode pelaksanaan berupa edukasi kesehatan menggunakan leaflet, diskusi dan tanya jawab serta evaluasi kegiatan melalui pre dan post kuisioner tentang perawatan luka terhadap 30 peserta. Hasil kegiatan menunjukkan adanya peningkatan pengetahuan terhadap materi manajemen perawatan luka yaitu peserta memiliki pengetahuan baik pre test 5 peserta (16,7%) dan post test 21 peserta (70). Implementasi esensi dan kebermanfaatan hasil riset yaitu terjalinnya kolaborasi kemitraan link and match dengan stake holder, DUDI dan masyarakat guna mendukung suksesnya program Pemerintah untuk menunjang efektivitas terapi perawatan luka kronis.
Effects of Hypnotherapy on Pain Scale, Interleukin-6 Levels, and Quality of Life in Lung Cancer Patients Who Experience Cancer Pain Widyasanti, Diana; Sutanto, Yusup Subagio; Septiawan, Debree; Aphridasari, Jatu; Reviono, Reviono
Jurnal Respirologi Indonesia Vol 45 No 3 (2025)
Publisher : Perhimpunan Dokter Paru Indonesia (PDPI)/The Indonesian Society of Respirology (ISR)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36497/jri.v45i3.624

Abstract

Background: Pain is a common symptom in lung cancer patients and can affect their quality of life. Interleukin 6 (IL-6) plays a role in malignant cell proliferation and differentiation as well as the initiation and persistence of cancer pain. Hypnosis can reduce pain by reducing anxiety through relaxation and/or directly affecting neurophysiological activity that underlies the subjective experience of pain. This study aimed to evaluate hypnotherapy as a non-pharmacological method for managing cancer pain. Methods: Clinical trial of 30 subjects with quasi-experimental pre-test and post-test in treatment and control groups of lung cancer patients of NSCLC and SCLC stage III and IV who experienced cancer pain with pain scale ≥3 at RSUD Dr. Moewardi Surakarta in June to August 2023 with a consecutive sampling method. The treatment group received hypnotherapy intervention for 4 weeks. Subjects were assessed for pain scale, interleukin-6 levels, and FACT-L quality of life questionnaire. Results: A 4-week hypnotherapy intervention can significantly reduce the pain scale (P=0.0001) and improve the quality-of-life FACT-L (P=0.002) in lung cancer patients experiencing cancer pain. Hypnotherapy also significantly reduced IL-6 in the treatment group (P=0.008), but when compared with the control, the results were not significant (P=0.345). Conclusion: Hypnotherapy may reduce the pain scale and improve the quality of life of lung cancer patients who experience cancer pain, but does not significantly lower IL-6 levels.
The Effect of Magnesium Citrate on %FEV1, %PEFR, and Asthma Control Test Score in Patients with Controlled Asthma and Uncontrolled Asthma Atmojo, Anang Purwoko; Sutanto, Yusup Subagio; Adhiputri, Artrien; Reviono, Reviono; Setijadi, Ana Rima
Jurnal Respirologi Indonesia Vol 45 No 3 (2025)
Publisher : Perhimpunan Dokter Paru Indonesia (PDPI)/The Indonesian Society of Respirology (ISR)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36497/jri.v45i3.503

Abstract

Background: Asthma is one of the most common non-communicable diseases in the world and affected an estimated 262 million people in 2019. Magnesium is one of the nutrients known to improve lung function in asthma by inhibiting the production of proinflammatory cytokines, exhibiting anti-inflammatory benefits, and having beneficial muscle-relaxing and bronchodilatation effects. Measurement of percent predicted forced expiratory volume in 1 second (%FEV1), percent predicted peak expiratory flow rate (%PEFR), and asthma control test (ACT) score is are indicator of lung function. Magnesium citrate may be used as an adjunct therapy in patients with controlled and uncontrolled asthma. Methods: Clinical trial research with quasi quasi-experimental method using a pre-test and post-test design. The study subjects were 34 controlled and uncontrolled asthma patients at the outpatient clinic of Universitas Sebelas Maret Hospital and dr. Soehadi Prijonegoro Hospital in February - March 2023, using consecutive sampling. The control group (n=17) received standard therapy, while the treatment group (n=17) received standard therapy plus 300 mg magnesium citrate for 42 days. Serum magnesium level, %FEV1, %PEFR, and ACT score were measured at enrollment and on the forty-third day of treatment. Results: There were significant differences between the treatment group compared to the control group in increasing %PEFR (P=0.001), increasing ACT score (P=0.011), and increasing %FEV1 (P=0.071). Conclusion: Administration of magnesium citrate to patients with controlled and uncontrolled asthma can increase levels of %PEFR, ACT score, and %FEV1.
The Dissemination of Synbiotic Tempe Extract Krenova Soygurt Products as Functional Drinks for Stunting Prevention through Community Partnership Programs Harti, Agnes Sri; Irdianty, Mellia Silvy; Ardiani, Nurul Devi; Syukur, Bambang Abdul; Sutanto, Yusup Subagio
Jurnal Ilmiah Pengabdian Masyarakat Bidang Kesehatan (Abdigermas) Vol. 2 No. 3 (2024): Jurnal Ilmiah Pengabdian Kepada Masyarakat Bidang Kesehatan (Abdigermas)
Publisher : CV Media Inti Teknologi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58723/abdigermas.v2i3.309

Abstract

This activity aimed to educate the public about Synbiotic Tempe Extract Krenova Soygurt Products as Functional Drinks for Stunting Prevention. The implementation of activities as community service in the form of health education and counseling on stunting prevention involved 10 lecturers, 12 students along with 9 cadres and 30 people from the Cempaka Integrated Health Post, Wonorejo Village, Gondangrejo, Karanganyar Regency. The social community activity was carried out on August 26, 2024, and the community received a response and enthusiasm through active participation and involvement in the discussion and question and answer sessions. The essence of the implementation and dissemination of the benefits of synbiotic soygurt tempeh can function as a functional drink based on science and technology, halal and economical through a community partnership program carried out sustainably, completely, and meaningfully at the Cempaka Integrated Health Post, Wonorejo Village, Gondangrejo District, Karanganyar Regency to achieve the target of down streaming Kreova health products that are beneficial to the community and support the success of the Government's program in overcoming and reducing the incidence of stunting in Indonesia.
The Effectiveness of Anti-Inflammatory Cream Galenic Preparations Based on Snail Seromucoid, Durian Peel Extract Polysaccharides and Chitosan in the Wound Healing Process (In Vivo) Harti, Agnes Sri; Sutanto, Yusup Subagio; Agustin, Wahyu Rima; Putriningrum, Rahajeng; Irdianty, Mellia Silvy; Saelan, Saelan; Ardiani, Nurul Devi
International Journal of Public Health Excellence (IJPHE) Vol. 3 No. 2 (2024): January-May
Publisher : PT Inovasi Pratama Internasional

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55299/ijphe.v3i2.876

Abstract

Development of galenic preparation formulations that can be used to make anti-inflammatory cream preparations. Snail seromucoid contains glycoproteins, mannose carbohydrates, glucose, N-acetyl muramic acid and the α-1 globulin-oromucoid fraction which functions as a bioimmunostimulator. Durian peel (Durio zibethinus L.) contains a polar polysaccharide polymer compound such as D-galacturonic acid which has anti-microbial properties. Chitosan is a polymer compound resulting from derivatization of chitin which has antimicrobial polycationic properties; biodegradable, and biocompatible with animal body tissue. The aim of the research was to examine the effectiveness of a galenic anti-inflammatory cream preparation based on snail seromucoid, durian skin extract, and chitosan for healing acute and chronic wounds in vivo. The research method is experimental research, namely the effectiveness of anti-inflammatory galenic cream preparations made from snail seromucoid, durian peel extract and chitosan on various types of wounds in vivo. Analysis of observation data using the one way anova test. A galenic preparation based on a combination of 2% snail seromucoid, 2% durian peel extract polysaccharide and 2% chitosan ratio 1:1:1 is effective in the healing process based on the formation of granulation tissue thickness in incision injuries, hot objects injuries, second degree burns and ulcers. diabetes. The bioformulation galenic preparation of 2% snail seromucoid, 2% polysaccharide of durian peel extract; 2% chitosan and their combination with ratio 1:1:1 is effective as an anti-inflammatory galenic cream preparation so that it can be applied for healing chronic wounds, acute wounds and diabetic ulcers.
Synbiotic Soygurt Tempe Extract as A Functional Beverage Harti, Agnes Sri; Irdianty, Mellia Silvy; Muhlishoh, Arwin; Sutanto, Yusup Subagio
International Journal of Public Health Excellence (IJPHE) Vol. 4 No. 1 (2024): June-December
Publisher : PT Inovasi Pratama Internasional

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55299/ijphe.v4i1.1124

Abstract

Synbiotic tempeh extract soyghurt is a Krenova (creative and innovative) food product because it is novelty and unique as healthy and safe food, functional food, fun for diet and one for all. The result of probiotic fermentation of Lactic Acid Bacteria (LAB) and based on synbiotic tempeh extract (rice bran and chitosan) which has multifunctional anti-hyperglycemia and anti-hypercholesterolemia properties. Research objective: to analyze the effectiveness of synbiotic tempeh soyghurt as a functional drink. The research method analyzes the nutritional content and quality of synbiotic tempeh soygurt products which refer to SNI 7552:2009 concerning flavored fermented milk. Data analysis used bivariate and multivariate Anova tests. The Hedonic test results showed a semi-solid texture, white color, synbiotic tempeh extract aroma, sour taste in the formulation with the addition of 15% skim milk, 1% chitosan, 1:1 ratio LAB starter mix and 5% inoculum. The results of physical chemical and mycobiological quality tests show that the synbiotic tempeh extract meets the quality test as a functional drink.
Carcinoembryonic Antigen (CEA) and Cancer Antigen 125 (CA-125) as Diagnostic Biomarkers for Malignant Pleural Effusion Harsini, Harsini; Kurniawan, Yoseph Dwi; Sutanto, Yusup Subagio
Respiratory Science Vol. 4 No. 3 (2024): Respiratory Science
Publisher : Indonesian Society of Respirology (ISR)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36497/respirsci.v4i3.142

Abstract

Background: The etiology of pleural effusion is very important in malignant pleural effusion management and prognosis. Pleural fluid cytology examination is a simple diagnostic tool and has been widely used to differentiate the etiology of pleural fluid with high specificity albeit its relatively low sensitivity. The use of tumor markers for malignant pleural effusion in Indonesia is still sparse. This study was intended to determine the sensitivity and specificity of CEA and CA-125 examinations in diagnosing malignant pleural effusion. Method: This was an observational analytic study with a cross-sectional approach to find the diagnostic value of CA-125 and CEA of pleural fluid in malignant pleural effusion. Subjects were patients with suspicion of malignant pleural effusion who underwent treatment in the emergency room, polyclinic, and inpatient ward at RSDM from October - November 2022. Results: CEA value with a cutoff of ≥32.00 had a sensitivity of 83.3%; specificity of 87.8%; PPV of 90.9%; NPV of 77.8% with an accuracy of 85.0% (P=0.001), a CA-125 value with a cutoff of >152.40 had a sensitivity of 83.3%; specificity 81.3%; PPV 87.0%; NPV 76.5%; with an accuracy of 82.5% (P=0.001). An increase in CEA and CA-125 signified a significant risk of malignant pleural effusion (P<0.05). Patients with increased CEA and CA-125 had 105 times the risk of developing malignant pleural effusion. Conclusion: CEA ≥32.00 and CA-125 >152.40 are potential biomarkers to predict malignant pleural effusion with CEA having better specificity than CA-125.
Co-Authors -, Harsini -, Reviono . Reviono Adhiputri, Artrien Agnes Sri Harti Agnes Sri Harti Akhmad Syaikhu Ana Rima Ana Rima Setijadi Apridasari, Jatu Apriningsih, Hendrastutik Ari Natalia Probandari Arwin Muhlishoh Atmojo, Anang Purwoko Avamira Rosita Pranoto Bambang Abdul Syukur Bhisma Murti Brian Wasita Caesaria Sarah Selleca Dhani Redhono, Dhani Harsini , Harsini Harsini Harsini Jatu Aphridasari Kurniawan, Yoseph Dwi Leli Saptawati Lestari, Anggraini Dwi Liana Herlina Maria Dewi Caetline marwoto marwoto Mellia Silvy Irdianty, Mellia Silvy Mochammad Imron Awalludin Murti, Paulus Wisnu Kuncoro Nony Puspawati Nugroho, I.G.B Indro Nurul Devi Ardiani, Nurul Devi Putranto, Wachid R, Sari Apriliana Rahajeng Putriningrum Raharjo, A. Farih Reviono Reviono Saelan, Saelan Samuel - Santi, Nur Sebayang, Pribadi M Septiawan, Debree Sibarani, Lia Priscilia Sigit, Indarto Siregar, Sihsusetyaningtyas Tiominar Soetejo, FX Sri Haryati Subandrio, Subandrio SURYAWATI, BETTY Sutanto, Magdalena Sutanto, Magdalena Sutanto Wahyu Rima Agustin Wahyuningsih Safitri, Wahyuningsih Wati, Martha Ratna Widyasanti, Diana Windu Prasetya Yogie Irawan Yundari, Yundari